-
1
-
-
0344622606
-
The serial cultivation of human diploid cell strains
-
Hayflick L and Moorhead PS: The serial cultivation of human diploid cell strains. Exptl Cell Res 25: 585-621, 1961.
-
(1961)
Exptl Cell Res
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.S.2
-
2
-
-
0025729836
-
Defining the molecular mechanisms of human cell immortalization
-
Shay JW, Wright WE and Werbin H: Defining the molecular mechanisms of human cell immortalization. Biochim Biophys Acta 1072: 1-7, 1991.
-
(1991)
Biochim Biophys Acta
, vol.1072
, pp. 1-7
-
-
Shay, J.W.1
Wright, W.E.2
Werbin, H.3
-
3
-
-
73649150958
-
The maintenance of the accuracy of protein synthesis and its relevance to ageing
-
Orgel LE: The maintenance of the accuracy of protein synthesis and its relevance to ageing. Proc Natl Acad Sci USA 49: 517-521, 1963.
-
(1963)
Proc Natl Acad Sci USA
, vol.49
, pp. 517-521
-
-
Orgel, L.E.1
-
4
-
-
0017812879
-
Genes in multiple copies as the primary cause of aging
-
Ohno S and Nagai Y: Genes in multiple copies as the primary cause of aging. Birth Defects Orig Articles Ser 14: 501-514, 1978.
-
(1978)
Birth Defects Orig Articles Ser
, vol.14
, pp. 501-514
-
-
Ohno, S.1
Nagai, Y.2
-
5
-
-
0016836493
-
Commitment to senescence: A model for the finite and infinite growth of diploid and transformed human fibroblasts in culture
-
Kirkwood TB and Holliday R: Commitment to senescence: a model for the finite and infinite growth of diploid and transformed human fibroblasts in culture. J Theor Biol 53: 481-496, 1975.
-
(1975)
J Theor Biol
, vol.53
, pp. 481-496
-
-
Kirkwood, T.B.1
Holliday, R.2
-
6
-
-
0019133206
-
Loss of gene repression activity: A theory of cellular senescence
-
Smith JR and Lumpkin CK: Loss of gene repression activity: a theory of cellular senescence. Mech Ageing Dev 13: 387-392, 1980.
-
(1980)
Mech Ageing Dev
, vol.13
, pp. 387-392
-
-
Smith, J.R.1
Lumpkin, C.K.2
-
7
-
-
0011208723
-
Genetic analysis of indefinite division in human cells: Identification of four complementation groups
-
Pereira-Smith OM and Smith JR: Genetic analysis of indefinite division in human cells: identification of four complementation groups. Proc Natl Acad Sci USA 85: 6042-6046, 1988.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 6042-6046
-
-
Pereira-Smith, O.M.1
Smith, J.R.2
-
9
-
-
0025787643
-
Telomere loss: Mitotic clock or genetic time bomb?
-
Harley CB: Telomere loss: mitotic clock or genetic time bomb? Mutat Res 256: 271-282, 1991.
-
(1991)
Mutat Res
, vol.256
, pp. 271-282
-
-
Harley, C.B.1
-
10
-
-
0015184804
-
Principles of marginotomy in template synthesis of polynucleotides
-
Olovnikov AM: Principles of marginotomy in template synthesis of polynucleotides. Dokl Acad Nauk (S S S R ) 201: 1496-1499, 1971.
-
(1971)
Dokl Acad Nauk (S S S R )
, vol.201
, pp. 1496-1499
-
-
Olovnikov, A.M.1
-
11
-
-
0015844590
-
A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon
-
Olovnikov AM: A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J Theor Biol 41: 181-190, 1973.
-
(1973)
J Theor Biol
, vol.41
, pp. 181-190
-
-
Olovnikov, A.M.1
-
12
-
-
0026735646
-
Telomere end-replication problem and cell aging
-
Levy MZ, Allsopp RC, Futcher AB, Greider CW and Harley CB: Telomere end-replication problem and cell aging. J Mol Biol 225: 951-960, 1992.
-
(1992)
J Mol Biol
, vol.225
, pp. 951-960
-
-
Levy, M.Z.1
Allsopp, R.C.2
Futcher, A.B.3
Greider, C.W.4
Harley, C.B.5
-
15
-
-
0024788528
-
Structure and function of telomeres
-
Zakian VA: Structure and function of telomeres. Annu Rev Genet 23: 579-604, 1989.
-
(1989)
Annu Rev Genet
, vol.23
, pp. 579-604
-
-
Zakian, V.A.1
-
16
-
-
0013462065
-
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
-
Moyzis RK, Buckingham JM, Cram LS et al: A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci USA 85: 6622-6626, 1988.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 6622-6626
-
-
Moyzis, R.K.1
Buckingham, J.M.2
Cram, L.S.3
-
18
-
-
0001294157
-
The stability of broken ends of chromosomes in zea mays
-
McClintock B: The stability of broken ends of chromosomes in Zea mays. Genetics 41: 234-282, 1941.
