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Volumn 16, Issue 2, 1996, Pages 685-693

E2F-1 blocks terminal differentiation and causes proliferation in transgenic megakaryocytes

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR; PLATELET DERIVED GROWTH FACTOR; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

EID: 0030031542     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.2.685     Document Type: Article
Times cited : (76)

References (58)
  • 1
    • 0028226814 scopus 로고
    • Interleukin-6 and erythropoietin act as direct potentiators and inducers of in vitro cytoplasmic process formation on purified mouse megakaryocytes
    • An, E., K. Ogata, S. Kuriya, and T. Nomura. 1994. Interleukin-6 and erythropoietin act as direct potentiators and inducers of in vitro cytoplasmic process formation on purified mouse megakaryocytes. Exp. Hematol. 22: 149-136.
    • (1994) Exp. Hematol. , vol.22 , pp. 149-1136
    • An, E.1    Ogata, K.2    Kuriya, S.3    Nomura, T.4
  • 2
    • 0027434084 scopus 로고
    • Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F
    • Bandara, L. R., V. M. Buck, M. Zamanian, L. H. Johnston, and N. B. La Thangue. 1993 Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F. EMBO J. 12:4317-4324
    • (1993) EMBO J. , vol.12 , pp. 4317-4324
    • Bandara, L.R.1    Buck, V.M.2    Zamanian, M.3    Johnston, L.H.4    La Thangue, N.B.5
  • 3
    • 0028343099 scopus 로고
    • Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl
    • Bartley, T. D., J. Bogenberger, P. Hunt, Y. S. Li, H. S. Lu, F. Martin, M. S. Chang, B. Samal, J. L. Nichol, S. Swift, et al. 1994. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl Cell 77:1117-1124.
    • (1994) Cell , vol.77 , pp. 1117-1124
    • Bartley, T.D.1    Bogenberger, J.2    Hunt, P.3    Li, Y.S.4    Lu, H.S.5    Martin, F.6    Chang, M.S.7    Samal, B.8    Nichol, J.L.9    Swift, S.10
  • 4
    • 0027985749 scopus 로고
    • E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo
    • Beijersbergen, R. L., R. M. Kerkhoven, L. Zhu, L. Carlee, P. M. Voorhoeve, and R. Bernards. 1994. E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes Dev 8:2680-2690.
    • (1994) Genes Dev , vol.8 , pp. 2680-2690
    • Beijersbergen, R.L.1    Kerkhoven, R.M.2    Zhu, L.3    Carlee, L.4    Voorhoeve, P.M.5    Bernards, R.6
  • 6
    • 0028361374 scopus 로고
    • Regulation of two E2F-related genes in presenescent and senescent human fibroblasts
    • Dimri, G. P., E. Hara, and J. Campisi. 1994. Regulation of two E2F-related genes in presenescent and senescent human fibroblasts. J. Biol. Chem. 269: 16180-16186
    • (1994) J. Biol. Chem. , vol.269 , pp. 16180-16186
    • Dimri, G.P.1    Hara, E.2    Campisi, J.3
  • 7
    • 0028054863 scopus 로고
    • G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter
    • Dou, Q. P., S. Zhao, A. H. Levin, J. Wang, K. Helin, and A. B. Pardee. 1994 G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter. J Biol. Chem. 269:1306-1313.
    • (1994) J Biol. Chem. , vol.269 , pp. 1306-1313
    • Dou, Q.P.1    Zhao, S.2    Levin, A.H.3    Wang, J.4    Helin, K.5    Pardee, A.B.6
  • 8
    • 0028025563 scopus 로고
    • Apoptosis in cancer therapy: Crossing the threshold
    • Fisher, D. E. 1994. Apoptosis in cancer therapy: crossing the threshold. Cell 78:539-542.
