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Volumn 8, Issue 4, 1997, Pages 435-441

Therapeutic peptides and peptidomimetics

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE; PEPTIDOMIMETIC AGENT; UNCLASSIFIED DRUG;

EID: 0030752336     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0958-1669(97)80065-1     Document Type: Article
Times cited : (87)

References (56)
  • 2
    • 0029557112 scopus 로고
    • The chemistry of peroxovanadium compounds relevant to insulin mimesis
    • Shaver A, Ng JB, Hall DA, Posner BI: The chemistry of peroxovanadium compounds relevant to insulin mimesis. Mol Cell Biochem 1995, 153:5-15.
    • (1995) Mol Cell Biochem , vol.153 , pp. 5-15
    • Shaver, A.1    Ng, J.B.2    Hall, D.A.3    Posner, B.I.4
  • 3
    • 0029798402 scopus 로고    scopus 로고
    • Functional mimicry of a protein hormone by a peptide agonist: The EPO receptor complex at 2.8Ȧ
    • Livnah O, Stura EA, Johnson DL, Middleton SA, Mulcahy LS, Wrighton NC, Dower WJ, Jolliffe LK, Wilson IA: Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8Ȧ. Science 1996, 273:464-471. This paper provides the first structural example of functional mimicry of a hormone by a cyclic peptide.
    • (1996) Science , vol.273 , pp. 464-471
    • Livnah, O.1    Stura, E.A.2    Johnson, D.L.3    Middleton, S.A.4    Mulcahy, L.S.5    Wrighton, N.C.6    Dower, W.J.7    Jolliffe, L.K.8    Wilson, I.A.9
  • 4
    • 0030040580 scopus 로고    scopus 로고
    • Crystallographic determination of the structures of human alpha-thrombin complexed with BMS-186282 and BMS-189090
    • Malley MF, Tabernero L, Chang CY, Ohringer SL, Roberts DG, Das J, Sack JS: Crystallographic determination of the structures of human alpha-thrombin complexed with BMS-186282 and BMS-189090. Protein Sci 1996, 5:221-228.
    • (1996) Protein Sci , vol.5 , pp. 221-228
    • Malley, M.F.1    Tabernero, L.2    Chang, C.Y.3    Ohringer, S.L.4    Roberts, D.G.5    Das, J.6    Sack, J.S.7
  • 5
    • 0028884260 scopus 로고
    • A paradigm for drug discovery using a conformation from the crystal structure of a presentation scaffold
    • Zhao B, Helms LR, DesJarlais RL, Abdel MS, Wetzel R: A paradigm for drug discovery using a conformation from the crystal structure of a presentation scaffold. Nat Struct Biol 1995, 2:1131-1137.
    • (1995) Nat Struct Biol , vol.2 , pp. 1131-1137
    • Zhao, B.1    Helms, L.R.2    DesJarlais, R.L.3    Abdel, M.S.4    Wetzel, R.5
  • 6
    • 0030068041 scopus 로고    scopus 로고
    • Single chain human interleukin 5 and its asymmetric mutagenesis for mapping receptor binding sites
    • Li J, Cook R, Dede K, Chaiken I: Single chain human interleukin 5 and its asymmetric mutagenesis for mapping receptor binding sites. J Biol Chem 1996, 271:1817-1820.
    • (1996) J Biol Chem , vol.271 , pp. 1817-1820
    • Li, J.1    Cook, R.2    Dede, K.3    Chaiken, I.4
  • 8
    • 15844372436 scopus 로고    scopus 로고
    • Synthesis of potent cyclic hexapeptide NK-1 antagonists. Use of a minilibrary in transforming a peptidal somatostatin receptor ligand into an NK-1 receptor ligand via a polyvalent peptidomimetic
    • Hirschmann R, Yao W, Cascieri MA, Strader CD, Maechler L, Cichy-Knight MA, Hynes J Jr, van Rijn RD, Sprengler PA, Smith AB III: Synthesis of potent cyclic hexapeptide NK-1 antagonists. Use of a minilibrary in transforming a peptidal somatostatin receptor ligand into an NK-1 receptor ligand via a polyvalent peptidomimetic. J Med Chem 1996, 39:2441-2448. This paper emphasizes a minilibrary/design strategy to develop the first potent, selective cyclic hexapeptide ligand for the NK-1 receptor.
