Bacteriophage display and discovery of peptide leads for drug development

Annual Review of Biophysics and Biomolecular Structure

Volumn 26, Issue , 1997, Pages 401-424

  Lowman, H B ^a  

^a GENENTECH INC   (United States)

Author keywords

Combinatorial library; Drug design; Molecular mimicry; Mutagenesis; Structural biology

Indexed keywords

LIGAND; PEPTIDE; RECEPTOR;

AMINO ACID SEQUENCE; BACTERIOPHAGE; CLONING VECTOR; DRUG DESIGN; DRUG SYNTHESIS; GENETIC ENGINEERING; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW;

AMINO ACID SEQUENCE; BACTERIOPHAGES; DRUG DESIGN; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY;

EID: 0030976150     PISSN: 10568700     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.biophys.26.1.401     Document Type: Review

References (70)

1. Adey NB, Mataragnon AH, Rider JE, Carter JM, Kay BK. 1995. Characterization of phage that bind plastic from phage-displayed random peptide libraries. Gene 156:27-31
2. Barrett RW, Cwirla SE, Ackerman MS, Olson AM, Peters EA, Dower WJ. 1992. Selective enrichment and characterization of high-affinity ligands from collections of random peptides on filamentous phage. Anal. Biochem. 204:357-64
3. Barry MA, Dower WJ, Johnston SA. 1996. Toward cell-targeting gene therapy vectors: selection of cell-binding peptides from random peptide-presenting phage libraries. Nature Med. 2:299-305
4. Bass S, Greene R, Wells JA. 1990. Hormone phage: An enrichment method for variant proteins with altered binding properties. Proteins 8:309-14
5. Bass SH, Mulkerrin MG, Wells JA. 1991. A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor. Proc. Natl. Acad. Sci. USA 88:4498-502
6. Braisted AC, Wells JA. 1996. Minimizing a binding domain from protein A. Proc. Natl. Acad. Sci. USA 93:5688-92
7. Clackson T, Wells JA. 1994. In vitro selection from protein and peptide libraries. Trends Biotechnol. 12:173-84
8. Cull MG, Miller JF, Schatz PJ. 1992. Screening for receptor ligands using large libraries of peptides linked to the C terminus of the lac repressor. Proc. Natl. Acad. Sci. USA 89:1865-69
9. Cunningham BC, Lowe DG, Li B, Bennett BD, Wells JA. 1994. Production of an atrial natriuretic peptide variant that is specific for type A receptor. EMBO J. 13:2508-15
10. Cunningham BC, Ultsch M, de Vos AM, Mulkerrin MG, Clauser KR, Wells JA. 1991. Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule. Science 254:821-25
11. Cwirla SE, Peters EA, Barrett RW, Dower WJ. 1990. Peptides on phage: a vast library of peptides for identifying ligands. Proc. Natl. Acad. Sci. USA 87:6378-82
12. Devlin JJ, Panganiban LC, Devlin PE. 1990. Random peptide libraries: a source of specific protein binding molecules. Science 249:404-6
13. deVos AM, Ultsch M, Kossiakoff AA. 1992. Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 255:306-12
14. Ding L, Coombs GS, Strandberg L, Navre M, Corey DR, Madison EL. 1995. Origins of the specificity of tissue-type plasminogen activator. Proc. Natl. Acad. Sci. USA 92:7627-31
15. Doorbar J, Winter G. 1994. Isolation of a peptide antagonist to the thrombin receptor using phage display. J. Mol. Biol. 244:361-69
16. Dyson MR, Germaschewski V, Murray K. 1995. Direct measurement via phage titer of the dissociation constants in solution of fusion phage-substrate complexes. Nucleic Acids Res. 23:1531-35
17. Felici F, Castagnoli L, Musacchio A, Jappelli R, Cesareni G. 1991. Selection of antibody ligands from a large library of oligopeptides expressed on a multivalent exposition vector. J. Mol. Biol. 222:301-10
18. Geysen HM, Rodda SJ, Mason TJ. 1986. A priori delineation of a peptide which mimics a discontinuous antigenic determinant. Mol. Immunol. 23:709-15
19. Geysen HM, Rodda SJ, Mason TJ, Tribbick G, Schoofs PG. 1987. Strategies for epitope analysis using peptide synthesis. J. Immunol. Methods 102:259-74
20. Giebel LB, Cass RT, Milligan DL, Young DC, Arze R, Johnson CR. 1995. Screening of cyclic peptide phage libraries identifies ligands that bind streptavidin with high affinities. Biochemistry 34:15430-35