    • (1994) Cell , vol.78 , pp. 539-542
    • Fisher, D.E.1
  • 9
    • 0027250860 scopus 로고
    • E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product
    • Flemington, E. K., S. H. Speck, and W. G. Kaelin, Jr. 1993. E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product Proc. Natl Acad Sci. USA 90:6914-6918
    • (1993) Proc. Natl Acad Sci. USA , vol.90 , pp. 6914-6918
    • Flemington, E.K.1    Speck, S.H.2    Kaelin Jr., W.G.3
  • 10
    • 0002999037 scopus 로고
    • Megakaryocytopoiesis and platelet production
    • R. Hoffman, E. J Benz, S. J. Shattil, B Furie, and H J. Cohen (ed.), Churchill Livingstone, New York
    • Gewirtz, A. M., and M. Poncz. 1991 Megakaryocytopoiesis and platelet production, p. 1148-1157. In R. Hoffman, E. J Benz, S. J. Shattil, B Furie, and H J. Cohen (ed.), Hematology: basic principles and practice. Churchill Livingstone, New York.
    • (1991) Hematology: Basic Principles and Practice , pp. 1148-1157
    • Gewirtz, A.M.1    Poncz, M.2
  • 13
    • 0027499060 scopus 로고
    • Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation
    • Gu, W., J. W. Schneider, G. Condorelli, S. Kaushal, V. Mahdavi, and B. Nadal Ginard. 1993. Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 72:309-324.
    • (1993) Cell , vol.72 , pp. 309-324
    • Gu, W.1    Schneider, J.W.2    Condorelli, G.3    Kaushal, S.4    Mahdavi, V.5    Nadal Ginard, B.6
  • 15
    • 0027382336 scopus 로고
    • Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein
    • Helin, K., E. Harlow, and A. Fattaey. 1993. Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. Mol. Cell. Biol 13: 6501-6508.
    • (1993) Mol. Cell. Biol , vol.13 , pp. 6501-6508
    • Helin, K.1    Harlow, E.2    Fattaey, A.3
  • 16
    • 0026652346 scopus 로고
    • A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F
    • Helin, K., J. A. Lees, M. Vidal, N. Dyson, E. Harlow, and A. Fattaey. 1992 A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell 70:337-350.
    • (1992) Cell , vol.70 , pp. 337-350
    • Helin, K.1    Lees, J.A.2    Vidal, M.3    Dyson, N.4    Harlow, E.5    Fattaey, A.6
  • 17
    • 0027426917 scopus 로고
    • Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation
    • Helin, K., C. L. Wu, A. R. Fattaey, J. A. Lees, B. D. Dynlacht, C. Ngwu, and E. Harlow. 1993. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes Dev. 7:1850-1861.
    • (1993) Genes Dev. , vol.7 , pp. 1850-1861
    • Helin, K.1    Wu, C.L.2    Fattaey, A.R.3    Lees, J.A.4    Dynlacht, B.D.5    Ngwu, C.6    Harlow, E.7
  • 18
    • 0024449946 scopus 로고
    • Regulation of megakaryocytopoiesis
    • Hoffman, R. 1989. Regulation of megakaryocytopoiesis Blood 74:1196-1212.
    • (1989) Blood , vol.74 , pp. 1196-1212
    • Hoffman, R.1
  • 20
    • 0028276864 scopus 로고
    • Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter
    • Hsiao, K. M., S. L. McMahon, and P. J. Farnham. 1994. Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter. Genes Dev. 8:1526-1537.
    • (1994) Genes Dev. , vol.8 , pp. 1526-1537
    • Hsiao, K.M.1    McMahon, S.L.2    Farnham, P.J.3
  • 22
    • 0027367144 scopus 로고
    • Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F
    • Ivey, H.-M., R. Conroy, H. E. Huber, P. J. Goodhart, A. Oliff, and D. C. Heimbrook. 1993. Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F. Mol. Cell. Biol. 13:7802-7812.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 7802-7812
    • Ivey, H.-M.1    Conroy, R.2    Huber, H.E.3    Goodhart, P.J.4    Oliff, A.5    Heimbrook, D.C.6
  • 25
    • 0028364529 scopus 로고
    • Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression
    • Johnson, D. G., K. Ohtani, and J. R. Nevins. 1994. Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes Dev. 8:1514-1525.