    • (1996) J Med Chem , vol.39 , pp. 2441-2448
    • Hirschmann, R.1    Yao, W.2    Cascieri, M.A.3    Strader, C.D.4    Maechler, L.5    Cichy-Knight, M.A.6    Hynes J., Jr.7    Van Rijn, R.D.8    Sprengler, P.A.9    Smith A.B. III10
  • 9
    • 0030060179 scopus 로고    scopus 로고
    • Selection of a peptide with affinity for the tumor-associated TAG72 antigen from a phage-displayed library
    • Gui J, Moyana T, Xiang J: Selection of a peptide with affinity for the tumor-associated TAG72 antigen from a phage-displayed library. Biochem Biophys Res Commun 1996, 218:414-419.
    • (1996) Biochem Biophys Res Commun , vol.218 , pp. 414-419
    • Gui, J.1    Moyana, T.2    Xiang, J.3
  • 10
    • 0028945599 scopus 로고
    • The 'peptoid' approach to the design of non-peptide, small molecule agonists and antagonists of neuropeptides
    • Horwell DC: The 'peptoid' approach to the design of non-peptide, small molecule agonists and antagonists of neuropeptides. Trends Biotechnol 1995, 13:132-134.
    • (1995) Trends Biotechnol , vol.13 , pp. 132-134
    • Horwell, D.C.1
  • 11
    • 0028915475 scopus 로고
    • Identifying small-molecule lead compounds: The screening approach to drug discovery
    • Bevan P, Ryder H, Shaw I: Identifying small-molecule lead compounds: the screening approach to drug discovery. Trends Biotechnol 1995, 13:115-121.
    • (1995) Trends Biotechnol , vol.13 , pp. 115-121
    • Bevan, P.1    Ryder, H.2    Shaw, I.3
  • 12
    • 0029021159 scopus 로고
    • New approaches and technologies in drug design and discovery
    • Kleinberg ML, Wanke LA: New approaches and technologies in drug design and discovery. Am J Health Syst Pharm 1995, 52:1323-1336.
    • (1995) Am J Health Syst Pharm , vol.52 , pp. 1323-1336
    • Kleinberg, M.L.1    Wanke, L.A.2
  • 13
    • 0029944347 scopus 로고    scopus 로고
    • Macromolecular versus small-molecule therapeutics: Drug discovery, development and clinical considerations
    • Cho MJ, Juliano R: Macromolecular versus small-molecule therapeutics: drug discovery, development and clinical considerations. Trends Biotechnol 1996, 14:153-158. A good general review paper on small molecule development, emphasizing clinical concepts in the process.
    • (1996) Trends Biotechnol , vol.14 , pp. 153-158
    • Cho, M.J.1    Juliano, R.2
  • 14
    • 0029950789 scopus 로고    scopus 로고
    • A solution-phase strategy for the synthesis of chemical libraries containing small organic molecules: A universal and dipeptide mimetic template
    • Cheng S, Tarby CM, Comer DD, Williams JP, Caporale LH, Myers PL, Boger DL: A solution-phase strategy for the synthesis of chemical libraries containing small organic molecules: a universal and dipeptide mimetic template. Bioorgan Med Chem 1996, 4:727-737. A general approach to the solution phase, parallel synthesis of chemical libraries, exemplifying both a universal and dipeptide mimetic template.
    • (1996) Bioorgan Med Chem , vol.4 , pp. 727-737
    • Cheng, S.1    Tarby, C.M.2    Comer, D.D.3    Williams, J.P.4    Caporale, L.H.5    Myers, P.L.6    Boger, D.L.7
  • 15
    • 0038089976 scopus 로고    scopus 로고
    • Selection of chymotrypsin inhibitors from a conformationally-constrained combinatorial peptide library
    • McBride JD, Freeman N, Domingo GJ, Leatherbarrow RJ: Selection of chymotrypsin inhibitors from a conformationally-constrained combinatorial peptide library. J Mol Biol 1996, 259:819-827. This paper shows that directed randomization of a canonical protein-derived loop region is a powerful way of generating proteinase inhibitors with targeted specifities.