21. Glucksman MJ, Bhattacharjee S, Makowski L. 1992. Three-dimensional structure of a cloning vector. J. Mol. Biol. 226:455-70
22. Goodson RJ, Doyle MV, Kaufman SE. Rosenberg S. 1994. High-affinity urokinase receptor antagonists identified with bacteriophage peptide display. Proc. Natl. Acad. Sci. USA 91:7129-33
23. Greenwood J, Willis AE, Perham RN. 1991. Multiple display of foreign peptides on filamentous bacteriophage. J. Mol. Biol. 220:821-27
24. Hawkins RE, Russell SJ, Winter G. 1992. Selection of phage antibodies by binding affinity. J. Mol. Biol. 226:889-96
25. Iannolo G, Minenkova O, Petruzzelli R, Cesareni G. 1995. Modifying the filamentous phage capsid: limits in the size of the major capsid protein. J. Mol. Biol. 248:835-44
26. Il'ichev AA, Minenkova OO, Tat'kov SI, Karpyshev NN, Eroshkin AM, et al. 1989. Production of a viable variant of the M13 phage with a foreign peptide inserted into the basic coat protein. Dokl. Akad. Nauk SSSR 307:481-83
27. Katz BA. 1995. Binding to protein targets of peptidic leads discovered by phage display: crystal structures of streptavidin-bound linear and cyclic peptide ligands containing the HPQ sequence. Biochemistry 34:15421-29
28. Kay BK, Adey NB, He YS, Manfredi JP, Mataragnon AH, Fowlkes DM. 1993. An M13 phage library displaying random 38-amino-acid peptides as a source of novel sequences with affinity to selected targets. Gene 128:59-65
29. Kishchenko G, Batliwala H, Makowski L. 1994. Structure of a foreign peptide displayed on the surface of bacteriophage M13. J. Mol. Biol. 241:208-13
30. Koivunen E, Wang BC, Ruoslahti E. 1994. Isolation of a highly specific ligand for the alpha(5) beta(1) integrin from a phage display library. J. Cell Biol. 124:373-80
31. Ladner RC. 1995. Constrained peptides as binding entities. Trends Biotechnol. 13:426-30
32. Li B, Tom JYK, Oare D, Yen R, Fairbrother WJ, et al. 1995. Minimization of a polypeptide hormone. Science 270:1657-60
33. Liu G, Bryant RT, Hilderman RH. 1996. Isolation of a tripeptide from a random phage peptide library that inhibits P1, P4-diadenosine 5′-tetraphosphate binding to its receptor, Biochemistry 35:197-201
34. Livnah O, Stura EA, Johnson DL, Middleton SA, Mulcahy LS, et al. 1996. Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8. Science 273:464-71
35. Lowman HB. 1997. Phage display of peptides on protein scaffolds. In Methods in Molecular Biology: Combinatorial Peptide Chemistry, ed. C. Shmuel. Totowa, NJ: Humana. In press
36. Lowman HB, Bass SH, Simpson N, Wells JA. 1991. Selecting high-affinity binding proteins by monovalent phage display. Biochemistry 30:10832-38
37. Lowman HB, Wells JA. 1991. Monovalent phage display: a method for selecting variant proteins from random libraries. Methods Comp. Methods Enzymol. 3:205-16
38. Martens CL, Cwirla SE, Lee RY, Whitehorn E, Chen EY, et al. 1995. Peptides which bind to E-selectin and block neutrophil adhesion. J. Biol. Chem. 270:21129-36
39. Matthews DJ, Wells JA. 1993. Substrate phage: selection of protease substrates by monovalent phage display. Science 260:1113-17
40. Matthews DJ, Goodman LJ, Gorman CM, Wells JA. 1994. A survey of furin substrate specificity using substrate phage display. Prot. Sci. 3:1197-1205
41. McDowell RS, Blackburn BK, Gadek TR, McGee LR, Rawson T, et al. 1994. From peptide to non-peptide: 2. The de novo design of potent, non-peptidal inhibitors of platelet aggregation based on a benzodiazepinedione scaffold. J. Am. Chem. Soc. 116:5077-83
42. McLafferty MA, Kent RB, Ladner RC, Markland W. 1993. M13 bacteriophage displaying disulfide-constrained microproteins. Gene 128:29-36
43. Nambudripad R, Stark W, Makowski L. 1991. Neutron diffraction studies of the structure of filamentous bacteriophage Pf1. J. Mol. Biol. 220:359-79
44. Oldenburg KR, Loganathan D, Goldstein IJ, Schultz PG, Gallop MA. 1992. Peptide ligands for a sugar-binding protein isolated from a random peptide library. Proc. Natl. Acad. Sci. USA 89:5393-97