-
(1941)
Genetics
, vol.41
, pp. 234-282
-
-
McClintock, B.1
-
19
-
-
0026682717
-
Telomere positional effects and the regulation of cellular senescence
-
Wright WE and Shay JW: Telomere positional effects and the regulation of cellular senescence. Trends Genet 8: 193-197, 1992.
-
(1992)
Trends Genet
, vol.8
, pp. 193-197
-
-
Wright, W.E.1
Shay, J.W.2
-
20
-
-
0025900189
-
Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae
-
Aparicio OM, Billington BL and Gottschling DE: Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae. Cell 66: 1279-1287, 1991.
-
(1991)
Cell
, vol.66
, pp. 1279-1287
-
-
Aparicio, O.M.1
Billington, B.L.2
Gottschling, D.E.3
-
21
-
-
0025201982
-
Position effect at S. Cerevisiae telomeres: Reversible repression of Pol II transcription
-
Gottschling DE, Aparicio OM, Billington BL and Zakian VA: Position effect at S. Cerevisiae telomeres: reversible repression of Pol II transcription. Cell 63: 751-762, 1990.
-
(1990)
Cell
, vol.63
, pp. 751-762
-
-
Gottschling, D.E.1
Aparicio, O.M.2
Billington, B.L.3
Zakian, V.A.4
-
22
-
-
0025204569
-
Position-effect variegation after 60 years
-
Henikoff S: Position-effect variegation after 60 years. Trends Genet 6: 422-426, 1990.
-
(1990)
Trends Genet
, vol.6
, pp. 422-426
-
-
Henikoff, S.1
-
23
-
-
0022402513
-
Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
-
Greider CW and Blackburn EH: Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43: 405-413, 1985.
-
(1985)
Cell
, vol.43
, pp. 405-413
-
-
Greider, C.W.1
Blackburn, E.H.2
-
24
-
-
0023663881
-
The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity
-
Greider CW and Blackburn EH: The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell 51: 887-898, 1987.
-
(1987)
Cell
, vol.51
, pp. 887-898
-
-
Greider, C.W.1
Blackburn, E.H.2
-
25
-
-
0025914141
-
Telomerase is processive
-
Greider CW: Telomerase is processive. Mol Cell Biol 11: 4572-4580, 1991.
-
(1991)
Mol Cell Biol
, vol.11
, pp. 4572-4580
-
-
Greider, C.W.1
-
26
-
-
0024978857
-
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
-
Greider W and Blackburn EH: A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337: 331-337, 1989.
-
(1989)
Nature
, vol.337
, pp. 331-337
-
-
Greider, W.1
Blackburn, E.H.2
-
27
-
-
0029102354
-
Runaway telomere elongation caused by telomerase RNA gene mutations
-
McEachern MJ and Blackburn EH: Runaway telomere elongation caused by telomerase RNA gene mutations. Nature 376: 403-409, 1995.
-
(1995)
Nature
, vol.376
, pp. 403-409
-
-
McEachern, M.J.1
Blackburn, E.H.2
-
28
-
-
0025279059
-
In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
-
Guo-Liang Y, Bradley JD, Attardi LD and Blackburn EH: In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature 344: 126-132, 1990.
-
(1990)
Nature
, vol.344
, pp. 126-132
-
-
Guo-Liang, Y.1
Bradley, J.D.2
Attardi, L.D.3
Blackburn, E.H.4
-
29
-
-
0024325562
-
The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
-
Morin GB: The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 59: 521-529, 1989.
-
(1989)
Cell
, vol.59
, pp. 521-529
-
-
Morin, G.B.1
-
30
-
-
0028564951
-
Specific association of human telomerase activity with immortal cells and cancer
-
Kim NW, Piatyszek MA, Prowse KR et al: Specific association of human telomerase activity with immortal cells and cancer: Science 266: 2011-2015, 1994.
-
(1994)
Science
, vol.266
, pp. 2011-2015
-
-
Kim, N.W.1
Piatyszek, M.A.2
Prowse, K.R.3
-
31
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley CB, Futcher AB and Greider CW: Telomeres shorten during ageing of human fibroblasts. Nature 345: 458-460, 1990.
-
(1990)
Nature
, vol.345
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
32
-
-
0029156035
-
Telomere shortening is associated with cell division in vitro and in vivo
-
Allsopp RC, Chang E, Kashefiaazam M et al: Telomere shortening is associated with cell division in vitro and in vivo. Exptl Cell Res 220: 194-200, 1995.
