메뉴 건너뛰기




Volumn 11, Issue 5, 1999, Pages 532-537

Immunodeficient mice as models of human hematapoietic stem cell engraftment

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTEGRIN; VIRUS VECTOR;

EID: 0032849505     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(99)00006-0     Document Type: Review
Times cited : (28)

References (49)
  • 1
    • 0030863310 scopus 로고    scopus 로고
    • Sustained proliferation, multi-lineage differentiation and maintenance of primitive human haemopoietic cells in NOD/SCID mice transplanted with human cord blood
    • Cashman J, Bockhold K, Hogge DE, Eaves AC, Eaves CJ Sustained proliferation, multi-lineage differentiation and maintenance of primitive human haemopoietic cells in NOD/SCID mice transplanted with human cord blood. Br J Haematol. 98:1997;1026-1036.
    • (1997) Br J Haematol , vol.98 , pp. 1026-1036
    • Cashman, J.1    Bockhold, K.2    Hogge, D.E.3    Eaves, A.C.4    Eaves, C.J.5
  • 2
    • 0030685762 scopus 로고    scopus 로고
    • Assay of human stem cells by repopulation of NOD/SCID mice
    • Dick JE, Bhatia M, Gan O, Kapp U, Wang JC Assay of human stem cells by repopulation of NOD/SCID mice. Stem Cells. 15:1997;199-203.
    • (1997) Stem Cells , vol.15 , pp. 199-203
    • Dick, J.E.1    Bhatia, M.2    Gan, O.3    Kapp, U.4    Wang, J.C.5
  • 3
    • 0031598795 scopus 로고    scopus 로고
    • Use of the bnx/hu xenograft model of human hematopoiesis to optimize methods for retroviral-mediated stem cell transduction
    • Dao MA, Nolta JA Use of the bnx/hu xenograft model of human hematopoiesis to optimize methods for retroviral-mediated stem cell transduction. Int J Mol Med. 1:1998;257-264.
    • (1998) Int J Mol Med , vol.1 , pp. 257-264
    • Dao, M.A.1    Nolta, J.A.2
  • 4
    • 0032994401 scopus 로고    scopus 로고
    • Cytokine treatment or accessory cells are required to initiate engraftment of purified primitive human hematopoietic cells transplanted at limiting doses into NOD/SCID mice
    • Bonnet D, Bhatia M, Wang JC, Kapp U, Dick JE Cytokine treatment or accessory cells are required to initiate engraftment of purified primitive human hematopoietic cells transplanted at limiting doses into NOD/SCID mice. Bone Marrow Transplant. 23:1999;203-209.
    • (1999) Bone Marrow Transplant , vol.23 , pp. 203-209
    • Bonnet, D.1    Bhatia, M.2    Wang, J.C.3    Kapp, U.4    Dick, J.E.5
  • 5
    • 0031805237 scopus 로고    scopus 로고
    • SCID mouse models of human stem cell engraftment
    • Greiner DL, Hesselton RA, Shultz LD SCID mouse models of human stem cell engraftment. Stem Cells. 16:1998;166-177.
    • (1998) Stem Cells , vol.16 , pp. 166-177
    • Greiner, D.L.1    Hesselton, R.A.2    Shultz, L.D.3
  • 6
    • 0030863757 scopus 로고    scopus 로고
    • Immune-deficient SCID and NOD/SCID mice models as functional assays for studying normal and malignant human hematopoiesis
    • Lapidot T, Fajerman Y, Kollet O Immune-deficient SCID and NOD/SCID mice models as functional assays for studying normal and malignant human hematopoiesis. J Mol Med. 75:1997;664-673.
    • (1997) J Mol Med , vol.75 , pp. 664-673
    • Lapidot, T.1    Fajerman, Y.2    Kollet, O.3
  • 7
    • 0031466121 scopus 로고    scopus 로고
    • Cytokine responsiveness of primitive progenitors in acute myelogenous leukemia
    • Hogge DE, Ailles LE, Gerhard B Cytokine responsiveness of primitive progenitors in acute myelogenous leukemia. Leukemia. 11:1997;2220-2221.
