메뉴 건너뛰기




Volumn 55, Issue 5, 1999, Pages 629-642

Death of PC12 cells and hippocampal neurons induced by adenoviral- mediated FAD human amyloid precursor protein gene expression

Author keywords

Alzheimer's disease; Cell culture; Cell death; Gene transfer; Neurodegeneration

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BETA GALACTOSIDASE; FLAVINE ADENINE NUCLEOTIDE; VIRUS VECTOR;

EID: 0033104420     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19990301)55:5<629::AID-JNR10>3.0.CO;2-Y     Document Type: Article
Times cited : (41)

References (93)
  • 3
    • 0027477148 scopus 로고
    • Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors
    • Bajocchi G, Feldman SH, Crystal RG, Mastrangeli A. 1993. Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors. Nat Genet 3:229-234.
    • (1993) Nat Genet , vol.3 , pp. 229-234
    • Bajocchi, G.1    Feldman, S.H.2    Crystal, R.G.3    Mastrangeli, A.4
  • 6
    • 0031004788 scopus 로고    scopus 로고
    • Amyloid β-peptide induces cell monolayer albumin permeability, impairs glucose transport, and induces apoptosis in vascular endothelial cells
    • Blanc EM, Toborek M, Mark RJ, Henning B, Mattson MP. 1997. Amyloid β-peptide induces cell monolayer albumin permeability, impairs glucose transport, and induces apoptosis in vascular endothelial cells. J Neurochem 68:1870-1881.
    • (1997) J Neurochem , vol.68 , pp. 1870-1881
    • Blanc, E.M.1    Toborek, M.2    Mark, R.J.3    Henning, B.4    Mattson, M.P.5
  • 7
    • 0027512404 scopus 로고
    • Gene delivery into the brain using virus vectors
    • Breakefield XO. 1993. Gene delivery into the brain using virus vectors. Nat Genet 3:187-189.
    • (1993) Nat Genet , vol.3 , pp. 187-189
    • Breakefield, X.O.1
  • 8
    • 0027429732 scopus 로고
    • β-Amyloid neurotoxicity in human cortical culture is not mediated by excitotoxins
    • Busciglio J, Yeh J, Yankner BA. 1993. β-Amyloid neurotoxicity in human cortical culture is not mediated by excitotoxins. J Neurochem 61:1565-1568.
    • (1993) J Neurochem , vol.61 , pp. 1565-1568
    • Busciglio, J.1    Yeh, J.2    Yankner, B.A.3
  • 9
    • 0027096150 scopus 로고
    • Beta A4 amyloid protein and its precursor in Alzheimer's disease
    • Bush AI, Beyreuther K, Masters CL. 1992. Beta A4 amyloid protein and its precursor in Alzheimer's disease. Pharmacol Ther 56:97-117.
    • (1992) Pharmacol Ther , vol.56 , pp. 97-117
    • Bush, A.I.1    Beyreuther, K.2    Masters, C.L.3
  • 10
    • 0024386288 scopus 로고
    • Neurotrophic agents may exacerbate the pathologic cascade of Alzheimer's disease
    • Butcher LL, Woolf NJ. 1989. Neurotrophic agents may exacerbate the pathologic cascade of Alzheimer's disease. Neurobiol Aging 10:557-570.
    • (1989) Neurobiol Aging , vol.10 , pp. 557-570
    • Butcher, L.L.1    Woolf, N.J.2
  • 11
    • 0027526419 scopus 로고
    • Release of excess amyloid β protein from a mutant amyloid β protein precursor
    • Cai X-D, Golde TE, Younkin SG. 1993. Release of excess amyloid β protein from a mutant amyloid β protein precursor. Science 259:514-516.
    • (1993) Science , vol.259 , pp. 514-516
    • Cai, X.-D.1    Golde, T.E.2    Younkin, S.G.3
  • 16
    • 0028292343 scopus 로고
    • Secretion of nerve growth factor from septum stimulates neurite outgrowth and release of the amyloid protein precursor of Alzheimer's disease from hippocampal explants
    • Clarris HJ, Nurcombe V, Small DH, Beyreuther K, Masters CL. 1994. Secretion of nerve growth factor from septum stimulates neurite outgrowth and release of the amyloid protein precursor of Alzheimer's disease from hippocampal explants. J Neurosci Res 38:248-258.