-
(1995)
Exptl Cell Res
, vol.220
, pp. 194-200
-
-
Allsopp, R.C.1
Chang, E.2
Kashefiaazam, M.3
-
33
-
-
0025143252
-
Telomere reduction in human colorectal carcinoma and with ageing
-
Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK and Allshire RC: Telomere reduction in human colorectal carcinoma and with ageing. Nature 346: 866-868, 1990.
-
(1990)
Nature
, vol.346
, pp. 866-868
-
-
Hastie, N.D.1
Dempster, M.2
Dunlop, M.G.3
Thompson, A.M.4
Green, D.K.5
Allshire, R.C.6
-
34
-
-
0026523228
-
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
-
Counter CM, Avilion AA, LeFeuvre CE et al: Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 11: 1921-1929, 1992.
-
(1992)
EMBO J
, vol.11
, pp. 1921-1929
-
-
Counter, C.M.1
Avilion, A.A.2
LeFeuvre, C.E.3
-
35
-
-
0028198679
-
Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes
-
Counter CM, Botelho FM, Wang P, Harley CB and Bacchetti S: Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. J Virol 68: 3410-3414, 1994.
-
(1994)
J Virol
, vol.68
, pp. 3410-3414
-
-
Counter, C.M.1
Botelho, F.M.2
Wang, P.3
Harley, C.B.4
Bacchetti, S.5
-
36
-
-
0028140264
-
Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells
-
Klingelhutz AJ, Barber SA, Smith PP, Dyer K and McDougall JK: Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells. Mol Cell Biol 14: 961-969, 1994.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 961-969
-
-
Klingelhutz, A.J.1
Barber, S.A.2
Smith, P.P.3
Dyer, K.4
McDougall, J.K.5
-
37
-
-
0029096515
-
The RNA component of human telomerase
-
Feng JL, Funk WD, Wang SS et al: The RNA component of human telomerase. Science 269: 1236-1241, 1995.
-
(1995)
Science
, vol.269
, pp. 1236-1241
-
-
Feng, J.L.1
Funk, W.D.2
Wang, S.S.3
-
38
-
-
0031047642
-
Block in anaphase chromosome separation caused by a telomerase template mutation
-
Kirk KE, Harmon BP, Reichardt IK, Sedat JW and Blackburn EH: Block in anaphase chromosome separation caused by a telomerase template mutation. Science 275: 1478-1481, 1997.
-
(1997)
Science
, vol.275
, pp. 1478-1481
-
-
Kirk, K.E.1
Harmon, B.P.2
Reichardt, I.K.3
Sedat, J.W.4
Blackburn, E.H.5
-
39
-
-
1842339879
-
Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomercs that correlate with reduced cell viability
-
Marusic L, Anton M, Tidy A, Wang P, Villeponteau B and Bacchetti S: Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomercs that correlate with reduced cell viability. Mol Cell Biol 17: 6394-6401, 1997.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 6394-6401
-
-
Marusic, L.1
Anton, M.2
Tidy, A.3
Wang, P.4
Villeponteau, B.5
Bacchetti, S.6
-
40
-
-
0030067487
-
Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues
-
Avilion AA, Piatyszek MA, Gupta J, Shay JW, Bacchetti S and Grcider CW: Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues. Cancer Res 56: 645-650, 1996.
-
(1996)
Cancer Res
, vol.56
, pp. 645-650
-
-
Avilion, A.A.1
Piatyszek, M.A.2
Gupta, J.3
Shay, J.W.4
Bacchetti, S.5
Grcider, C.W.6
-
41
-
-
0030892905
-
Amplification, increased dosage and in situ expression of the telomerase RNA gene in human cancer
-
Soder AI, Hoare SF, Muir S, Going JE, Parkinson EK and Keith WN: Amplification, increased dosage and in situ expression of the telomerase RNA gene in human cancer. Oncogene 14: 1013-1021, 1997.
-
(1997)
Oncogene
, vol.14
, pp. 1013-1021
-
-
Soder, A.I.1
Hoare, S.F.2
Muir, S.3
Going, J.E.4
Parkinson, E.K.5
Keith, W.N.6
-
42
-
-
0030938901
-
Reverse transcriptase motifs in the catalytic subunit of telomerase
-
Lingner J, Hughes TR, Shevchenko A, Mann M, Lundblad V and Cech TR: Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276, 561-567, 1997.
-
(1997)
Science
, vol.276
, pp. 561-567
-
-
Lingner, J.1
Hughes, T.R.2
Shevchenko, A.3
Mann, M.4
Lundblad, V.5
Cech, T.R.6
-
43
-
-
0030681073
-
Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types
-
Kilian A, Bowtell DDL, Abud HE et al: Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Hum Mol Genet 6: 2011-2019, 1997.
