Ubiquitin system: Selectivity and timing of protein destruction

Journal of Biochemistry

Volumn 125, Issue 2, 1999, Pages 223-229

  Yamao, Fumiaki ^a  

^a NATIONAL INSTITUTE OF GENETICS   (Japan)

Author keywords

Cell cycle control; Proteolysis; Ubiquitin; Ubiquitin conjugating enzyme; Ubiquitin ligase

Indexed keywords

LIGASE; PROTEIN; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME;

CELL CYCLE; CONJUGATION; ENZYME SPECIFICITY; PROTEIN DEGRADATION; REVIEW;

EID: 0033034101     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a022277     Document Type: Review

References (48)

1. Hershko, A. and Ciechanover, A. (1998) The ubiquitin system. Annu. Rev. Biochem. 67, 425-479
2. Hochstrasser, M. (1996) Ubiquitin-dependent protein degradation. Annu. Rev. Genet. 30, 405-440
3. Yamao, F., Nagai, Y., Kaneda, S., Yoshida, S., and Seno, T. (1993) Conditional resistance to thymineless death predominantly selects DNA synthesis-deficient mutants of mammalian cells. Mutat. Res. 289, 83-89
4. Finley, D., Ciechanover, A., and Varshavsky, A. (1984) Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85. Cell 37, 43-55
5. Osaka, F., Kawasaki, H., Aida, N., Saeki, M., Chiba, T., Kawashima, S., Tanaka, K., and Kato, S. (1998) A new NEDD8-ligating system for cullin-4A. Genes Dev. 12, 2263-2268
6. Saitoh, H., Pu, R.T., and Dasso, M. (1997) SUMO-1: wrestling with a new ubiquitin-related modifier. Trends Biochem. Sci. 22, 374-376
7. Jentsch, S., Seufert, W., Sommer, T., and Reins, H.A. (1990) Ubiquitin-conjugating enzymes: novel regulators of eukaryotic cells. Trends Biochem. Sci. 15, 195-198
8. Schwarz, S.E., Matuschewski, K., Liakopoulos, D., Scheffner, M., and Jentsch, S. (1998) The ubiquitin-like proteins SMT3 and SUMO-1 are conjugated by the UBC9 E2 enzyme. Proc. Natl. Acad. Sci. USA 95, 560-564
9. Varshavsky, A. (1996) The N-end rule: functions, mysteries, uses. Proc. Natl. Acad. Sci. USA 93, 12142-12149
10. Rechsteiner, M. and Rogers, S.W. (1996) PEST sequences and regulation by proteolysis. Trends Biochem. Sci. 21, 267-271
11. King, R.W., Glotzer, M., and Kirschner, M.W. (1996) Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates. Mol. Biol. Cell 7, 1343-1357
12. Scheffner, M., Huibregtse, J.M., Vierstra, R.D., and Howley, P.M. (1993) The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 75, 495-505
13. Ciechanover, A., Shkedy, D., Oren, M., and Bercovich, B. (1994) Degradation of the tumor suppressor protein p53 by the ubiquitin-mediated proteolytic system requires a novel species of ubiquitin-carrier protein, E2. J. Biol. Chem. 269, 9582-9589
14. Scheffner, M., Nuber, U., and Huibregtse, J.M. (1995) Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade. Nature 373, 81-83
15. Huibregtse, J.M., Scheffner, M., Beaudenon, S., and Howley, P.M. (1995) A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc. Natl. Acad. Sci. USA 92, 2563-2567
16. Huibregtse, J.M., Yang, J.C., and Beaudenon, S.L. (1997) The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase. Proc. Natl. Acad. Sci. USA 94, 3656-3661
17. Nefsky, B. and Beach, D. (1996) Pub1 acts as an E6-AP-like protein ubiquitin ligase in the degradation of cdc25. EMBO J. 15, 1301-1312
18. Aristarkhov, A., Eytan, E., Moghe, A., Admon, A., Hershko, A., and Ruderman, J.V. (1996) E2-C, a cyclin-selective ubiquitin carrier protein required for the destruction of mitotic cyclins. Proc. Natl. Acad. Sci. USA 93, 4294-4299
19. Hershko, A., Ganoth, D., Sudakin, V., Dahan, A., Cohen, L.H., Luca, F.C., Ruderman, J.V., and Eytan, E. (1994) Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2. J. Biol. Chem. 269, 4940-4946
20. Yu, H., King, R.W., Peters, J.M., and Kirschner, M.W. (1996) Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation. Curr. Biol. 6, 455-466
21. Osaka, F., Seino, H., Seno, T., and Yamao, F. (1997) A ubiquitin-conjugating enzyme in fission yeast that is essential for the onset of anaphase in mitosis. Mol. Cell. Biol. 17, 3388-3397
22. King, R.W., Peters, J.M., Tugendreich, S., Rolfe, M., Hieter, P., and Kirschner, M.W. (1995) A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 81, 279-288
23. Irniger, S., Piatti, S., Michaelis, C., and Nasmyth, K. (1995) Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast. Cell 81, 269-278
24. Zachariae, W., Shin, T.H., Galova, M., Obermaier, B., and Nasmyth, K. (1996) Identification of subunits of the anaphasepromoting complex of Saccharomyces cerevisiae. Science 274, 1201-1204