    • (1996) J Mol Biol , vol.259 , pp. 819-827
    • McBride, J.D.1    Freeman, N.2    Domingo, G.J.3    Leatherbarrow, R.J.4
  • 16
    • 0029995902 scopus 로고    scopus 로고
    • Novel cyclic analogs of angiotensin II with cyclization between positions 5 and 7: Conformational and biological implications
    • Zhang WJ, Nikiforovich GV, Perodin J, Richard DE, Escher E, Marshall GR: Novel cyclic analogs of angiotensin II with cyclization between positions 5 and 7: conformational and biological implications. J Med Chem 1996, 39:2738-2744.
    • (1996) J Med Chem , vol.39 , pp. 2738-2744
    • Zhang, W.J.1    Nikiforovich, G.V.2    Perodin, J.3    Richard, D.E.4    Escher, E.5    Marshall, G.R.6
  • 17
    • 0029024034 scopus 로고
    • Conformational mimicry: Synthesis and solution conformation of a cyclic somatostatin hexapeptide containing a tetrazole cis amide bond surrogate
    • Beusen DD, Zabrocki J, Slomczynska U, Head RD, Kao JL, Marshall GR: Conformational mimicry: synthesis and solution conformation of a cyclic somatostatin hexapeptide containing a tetrazole cis amide bond surrogate. Biopolymers 1995, 36:181-200.
    • (1995) Biopolymers , vol.36 , pp. 181-200
    • Beusen, D.D.1    Zabrocki, J.2    Slomczynska, U.3    Head, R.D.4    Kao, J.L.5    Marshall, G.R.6
  • 18
    • 0029835341 scopus 로고    scopus 로고
    • The use of topographical constraints in receptor mapping: Investigation of the topographical requirements of the tryptophan 30 residue for receptor binding of Asp-Tyr-D-Phe-Gly-Trp-(N-Me)Nle-Asp-Phe-NH2 (SNF 9007), a cholecystokinin (26-33) analogue that binds to both CCK-B and delta-opioid receptors
    • Boteju LW, Nikiforovich GV, Haskell-Luevano C, Fang SN, Zalewska T, Stropova D, Yamamura HI, Hruby VJ: The use of topographical constraints in receptor mapping: investigation of the topographical requirements of the tryptophan 30 residue for receptor binding of Asp-Tyr-D-Phe-Gly-Trp-(N-Me)Nle-Asp-Phe-NH2 (SNF 9007), a cholecystokinin (26-33) analogue that binds to both CCK-B and delta-opioid receptors. J Med Chem 1996, 39:4120-4124.
    • (1996) J Med Chem , vol.39 , pp. 4120-4124
    • Boteju, L.W.1    Nikiforovich, G.V.2    Haskell-Luevano, C.3    Fang, S.N.4    Zalewska, T.5    Stropova, D.6    Yamamura, H.I.7    Hruby, V.J.8
  • 19
    • 0030037388 scopus 로고    scopus 로고
    • Molecular recognition of peptide and non-peptide ligands by the extracellular domains of neurohypophysial hormone receptors
    • Howl J, Wheatley M: Molecular recognition of peptide and non-peptide ligands by the extracellular domains of neurohypophysial hormone receptors. Biochem J 1996, 317:577-582.
    • (1996) Biochem J , vol.317 , pp. 577-582
    • Howl, J.1    Wheatley, M.2
  • 20
    • 0029819214 scopus 로고    scopus 로고
    • A novel bicyclic enzyme-inhibitor as a consensus peptidomimetic for the receptor-bound conformations of 12 peptidic inhibitors of HIV-1 protease
    • Reid RC, March DR, Dooley MJ, Bergman DA, Abbenante G, Fairlie DP: A novel bicyclic enzyme-inhibitor as a consensus peptidomimetic for the receptor-bound conformations of 12 peptidic inhibitors of HIV-1 protease. J Am Chem Soc 1996, 118:8511-8517. An excellent example of using structural information in the rational design of bicyclics that fix receptor-bound conformations of bioactive peptides.
    • (1996) J Am Chem Soc , vol.118 , pp. 8511-8517
    • Reid, R.C.1    March, D.R.2    Dooley, M.J.3    Bergman, D.A.4    Abbenante, G.5    Fairlie, D.P.6
  • 21
    • 0028807052 scopus 로고
    • Crystallographic studies on the binding modes of P2-P3 butanediamide renin inhibitors
    • Tong L, Pav S, Lamarre D, Simoneau B, Lavallee P, Jung G: Crystallographic studies on the binding modes of P2-P3 butanediamide renin inhibitors. J Biol Chem 1995, 270:29520-29524.