-
(1997)
Hum Mol Genet
, vol.6
, pp. 2011-2019
-
-
Kilian, A.1
Bowtell, D.D.L.2
Abud, H.E.3
-
44
-
-
0030819894
-
Telomerase catalytic subunit homologs from fission yeast and human
-
Nakamura TM, Morin GB, Chapman KB et al: Telomerase catalytic subunit homologs from fission yeast and human. Science 277: 955-959, 1997.
-
(1997)
Science
, vol.277
, pp. 955-959
-
-
Nakamura, T.M.1
Morin, G.B.2
Chapman, K.B.3
-
45
-
-
0030745448
-
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
-
Meyerson M, Counter CM, Eaton EN et al: hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90: 785-795, 1997.
-
(1997)
Cell
, vol.90
, pp. 785-795
-
-
Meyerson, M.1
Counter, C.M.2
Eaton, E.N.3
-
46
-
-
0031703757
-
Telomerase activity and expression of telomerase RNA component and telomerase catalytic subunit gene in cervical cancer
-
In Press
-
Nakano K, Watney E and McDougall JK: Telomerase activity and expression of telomerase RNA component and telomerase catalytic subunit gene in cervical cancer. Amer J Pathol In Press: 1998.
-
(1998)
Amer J Pathol
-
-
Nakano, K.1
Watney, E.2
McDougall, J.K.3
-
47
-
-
0032576733
-
Reconstitution of human telomerase activity in vitro
-
Beattie TL, Zhou W, Robinson MO, and Harrington L: Reconstitution of human telomerase activity in vitro. Curr Biol 8: 177-180, 1997.
-
(1997)
Curr Biol
, vol.8
, pp. 177-180
-
-
Beattie, T.L.1
Zhou, W.2
Robinson, M.O.3
Harrington, L.4
-
48
-
-
0030659644
-
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
-
Weinrich SL, Pruzan R, Ma L et al: Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Gen 17: 498-502, 1997.
-
(1997)
Nat Gen
, vol.17
, pp. 498-502
-
-
Weinrich, S.L.1
Pruzan, R.2
Ma, L.3
-
49
-
-
17344363008
-
Telomerase activation hy hTRT in human normal fibroblasts and hepatocellular carcinomas
-
Nakayama J, Tahara H, Tahara E et al: Telomerase activation hy hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat Gen 18: 65-68, 1998.
-
(1998)
Nat Gen
, vol.18
, pp. 65-68
-
-
Nakayama, J.1
Tahara, H.2
Tahara, E.3
-
50
-
-
0032485416
-
Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase
-
Counter CM, Meyerson M, Eaton EN et al: Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. Oncogene 16: 1217-1222, 1998.
-
(1998)
Oncogene
, vol.16
, pp. 1217-1222
-
-
Counter, C.M.1
Meyerson, M.2
Eaton, E.N.3
-
51
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar AG, Ouellette M, Frolkis M et al: Extension of life-span by introduction of telomerase into normal human cells. Science 279: 349-352, 1998.
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
-
52
-
-
0343933288
-
Telomerase activity and inactivation of Rh/p16INK4a are required for immortalization of epithelial cells
-
In Press
-
Kiyono T, Foster SA, Koop JI, McDougall JK, Galloway DA and Klingelhutz AJ: Telomerase activity and inactivation of Rh/p16INK4a are required for immortalization of epithelial cells. Nature In Press: 1998.
-
(1998)
Nature
-
-
Kiyono, T.1
Foster, S.A.2
Koop, J.I.3
McDougall, J.K.4
Galloway, D.A.5
Klingelhutz, A.J.6
-
53
-
-
0031027618
-
Control of telomere length by the human telomeric protein TRF-1
-
van Steensel B and de Lange T: Control of telomere length by the human telomeric protein TRF-1. Nature 385: 740-743, 1997.
-
(1997)
Nature
, vol.385
, pp. 740-743
-
-
Van Steensel, B.1
De Lange, T.2
-
54
-
-
0032489012
-
TRF2 protects human telomeres from end-to-end fusions
-
van Steensel B, Smogorzewska A and de Lange T: TRF2 protects human telomeres from end-to-end fusions. Cell 92: 401-413, 1998.
