Role of the thymus in transplantation tolerance in miniature swine: III. Surgical manipulation of the thymus interferes with stable induction of tolerance to class I-mismatched renal allografts

Transplantation

Volumn 67, Issue 8, 1999, Pages 1112-1119

  Yamada, Kazuhiko ^a   Ierino, Francesco L ^a   Gianello, Pierre R ^a   Shimizu, Akira ^a   Colvin, Robert B ^a   Sachs, David H ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; IMMUNOGLOBULIN G;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEDIATED LYMPHOLYSIS; CREATININE BLOOD LEVEL; FLOW CYTOMETRY; HISTOPATHOLOGY; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; SWINE; THYMECTOMY; THYMUS; TREATMENT OUTCOME;

ANIMALS; BIOPSY; CYCLOSPORINE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY TESTING; IMMUNE TOLERANCE; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; PREOPERATIVE CARE; SWINE; SWINE, MINIATURE; THYMECTOMY; THYMUS GLAND;

EID: 0033609091     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199904270-00005     Document Type: Article

References (34)

1. Sachs DH. MHC Homozygous miniature swine. In: Swindle MM, Moody DC, Phillips LD, eds. Swine as models in biomedical research, Ames, Iowa: Iowa State University Press, 1992; 3.
2. Rosengard BR, Ojikutu CA, Guzzetta PC, et al. Induction of specific tolerance to class I disparate renal allografts in miniature swine with cyclosporine. Transplantation 1992; 54: 490.
3. Yamada K, Gianello PR, Ierino FL, et al. Role of the thymus in transplantation tolerance in miniature swine. I. Requirement of the thymus for rapid and stable induction of tolerance to class I-mismatched renal allografts. J Exp Med 1997; 186: 497.
4. Gianello PR, Sachs DH. Effect of major histocompatibility complex matching on the development of tolerance to primarily vascularized renal allografts: a study in miniature swine. Hum Immunol 1996; 50: 1.
5. Billingham RE, Brent L, Medawar PB. Actively acquired tolerance to foreign cells. Nature 1953; 172: 603.
6. Ildstad ST, Sachs DH. Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts. Nature 1984; 307(5947): 168.
7. Sharabi Y, Sachs DH. Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen. J Exp Med 1989; 169: 493.
8. Kawai T, Cosimi AB, Colvin RB, et al. Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation 1995; 59: 256.
9. Zhao Y, Swenson K, Sergio JJ, Arn JS, Sachs DH, Sykes M. Skin graft tolerance across a discordant xenogeneic barrier [see Comments]. Nat Med 1996; 2: 1211.
10. Khan A, Tomita Y, Sykes M. Thymic dependence of loss of tolerance in mixed allogeneic bone marrow chimeras after depletion of donor antigen. Peripheral mechanisms do not contribute to maintenance of tolerance. Transplantation 1996; 62: 380.
11. Ruiz P, Nassiri M, Gregorian S, Viciana AL, Streilein JW. Neonatal transplantation tolerance is associated with a systemic reduction in memory cells, altered chimeric cell phenotype, and modified eicosanoid and cytokine production. Transplantation 1996; 61; 1198.
12. Goss JA, Nakafusa Y, Yu S, Flye MW. Intrathymic injection of donor alloantigens induces specific tolerance to cardiac allografts. Transplantation 1993; 56: 166.
13. Nakafusa Y, Goss JA, Mohanakumar T, Flye MW. Induction of donor-specific tolerance to cardiac but not skin or renal allografts by intrathymic injection of splenocyte alloantigen. Transplantation 1993; 55: 877.
14. Posselt AM, Barker CF, Tomaszewski JE, Markmann JF, Choti MA, Naji A. Induction of donor-specific unresponsiveness by intrathymic islet transplantation [see Comments]. Science 1990; 249: 1293.
