Tolerance and suppression in a primed immune system

Transplantation

Volumn 62, Issue 11, 1996, Pages 1614-1621

  Marshall, Sara E ^a   Cobbold, Stephen P ^b   Davies, Joanna D ^a   Martin, Gilly M ^a   Phillips, Jenny M ^a   Waldmann, Herman ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; OKT 4; OKT 8;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL SUBPOPULATION; CONTROLLED STUDY; IMMUNOLOGICAL TOLERANCE; IMMUNOREACTIVITY; IMMUNOSUPPRESSIVE TREATMENT; MINOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD4; ANTIGENS, CD8; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNE TOLERANCE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED CBA; SKIN TRANSPLANTATION; SPLEEN; TRANSPLANTATION CONDITIONING;

EID: 0030479490     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199612150-00015     Document Type: Article

References (39)

1. Medawar PB. Theories of immunological tolerance. Ciba Foundation Symposium on Cellular Aspects of Immunity. Amsterdam: Elsevier, 1960: 134.
2. Qin S, Wise M, Cobbold SP, et al. Induction of tolerance in peripheral T cells with monoclonal antibodies. Eur J Immunol 1990; 20: 2737.
3. Powrie F, Mason D. OX-22 high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-221ow subset. J Exp Med 1990; 172: 1701.
4. Schonrich G, Kalinke U, Momburg F, et al. Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction. Cell 1991; 65: 293.
5. Cobbold SP, Martin GM, Waldmann H. The induction of skin graft tolerance in major histocompatibility complex-mismatched or primed recipients: primed T cells can be tolerized in the periphery with anti-CD4 and anti-CD8 antibodies. Eur J Immunol 1990; 20: 2745.
6. Sablinski T, Sayegh MH, Hancock WW, et al. Differential role of CD4+ cells in the sensitization and effector phases of accelerated graft rejection. Transplantation 1991; 51: 226.
7. Cobbold SP, Qin S, Leong LYW, Martin G, Waldmann H. Reprogramming the immune system for peripheral tolerance with CD4 and CD8 monoclonal antibodies. Immunol Rev 1992; 129: 165.
8. Waldmann H. Manipulation of T-cell responses with monoclonal antibodies. Annu Rev Immunol 1989; 7: 407.
9. Shizuru JA, Seydel KB, Flavin TF, et al. Induction of donor-specific unresponsiveness to cardiac allografts in rats by pre-transplant anti-CD4 monoclonal antibody therapy. Transplantation 1990; 50: 366.
10. Sablinski T, Hancock WW, Tilney NL, Kupiec-Weglinski JW. CD4 monoclonal antibodies in organ transplantation - a review of progress. Transplantation 1991; 52: 579.
11. Cobbold SP, Jayasuriya A, Nash A, Prospero TD, Waldmann H. Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature 1984; 312: 548.
12. Benjamin RJ, Waldmann H. Induction of tolerance by monoclonal antibody therapy. Nature 1986; 320: 449.
13. Benjamin R, Qin S, Wise M, Cobbold S, Waldmann H. Mechanisms of monoclonal antibody-facilita ted tolerance induction: a possible role for the CD4 (L3T4) and CD11a (LFA1) molecules in self-non-self discrimination. Eur J Immunol 1988; 18: 1079.
14. Gutstein NL, Wofsy D. Administration of F(ab′)2 fragments of monoclonal antibody to L3T4 inhibits humoral immunity in mice without depleting L3T4+ cells. J Immunol 1986; 137: 3414.
15. Qin S, Cobbold S, Tighe H, Benjamin R, Waldmann H. CD4 monoclonal antibody pairs for immunosuppression and tolerance induction. Eur J Immunol 1987; 17: 1159.
16. Monaco A, Wood M, Gray JG, Russell P. Studies on heterologous antilymphocyte serum in mice. II: Effect on the immune response. J Immunol 1966; 96: 229.