    • (1994) Genes Dev. , vol.8 , pp. 1514-1525
    • Johnson, D.G.1    Ohtani, K.2    Nevins, J.R.3
  • 26
    • 0027491775 scopus 로고
    • Expression of transcription factor E2F1 induces quiescent cells to enter S phase
    • Johnson, D. G., J. K. Schwarz, W. D. Cress, and J. R. Nevins. 1993 Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature (London) 365:349-352
    • (1993) Nature (London) , vol.365 , pp. 349-352
    • Johnson, D.G.1    Schwarz, J.K.2    Cress, W.D.3    Nevins, J.R.4
  • 28
    • 0027769885 scopus 로고
    • Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members
    • Krek, W., D. M. Livingston, and S. Shirodkar. 1993. Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members. Science 262:1557-1560.
    • (1993) Science , vol.262 , pp. 1557-1560
    • Krek, W.1    Livingston, D.M.2    Shirodkar, S.3
  • 29
    • 0027316813 scopus 로고
    • An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription
    • Lam, E. W., and R. J. Watson. 1993. An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription. EMBO J. 12:2705-2713.
    • (1993) EMBO J. , vol.12 , pp. 2705-2713
    • Lam, E.W.1    Watson, R.J.2
  • 30
    • 0028267869 scopus 로고
    • DRTF1/E2F: An expanding family of heterodimeric transcription factors implicated in cell-cycle control
    • La Thangue, N. B. 1994. DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control. Trends Biochem. Sci. 19:108-114.
    • (1994) Trends Biochem. Sci. , vol.19 , pp. 108-114
    • La Thangue, N.B.1
  • 34
    • 0028207252 scopus 로고
    • Coordinated trans activation of DNA synthesis- and precursor-producing enzymes by polyomavirus large T antigen through interaction with the retinoblastoma protein
    • Mudrak, I., E. Ogris, H. Rotheneder, and E. Wintersberger. 1994. Coordinated trans activation of DNA synthesis- and precursor-producing enzymes by polyomavirus large T antigen through interaction with the retinoblastoma protein. Mol. Cell. Biol. 14:1886-1892.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 1886-1892
    • Mudrak, I.1    Ogris, E.2    Rotheneder, H.3    Wintersberger, E.4
  • 35
    • 0025354047 scopus 로고
    • A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway
    • Mudryj, M., S. W. Hiebert, and J. R. Nevins. 1990. A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway. EMBO J. 9:2179-2184.
    • (1990) EMBO J. , vol.9 , pp. 2179-2184
    • Mudryj, M.1    Hiebert, S.W.2    Nevins, J.R.3
  • 36
    • 0028136903 scopus 로고
    • Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter
    • Neuman, E., E. K. Flemington, W. R. Sellers, and W. G. Kaelin, Jr. 1994. Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter. Mol. Cell. Biol. 14:6607-6615.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 6607-6615
    • Neuman, E.1    Flemington, E.K.2    Sellers, W.R.3    Kaelin Jr., W.G.4
  • 37
    • 0026526437 scopus 로고
    • E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
    • Nevins, J. R. 1992 E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429.
    • (1992) Science , vol.258 , pp. 424-429
    • Nevins, J.R.1
  • 38
    • 0028963807 scopus 로고
    • Inherited thrombocytopenia caused by reduced platelet production in mice with the gunmetal pigment gene mutation
    • Novak, E. K., M. Reddington, L. Zhen, P. E. Sternberg, C. W. Jackson, M. P. McGarry, and R. T. Swank. 1995 Inherited thrombocytopenia caused by reduced platelet production in mice with the gunmetal pigment gene mutation. Blood 85:1781-1789.
