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14
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Genetic analysis of netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons
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Mitchell KJ, Doyle JL, Serafini T, Kennedy TE, Tessier-Lavigne M, Goodman CS, Dickson BJ. Genetic analysis of netrin genes in Drosophila: netrins guide CNS commissural axons and peripheral motor axons. Neuron. 17:1996;203-215.
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Mitchell, K.J.1
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0030062518
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Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans
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Wadsworth WG, Bhatt H, Hedgecock EM. Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans. Neuron. 16:1996;35-46.
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Wadsworth, W.G.1
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Axonin-1, Nr-CAM, and Ng-CAM play different roles in the in vivo guidance of chick commissural neurons
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Stoeckli ET, Landmesser LT. Axonin-1, Nr-CAM, and Ng-CAM play different roles in the in vivo guidance of chick commissural neurons. Neuron. 14:1995;1165-1179.
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Interference with axonin-1 and NrCAM interactions unmasks a floor-plate activity inhibitory for commissural axons
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of outstanding interest. Time-lapse recordings of commissural axons contacting floor-plate explants in culture suggest that the behavior of the growth cone is determined by a balance between positive and negative cues derived from multiple molecular interactions. Ig superfamily CAMs contribute positive signals for floor-plate crossing.
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Stoeckli ET, Sonderegger P, Pollerberg GE, Landmesser LT. Interference with axonin-1 and NrCAM interactions unmasks a floor-plate activity inhibitory for commissural axons. of outstanding interest Neuron. 18:1997;209-221 Time-lapse recordings of commissural axons contacting floor-plate explants in culture suggest that the behavior of the growth cone is determined by a balance between positive and negative cues derived from multiple molecular interactions. Ig superfamily CAMs contribute positive signals for floor-plate crossing.
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Stoeckli, E.T.1
Sonderegger, P.2
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Eph receptor tyrosine kinases, axon repulsion, and the development of topographic maps
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Tessier-Lavigne M. Eph receptor tyrosine kinases, axon repulsion, and the development of topographic maps. Cell. 82:1995;345-348.
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Mutations affecting growth cone guidance in Drosophila: Genes necessary for guidance toward or away from the midline.
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Seeger M, Tear G, Ferres-Marco D, Goodman CS. Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline. Neuron. 10:1993;409-426.
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Seeger, M.1
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Goodman, C.S.4
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23
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Commissureless controls growth cone guidance across the CNS midline in Drosophila and encodes a novel membrane protein
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of outstanding interest. Comm protein is transferred by an unknown mechanism from midline cells to commissural axons as they cross the ventral midline. Comm appears to be part of the mechanism that helps commissural axons overcome the negative cues emanating from the floor plate, as commissures fail to form in Comm mutants.
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Tear G, Harris R, Sutaria S, Kilomanski K, Goodman CS, Seeger MA. Commissureless controls growth cone guidance across the CNS midline in Drosophila and encodes a novel membrane protein. of outstanding interest Neuron. 16:1996;501-514 Comm protein is transferred by an unknown mechanism from midline cells to commissural axons as they cross the ventral midline. Comm appears to be part of the mechanism that helps commissural axons overcome the negative cues emanating from the floor plate, as commissures fail to form in Comm mutants.
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Tear, G.1
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Seeger, M.A.6
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24
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0032559219
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Roundabout controls axon crossing of the CNS midline and defines a new subfamily of evolutionarily conserved guidance receptors
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of outstanding interest. The cloning of the robo gene in Drosophila and its subsequent comparison with human and rat genes revealed that Robo is a member of a new Ig superfamily subgroup with five Ig and three fibronectin type III (FnIII) domains. Robo is expressed on ipsilaterally projecting axons from the onset of growth, whereas on commissural axons, it is upregulated only after they have crossed the midline and turned longitudinally.