17. Billingham RE, Brent L, Medawar PB. Actively acquired tolerance to foreign cells. Nature 1953; 172: 603.
18. Peto R, Pike PC, Armitage P, et al. Design of randomized patient trials. II. Analysis and examples. Br J Cancer 1971; 35: 1.
19. Qin S, Cobbold SP, Pope H, et al. "Infectious" transplantation tolerance. Science 1993; 259: 974.
20. Wheelehan J, McKenzie IF. The role of T4+ and Ly-2+ cells in skin graft rejection in the mouse. Transplantation 1987; 44: 273.
21. Rosenberg AS, Mizuochi T, Sharrow S, Singer A. Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection. J Exp Med 1987; 165: 1296.
22. Roopenian DC, Anderson PS. Generation of helper cell-independent cytotoxic T lymphocytes is dependent upon L3T4+ helper T cells. J Immunol 1988; 141: 391.
23. Cobbold S, Waldmann H. Skin allograft rejection by L3/T4+ and LYT-2+ T cell subsets. Transplantation 1986; 41: 634.
24. Chen Z, Cobbold SP, Metcalfe S, Waldmann H. Tolerance in the mouse to major histocompatibility complex-mismatched heart allografts, and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8. Eur J Immunol 1992; 22: 805.
25. Moller G. Do suppressor T cells exist? Scand J Immunol 1988; 27: 247.
26. Batchelor JR, Lombardi G, Lechler RI. Speculations on the specificity of suppression. Immunol Today 1989; 10: 37.
27. Bloom Br, Salgame P, Diamond B. Revisiting and revising suppressor T cells. Immunol Today 1992; 13: 131.
28. Hall BM, Jelbart ME, Gurley KE, Dorsch SE. Specific unresponsiveness in rats with prolonged cardiac allograft survival after cyclosporine. Mediation of specific suppression by T helper/ inducer cells. J Exp Med 1985; 162: 1683.
29. Padberg WM, Kupiec-Weglinski JW, Lord RH, Araneda DH, Tilney NL. W3/25+ T cells mediate the induction of immunologic unresponsiveness in enhanced rat recipients of cardiac allografts. J Immunol 1987; 138: 3669.
30. Pearce NW, Spinelli A, Gurley KE, Dorsch SE, Hall BM. Mechanisms maintaining antibody-induced enhancement of allografts. II. Mediation of specific suppression by short lived CD4+ T cells. J Immunol 1989; 143: 499.
31. Hall BM, Pearce NW, Gurley KE, Dorsch SE. Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. HI. Further characterization of the CD4+ suppressor cell and its mechanism of action. J Exp Med 1990; 171: 141.
32. Roser BJ. Cellular mechanisms in neonatal and adult transplantation tolerance. Immunol Rev 1989; 107: 179.
33. Sakaguchi S, Takahashi T, Nishizuka Y. Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis. 1982; 156: 1577.
34. Parish NM, Roitt IM, Cooke A. Phenotypic characteristics of cells involved in induced suppression to murine experimental autoimmune thyroiditis. Eur J Immunol 1988; 18: 1463.
35. Sedgwick JD. Long-term depletion of CD8+ T cells in vivo in the rat: no observed role for CD8+ (cytotoxic/suppressor) cells in the immunoregulation of experimental allergic encephalomyelitis. Eur J Immunol 1988; 18: 495.
36. Ellerman KE, Powers JM, Brostoff SW. A suppressor T-lymphocyte cell line for autoimmune encephalomyelitis. Nature 1988; 331: 265.
37. Fowell D, Mason D. Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential. J Exp Med 1993; 177: 627.
38. Cobbold SP, Adams E, Marshall SE, Davies JD, Waldmann H. Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CD8. Immunol Rev 1996; 149: 5.
39. Cobbold S, Martin G, Waldmann H. Monoclonal antibodies for the prevention of graft-versus-host disease and marrow graft rejection: the depletion of T cell subsets in vitro and in vivo. Transplantation 1986; 42: 239.