Physicochemical and immunological studies on the stability of free and microsphere-encapsulated tetanus toxoid in vitro

Vaccine

Volumn 14, Issue 13, 1996, Pages 1205-1213

  Xing, Dorothy K L ^a   Crane, Dennis T ^a   Bolgiano, Barbara ^a   Corbel, Michael J ^a   Jones, Christopher ^a   Sesardic, Dorothea ^a  

^a NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

Author keywords

Circular dichroism; Controlled release vaccines; Fluorescence spectroscopy; Tetanus toxoid; Tryptophan

Indexed keywords

MICROSPHERE; TETANUS TOXOID;

ARTICLE; CIRCULAR DICHROISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE SPECTROSCOPY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; TETANUS;

DRUG STABILITY; HYDROGEN-ION CONCENTRATION; MICROSPHERES; TEMPERATURE; TETANUS TOXOID;

EID: 0030250848     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(96)00032-1     Document Type: Article

References (25)

1. 1 Cohen, S., Yoshioka, T., Lucarelli, M., Hwang, L.H. and Langer, R. Controlled delivery systems for proteins based on poly(lactic/ glycolic acid) microspheres. Pharmaceut. Res. 1991, 8, 713-720
2. 2 Alonso, M.J., Gupta, R.K., Min, C., Siber, G.R. and Langer, R. Biodegradable microspheres as controlled-release tetanus toxoid delivery systems. Vaccine 1994, 12, 299-306
3. 3 Aguado, M.T. Future approaches to vaccine development: single-dose vaccines using controlled-release delivery systems. Vaccine 1993, 11, 596-597
4. 4 Esparza, I. and Kissel, T. Parameters affecting the immunogenicity of microencapsulated tetanus toxoid. Vaccine 1992, 10, 714-720
5. 5 Langer, R. WHO Progress Report (89 TV 1016), 1993
6. 6 Gander, B. WHO Progress Report (89 TV 0017), 1993
7. 7 Sandoz Pharma, AG. WHO Report, 1992
8. 8 Xing, D.K.-L., McLellan, K., Corbel, M.J. and Sesardic, D. Estimation of antigenic tetanus toxoid extracted from biodegradable microspheres. J. biol. Stand. 1996, 24, 57-65
9. 9 Creighton, T.E. Proteins: Structures and Molecular Properties. W.H. Freeman, New York, 1993, p.14
10. 10 Patchornik, A., Lawson, W.B., Gross, E. and Witkop, B. The use of N-bromosuccinimide and N-bromoacetamide for the selective cleavage of C-tryptophyl peptide bonds in model peptides and glucagon. J. Am. Chem. Soc. 1960, 82, 5923-5927
11. 11 Ledvina, M. and LaBella, F.S. Fluorescent substances in protein hydrolyzates I. Acid "hydrolyzates" of individual amino acids. Analyt. Biochem. 1970, 36, 174-181
12. 12 Robinson, J.P., Holladay, L.A., Hash, J.H. and Puett, D. Conformational and molecular weight studies of tetanus toxin and its major peptides. J. biol. Chem. 1982, 257, 407-411
13. 13 Strickland, E.H. Aromatic contributions to circular dichroism spectra of proteins. CRC Crit. Rev. Biochem. 1974, 1, 113-175
14. 14 Sheppard, A.J., Cussell, D. and Hughes, M. Production and characterization of monoclonal antibodies to tetanus toxin. Infect. Immunity 1984, 43, 710-714
15. 15 Arakawa, T., Kita, Y. and Carpenter, F. Protein-solvent interactions in pharmaceutical formulations. Pharmac. Res. 1991, 8, 285-291
16. 16 Liu, W.R., Langer, R. and Klibanov, A. Moisture-induced aggregation of lyophilized proteins in the solid state. Biotech. Bioengng 1991, 37, 177-184
17. 17 Hora, M.S., Rana, R.K., Nunberg, J.H., Tice, T.R., Gilley, R.M. and Hudson, M.E. Release of human serum albumin from poly(lactide-co-glycolide) microspheres. Pharmceut. Res. 1990, 7, 1190-1194
18. 18 Blewitt, M.G., Chung, L.A. and London, E. Effect of pH on the conformation of diphtheria toxin and its implications for membrane penetration. Biochemistry 1985, 24, 5458-5464
19. 19 Zhao, J.M. and London, E. Similarity of the conformation of diphtheria toxin at high temperature to that in the membrane-penetrating low-pH state. Proc. natl. Acad. Sci. USA 1986, 83, 2002-2006
20. 20 Holland, S.J. and Tighe, B.J. Polymers for biodegradable medical devices. 1. The potential of polyesters as controlled macromolecular release systems. J. Control. Rel. 1986, 4, 155-180
21. 21 Langer, R. New methods of drug delivery. Science 1990, 249, 1527-1533
22. 22 Alonso, M.J., Cohen, S., Park, T.G., Gupta, R.K., Siber, G.R. and Langer, R. Determinants of release rate of tetanus vaccine from polyester microspheres. Pharmaceut. Res. 1993, 10, 945-953
23. 23 Wang, H.T., Schmitt, E., Flanagan, D.R. and Linhardt, R.J. Influence of formulation methods on the in vitro controlled release of protein from poly(ester) microspheres. J. Control. Rel. 1991, 17, 23-32
24. 24 Heya, T., Okada, H., Ogawa, Y. and Toguchi, H. Factors influencing the profiles of TRH release from copoly(d.l-lactic/ glycolic acid) microspheres. Int. J. Pharm. 1991, 72, 199-205
25. 25 Su Ming, L., Garreau, H. and Vert, M. Structure-property relationship in the case of the degradation of massive aliphatic poly-(α-hydroxy acids) in aqueous media. J. Mater. Sci. (Mater. Med.) 1990, 1, 123-130