    • (1997) Leukemia , vol.11 , pp. 2220-2221
    • Hogge, D.E.1    Ailles, L.E.2    Gerhard, B.3
  • 8
    • 0031671642 scopus 로고    scopus 로고
    • A newly discovered class of human hematopoietic cells with SCID-repopulating activity
    • The authors demonstrate the existence of a rare human stem-cell population that performs poorly in vitro but reconstitutes NOD/SCID mice. This stem cell lacks expression of the cell surface molecule CD34, previously thought to be present on all stem and progenitor cells.
    • Bhatia M, Bonnet D, Murdoch B, Gan OI, Dick JE A newly discovered class of human hematopoietic cells with SCID-repopulating activity. Nat Med. 4:1998;1038-1045. The authors demonstrate the existence of a rare human stem-cell population that performs poorly in vitro but reconstitutes NOD/SCID mice. This stem cell lacks expression of the cell surface molecule CD34, previously thought to be present on all stem and progenitor cells.
    • (1998) Nat Med , vol.4 , pp. 1038-1045
    • Bhatia, M.1    Bonnet, D.2    Murdoch, B.3    Gan, O.I.4    Dick, J.E.5
  • 9
    • 14444282451 scopus 로고    scopus 로고
    • CD34+AC133+ cells isolated from cord blood are highly enriched in long-term culture-initiating cells, NOD/SCID-repopulating cells and dendritic cell progenitors
    • De Wynter EA, Buck D, Hart C, Heywood R, Coutinho LH, Clayton A, Rafferty JA, Burt D, Guenechea G, Bueren JAet al. CD34+AC133+ cells isolated from cord blood are highly enriched in long-term culture-initiating cells, NOD/SCID-repopulating cells and dendritic cell progenitors. Stem Cells. 16:1998;387-396.
    • (1998) Stem Cells , vol.16 , pp. 387-396
    • De Wynter, E.A.1    Buck, D.2    Hart, C.3    Heywood, R.4    Coutinho, L.H.5    Clayton, A.6    Rafferty, J.A.7    Burt, D.8    Guenechea, G.9    Bueren, J.A.10
  • 10
    • 0032519764 scopus 로고    scopus 로고
    • Engraftment and retroviral marking of CD34+ and CD34+CD38- human hematopoietic progenitors assessed in immune-deficient mice
    • Dao MA, Shah AJ, Crooks GM, Nolta JA Engraftment and retroviral marking of CD34+ and CD34+CD38- human hematopoietic progenitors assessed in immune-deficient mice. Blood. 91:1998;1243-1255.
    • (1998) Blood , vol.91 , pp. 1243-1255
    • Dao, M.A.1    Shah, A.J.2    Crooks, G.M.3    Nolta, J.A.4
  • 11
    • 0030788152 scopus 로고    scopus 로고
    • Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture
    • Bhatia M, Bonnet D, Kapp U, Wang JC, Murdoch B, Dick JE Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture. J Exp Med. 186:1997;619-624.
    • (1997) J Exp Med , vol.186 , pp. 619-624
    • Bhatia, M.1    Bonnet, D.2    Kapp, U.3    Wang, J.C.4    Murdoch, B.5    Dick, J.E.6
  • 12
    • 0030611385 scopus 로고    scopus 로고
    • Individual CD34+CD38lowCD19-CD10-progenitor cells from human cord blood generate B lymphocytes and granulocytes
    • Berardi AC, Meffre E, Pflumio F, Katz A, Vainchenker W, Schiff C, Coulombel L Individual CD34+CD38lowCD19-CD10-progenitor cells from human cord blood generate B lymphocytes and granulocytes. Blood. 89:1997;3554-3564.
    • (1997) Blood , vol.89 , pp. 3554-3564
    • Berardi, A.C.1    Meffre, E.2    Pflumio, F.3    Katz, A.4    Vainchenker, W.5    Schiff, C.6    Coulombel, L.7
  • 13
    • 0033524834 scopus 로고    scopus 로고
    • Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4
    • Treatment of a human hematopoietic stem cell inoculum with antibodies to the SDF-1 receptor, CXCR4, blocked engraftment of the cells in NOD/SCID mice. Treatment with SCF and IL-6, which upregulate CXCR4, augmented engraftment.