    • (1994) J Neurosci Res , vol.38 , pp. 248-258
    • Clarris, H.J.1    Nurcombe, V.2    Small, D.H.3    Beyreuther, K.4    Masters, C.L.5
  • 17
    • 0345263001 scopus 로고
    • A transgenic mouse model of Alzheimer's disease
    • Masters CL, Beyreuther K, Trillet M, Christen Y, editors. Berlin: Springer-Verlag
    • Cordell B, Higgins L. 1994. A transgenic mouse model of Alzheimer's disease. In: Masters CL, Beyreuther K, Trillet M, Christen Y, editors. Amyloid protein precursor in development, aging and Alzheimer's disease. Berlin: Springer-Verlag. p 144-145.
    • (1994) Amyloid Protein Precursor in Development, Aging and Alzheimer's Disease , pp. 144-145
    • Cordell, B.1    Higgins, L.2
  • 18
    • 0029888642 scopus 로고    scopus 로고
    • Nerve growth factor and ras regulate beta-amyloid precursor protein gene expression in PC12 cells
    • Cosgaya JM, Latasa MJ, Pascual A. 1996. Nerve growth factor and ras regulate beta-amyloid precursor protein gene expression in PC12 cells. J Neurochem 67:98-104.
    • (1996) J Neurochem , vol.67 , pp. 98-104
    • Cosgaya, J.M.1    Latasa, M.J.2    Pascual, A.3
  • 19
    • 0026713423 scopus 로고
    • β-Amyloid neurotoxicity: A discussion of in vitro findings
    • Cotman CW, Pike CJ, Copani A. 1992. β-Amyloid neurotoxicity: a discussion of in vitro findings. Neurobiol Aging 13:587-590.
    • (1992) Neurobiol Aging , vol.13 , pp. 587-590
    • Cotman, C.W.1    Pike, C.J.2    Copani, A.3
  • 20
    • 0027522920 scopus 로고
    • A model system for in vivo gene transfer into the central nervous system using an adenoviral vector
    • Davidson BL, Allen ED, Kozarsky KF, Wilson JM, Roessler BJ. 1993. A model system for in vivo gene transfer into the central nervous system using an adenoviral vector. Nat Genet 3:219-223.
    • (1993) Nat Genet , vol.3 , pp. 219-223
    • Davidson, B.L.1    Allen, E.D.2    Kozarsky, K.F.3    Wilson, J.M.4    Roessler, B.J.5
  • 21
    • 0028280433 scopus 로고
    • Expression of Escherichia coli beta-galactosidase and rat HPRT in the CNS of Macaca mulatta following adenoviral mediated gene transfer
    • Davidson BL, Doran SE, Shewach DS, Latta JM, Hartman JW, Roessler BJ. 1994. Expression of Escherichia coli beta-galactosidase and rat HPRT in the CNS of Macaca mulatta following adenoviral mediated gene transfer. Exp Neurol 125: 258-267.
    • (1994) Exp Neurol , vol.125 , pp. 258-267
    • Davidson, B.L.1    Doran, S.E.2    Shewach, D.S.3    Latta, J.M.4    Hartman, J.W.5    Roessler, B.J.6
  • 23
    • 0029787071 scopus 로고    scopus 로고
    • Induction of cell death by endogenous nerve growth factor through its p75 receptor
    • Frade JM, Rodríguez-Tébar, Barde Y-A. 1996. Induction of cell death by endogenous nerve growth factor through its p75 receptor. Nature 383:166-168.
    • (1996) Nature , vol.383 , pp. 166-168
    • Frade, J.M.1    Rodríguez-Tébar2    Barde, Y.-A.3
  • 24
    • 0029934027 scopus 로고    scopus 로고
    • Rodent models of Alzheimer's disease: Rat A beta infusion approaches to amyloid deposits
    • Frautschy SA, Yang F, Calderon L, Cole GM. 1996. Rodent models of Alzheimer's disease: rat A beta infusion approaches to amyloid deposits. Neurobiol Aging 17:311-321.