-
(1998)
Cell
, vol.92
, pp. 401-413
-
-
Van Steensel, B.1
Smogorzewska, A.2
De Lange, T.3
-
55
-
-
0029973653
-
Regulation of telomerase activity in immortal cell lines
-
Holt SE, Wright WE, and Shay JW: Regulation of telomerase activity in immortal cell lines. Mol Cell Biol 16: 2932-2939, 1996.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 2932-2939
-
-
Holt, S.E.1
Wright, W.E.2
Shay, J.W.3
-
56
-
-
0029901910
-
Telomerase activity in the regenerative basal layer of the epidermis in human skin and in immortal and carcinoma-derived skin keratinocytes
-
Harle-Bachor C and Boukamp P: Telomerase activity in the regenerative basal layer of the epidermis in human skin and in immortal and carcinoma-derived skin keratinocytes. Proc Natl Acad Sci USA 93: 6476-6481, 1996.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 6476-6481
-
-
Harle-Bachor, C.1
Boukamp, P.2
-
57
-
-
0029808357
-
Telomerase activity in normal human epithelial cells
-
Yasumoto S, Kunimura C, Kikuchi K et al: Telomerase activity in normal human epithelial cells. Oncogene 13: 433-439, 1996.
-
(1996)
Oncogene
, vol.13
, pp. 433-439
-
-
Yasumoto, S.1
Kunimura, C.2
Kikuchi, K.3
-
58
-
-
0028938262
-
Telomerase activity in normal leukocytes and in hematologic malignancies
-
Counter CM, Gupta J, Harley CB, Leber B, and Bacchelti S: Telomerase activity in normal leukocytes and in hematologic malignancies. Blood 85: 2315-2320, 1995.
-
(1995)
Blood
, vol.85
, pp. 2315-2320
-
-
Counter, C.M.1
Gupta, J.2
Harley, C.B.3
Leber, B.4
Bacchelti, S.5
-
59
-
-
0029066169
-
Telomerase activity in normal and malignant hematopoietic cells
-
Broccoli D, Young JW and de Lange T: Telomerase activity in normal and malignant hematopoietic cells. Proc Natl Acad Sci USA 92: 9082-9086, 1995.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 9082-9086
-
-
Broccoli, D.1
Young, J.W.2
De Lange, T.3
-
60
-
-
0029924986
-
Telomerase activity is induced by the stimulation of antigen receptor in human peripheral lymphocytes
-
Igarashi H and Sakaguchi N: Telomerase activity is induced by the stimulation of antigen receptor in human peripheral lymphocytes. Biochem Biophys Res Comm 219: 649-655, 1996.
-
(1996)
Biochem Biophys Res Comm
, vol.219
, pp. 649-655
-
-
Igarashi, H.1
Sakaguchi, N.2
-
61
-
-
0029091386
-
Activation of telomerase in human lymphocytes and hematopoietic progenitor cells
-
Hiyama K, Hirai Y, Kyoizumi S et al: Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J Immunol 155: 3711-3715, 1995.
-
(1995)
J Immunol
, vol.155
, pp. 3711-3715
-
-
Hiyama, K.1
Hirai, Y.2
Kyoizumi, S.3
-
62
-
-
0030010433
-
Detection of telomerase activity in malignant and nonmalignant skin conditions
-
Taylor RS, Ramirez RD, Ogoshi M, Chaffins M, Piatyszek MA and Shay JW: Detection of telomerase activity in malignant and nonmalignant skin conditions. J Invest Dermatol 106: 759-765, 1996.
-
(1996)
J Invest Dermatol
, vol.106
, pp. 759-765
-
-
Taylor, R.S.1
Ramirez, R.D.2
Ogoshi, M.3
Chaffins, M.4
Piatyszek, M.A.5
Shay, J.W.6
-
63
-
-
0031456031
-
Telomerase activity: A biomarker of cell proliferation, not malignant transformation
-
Belair CD, Yeager TR, Lopez PM, and Reznikoff CA: Telomerase activity: a biomarker of cell proliferation, not malignant transformation. Proc Natl Acad Sci USA 94: 13677-13682, 1997.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 13677-13682
-
-
Belair, C.D.1
Yeager, T.R.2
Lopez, P.M.3
Reznikoff, C.A.4
-
64
-
-
0031590735
-
Telomerase activity in human leukemic cell lines is inhibited by antisense pentadecadeoxy-nucleotides targeted against c-myc mRNA
-
Fujimoto K and Takahashi M: Telomerase activity in human leukemic cell lines is inhibited by antisense pentadecadeoxy-nucleotides targeted against c-myc mRNA. Biochem Biophys Res Comm 241: 775-781, 1997.
-
(1997)
Biochem Biophys Res Comm
, vol.241
, pp. 775-781
-
-
Fujimoto, K.1
Takahashi, M.2
-
65
-
-
2642610318
-
Myc activates telomerase
-
Wang J, Xie LY, Allan S, Beach D, and Hannon GJ: Myc activates telomerase. Genes Devel 12: 1769-1774, 1998.