    • (1995) J Biol Chem , vol.270 , pp. 29520-29524
    • Tong, L.1    Pav, S.2    Lamarre, D.3    Simoneau, B.4    Lavallee, P.5    Jung, G.6
  • 22
    • 0030175693 scopus 로고    scopus 로고
    • Characterization of the bioactive form of linear peptide antagonists at the omega-opioid receptor
    • Chao TM, Perez JJ, Loew GH: Characterization of the bioactive form of linear peptide antagonists at the omega-opioid receptor. Biopolymers 1996, 38:759-768. A good example of theoretical conformational studies and the role played by amino acid residues at particular positions.
    • (1996) Biopolymers , vol.38 , pp. 759-768
    • Chao, T.M.1    Perez, J.J.2    Loew, G.H.3
  • 23
    • 0028839787 scopus 로고
    • Constrained peptide as binding entities
    • Ladner RC: Constrained peptide as binding entities. Trends Biotechnol 1995, 13:426-430.
    • (1995) Trends Biotechnol , vol.13 , pp. 426-430
    • Ladner, R.C.1
  • 25
    • 0030063097 scopus 로고    scopus 로고
    • Rational design of granulocyte-macrophage colony-stimulating factor antagonist peptides
    • Monfardini C, Kieber-Emmons T, Voet D, Godillot AP, Weiner DB, Williams WV: Rational design of granulocyte-macrophage colony-stimulating factor antagonist peptides. J Biol Chem 1996, 271:2966-2971. This paper suggests strategies for mimicking binding sites on four-helix bundle proteins with cyclic peptides.
    • (1996) J Biol Chem , vol.271 , pp. 2966-2971
    • Monfardini, C.1    Kieber-Emmons, T.2    Voet, D.3    Godillot, A.P.4    Weiner, D.B.5    Williams, W.V.6
  • 26
    • 0028912281 scopus 로고
    • Small peptide mimics of nerve growth factor bind TrkA receptors and affect biological responses
    • LeSauteur L, Wei L, Gibbs BF, Saragovi HU: Small peptide mimics of nerve growth factor bind TrkA receptors and affect biological responses. J Biol Chem 1995, 270:6564-6569.
    • (1995) J Biol Chem , vol.270 , pp. 6564-6569
    • LeSauteur, L.1    Wei, L.2    Gibbs, B.F.3    Saragovi, H.U.4
  • 27
    • 0030561455 scopus 로고    scopus 로고
    • Omega-amino acids in peptide design: Incorporation into helices
    • Banerjee A, Pramanik A, Bhattacharjya S, Balaram P: Omega-amino acids in peptide design: incorporation into helices. Biopolymers 1996, 39:769-777.
    • (1996) Biopolymers , vol.39 , pp. 769-777
    • Banerjee, A.1    Pramanik, A.2    Bhattacharjya, S.3    Balaram, P.4
  • 29
    • 0029896629 scopus 로고    scopus 로고
    • Branched synthetic constructs that mimic the physico-chemical properties of apolipoprotein Al in reconstituted high-density lipoproteins
    • Demoor L, Boutillon C, Fievet C, Vanloo B, Baert J, Rosseneu M, Fruchart JC, Tartar A: Branched synthetic constructs that mimic the physico-chemical properties of apolipoprotein Al in reconstituted high-density lipoproteins. Eur J Biochem 1996, 239:74-84. This paper provides evidence for the increased abilities of multimeric peptides to associate with phospholipids compared with the short linear peptides, constituting an alternative approach to linear peptides, which are typically poor mimics.
    • (1996) Eur J Biochem , vol.239 , pp. 74-84
    • Demoor, L.1    Boutillon, C.2    Fievet, C.3    Vanloo, B.4    Baert, J.5    Rosseneu, M.6    Fruchart, J.C.7    Tartar, A.8
  • 30
    • 0028949426 scopus 로고
    • Design and development of a vasoactive intestinal peptide analog as a novel therapeutic for bronchial asthma
    • Bolin DR, Michalewsky J, Wasserman MA, O'Donnell M: Design and development of a vasoactive intestinal peptide analog as a novel therapeutic for bronchial asthma. Biopolymers 1995, 37:57-66.