    • (1996) Neurobiol Aging , vol.17 , pp. 311-321
    • Frautschy, S.A.1    Yang, F.2    Calderon, L.3    Cole, G.M.4
  • 27
    • 0030702916 scopus 로고    scopus 로고
    • Alzheimer's disease
    • Gilman S. 1996. Alzheimer's disease. Perspect Biol Med 40:230-245.
    • (1996) Perspect Biol Med , vol.40 , pp. 230-245
    • Gilman, S.1
  • 29
    • 0017710978 scopus 로고
    • Characteristics of a human cell line transformed by DNA from human adenovirus type 5
    • Graham FL, Smiley J, Russell WC, Nairn R. 1977. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol 36:59-74.
    • (1977) J Gen Virol , vol.36 , pp. 59-74
    • Graham, F.L.1    Smiley, J.2    Russell, W.C.3    Nairn, R.4
  • 31
    • 0026735070 scopus 로고
    • Targeting of cell-surface β-amyloid precursor protein to lysosomes: Alternative processing into amyloid-bearing fragments
    • Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ. 1992. Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature 357:500-503.
    • (1992) Nature , vol.357 , pp. 500-503
    • Haass, C.1    Koo, E.H.2    Mellon, A.3    Hung, A.Y.4    Selkoe, D.J.5
  • 32
    • 0031052381 scopus 로고    scopus 로고
    • Amyloid, the presenilins and Alzheimer's disease
    • Hardy J. 1997. Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci 20:154-159.
    • (1997) Trends Neurosci , vol.20 , pp. 154-159
    • Hardy, J.1
  • 35
    • 0031240834 scopus 로고    scopus 로고
    • Gene therapy for Parkinson's disease
    • Horellou P, Mallet J. 1997. Gene therapy for Parkinson's disease. Mol Neurobiol 15:241-256.
    • (1997) Mol Neurobiol , vol.15 , pp. 241-256
    • Horellou, P.1    Mallet, J.2
  • 36
    • 0028606905 scopus 로고
    • Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease
    • Horellou P, Vigne E, Castel MN, Barneoud P, Colin P, Perricaudet M, Delaere P, Mallet J. 1994. Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease. NeuroReport 6:49-53.
    • (1994) NeuroReport , vol.6 , pp. 49-53
    • Horellou, P.1    Vigne, E.2    Castel, M.N.3    Barneoud, P.4    Colin, P.5    Perricaudet, M.6    Delaere, P.7    Mallet, J.8
  • 37
    • 0027967549 scopus 로고
    • Neurodegeneration, Alzheimer's disease, and beta-amyloid toxicity
    • Hoyer S. 1994. Neurodegeneration, Alzheimer's disease, and beta-amyloid toxicity. Life Sci 55:1977-1983.
    • (1994) Life Sci , vol.55 , pp. 1977-1983
    • Hoyer, S.1
  • 40
    • 0030038473 scopus 로고    scopus 로고
    • Dysfunction of cholinergic and dopaminergic neuronal systems in beta-amyloid protein-infused rats
    • Itoh A, Nitta A, Nadai M, Nishimura K, Hirose M, Hasegawa T, Nabeshima T. 1996. Dysfunction of cholinergic and dopaminergic neuronal systems in beta-amyloid protein-infused rats. J Neurochem 66:1113-1137.
    • (1996) J Neurochem , vol.66 , pp. 1113-1137
    • Itoh, A.1    Nitta, A.2    Nadai, M.3    Nishimura, K.4    Hirose, M.5    Hasegawa, T.6    Nabeshima, T.7
  • 42
    • 0028169925 scopus 로고
    • Visualization of A beta 42(43): And A beta 40 in senile plaques with end-specific A beta monoclonals: Evidence that an initially deposited species is A beta 42(43)
    • Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y. 1994. Visualization of A beta 42(43): and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron 13:45-53.