    • Peled A, Petit I, Kollet O, Magid M, Ponomaryov T, Byk T, Nagler A, Ben-Hur H, Many A, Shultz Let al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science. 283:1999;845-848. Treatment of a human hematopoietic stem cell inoculum with antibodies to the SDF-1 receptor, CXCR4, blocked engraftment of the cells in NOD/SCID mice. Treatment with SCF and IL-6, which upregulate CXCR4, augmented engraftment.
    • (1999) Science , vol.283 , pp. 845-848
    • Peled, A.1    Petit, I.2    Kollet, O.3    Magid, M.4    Ponomaryov, T.5    Byk, T.6    Nagler, A.7    Ben-Hur, H.8    Many, A.9    Shultz, L.10
  • 14
    • 0032167596 scopus 로고    scopus 로고
    • VLA-5 is expressed by mouse and human long-term repopulating hematopoietic cells and mediates adhesion to extracellular matrix protein fibronectin
    • Van der Loo JC, Xiao X, McMillin D, Hashino K, Kato I, Williams DA VLA-5 is expressed by mouse and human long-term repopulating hematopoietic cells and mediates adhesion to extracellular matrix protein fibronectin. J Clin Invest. 102:1998;1051-1061.
    • (1998) J Clin Invest , vol.102 , pp. 1051-1061
    • Van Der Loo, J.C.1    Xiao, X.2    McMillin, D.3    Hashino, K.4    Kato, I.5    Williams, D.A.6
  • 15
    • 0032535694 scopus 로고    scopus 로고
    • Adhesion to fibronectin maintains regenerative capacity during ex vivo culture and transduction of human hematopoietic stem and progenitor cells
    • Culture of human bone-marrow-derived stem and progenitor cells in suspension culture with serum and cytokines significantly reduced their capacity for hematopoietic reconstitution. If the same cells were cultured in the same conditions but on the carboxy-terminal fragment of fibronectin, they retained the capacity for long-term hematopoiesis.
    • Dao MA, Hashino K, Kato I, Nolta JA Adhesion to fibronectin maintains regenerative capacity during ex vivo culture and transduction of human hematopoietic stem and progenitor cells. Blood. 92:1998;4612-4621. Culture of human bone-marrow-derived stem and progenitor cells in suspension culture with serum and cytokines significantly reduced their capacity for hematopoietic reconstitution. If the same cells were cultured in the same conditions but on the carboxy-terminal fragment of fibronectin, they retained the capacity for long-term hematopoiesis.
    • (1998) Blood , vol.92 , pp. 4612-4621
    • Dao, M.A.1    Hashino, K.2    Kato, I.3    Nolta, J.A.4
  • 16
    • 0344198284 scopus 로고    scopus 로고
    • Retroviral-mediated transduction of human hematopoietic stem cells
    • Edited by Boyle A. Chichester, UK: John Wiley and Sons unit 13.7
    • Nolta JA, Kohn DB: Retroviral-mediated transduction of human hematopoietic stem cells. In Current Protocols in Human Genetics, vol 13. Edited by Boyle A. Chichester, UK: John Wiley and Sons; 1997:unit 13.7.
    • (1997) In Current Protocols in Human Genetics , vol.13
    • Nolta, J.A.1    Kohn, D.B.2
  • 17
    • 0032190418 scopus 로고    scopus 로고
    • Nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mouse as a model system to study the engraftment and mobilization of human peripheral blood stem cells
    • Van der Loo JC, Hanenberg H, Cooper RJ, Luo FY, Lazaridis EN, Williams DA Nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mouse as a model system to study the engraftment and mobilization of human peripheral blood stem cells. Blood. 92:1998;2556-2570.
    • (1998) Blood , vol.92 , pp. 2556-2570
    • Van Der Loo, J.C.1    Hanenberg, H.2    Cooper, R.J.3    Luo, F.Y.4    Lazaridis, E.N.5    Williams, D.A.6
  • 18
    • 0024213526 scopus 로고
    • Engraftment of immune-deficient mice with human hematopoietic stem cells
    • Kamel-Reid S, Dick JE Engraftment of immune-deficient mice with human hematopoietic stem cells. Science. 242:1988;1706-1712.