    • (1995) Biopolymers , vol.37 , pp. 57-66
    • Bolin, D.R.1    Michalewsky, J.2    Wasserman, M.A.3    O'Donnell, M.4
  • 32
    • 0030028449 scopus 로고    scopus 로고
    • Conformational analysis of cyclic hexapeptides designed as constrained ligands for the SH2 domain of the p85 subunit of phosphatidylinositol-3-OH kinase
    • Barchi JJ Jr, Nomizu M, Otaka A, Roller PP, Burke TR Jr: Conformational analysis of cyclic hexapeptides designed as constrained ligands for the SH2 domain of the p85 subunit of phosphatidylinositol-3-OH kinase. Biopolymers 1996, 38:191-208. A very detailed study using NMR, calculations and assays to elucidate structure/function relationships.
    • (1996) Biopolymers , vol.38 , pp. 191-208
    • Barchi J.J., Jr.1    Nomizu, M.2    Otaka, A.3    Roller, P.P.4    Burke T.R., Jr.5
  • 34
    • 0028875452 scopus 로고
    • Recent developments in retro peptides and proteins - An ongoing topochemical exploration
    • Chorev M, Goodman M: Recent developments in retro peptides and proteins - an ongoing topochemical exploration. Trends Biotechnol 1995, 13:438-445.
    • (1995) Trends Biotechnol , vol.13 , pp. 438-445
    • Chorev, M.1    Goodman, M.2
  • 35
    • 0343026460 scopus 로고    scopus 로고
    • Prodrugs of peptides and peptidomimetics for improved formulation and delivery
    • Oliyai R: Prodrugs of peptides and peptidomimetics for improved formulation and delivery. Adv Drug Del Rev 1996, 19:275-286. This paper is an excellent review of the utility of prodrugs to circumvent the obstacles associated with delivery and formulation of peptides and peptidomimetics.
    • (1996) Adv Drug Del Rev , vol.19 , pp. 275-286
    • Oliyai, R.1
  • 36
    • 12644261424 scopus 로고    scopus 로고
    • Enkephalin analog prodrugs: Assessment of in vitro conversion, enzyme cleavage characterization and blood-brain barrier permeability
    • Greene DL, Hau VS, Abbruscato TJ, Bartosz H, Misicka A, Lipkowski AW, Hom S, Gillespie TJ, Hruby VJ, Davis TP: Enkephalin analog prodrugs: assessment of in vitro conversion, enzyme cleavage characterization and blood-brain barrier permeability. J Pharmacol Exp Ther 1996, 277:1366-1375. This paper provides a good example of the importance of residue placement in the peptide backbone and lipophilicity for membrane association.
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 1366-1375
    • Greene, D.L.1    Hau, V.S.2    Abbruscato, T.J.3    Bartosz, H.4    Misicka, A.5    Lipkowski, A.W.6    Hom, S.7    Gillespie, T.J.8    Hruby, V.J.9    Davis, T.P.10
  • 37
    • 0029670575 scopus 로고    scopus 로고
    • Synthetic CD4 exocyclic peptides antagonize CD4 holoreceptor binding and T-cell activation
    • Zhang X, Piatiertonneau D, Auffray C, Murali R, Mahapatra A, Zhang FQ, Maier CC, Saragovi H, Greene MI: Synthetic CD4 exocyclic peptides antagonize CD4 holoreceptor binding and T-cell activation. Nat Biotechnol 1996, 14:472-475. This paper suggests a strategy for creating novel synthetic antagonistic receptor complexes using self-peptides, representing a new receptor specific pharmaceutical approach to modulate biological function.
    • (1996) Nat Biotechnol , vol.14 , pp. 472-475
    • Zhang, X.1    Piatiertonneau, D.2    Auffray, C.3    Murali, R.4    Mahapatra, A.5    Zhang, F.Q.6    Maier, C.C.7    Saragovi, H.8    Greene, M.I.9
  • 38
    • 0031052394 scopus 로고    scopus 로고
    • Synthetic CD4 exocyclics inhibit binding of human-immunodeficiency-virus type-1 envelope to CD4 and virus-replication in T-lymphocytes
    • Zhang X, Gaubin M, Briant L, Srikantam V, Murali R, Saragovi U, Weiner D, Devaux C, Auterio M, Piatiertonneau D, Greene MI: Synthetic CD4 exocyclics inhibit binding of human-immunodeficiency-virus type-1 envelope to CD4 and virus-replication in T-lymphocytes. Nat Biotechnol 1997, 15:150-154. This paper provides an example of how exocyclic compounds based on the structure of a native protein can impair virus binding.