45. O'Neil KT, Hoess RH, Jackson SA, Ramachandran NS, Mousa SA, DeGrado WF. 1992. Identification of novel peptide antagonists for GPIIb/IIIa from a conformationally constrained phage peptide library. Proteins 14:509-15
46. Parmley SF, Smith GP. 1988. Antibody-selectable filamentous fd phage vectors: affinity purification of target genes. Gene 73:305-18
47. Pasqualini R, Ruoslahti E. 1996. Organ targeting in vivo using phage display peptide libraries. Nature 380:364-66
48. Rasched I, Oberer E. 1986. Ff coliphages: structural and functional relationships. Microbiol. Rev. 50:401-27
49. Rickles RJ, Botfield MC, Weng Z, Taylor JA, Green OM, et al. 1994. Identification of Src, Fyn, Lyn, PI3K and Abl SH3 domain ligands using phage display libraries. EMBO J. 13:5598-604
50. Rickles RJ, Botfield MC, Zhou XM, Henry PA, Brugge JS, Zoller MJ. 1995. Phage display selection of ligand residues important for Src homology 3 domain binding. Proc. Natl. Acad. Sci. USA 92:10909-13
51. Roberts D, Guegler K, Winter J. 1993. Antibody as a surrogate receptor in the screening of a phage display library. Gene 128:67-69
52. Russell M. 1991. Filamentous phage assembly. Mol. Microbiol. 5:1607-13
53. Schatz PJ. 1993. Use of peptide libraries to map the substrate specificity of a peptide-modifying enzyme, a 13 residue consensus peptide specifies biotinylation in Escherichia coli. Bio/Technol. 11:1138-43
54. Schumacher TNM, Mayr LM, Minor DL Jr, Milhollen MA, Burgess MW, Kim PS. 1996. Identification of D-peptide ligands through mirror-image phage display. Science 271:1854-57
55. Scott JK. 1992. Discovering peptide ligands using epitope libraries. Trends Biochem. Sci. 17:241-45
56. Scott JK, Loganathan D, Easley RB, Gong X, Goldstein IJ. 1992. A family of concanavalin A-binding peptides from a hexapeptide epitope library. Proc. Natl. Acad. Sci. USA 89:5398-402
57. Scott JK, Smith GP. 1990. Searching for peptide ligands with an epitope library. Science 249:386-90
58. Smith GP. 1985. Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. Science 228:1315-17
59. Smith GP, Schultz DA, Ladbury JE. 1993. A ribonuclease S-peptide antagonist discovered with a bacteriophage display library. Gene 128:37-42
60. Smith MM, Shi L, Navre M. 1995. Rapid identification of highly active and selective substrates for stromelysin and matrilysin using bacteriophage peptide display libraries. J. Biol. Chem. 270:6440-49
61. South V, Searfoss GH, French S, Cheadle C, Murray E, et al. 1995. Identification of novel peptide antagonists for von Willebrand factor binding to the platelet glycoprotein Ib receptor from a phage epitope library. Thromb. Haemost. 73:144-50
62. Sparks AB, Adey NB, Quilliam LA, Thorn JM, Kay BK. 1995. Screening phage-displayed random peptide libraries for SH3 ligands. Methods Enzymol. 255:498-509
63. Sparks AB, Quilliam LA, Thorn JM, Der CJ, Kay BK. 1994. Identification and characterization of Src SH3 ligands from phage- displayed random peptide libraries. J. Biol. Chem. 269:23853-56
64. van Wezenbeek P, Schoenmakers JGG. 1979. Nucleotide sequence of the genes III, VI and I of bacteriophage M13. Nucl. Acids Res. 6:2799-818
65. Vierra J, Messing J. 1987. Production of single-stranded plasmid DNA. Methods Enzymol. 153:3-11
66. Weber PC, Pantoliano MW, Thompson LD. 1992. Crystal structure and ligand-binding studies of a screened peptide complexed with streptavidin. Biochemistry 31:9350-54
67. Wood SP, Tickle IJ, Treharne AM, Pitts JE, Mascarenhas Y, et al. 1986. Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding. Science 232:633-36
68. Wrighton NC, Farrell FX, Chang R, Kashyap AK, Barbone FP, et al. 1996. Small peptides as potent mimetics of the protein hormone erythropoietin. Science 273:458-63
69. Yanofsky SD, Baldwin DN, Butler JH, Holden FR, Jacobs JW, et al. 1996. High affinity type I interleukin 1 receptor antagonists discovered by screening recombinant peptide libraries. Proc. Natl. Acad. Sci. USA 93:7381-86
70. Zhang R, Snyder GH. 1991. Factors governing selective formation of specific disulfides in synthetic variants of a-conotoxin. Biochemistry 30:11343-48