15. Sayegh MH, Perico N, Gallon L, et al. Mechanisms of acquired thymic unresponsiveness to renal allografts. Thymic recognition of immunodominant allo-MHC peptides induces peripheral T cell anergy. X. Transplantation 1994; 58: 125.
16. Dono K, Maki T, Wood ML, Monaco AP. Induction of tolerance to skin allografts by intrathymic injection of donor splenocytes. Effect of donor-recipient strain combination and supplemental rapamycin. Transplantation 1995; 60: 1268.
17. Chowdhury NC, Murphy B, Sayegh MH, et al. Acquired systemic tolerance to rat cardiac allografts induced by intrathymic inoculation of synthetic polymorphic MHC class I allopeptides. Transplantation 1996; 62: 1878.
18. Kirkman RL, Colvin RB, Flye MW, Williams GM, Sachs DH. Transplantation in miniature swine. VII. Evidence for cellular immune mechanisms in hyperacute rejection of renal allografts. Transplantation 1979; 28: 24.
19. Kortz EO, Sakamoto K, Suzuki T, et al. Mechanism of tolerance following class I disparate renal allografts in miniature swine: Cellular responses of tolerant animals. Transplantation 1990; 49: 1142.
20. Sykes M. Chimerism and central tolerance. Curr Opin Immunol 1996; 8: 694.
21. Charlton B, Auchincloss H Jr, Fathman CG. Mechanisms of transplantation tolerance. Annu Rev Immunol 1994; 12; 707.
22. Waldmann H, Cobbold S. The use of monoclonal antibodies to achieve immunological tolerance. Immunol Today 1993; 14: 247.
23. Pearson TC, Madsen JC, Larsen CP, Morris PJ, Wood KJ. Induction of transplantation tolerance in adults using donor antigen and anti-CD4 monoclonal antibody. Transplantation 1992; 54: 475.
24. Sayegh MH, Akalin E, Hancock WW, et al. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th 1 cytokines but spares Th 2. J Exp Med 1995; 181: 1869.
25. Kirk AD, Harlan DM, Armstrong NN, et al. CTLA4-Ig and anti-CD4O ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci USA 1997; 94: 8789.
26. Herbert J, Roser B. Strategies of monoclonal antibody therapy that induce permanent tolerance of organ transplants. Transplantation 1988; 46 (suppl 2): 128S.
27. Remuzzi G, Noris M, Benigni A, Imberti O, Sayegh MH, Perico N. Thromboxane A2 receptor blocking abrogates donor-specific unresponsiveness to renal allografts induced by thymic recognition of major histocompatibility allopeptides. J Exp Med 1994; 180: 1967.
28. Blancho G, Gianello P, Germana S, Baetscher M, Sachs DH, LeGuern C. Molecular identification of porcine interleukin-10: regulation of expression in a kidney allograft model. Proc Natl Acad Sci USA 1995; 92: 2800.
29. Blancho G, Gianello PR, Lorf T, et al. Molecular and cellular events implicated in local tolerance to kidney allografts in miniature swine. Transplantation 1997; 63: 26.
30. Gianello PR, Blancho G, Fishbein JF, et al. Mechanism of cyclosporin-induced tolerance to primarily vascularized allografts in miniature swine. Effect of administration of exogenous IL-2. J Immunol 1994; 153: 4788.
31. Pescovitz MD, Thistlethwaite JR Jr, Auchincloss H Jr, et al. Effect of class II antigen matching on renal allograft survival in miniature swine. J Exp Med 1984; 160: 1495.
32. Agus DB, Surh CD, Sprent J. Reentry of T cells to the adult thymus is restricted to activated T cells. J Exp Med 1991; 173: 1039.
33. Naji A. Induction of tolerance by intrathymic inoculation of alloantigen. Curr Opin Immunol 1996; 8: 704.
34. Yamada K, Gianello PR, Ierino FL, et al. Role of the thymus in transplantation tolerance in miniature swine: II. Effect of steroids and age on the induction of tolerance to class I mismatched renal allografts. Transplantation 1999; 67: 458.