    • (1997) Nat Biotechnol , vol.15 , pp. 150-154
    • Zhang, X.1    Gaubin, M.2    Briant, L.3    Srikantam, V.4    Murali, R.5    Saragovi, U.6    Weiner, D.7    Devaux, C.8    Auterio, M.9    Piatiertonneau, D.10    Greene, M.I.11
  • 39
  • 40
    • 0030069661 scopus 로고    scopus 로고
    • A mimetic of the RGDF-peptide [arginine-glycine-aspartic acid-phenylalanine] blocks aggregation and flow-induced platelet deposition on severely injured stenotic arterial wall. Effects on different animal models and in humans
    • Pueyo C, Badimon JJ, Royo T, Feigen LP, Badimon L: A mimetic of the RGDF-peptide [arginine-glycine-aspartic acid-phenylalanine] blocks aggregation and flow-induced platelet deposition on severely injured stenotic arterial wall. Effects on different animal models and in humans. Thromb Res 1996, 81:101-112.
    • (1996) Thromb Res , vol.81 , pp. 101-112
    • Pueyo, C.1    Badimon, J.J.2    Royo, T.3    Feigen, L.P.4    Badimon, L.5
  • 41
    • 0029055340 scopus 로고
    • Antithrombotic agents: From RGD to peptide mimetics
    • Ojima I, Chakravarty S, Dong Q: Antithrombotic agents: from RGD to peptide mimetics. Bioorg Med Chem 1995, 3:337-360.
    • (1995) Bioorg Med Chem , vol.3 , pp. 337-360
    • Ojima, I.1    Chakravarty, S.2    Dong, Q.3
  • 42
    • 0029984165 scopus 로고    scopus 로고
    • Anti-idiotypic antibody as an oestrogen mimetic in vivo: Stimulation of creatine kinase specific activity in rat animal models
    • Somjen D, Amir-Zaltsman Y, Mor G, Gayer B, Lichter S, Barnard G, Kohen F: Anti-idiotypic antibody as an oestrogen mimetic in vivo: stimulation of creatine kinase specific activity in rat animal models. J Endocrinol 1996, 149:305-312.
    • (1996) J Endocrinol , vol.149 , pp. 305-312
    • Somjen, D.1    Amir-Zaltsman, Y.2    Mor, G.3    Gayer, B.4    Lichter, S.5    Barnard, G.6    Kohen, F.7
  • 43
    • 0031044651 scopus 로고    scopus 로고
    • Therapeutic potential of antiidiotypic single chain antibodies with yeast killer toxin activity
    • Magliani W, Conti S, De Bernardis F, Gerloni M, Bertolotti D, Mozzoni P, Cassone A, Polonelli L: Therapeutic potential of antiidiotypic single chain antibodies with yeast killer toxin activity. Nat Biotechnol 1997, 15:155-158. A good example of how recombinant antibody fragments can have potential therapeutic applications.
    • (1997) Nat Biotechnol , vol.15 , pp. 155-158
    • Magliani, W.1    Conti, S.2    De Bernardis, F.3    Gerloni, M.4    Bertolotti, D.5    Mozzoni, P.6    Cassone, A.7    Polonelli, L.8
  • 44
    • 0028895156 scopus 로고
    • SH2 and SH3 domains: Potential targets for anti-cancer drug design
    • Smithgall TE: SH2 and SH3 domains: potential targets for anti-cancer drug design. J Pharmacol Toxicol Methods 1995, 34:125-132.
    • (1995) J Pharmacol Toxicol Methods , vol.34 , pp. 125-132
    • Smithgall, T.E.1
  • 45
    • 0028939032 scopus 로고
    • Conformationally constrained phosphotyrosyl mimetics designed as monomeric Src homology 2 domain inhibitors
    • Burke TJ, Barchi JJ, George C, Wolf G, Shoelson SE, Yan X: Conformationally constrained phosphotyrosyl mimetics designed as monomeric Src homology 2 domain inhibitors. Med Chem 1995, 38:1386-1396.