    • (1995) Blood , vol.85 , pp. 1781-1789
    • Novak, E.K.1    Reddington, M.2    Zhen, L.3    Sternberg, P.E.4    Jackson, C.W.5    McGarry, M.P.6    Swank, R.T.7
  • 39
    • 0014313727 scopus 로고
    • Polyploidy and maturation of megakaryocytes
    • Odell, T. T., and C. W. Jackson. 1968. Polyploidy and maturation of megakaryocytes. Blood 32:102-110.
    • (1968) Blood , vol.32 , pp. 102-110
    • Odell, T.T.1    Jackson, C.W.2
  • 41
    • 0027947383 scopus 로고
    • Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
    • Qin, X. Q., D. M. Livingston, W. G. Kaelin, Jr., and P. D. Adams. 1994. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA 91:10918-10922.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 10918-10922
    • Qin, X.Q.1    Livingston, D.M.2    Kaelin Jr., W.G.3    Adams, P.D.4
  • 42
    • 0025975187 scopus 로고
    • Selective targeting of gene products with the megakaryocyte platelet factor 4 promoter
    • Ravid, K., D. L. Beeler, M. S. Rabin, H. E. Ruley, and R. D. Rosenberg. 1991. Selective targeting of gene products with the megakaryocyte platelet factor 4 promoter. Proc. Natl. Acad. Sci. USA 88:1521-1525.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 1521-1525
    • Ravid, K.1    Beeler, D.L.2    Rabin, M.S.3    Ruley, H.E.4    Rosenberg, R.D.5
  • 43
    • 0025731666 scopus 로고
    • Determining transcript number using the polymerase chain reaction: Pgk-2, mP2, and PGK-2 transgene mRNA levels during spermatogenesis
    • Robinson, M. O., and M. I. Simon. 1991. Determining transcript number using the polymerase chain reaction: Pgk-2, mP2, and PGK-2 transgene mRNA levels during spermatogenesis. Nucleic Acids Res. 19:1557-1562.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 1557-1562
    • Robinson, M.O.1    Simon, M.I.2
  • 46
    • 0027987265 scopus 로고
    • Activation of the E2F transcription factor by cyclin D1 is blocked by p16INK4, the product of the putative tumor suppressor gene MTS1
    • Schulze, A., K. Zerfass, D. Spitkovsky, B. Henglein, and D.-P. Jansen. 1994. Activation of the E2F transcription factor by cyclin D1 is blocked by p16INK4, the product of the putative tumor suppressor gene MTS1. Oncogens 9:3475-3482
    • (1994) Oncogens , vol.9 , pp. 3475-3482
    • Schulze, A.1    Zerfass, K.2    Spitkovsky, D.3    Henglein, B.4    Jansen, D.-P.5
  • 48
    • 0028061670 scopus 로고
    • Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis Mol
    • Shan, B., and W. H. Lee. 1994. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis Mol. Cell. Biol. 14:8166-8173.
    • (1994) Cell. Biol. , vol.14 , pp. 8166-8173
    • Shan, B.1    Lee, W.H.2
  • 49
    • 0026484975 scopus 로고
    • Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: Identification of a gene with properties of the transcription factor E2F
    • Shan, B., X. Zhu, P. L. Chen, T. Durfee, Y. Yang, D. Sharp, and W. H. Lee. 1992. Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F. Mol. Cell. Biol. 12:5620-5631.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 5620-5631
    • Shan, B.1    Zhu, X.2    Chen, P.L.3    Durfee, T.4    Yang, Y.5    Sharp, D.6    Lee, W.H.7
  • 50
    • 0029051295 scopus 로고
    • Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development
    • Shivdasani, R. A., M. F. Rosenblatt, D. Zucker-Franklin, C. W. Jackson, P. Hunt, C. J. M. Saris, and S. H. Orkin. 1995. Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell 81:695-704.