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Kidd T, Brose K, Mitchell KJ, Fetter RD, Tessier-Lavigne M, Goodman CS, Tear G. Roundabout controls axon crossing of the CNS midline and defines a new subfamily of evolutionarily conserved guidance receptors. of outstanding interest Cell. 92:1998;205-215 The cloning of the robo gene in Drosophila and its subsequent comparison with human and rat genes revealed that Robo is a member of a new Ig superfamily subgroup with five Ig and three fibronectin type III (FnIII) domains. Robo is expressed on ipsilaterally projecting axons from the onset of growth, whereas on commissural axons, it is upregulated only after they have crossed the midline and turned longitudinally.
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Cell
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Kidd, T.1
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Goodman, C.S.6
Tear, G.7
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25
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0032559170
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The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans
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of outstanding interest. A genetic screen for C. elegans mutants with aberrant axonal pathfinding has resulted in the identification of the sax-3 gene, sax-3 is homologous to Drosophila, human and rat robo (see [24]). Consistent with the function postulated for robo, sax-3 mutants have ectopic axons crossing the midline. Interestingly, no comm homologue has been identified so far, indicating that the almost complete absence of commissures in wild-type nematodes may be explained by a lack of positive cues for midline crossing.
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Zallen J, Yi BA, Bargmann CI. The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans. of outstanding interest Cell. 92:1998;217-227 A genetic screen for C. elegans mutants with aberrant axonal pathfinding has resulted in the identification of the sax-3 gene, sax-3 is homologous to Drosophila, human and rat robo (see [24]). Consistent with the function postulated for robo, sax-3 mutants have ectopic axons crossing the midline. Interestingly, no comm homologue has been identified so far, indicating that the almost complete absence of commissures in wild-type nematodes may be explained by a lack of positive cues for midline crossing.
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Cell
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Zallen, J.1
Yi, B.A.2
Bargmann, C.I.3
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26
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Dosage sensitive and complementary functions of Roundabout and Commissureless control axon crossing of the CNS midline
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of outstanding interest. Robo acts as a receptor for a midline-derived inhibitory activity; thus, it prevents ipsilaterally projecting fibers, which express Robo from the onset of elongation, from crossing the midline. On commissural axons, Robo is upregulated on the distal part of the axon after crossing the midline, and therefore prevents axons from recrossing the midline. Loss-of-function and gain-of-function experiments have revealed that the expression of Robo is coupled to the expression of Comm. Overexpression of Comm downregulates Robo, resulting in additional axons crossing the midline.
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Kidd T, Russell C, Goodman CS, Tear G. Dosage sensitive and complementary functions of Roundabout and Commissureless control axon crossing of the CNS midline. of outstanding interest Neuron. 20:1998;25-33 Robo acts as a receptor for a midline-derived inhibitory activity; thus, it prevents ipsilaterally projecting fibers, which express Robo from the onset of elongation, from crossing the midline. On commissural axons, Robo is upregulated on the distal part of the axon after crossing the midline, and therefore prevents axons from recrossing the midline. Loss-of-function and gain-of-function experiments have revealed that the expression of Robo is coupled to the expression of Comm. Overexpression of Comm downregulates Robo, resulting in additional axons crossing the midline.
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Kidd, T.1
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Change in chemoattractant responsiveness of developing axons at intermediate target
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of outstanding interest. Commissural axons are attracted toward the midline by netrin; however, as shown in a series of co-culture experiments, they lose their responsiveness to netrin by crossing the floor plate. Commissural axons that had been in contact with floor-plate cells no longer respond to netrin coming from a second floor-plate or to a cluster of netrin-expressing 293 cells.
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Shirasaki R, Katsumata R, Murakami F. Change in chemoattractant responsiveness of developing axons at intermediate target. of outstanding interest Science. 279:1998;105-107 Commissural axons are attracted toward the midline by netrin; however, as shown in a series of co-culture experiments, they lose their responsiveness to netrin by crossing the floor plate. Commissural axons that had been in contact with floor-plate cells no longer respond to netrin coming from a second floor-plate or to a cluster of netrin-expressing 293 cells.
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Science
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Shirasaki, R.1
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Deleted in Colorectal Cancer (DCC) encodes a netrin receptor
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Keino-Masu K, Masu M, Hinck L, Leonardo ED, Chan SS-Y, Culotti JG, Tessier-Lavigne M. Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. Cell. 87:1996;175-185.
