pRb and E2f-1 in mouse development and tumorigenesis

Current Opinion in Genetics and Development

Volumn 9, Issue 1, 1999, Pages 31-39

  MacLeod, Kay ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F;

APOPTOSIS; CARCINOGENESIS; CELL CYCLE; CELL DIFFERENTIATION; EMBRYO DEVELOPMENT; ONCOGENE; PRIORITY JOURNAL; REVIEW; TUMOR SUPPRESSOR GENE;

ANIMALIA;

EID: 0033040967     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(99)80005-7     Document Type: Article

References (64)

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61. 1 arrest but which retained the ability to induce the 'flat cell phenotype' and induce specific markers of differentiation. The naturally occurring RB mutation, R661W, has similar properties when tested in these assays. This is a key paper illustrating the important role played by RB in differentiation and its significance to tumorigenesis. It also suggests that RB has E2F-independent functions in differentiation and in tumorigenesis.
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