    • (1988) Science , vol.242 , pp. 1706-1712
    • Kamel-Reid, S.1    Dick, J.E.2
  • 19
    • 0028325345 scopus 로고
    • Sustained human hematopoiesis in immunodeficient mice by cotransplantation of marrow stroma expressing human interleukin-3: Analysis of gene transduction of long-lived progenitors
    • Nolta JA, Hanley MB, Kohn DB Sustained human hematopoiesis in immunodeficient mice by cotransplantation of marrow stroma expressing human interleukin-3: analysis of gene transduction of long-lived progenitors. Blood. 83:1994;3041-3051.
    • (1994) Blood , vol.83 , pp. 3041-3051
    • Nolta, J.A.1    Hanley, M.B.2    Kohn, D.B.3
  • 20
    • 0031854820 scopus 로고    scopus 로고
    • Transplantation of stromal cells transduced with the human IL3 gene to stimulate hematopoiesis in human fetal bone grafts in non-obese, diabetic-severe combined immunodeficiency mice
    • Brouard N, Chapel A, Neildez-Nguyen TMM, Granotier C, Khazaal I, Peault B, Thierry D Transplantation of stromal cells transduced with the human IL3 gene to stimulate hematopoiesis in human fetal bone grafts in non-obese, diabetic-severe combined immunodeficiency mice. Leukemia. 12:1998;1128-1135.
    • (1998) Leukemia , vol.12 , pp. 1128-1135
    • Brouard, N.1    Chapel, A.2    Neildez-Nguyen, T.M.M.3    Granotier, C.4    Khazaal, I.5    Peault, B.6    Thierry, D.7
  • 21
    • 0033555492 scopus 로고    scopus 로고
    • Human growth factor-enhanced regeneration of transplantable human hematopoietic stem cells in nonobese diabetic/severe combined immunodeficient mice
    • The authors report that administration of human SCF, IL-3, GM-CSF and erythropoietin to human cord NOD/SCID mice engrafted with human cord blood for the 14 days prior to harvest results in a ten-fold increase in the number of re-transplantable human lymphomyeloid repopulating cells.
    • Cashman JD, Eaves CJ Human growth factor-enhanced regeneration of transplantable human hematopoietic stem cells in nonobese diabetic/severe combined immunodeficient mice. Blood. 93:1999;481-487. The authors report that administration of human SCF, IL-3, GM-CSF and erythropoietin to human cord NOD/SCID mice engrafted with human cord blood for the 14 days prior to harvest results in a ten-fold increase in the number of re-transplantable human lymphomyeloid repopulating cells.
    • (1999) Blood , vol.93 , pp. 481-487
    • Cashman, J.D.1    Eaves, C.J.2
  • 22
    • 0030831145 scopus 로고    scopus 로고
    • Long-term cytokine production from engineered primary human stromal cells influences human hematopoiesis in an in vivo xenograft model
    • Dao MA, Pepper KA, Nolta JA Long-term cytokine production from engineered primary human stromal cells influences human hematopoiesis in an in vivo xenograft model. Stem Cells. 15:1997;443-454.
    • (1997) Stem Cells , vol.15 , pp. 443-454
    • Dao, M.A.1    Pepper, K.A.2    Nolta, J.A.3
  • 23
    • 0032530741 scopus 로고    scopus 로고
    • Treatment of non-obese diabetic (NOD)/severe-combined immunodeficient mice (SCID) with flt3 ligand and interleukin-7 impairs the B-lineage commitment of repopulating cells after transplantation of human hematopoietic cells
    • Kapp U, Bhatia M, Bonnet D, Murdoch B, Dick JE Treatment of non-obese diabetic (NOD)/severe-combined immunodeficient mice (SCID) with flt3 ligand and interleukin-7 impairs the B-lineage commitment of repopulating cells after transplantation of human hematopoietic cells. Blood. 92:1998;2024-2031.
    • (1998) Blood , vol.92 , pp. 2024-2031
    • Kapp, U.1    Bhatia, M.2    Bonnet, D.3    Murdoch, B.4    Dick, J.E.5
  • 24
    • 0345196594 scopus 로고    scopus 로고
    • Delayed engraftment of nonobese diabetic/severe combined immunodeficient mice transplanted with ex vivo-expanded human CD34(+) cord blood cells
    • Guenechea G, Segovia JC, Albella B, Lamana M, Ramirez M, Regidor C, Fernandez MN, Bueren JA Delayed engraftment of nonobese diabetic/severe combined immunodeficient mice transplanted with ex vivo-expanded human CD34(+) cord blood cells. Blood. 93:1999;1097-1105.
