Selection of the solvent system for the preparation of poly(D,L-lactic-co-glycolic acid) microspheres containing tumor necrosis factor-alpha (TNF-α)

International Journal of Pharmaceutics

Volumn 160, Issue 2, 1998, Pages 145-156

  Iwata, Motokazu ^a   Tanaka, Terukazu ^a   Nakamura, Yasuhiko ^a   McGinity, J W ^b  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Acetonitrile; Anhydrous solvent evaporation system; Dichloromethane; Matrix type microspheres; Multiphase microspheres; Poly(D,L lactic co glycolic acid); Stability of TNF

Indexed keywords

MICROSPHERE; POLYGLACTIN; SOLVENT; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; DRUG FORMULATION; DRUG STABILITY; EMULSION; PRIORITY JOURNAL;

EID: 0344588871     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)00306-2     Document Type: Article

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