-
(1998)
Genes Devel
, vol.12
, pp. 1769-1774
-
-
Wang, J.1
Xie, L.Y.2
Allan, S.3
Beach, D.4
Hannon, G.J.5
-
66
-
-
0031006856
-
Bcl-2 modulates telomerase activity
-
Mandal M and Kumar R: Bcl-2 modulates telomerase activity. J Biol Chem 272: 14183-14187, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 14183-14187
-
-
Mandal, M.1
Kumar, R.2
-
67
-
-
0030008177
-
Telomerase activation by the E6 gene product of human papillomavirus type 16
-
Klingelhutz AJ, Foster SA and McDougall JK: Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature 380: 79-82, 1996.
-
(1996)
Nature
, vol.380
, pp. 79-82
-
-
Klingelhutz, A.J.1
Foster, S.A.2
McDougall, J.K.3
-
68
-
-
0030886553
-
Lack of cell cycle regulation of telomerase activity in human cells
-
Holt SE, Aisner DL, Shay JW and Wright WE: Lack of cell cycle regulation of telomerase activity in human cells, Proc Natl Acad Sci US 94: 10687-10692, 1997.
-
(1997)
Proc Natl Acad Sci US
, vol.94
, pp. 10687-10692
-
-
Holt, S.E.1
Aisner, D.L.2
Shay, J.W.3
Wright, W.E.4
-
69
-
-
13344249773
-
Differentiation of immortal cells inhibits telomerase activity
-
Sharma HW, Sokoloski JA, Perez JR et al: Differentiation of immortal cells inhibits telomerase activity. Proc Natl Acad Sci USA 92: 12343-12346, 1995.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 12343-12346
-
-
Sharma, H.W.1
Sokoloski, J.A.2
Perez, J.R.3
-
70
-
-
0029666139
-
Suppression of telomerase activity in HL60 cells after treatment with differentiating agents
-
Xu D, Gruber A, Peterson C et al: Suppression of telomerase activity in HL60 cells after treatment with differentiating agents. Leukemia 10: 1354-1357, 1996.
-
(1996)
Leukemia
, vol.10
, pp. 1354-1357
-
-
Xu, D.1
Gruber, A.2
Peterson, C.3
-
71
-
-
9844232032
-
Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition
-
Xu HJ, Zhou Y, Ji W et al: Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition. Oncogene 15: 2589-2596, 1997.
-
(1997)
Oncogene
, vol.15
, pp. 2589-2596
-
-
Xu, H.J.1
Zhou, Y.2
Ji, W.3
-
72
-
-
0029991014
-
Telomerase activity in human cancer
-
Shay JW and Wright WE: Telomerase activity in human cancer. Curr Opin Oncol 8: 66-71, 1996.
-
(1996)
Curr Opin Oncol
, vol.8
, pp. 66-71
-
-
Shay, J.W.1
Wright, W.E.2
-
73
-
-
0029013631
-
Telomerase activity associated with acquisition of malignancy in human colorectal cancer
-
Chadeneau C, Hay K, Hirtc HW, Gallinger S and Bacchetti S: Telomerase activity associated with acquisition of malignancy in human colorectal cancer. Cancer Res 55: 2533-2536, 1995.
-
(1995)
Cancer Res
, vol.55
, pp. 2533-2536
-
-
Chadeneau, C.1
Hay, K.2
Hirtc, H.W.3
Gallinger, S.4
Bacchetti, S.5
-
75
-
-
0030958979
-
Application of telomerase assay for the screening of cervical lesions
-
Kyo S, Takakura M, Ishikawa H et al: Application of telomerase assay for the screening of cervical lesions. Cancer Res 57: 1863-1867, 1997.
-
(1997)
Cancer Res
, vol.57
, pp. 1863-1867
-
-
Kyo, S.1
Takakura, M.2
Ishikawa, H.3
-
76
-
-
84993876589
-
Correlating telomerase activity levels with human neuroblastoma outcomes
-
Hiyama E, Hiyama K, Yokoyama T, Matsuura Y, Piatyszek MA and Shay JW: Correlating telomerase activity levels with human neuroblastoma outcomes. Nat Med 1: 249-255, 1995.
-
(1995)
Nat Med
, vol.1
, pp. 249-255
-
-
Hiyama, E.1
Hiyama, K.2
Yokoyama, T.3
Matsuura, Y.4
Piatyszek, M.A.5
Shay, J.W.6
-
77
-
-
0032548969
-
Telomerase activity correlates with tumor aggressiveness and reflects therapy effect in breast cancer
-
Hoos A, Hepp HH, Kaul S, Ahlert T, Bastert G and Wallwiener D: Telomerase activity correlates with tumor aggressiveness and reflects therapy effect in breast cancer. Inter J Cancer 79: 8-12, 1998.