    • (1994) Neuron , vol.13 , pp. 45-53
    • Iwatsubo, T.1    Odaka, A.2    Suzuki, N.3    Mizusawa, H.4    Nukina, N.5    Ihara, Y.6
  • 43
    • 0027258525 scopus 로고
    • The carboxy terminus of the β amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
    • Jarrett JT, Berger EP, Lansbury PT Jr. 1993. The carboxy terminus of the β amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry 32:4693-4697.
    • (1993) Biochemistry , vol.32 , pp. 4693-4697
    • Jarrett, J.T.1    Berger, E.P.2    Lansbury P.T., Jr.3
  • 45
    • 0028850087 scopus 로고
    • Suppression of mitochondrial succinate dehydrogenase, a primary target of β amyloid, and its derivative racemized at ser residue
    • Kaneko I, Yamada N, Sakuraba Y, Kamenosono M, Tutumi S. 1995. Suppression of mitochondrial succinate dehydrogenase, a primary target of β amyloid, and its derivative racemized at ser residue. J Neurochem 65:2585-2593.
    • (1995) J Neurochem , vol.65 , pp. 2585-2593
    • Kaneko, I.1    Yamada, N.2    Sakuraba, Y.3    Kamenosono, M.4    Tutumi, S.5
  • 47
    • 0025110182 scopus 로고
    • β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage
    • Koh J-Y, Yang LL, Cotman CW. 1990. β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage. Brain Res 333:315-320.
    • (1990) Brain Res , vol.333 , pp. 315-320
    • Koh, J.-Y.1    Yang, L.L.2    Cotman, C.W.3
  • 49
    • 0028981717 scopus 로고
    • The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice
    • LaFerla FM, Tinkle BT, Bieberich CJ, Haudenschild CC, Jay G. 1995. The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat Genet 9:21-30.
    • (1995) Nat Genet , vol.9 , pp. 21-30
    • LaFerla, F.M.1    Tinkle, B.T.2    Bieberich, C.J.3    Haudenschild, C.C.4    Jay, G.5
  • 50
    • 0029114162 scopus 로고
    • Promoter activity of the gene encoding the beta-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1
    • Lahiri DK, Nall C. 1995. Promoter activity of the gene encoding the beta-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1. Brain Res Mol Brain Res 32:233-240.
    • (1995) Brain Res Mol Brain Res , vol.32 , pp. 233-240
    • Lahiri, D.K.1    Nall, C.2
  • 54
    • 0028630640 scopus 로고
    • Modulation of the PC12 cell response to nerve growth factor by antisense oligonucleotide to amyloid precursor protein
    • Majocha RE, Agrawal S, Tang JY, Humke EW, Marotta CA. 1994. Modulation of the PC12 cell response to nerve growth factor by antisense oligonucleotide to amyloid precursor protein. Cell Mol Neurobiol 14:425-437.
    • (1994) Cell Mol Neurobiol , vol.14 , pp. 425-437
    • Majocha, R.E.1    Agrawal, S.2    Tang, J.Y.3    Humke, E.W.4    Marotta, C.A.5
  • 55
    • 0026688163 scopus 로고
    • Effect of beta amyloid peptides on neurons in hippocampal slice cultures
    • Malouf AT. 1992. Effect of beta amyloid peptides on neurons in hippocampal slice cultures. Neurobiol Aging 13:543-551.
    • (1992) Neurobiol Aging , vol.13 , pp. 543-551
    • Malouf, A.T.1
  • 56
    • 0031020993 scopus 로고    scopus 로고
    • Amyloid β-peptide impairs glucose transport in hippocampal and cortical neurons: Involvement of membrane lipid peroxidation
    • Mark RJ, Pang Z, Geddes JW, Uchida K, Mattson MP. 1997. Amyloid β-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation. J Neurosci 17:1046-1054.
    • (1997) J Neurosci , vol.17 , pp. 1046-1054
    • Mark, R.J.1    Pang, Z.2    Geddes, J.W.3    Uchida, K.4    Mattson, M.P.5
  • 58
    • 0030779677 scopus 로고    scopus 로고
    • Cellular actions of β-amyloid precursor protein and its soluble and fibrillogenic derivatives
    • Mattson MP. 1997. Cellular actions of β-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol Rev 77:1081-1132.