    • (1995) Cell , vol.81 , pp. 695-704
    • Shivdasani, R.A.1    Rosenblatt, M.F.2    Zucker-Franklin, D.3    Jackson, C.W.4    Hunt, P.5    Saris, C.J.M.6    Orkin, S.H.7
  • 51
    • 0028360766 scopus 로고
    • Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation
    • Singh, P., S. H. Wong, and W. Hong. 1994. Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation EMBO J. 13:3329-3338.
    • (1994) EMBO J. , vol.13 , pp. 3329-3338
    • Singh, P.1    Wong, S.H.2    Hong, W.3
  • 52
    • 0028928036 scopus 로고
    • Inhibition of myogenic differentiation m proliferating myoblasts by cyelin D1-dependent kinase
    • Skapek, S. X., J. Rhee, D. B. Spicer, and A. B. Lassar. 1995. Inhibition of myogenic differentiation m proliferating myoblasts by cyelin D1-dependent kinase. Science 267:1022-1024.
    • (1995) Science , vol.267 , pp. 1022-1024
    • Skapek, S.X.1    Rhee, J.2    Spicer, D.B.3    Lassar, A.B.4
  • 53
    • 0027403342 scopus 로고
    • A protein synthesis-dependent increase m E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter
    • Slansky, J. E., Y. Li, W. G. Kaelin, and P. J. Farnham. 1993. A protein synthesis-dependent increase m E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter. Mol. Cell. Biol 13:1610-1618.
    • (1993) Mol. Cell. Biol , vol.13 , pp. 1610-1618
    • Slansky, J.E.1    Li, Y.2    Kaelin, W.G.3    Farnham, P.J.4
  • 54
    • 0028054017 scopus 로고
    • T-cell apoptosis detected in situ during positive and negative selection in the thymus
    • Surh, C. D., and J. Sprent. 1994. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature (London) 372:100-103.
    • (1994) Nature (London) , vol.372 , pp. 100-103
    • Surh, C.D.1    Sprent, J.2
  • 55
    • 0026826377 scopus 로고
    • Cell type and differentiation dependent heterogeneity in retinoblastoma protein expression in SCID mouse fetuses
    • Szekely, L., W. Q. Jiang, F. Bulic Jakus, A. Rosen, N. Ringertz, G. Klein, and K. G. Wiman. 1992. Cell type and differentiation dependent heterogeneity in retinoblastoma protein expression in SCID mouse fetuses. Cell Growth Differ 3:149-156.
    • (1992) Cell Growth Differ , vol.3 , pp. 149-156
    • Szekely, L.1    Jiang, W.Q.2    Bulic Jakus, F.3    Rosen, A.4    Ringertz, N.5    Klein, G.6    Wiman, K.G.7
  • 56
    • 0027320426 scopus 로고
    • The retinoblastoma gene: Role in cell cycle control and cell differentiation
    • Wiman, K. G. 1993. The retinoblastoma gene: role in cell cycle control and cell differentiation. FASEB J. 7:841-845.
    • (1993) FASEB J. , vol.7 , pp. 841-845
    • Wiman, K.G.1
  • 57
    • 0028222124 scopus 로고
    • E2F-1 and p53 cooperate to mediate apoptosis
    • Wu, X., and A. J. Levine. 1994. E2F-1 and p53 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. USA 91:3602-3606.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 3602-3606
    • Wu, X.1    Levine, A.J.2
  • 58
    • 0028945789 scopus 로고
    • Multiple members of the E2F transcription factor family are the products of oncogenes
    • Xu, G., D. M. Livingston, and W. Krek. 1995. Multiple members of the E2F transcription factor family are the products of oncogenes. Proc Natl. Acad. Sci. USA 92:1357-1361.
    • (1995) Proc Natl. Acad. Sci. USA , vol.92 , pp. 1357-1361
    • Xu, G.1    Livingston, D.M.2    Krek, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.