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Keino-Masu, K.1
Masu, M.2
Hinck, L.3
Leonardo, E.D.4
Chan Ss-Y5
Culotti, J.G.6
Tessier-Lavigne, M.7
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Embryonic neurons of the developing optic chiasm express L1 and CD44, cell surface molecules with opposing effects on retinal axon growth
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Sretavan DW, Feng L, Pure E, Reichardt LF. Embryonic neurons of the developing optic chiasm express L1 and CD44, cell surface molecules with opposing effects on retinal axon growth. Neuron. 12:1994;957-975.
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Sretavan, D.W.1
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Sretavan, D.W.1
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Chemosuppression of retinal axon growth by the mouse optic chiasm
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of special interest. The midline expresses a diffusible factor with a chemosuppressant effect on retinal, but not other CNS axons tested in a collagen gel assay. As crossed and uncrossed axons are equally affected by this factor, it is unlikely to have a direct effect on sorting out the two classes of retinal axons. However, it is conceivable that the slowing down of axons at the chiasm allows the growth cones to respond to more specific guidance cues associated with the midline.
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Wang LC, Rachel RA, Marcus RC, Mason CA. Chemosuppression of retinal axon growth by the mouse optic chiasm. of special interest Neuron. 17:1996;849-862 The midline expresses a diffusible factor with a chemosuppressant effect on retinal, but not other CNS axons tested in a collagen gel assay. As crossed and uncrossed axons are equally affected by this factor, it is unlikely to have a direct effect on sorting out the two classes of retinal axons. However, it is conceivable that the slowing down of axons at the chiasm allows the growth cones to respond to more specific guidance cues associated with the midline.
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(1996)
Neuron
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Wang, L.C.1
Rachel, R.A.2
Marcus, R.C.3
Mason, C.A.4
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Growth cone form is behavior-specific and consequently, position-specific along the retinal axon pathway
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Mason CA, Wang LC. Growth cone form is behavior-specific and consequently, position-specific along the retinal axon pathway. J Neurosci. 17:1997;1086-1100.
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Mason, C.A.1
Wang, L.C.2
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Crossed and uncrossed retinal axons respond differently to cells of the optic chiasm midline in vitro
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Wang LC, Dani J, Godement P, Marcus RC, Mason CA. Crossed and uncrossed retinal axons respond differently to cells of the optic chiasm midline in vitro. Neuron. 15:1995;1349-1364.
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Wang, L.C.1
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Differential reaction of crossing and non-crossing rat retinal axons on cell membrane preparations from the chiasm midline: An in vitro study
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Wizenmann, A.1
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Bonhoeffer, F.4
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Retinal axon divergence in the optic chiasm: Midline cells are unaffected by the albino mutation
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of special interest. The finding that albino mice have a smaller number of ipsilaterally projecting retinal fibers than normal mice is correlated to a change in the retinal axons rather than to the optic chiasm in these animals. The results are consistent with the hypothesis that crossed and uncrossed axons diverge at the chiasm because they experience a different balance between positive and negative cues. In albino mice, more retinal axons are specified as contralaterally projecting. Either they lack the receptors to respond to negative cues or they overexpress the molecules that provide positive cues for crossing the midline
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Marcus RC, Wang LC, Mason CA. Retinal axon divergence in the optic chiasm: midline cells are unaffected by the albino mutation. of special interest Development. 122:1996;859-868 The finding that albino mice have a smaller number of ipsilaterally projecting retinal fibers than normal mice is correlated to a change in the retinal axons rather than to the optic chiasm in these animals. The results are consistent with the hypothesis that crossed and uncrossed axons diverge at the chiasm because they experience a different balance between positive and negative cues. In albino mice, more retinal axons are specified as contralaterally projecting. Either they lack the receptors to respond to negative cues or they overexpress the molecules that provide positive cues for crossing the midline.
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Development
, vol.122
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Marcus, R.C.1
Wang, L.C.2
Mason, C.A.3
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