    • (1997) Physiol Rev , vol.77 , pp. 1081-1132
    • Mattson, M.P.1
  • 59
    • 0030867815 scopus 로고    scopus 로고
    • Neuronal expression of beta-amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains
    • McPhie DL, Lee RKK, Eckman CB, Olstein DH, Durham S, Yager D, Younkin SG, Wurtman RJ, Neve RL. 1997. Neuronal expression of beta-amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains. J Biol Chem 272:24743-24746.
    • (1997) J Biol Chem , vol.272 , pp. 24743-24746
    • McPhie, D.L.1    Lee, R.K.K.2    Eckman, C.B.3    Olstein, D.H.4    Durham, S.5    Yager, D.6    Younkin, S.G.7    Wurtman, R.J.8    Neve, R.L.9
  • 60
    • 0026794746 scopus 로고
    • Mass spectrometry of purified amyloid β protein in Alzheimer's disease
    • Mori H, Takio K, Ogawara M, Selkoe DJ. 1992. Mass spectrometry of purified amyloid β protein in Alzheimer's disease. J Biol Chem 267:17028-17086.
    • (1992) J Biol Chem , vol.267 , pp. 17028-17086
    • Mori, H.1    Takio, K.2    Ogawara, M.3    Selkoe, D.J.4
  • 62
    • 0032053984 scopus 로고    scopus 로고
    • Degeneration in vivo of rat hippocampal neurons by wild type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer
    • Nishimura I, Uetsuki T, Dani SU, Ohsawa Y, Saito I, Okamura H, Uchiyama Y, Yoshikawa K. 1998. Degeneration in vivo of rat hippocampal neurons by wild type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer. J Neurosci 18:2387-2398.
    • (1998) J Neurosci , vol.18 , pp. 2387-2398
    • Nishimura, I.1    Uetsuki, T.2    Dani, S.U.3    Ohsawa, Y.4    Saito, I.5    Okamura, H.6    Uchiyama, Y.7    Yoshikawa, K.8
  • 63
    • 0029862137 scopus 로고    scopus 로고
    • Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein
    • Oster-Granite ML, McPhie DL, Greenan J, Neve RL. 1996. Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein. J Neurosci 16:6732-6741.
    • (1996) J Neurosci , vol.16 , pp. 6732-6741
    • Oster-Granite, M.L.1    McPhie, D.L.2    Greenan, J.3    Neve, R.L.4
  • 64
    • 0031453752 scopus 로고    scopus 로고
    • The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity
    • Perez RG, Zheng H, Van der Ploeg LH, Koo EH. 1997. The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity. J Neurosci 17:9407-9414.
    • (1997) J Neurosci , vol.17 , pp. 9407-9414
    • Perez, R.G.1    Zheng, H.2    Van Der Ploeg, L.H.3    Koo, E.H.4
  • 65
    • 0031921466 scopus 로고    scopus 로고
    • Mutant genes in familial Alzheimer's disease and transgenic models
    • Price DL, Sisodia SS. 1998. Mutant genes in familial Alzheimer's disease and transgenic models. Annu Rev Neurosci 21:479-505.
    • (1998) Annu Rev Neurosci , vol.21 , pp. 479-505
    • Price, D.L.1    Sisodia, S.S.2
  • 67
  • 68
    • 0025264747 scopus 로고
    • Fibroblast growth factor induces β-amyloid precursor mRNA in glia but not neuronal cultured cells
    • Quon D, Catalano R, Cordell B. 1990. Fibroblast growth factor induces β-amyloid precursor mRNA in glia but not neuronal cultured cells. Biochem Biophys Res Commun 167:96-102.
    • (1990) Biochem Biophys Res Commun , vol.167 , pp. 96-102
    • Quon, D.1    Catalano, R.2    Cordell, B.3
  • 69
    • 0024466345 scopus 로고
    • Nerve and epidermal growth factors induce the release of the Alzheimer amyloid precursor from PC 12 cell cultures
    • Refolo LM, Salton SRJ, Anderson JP, Mehta P, Robakis NK. 1989. Nerve and epidermal growth factors induce the release of the Alzheimer amyloid precursor from PC 12 cell cultures. Biochem Biophys Res Commun 164:664-670.