25. Peters, J.M., King, R.W., Hoog, C., and Kirschner, M.W. (1996) Identification of BIME as a subunit of the anaphase-promoting complex. Science 274, 1199-1201
26. Zachariae, W., Shevchenko, A., Andrews, P.D., Ciosk, R., Galova, M., Stark, M.J., Mann, M., and Nasmyth, K. (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279, 1216-1219
27. Yu, H., Peters, J.M., King, R.W., Page, A.M., Hieter, P., and Kirschner, M.W. (1998) Identification of a cullin homology region in a subunit of the anaphase-promoting complex. Science 279, 1219-1222
28. Townsley, F.M., Aristarkhov, A., Beck, S., Hershko, A., and Ruderman, J.V. (1997) Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase. Proc. Natl. Acad. Sci. USA 94, 2362-2367
29. Holloway, S.L., Glotzer, M., King, R.W., and Murray, A.W. (1993) Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor. Cell 73, 1393-1402
30. Surana, U., Amon, A., Dowzer, C., McGrew, J., Byers, B., and Nasmyth, K. (1993) Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast. EMBO J. 12, 1969-1978
31. Yamano, H., Gannon, J., and Hunt, T. (1996) The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe. EMBO J. 15, 5268-5279
32. Funabiki, H., Yamano, H., Kumada, K., Nagao, K., Hunt, T., and Yanagida, M. (1996) Cut2 proteolysis required for sister-chromatid separation in fission yeast. Nature 381, 438-441
33. Funabiki, H., Yamano, H., Nagao, K., Tanaka, H., Yasuda, H., Hunt, T., and Yanagida, M. (1997) Fission yeast Cut2 required for anaphase has two destruction boxes. EMBO J. 16, 5977-5987
34. Kotani, S., Tugendreich, S., Fujii, M., Jorgensen, P.M., Watanabe, N., Hoog, C., Hieter, P., and Todokoro, K. (1998) PKA and MPF-activated polo-like kinase regulate anaphase-promoting complex activity and mitosis progression. Mol. Cell 1, 371-380
35. Yamashita, Y.M., Nakaseko, Y., Samejima, I., Kumada, K., Yamada, H., Michaelson, D., and Yanagida, M. (1996) 20S cyclosome complex formation and proteolytic activity inhibited by the cAMP/PKA pathway. Nature 384, 276-279
36. Hwang, L.H., Lau, L.F., Smith, D.L., Mistrot, C.A., Hardwick, K.G., Hwang, E.S., Amon, A., and Murray, A.W. (1998) Budding yeast Cdc20: a target of the spindle checkpoint. Science 279, 1041-1044
37. Kim, S.H., Lin, D.P., Matsumoto, S., Kitazono, A., and Matsumoto, T. (1998) Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint. Science 279, 1045-1047
38. Schwob, E., Bohm, T., Mendenhall, M.D., and Nasmyth, K. (1994) The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79, 233-244
39. Mathias, N., Johnson, S.L., Winey, M., Adams, A.E., Goetsch, L., Pringle, J.R., Byers, B., and Goebl, M.G. (1996) Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins. Mol. Cell. Biol. 16, 6634-6643
40. Bai, C., Sen, P., Hofmann, K., Ma, L., Goebl, M., Harper, J.W., and Elledge, S.J. (1996) SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86, 263-274
41. Skowyra, D., Craig, K.L., Tyers, M., Elledge, S.J., and Harper, J.W. (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91, 209-219
42. Willems, A.R., Lanker, S., Patton, E.E., Craig, K.L., Nason, T.F., Mathias, N., Kobayashi, R., Wittenberg, C., and Tyers, M. (1996) Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway. Cell 86, 453-463
43. Li, F.N. and Johnston, M. (1997) Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: coupling glucose sensing to gene expression and the cell cycle. EMBO J. 16, 5629-5638
44. Kishi, T., Seno, T., and Yamao, F. (1998) Grr1 functions in the ubiquitin pathway in Saccharomyces cerevisiae through association with Skp1. Mol. Gen. Genet, 257, 143-148
45. Patton, E.E., Willems, A.R., Sa, D., Kuras, L., Thomas, D., Craig, K.L., and Tyers, M. (1998) Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box protein complexes that regulate cell division and methionine biosynthesis in yeast. Genes Dev. 12, 692-705
46. Kominami, K. and Toda, T. (1997) Fission yeast WD-repeat protein pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18. Genes Dev. 11, 1548-1560
47. Lammer, D., Mathias, N., Laplaza, J.M., Jiang, W., Liu, Y., Callis, J., Goebl, M., and Estelle, M. (1998) Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex. Genes Dev. 12, 914-926
48. Liakopoulos, D., Doenges, G., Matuschewski, K., and Jentsch, S. (1998) A novel protein modification pathway related to the ubiquitin system. EMBO J. 17, 2208-2214