-
(1998)
Inter J Cancer
, vol.79
, pp. 8-12
-
-
Hoos, A.1
Hepp, H.H.2
Kaul, S.3
Ahlert, T.4
Bastert, G.5
Wallwiener, D.6
-
78
-
-
0031050032
-
Telomerase activity and cytogenetic changes in chronic myeloid leukemia with disease progression
-
Ohyashiki K, Ohyashiki JH, Iwama H, Hayashi S, Shay JW, and Toyama K: Telomerase activity and cytogenetic changes in chronic myeloid leukemia with disease progression. Leukemia 11: 190-194, 1997.
-
(1997)
Leukemia
, vol.11
, pp. 190-194
-
-
Ohyashiki, K.1
Ohyashiki, J.H.2
Iwama, H.3
Hayashi, S.4
Shay, J.W.5
Toyama, K.6
-
80
-
-
1842414238
-
Molecular basis of artifacts in the detection of telomerase activity and a modified primer for a more robust 'TRAP' assay
-
Krupp G, Kuhne K, Tamm T et al: Molecular basis of artifacts in the detection of telomerase activity and a modified primer for a more robust 'TRAP' assay. Nucl Acids Res 25: 919-921, 1997.
-
(1997)
Nucl Acids Res
, vol.25
, pp. 919-921
-
-
Krupp, G.1
Kuhne, K.2
Tamm, T.3
-
81
-
-
0029023065
-
Modifications of a telomeric repeat amplification protocol (TRAP) result in increase reliability, linearity and sensitivity
-
Wright WE, Shay JW and Piatyszek MA: Modifications of a telomeric repeat amplification protocol (TRAP) result in increase reliability, linearity and sensitivity. Nucl Acids Res 23: 3794-3795, 1995.
-
(1995)
Nucl Acids Res
, vol.23
, pp. 3794-3795
-
-
Wright, W.E.1
Shay, J.W.2
Piatyszek, M.A.3
-
82
-
-
0032004602
-
Increased sensitivity and reproducibility of TRAP assay by avoiding direct primer interaction
-
Falchetti ML, Levi A, Molinari P, Verna R and Dambrosio E: Increased sensitivity and reproducibility of TRAP assay by avoiding direct primer interaction. Nucl Acids Res 26: 862-863, 1998.
-
(1998)
Nucl Acids Res
, vol.26
, pp. 862-863
-
-
Falchetti, M.L.1
Levi, A.2
Molinari, P.3
Verna, R.4
Dambrosio, E.5
-
83
-
-
0030743347
-
Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP)
-
Kim NW and Wu F: Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP). Nucl Acids Res 25: 2595-2597, 1997.
-
(1997)
Nucl Acids Res
, vol.25
, pp. 2595-2597
-
-
Kim, N.W.1
Wu, F.2
-
84
-
-
2642693706
-
Detecting human bladder carcinoma cells in voided urine samples by assaying for the presence of telomerase activity
-
Kavaler E, Landman J, Chang YL, Droller MJ and Liu BCS: Detecting human bladder carcinoma cells in voided urine samples by assaying for the presence of telomerase activity. Cancer 82: 708-714, 1998.
-
(1998)
Cancer
, vol.82
, pp. 708-714
-
-
Kavaler, E.1
Landman, J.2
Chang, Y.L.3
Droller, M.J.4
Liu, B.C.S.5
-
85
-
-
0032054066
-
Telomerase activity in benign and malignant breast lesions-A pilot prospective study on fine-needle aspirates
-
Villa R, Zaffaroni N, Folini M et al: Telomerase activity in benign and malignant breast lesions-A pilot prospective study on fine-needle aspirates. J Natl Cancer Inst 90: 537-539, 1998.
-
(1998)
J Natl Cancer Inst
, vol.90
, pp. 537-539
-
-
Villa, R.1
Zaffaroni, N.2
Folini, M.3
-
86
-
-
0031954619
-
In Situ hybridization analysis of the expression of human telomerase RNA in normal and pathologic conditions of the skin
-
Ogoshi M, Le T, Shay JW and Taylor RS: In Situ hybridization analysis of the expression of human telomerase RNA in normal and pathologic conditions of the skin. J Invest Dermatol 110: 818-823, 1998.
-
(1998)
J Invest Dermatol
, vol.110
, pp. 818-823
-
-
Ogoshi, M.1
Le, T.2
Shay, J.W.3
Taylor, R.S.4
-
87
-
-
0029162563
-
Telomere elongation in immortal human cells without detectable telomerase activity
-
Bryan TM, Englezou A, Gupta J, Bacchetti S and Reddel RR: Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 14: 4240-4248, 1995.