    • (1989) Biochem Biophys Res Commun , vol.164 , pp. 664-670
    • Refolo, L.M.1    Salton, S.R.J.2    Anderson, J.P.3    Mehta, P.4    Robakis, N.K.5
  • 71
    • 0031885387 scopus 로고    scopus 로고
    • Adenovirus-mediated expression of an elastase-specific inhibitor (elafin): A comparison of different promoters
    • Sallenave JM, Xing Z, Simpson AJ, Graham FL, Gauldie J. 1998. Adenovirus-mediated expression of an elastase-specific inhibitor (elafin): a comparison of different promoters. Gene Ther 5:352-360.
    • (1998) Gene Ther , vol.5 , pp. 352-360
    • Sallenave, J.M.1    Xing, Z.2    Simpson, A.J.3    Graham, F.L.4    Gauldie, J.5
  • 72
    • 0029875801 scopus 로고    scopus 로고
    • Expression of the C terminus of the amyloid precursor protein alters growth factor responsiveness in stably transfected PC12 cells
    • Sandhu FA, Kim Y, Lapan KA, Salim M, Aliuddin V, Zain SB. 1996. Expression of the C terminus of the amyloid precursor protein alters growth factor responsiveness in stably transfected PC12 cells. Proc Natl Acad Sci USA 93:2180-2185.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2180-2185
    • Sandhu, F.A.1    Kim, Y.2    Lapan, K.A.3    Salim, M.4    Aliuddin, V.5    Zain, S.B.6
  • 73
    • 0029876963 scopus 로고    scopus 로고
    • The production of an amyloidogenic metabolite of the Alzheimer amyloid beta precursor protein (APP): In thyroid cells is stimulated by interleukin 1 beta, but inhibited by interferon gamma
    • Schmitt TL, Steiner E, Klinger P, Sztankay A, Grubeck-Loebenstein B. 1996. The production of an amyloidogenic metabolite of the Alzheimer amyloid beta precursor protein (APP): in thyroid cells is stimulated by interleukin 1 beta, but inhibited by interferon gamma. J Clin Endocrinol Metab 81:1666-1669.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1666-1669
    • Schmitt, T.L.1    Steiner, E.2    Klinger, P.3    Sztankay, A.4    Grubeck-Loebenstein, B.5
  • 74
    • 0027367764 scopus 로고
    • Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease
    • Selkoe DJ. 1993. Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease. Trends Neurosci 16:403-409.
    • (1993) Trends Neurosci , vol.16 , pp. 403-409
    • Selkoe, D.J.1
  • 75
    • 0029784838 scopus 로고    scopus 로고
    • Amyloid beta-protein and the genetics of Alzheimer's disease
    • Selkoe DJ. 1996. Amyloid beta-protein and the genetics of Alzheimer's disease. J Biol Chem 271:18295-18298.
    • (1996) J Biol Chem , vol.271 , pp. 18295-18298
    • Selkoe, D.J.1
  • 76
    • 0028118846 scopus 로고
    • Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of β-amyloid-mediated cell death
    • Shearman MS, Ragan CI, Iversen LL. 1994. Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of β-amyloid-mediated cell death. Proc Natl Acad Sci USA 91:1470-1474.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 1470-1474
    • Shearman, M.S.1    Ragan, C.I.2    Iversen, L.L.3
  • 77
    • 0024005801 scopus 로고
    • Alzheimer's disease amyloidogenic glycoprotein: Expression pattern in rat brain suggests a role in cell contact
    • Shivers BD, Hilbich C, Multhaup G, Salbaum M, Beyreuther K, Seeburg PH. 1988. Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact. EMBO J 7:1365-1370.
    • (1988) EMBO J , vol.7 , pp. 1365-1370
    • Shivers, B.D.1    Hilbich, C.2    Multhaup, G.3    Salbaum, M.4    Beyreuther, K.5    Seeburg, P.H.6
  • 79
    • 0030723893 scopus 로고    scopus 로고
    • Rapid stimulation of amyloid precursor protein release by epidermal growth factor: Role of protein kinase C
    • Slack BE, Breu J, Muchnicki L, Wurtman RJ. 1997. Rapid stimulation of amyloid precursor protein release by epidermal growth factor: role of protein kinase C. Biochem J 327:245-249.