    • (1995) Med Chem , vol.38 , pp. 1386-1396
    • Burke, T.J.1    Barchi, J.J.2    George, C.3    Wolf, G.4    Shoelson, S.E.5    Yan, X.6
  • 46
    • 0028969778 scopus 로고
    • Farnesyl transferase inhibitors (anti-Ras). A new class of anticancer agents
    • Levy R: [Farnesyl transferase inhibitors (anti-Ras). A new class of anticancer agents]. Presse Med 1995, 24:725-729.
    • (1995) Presse Med , vol.24 , pp. 725-729
    • Levy, R.1
  • 47
  • 48
    • 0029119373 scopus 로고
    • CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase
    • McGuire TF, Qian Y, Blaskovich MA, Fossum RD, Sun J, Marlowe T, Corey SJ, Wathen SP, Vogi A, Hamilton AD et al.: CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase. Biochem Biophys Res Commun 1995, 214:295-303.
    • (1995) Biochem Biophys Res Commun , vol.214 , pp. 295-303
    • McGuire, T.F.1    Qian, Y.2    Blaskovich, M.A.3    Fossum, R.D.4    Sun, J.5    Marlowe, T.6    Corey, S.J.7    Wathen, S.P.8    Vogi, A.9    Hamilton, A.D.10
  • 49
    • 0028869067 scopus 로고
    • Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956
    • Nagasu T, Yoshimatsu K, Rowell C, Lewis MD, Garcia AM: Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956. Cancer Res 1995, 55:5310-5314.
    • (1995) Cancer Res , vol.55 , pp. 5310-5314
    • Nagasu, T.1    Yoshimatsu, K.2    Rowell, C.3    Lewis, M.D.4    Garcia, A.M.5
  • 50
    • 0029586503 scopus 로고
    • Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells
    • Bishop WR, Bond R, Petrin J, Wang L, Patton R, Doll R, Njoroge G, Catino J, Schwartz J, Windsor W et al.: Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells. J Biol Chem 1995, 270:30611-30618.
    • (1995) J Biol Chem , vol.270 , pp. 30611-30618
    • Bishop, W.R.1    Bond, R.2    Petrin, J.3    Wang, L.4    Patton, R.5    Doll, R.6    Njoroge, G.7    Catino, J.8    Schwartz, J.9    Windsor, W.10
  • 52
    • 0028912593 scopus 로고
    • A non-peptide mimetic of Ras-CAAX: Selective inhibition of farnesyltransferase and Ras processing
    • Vogt A, Qian Y, Blaskovich MA, Fossum RD, Hamilton AD, Sebti SM: A non-peptide mimetic of Ras-CAAX: selective inhibition of farnesyltransferase and Ras processing. J Biol Chem 1995, 270:660-664.
    • (1995) J Biol Chem , vol.270 , pp. 660-664
    • Vogt, A.1    Qian, Y.2    Blaskovich, M.A.3    Fossum, R.D.4    Hamilton, A.D.5    Sebti, S.M.6
  • 55
    • 0030951314 scopus 로고    scopus 로고
    • Peptide mimicry of carbohydrate epitopes on human immunodeficiency virus
    • Agadjanyan M, Lou P, Westerink MAJ, Carey LA, Hutchins W, Stepewski Z, Weiner DB, Kieber-Emmons T: Peptide mimicry of carbohydrate epitopes on human immunodeficiency virus. Nat Biotechnol 1997, 15:547-551. A compelling manuscript showing that peptides that mimic associated and histo-blood group carbohydrate antigens can induce polyclonal immune responses in experimental animals that neutralize HIV in vitro.
    • (1997) Nat Biotechnol , vol.15 , pp. 547-551
    • Agadjanyan, M.1    Lou, P.2    Westerink, M.A.J.3    Carey, L.A.4    Hutchins, W.5    Stepewski, Z.6    Weiner, D.B.7    Kieber-Emmons, T.8
  • 56
    • 0029099769 scopus 로고
    • Thrombin active site inhibitors
    • Das J, Kimball SD: Thrombin active site inhibitors. Bioorg Med Chem 1995, 3:999-1007.
    • (1995) Bioorg Med Chem , vol.3 , pp. 999-1007
    • Das, J.1    Kimball, S.D.2


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