-
(1995)
EMBO J
, vol.14
, pp. 4240-4248
-
-
Bryan, T.M.1
Englezou, A.2
Gupta, J.3
Bacchetti, S.4
Reddel, R.R.5
-
88
-
-
0030697342
-
Evidence for an alternative mechanism for maintaining telomerc length in human tumors and tumor-derived cell lines
-
Bryan TM, Englezou A, Dalla-Pozza L, Dunham MA and Reddel RR: Evidence for an alternative mechanism for maintaining telomerc length in human tumors and tumor-derived cell lines. Nat Med 3: 1271-1274, 1997.
-
(1997)
Nat Med
, vol.3
, pp. 1271-1274
-
-
Bryan, T.M.1
Englezou, A.2
Dalla-Pozza, L.3
Dunham, M.A.4
Reddel, R.R.5
-
89
-
-
0029154735
-
Functional characterization and developmental regulation of mouse telomerase RNA
-
Blasco MA, Funk W, Villeponteau B and Greider CW: Functional characterization and developmental regulation of mouse telomerase RNA. Science 269: 1267-1270, 1995.
-
(1995)
Science
, vol.269
, pp. 1267-1270
-
-
Blasco, M.A.1
Funk, W.2
Villeponteau, B.3
Greider, C.W.4
-
90
-
-
0030070054
-
Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis
-
Blasco MA, Rizen M, Greider CW and Hanahan D: Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis. Nat Gen 12: 200-204, 1996.
-
(1996)
Nat Gen
, vol.12
, pp. 200-204
-
-
Blasco, M.A.1
Rizen, M.2
Greider, C.W.3
Hanahan, D.4
-
91
-
-
0032499210
-
Essential role of mouse telomerase in highly proliterative organs
-
Lee HW, Blasco MA, Gottlieb GJ, Horner JW, Greider CW and DePinho RA: Essential role of mouse telomerase in highly proliterative organs. Nature 392: 569-574, 1998.
-
(1998)
Nature
, vol.392
, pp. 569-574
-
-
Lee, H.W.1
Blasco, M.A.2
Gottlieb, G.J.3
Horner, J.W.4
Greider, C.W.5
DePinho, R.A.6
-
92
-
-
0029867408
-
Inhibition of human telomerase activity by peptide nucleic acids
-
Norton JC, Piatyszek MA, Wright WE, Shay JW and Corey DR: Inhibition of human telomerase activity by peptide nucleic acids. Nat Biotech 14: 615-619, 1996.
-
(1996)
Nat Biotech
, vol.14
, pp. 615-619
-
-
Norton, J.C.1
Piatyszek, M.A.2
Wright, W.E.3
Shay, J.W.4
Corey, D.R.5
-
93
-
-
0031590739
-
Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture
-
Ku WC, Cheng AJ and Wang TCV: Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture. Biochem Biophys Res Comm 241: 730-736, 1997.
-
(1997)
Biochem Biophys Res Comm
, vol.241
, pp. 730-736
-
-
Ku, W.C.1
Cheng, A.J.2
Wang, T.C.V.3
-
94
-
-
0030786928
-
Inhibition of human telomerase by a G-quadruplex-interactive compound
-
Sun DY, Thompson B, Cathers BE et al: Inhibition of human telomerase by a G-quadruplex-interactive compound. J Med Chem 40: 2113-2116, 1997.
-
(1997)
J Med Chem
, vol.40
, pp. 2113-2116
-
-
Sun, D.Y.1
Thompson, B.2
Cathers, B.E.3
-
95
-
-
0030583250
-
Hammerhead ribozyme-mediated inhibition of telomerase activity in extracts of human hepatocellular carcinoma cells
-
Kanazawa Y, Ohkawa K, Ueda K et al: Hammerhead ribozyme-mediated inhibition of telomerase activity in extracts of human hepatocellular carcinoma cells. Biochem Biophys Res Comm 225: 570-576, 1996.
-
(1996)
Biochem Biophys Res Comm
, vol.225
, pp. 570-576
-
-
Kanazawa, Y.1
Ohkawa, K.2
Ueda, K.3
-
96
-
-
0029655485
-
Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines
-
Strahl C and Blackburn EH: Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines. Mol Cell Biol 16: 53-65, 1996.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 53-65
-
-
Strahl, C.1
Blackburn, E.H.2
-
98
-
-
0031023664
-
Telomerase activation and cancer
-
Klingelhutz AJ: Telomerase activation and cancer. J Mol Med 75: 45-49, 1997.
-
(1997)
J Mol Med
, vol.75
, pp. 45-49
-
-
Klingelhutz, A.J.1
-
99
-
-
0031036350
-
A mammalian telomerase-associated protein
-
Harrington L, Mcphail T, Mar V et al: A mammalian telomerase-associated protein. Science 275: 973-977, 1997.
-
(1997)
Science
, vol.275
, pp. 973-977
-
-
Harrington, L.1
Mcphail, T.2
Mar, V.3
|