    • (1997) Biochem J , vol.327 , pp. 245-249
    • Slack, B.E.1    Breu, J.2    Muchnicki, L.3    Wurtman, R.J.4
  • 81
    • 0028322017 scopus 로고
    • An increased percentage of long amyloid β protein secreted by familial amyloid β protein precursor (βAPP717) mutants
    • Suzuki N, Cheung TT, Cai X-D, Odaka A, Otvos Jr. L, Eckman C, Golde TE, Younkin SG. 1994. An increased percentage of long amyloid β protein secreted by familial amyloid β protein precursor (βAPP717) mutants. Science 264:1336-1340.
    • (1994) Science , vol.264 , pp. 1336-1340
    • Suzuki, N.1    Cheung, T.T.2    Cai, X.-D.3    Odaka, A.4    Otvos L., Jr.5    Eckman, C.6    Golde, T.E.7    Younkin, S.G.8
  • 83
    • 0029013955 scopus 로고
    • Chronic elevation of secreted amyloid precursor protein in subcortically lesioned rats, and its exacerbation in aged rats
    • Wallace WC, Lieberburg I, Schenk D, Vigo-Pelfrey C, Davis KL, Haroutunian V. 1995. Chronic elevation of secreted amyloid precursor protein in subcortically lesioned rats, and its exacerbation in aged rats. J Neurosci 15:4896-4905.
    • (1995) J Neurosci , vol.15 , pp. 4896-4905
    • Wallace, W.C.1    Lieberburg, I.2    Schenk, D.3    Vigo-Pelfrey, C.4    Davis, K.L.5    Haroutunian, V.6
  • 84
    • 0031574345 scopus 로고    scopus 로고
    • Amyloid precursor protein potentiates the neurotrophic activity of NGF
    • Wallace WC, Akar CA, Lyons WE. 1997a. Amyloid precursor protein potentiates the neurotrophic activity of NGF. Brain Res Mol Brain Res 52:201-212.
    • (1997) Brain Res Mol Brain Res , vol.52 , pp. 201-212
    • Wallace, W.C.1    Akar, C.A.2    Lyons, W.E.3
  • 89
    • 0030042249 scopus 로고    scopus 로고
    • Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype
    • Yamatsuji T, Okamoto T, Takeda S, Murayama Y, Tanaka N, Nishimoto I. 1996. Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype. EMBO J 15:498-509.
    • (1996) EMBO J , vol.15 , pp. 498-509
    • Yamatsuji, T.1    Okamoto, T.2    Takeda, S.3    Murayama, Y.4    Tanaka, N.5    Nishimoto, I.6
  • 90
    • 0026686938 scopus 로고
    • Commentary and perspective on studies of beta amyloid neurotoxicity
    • Yankner BA. 1992. Commentary and perspective on studies of beta amyloid neurotoxicity. Neurobiol Aging 13:615-616.
    • (1992) Neurobiol Aging , vol.13 , pp. 615-616
    • Yankner, B.A.1
  • 91
    • 0025244165 scopus 로고
    • Nerve growth factor potentiates the neurotoxicity of β amyloid
    • Yankner BA, Cacere A, Duffy LK. 1990. Nerve growth factor potentiates the neurotoxicity of β amyloid. Proc Natl Acad Sci USA 87:9020-9023.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 9020-9023
    • Yankner, B.A.1    Cacere, A.2    Duffy, L.K.3
  • 92
    • 0028896735 scopus 로고
    • Altered processing of a mutant amyloid precursor protein in neuronal and endothelial cells
    • Zhao B, Sisodia SS, Kusiak JW. 1995. Altered processing of a mutant amyloid precursor protein in neuronal and endothelial cells. J Neurosci Res 40:261-268.
    • (1995) J Neurosci Res , vol.40 , pp. 261-268
    • Zhao, B.1    Sisodia, S.S.2    Kusiak, J.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.