    • (1999) Blood , vol.93 , pp. 1097-1105
    • Guenechea, G.1    Segovia, J.C.2    Albella, B.3    Lamana, M.4    Ramirez, M.5    Regidor, C.6    Fernandez, M.N.7    Bueren, J.A.8
  • 25
    • 0030886656 scopus 로고    scopus 로고
    • Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice
    • Conneally E, Cashman J, Petzer A, Eaves C Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice. Proc Natl Acad Sci USA. 94:1997;9836-9841.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 9836-9841
    • Conneally, E.1    Cashman, J.2    Petzer, A.3    Eaves, C.4
  • 26
    • 0032573177 scopus 로고    scopus 로고
    • Reduction in levels of the cyclin dependent kinase inhibitor p27(kip-1) coupled with transforming growth factor beta neutralization induces cell-cycle entry and increases retroviral transduction of primitive human hematopoietic cells
    • 1 phase - using the methods described in this paper - did not force the cells into differentiation, as measured in the bnx-hu xenograft system.
    • 1 phase - using the methods described in this paper - did not force the cells into differentiation, as measured in the bnx-hu xenograft system.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13006-13011
    • Dao, M.A.1    Taylor, N.2    Nolta, J.A.3
  • 27
    • 0025880646 scopus 로고
    • Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer
    • Eaves CJ, Cashman JD, Kay RJ, Dougherty GJ, Otsuka T, Gaboury LA, Hogge DE, Lansdorp PM, Eaves AC, Humphries RK Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer. Blood. 78:1991;110-117.
    • (1991) Blood , vol.78 , pp. 110-117
    • Eaves, C.J.1    Cashman, J.D.2    Kay, R.J.3    Dougherty, G.J.4    Otsuka, T.5    Gaboury, L.A.6    Hogge, D.E.7    Lansdorp, P.M.8    Eaves, A.C.9    Humphries, R.K.10
  • 28
    • 0031019451 scopus 로고    scopus 로고
    • FLT3 ligand preserves the ability of human CD34+ progenitors to sustain long-term hematopoiesis in immune-deficient mice after ex vivo retroviral-mediated transduction
    • Dao MA, Hannum CH, Kohn DB, Nolta JA FLT3 ligand preserves the ability of human CD34+ progenitors to sustain long-term hematopoiesis in immune-deficient mice after ex vivo retroviral-mediated transduction. Blood. 89:1997;446-456.
    • (1997) Blood , vol.89 , pp. 446-456
    • Dao, M.A.1    Hannum, C.H.2    Kohn, D.B.3    Nolta, J.A.4
  • 29
    • 0033526067 scopus 로고    scopus 로고
    • Bone morphogenetic proteins regulate the developmental program of human hematopoietic stem cells
    • Bhatia M, Bonnet D, Wu D, Murdoch B, Wrana J, Gallacher L, Dick JE Bone morphogenetic proteins regulate the developmental program of human hematopoietic stem cells. J Exp Med. 189:1999;1139-1148.
    • (1999) J Exp Med , vol.189 , pp. 1139-1148
    • Bhatia, M.1    Bonnet, D.2    Wu, D.3    Murdoch, B.4    Wrana, J.5    Gallacher, L.6    Dick, J.E.7
  • 30
    • 0031593688 scopus 로고    scopus 로고
    • T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates
    • Kohn DB, Hershfield MS, Carbonaro D, Shigeoka A, Brooks J, Smogorzewska EM, Barsky LW, Chan R, Burotto F, Annett Get al. T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates. Nat Med. 4:1998;775-780.
    • (1998) Nat Med , vol.4 , pp. 775-780
    • Kohn, D.B.1    Hershfield, M.S.2    Carbonaro, D.3    Shigeoka, A.4    Brooks, J.5    Smogorzewska, E.M.6    Barsky, L.W.7    Chan, R.8    Burotto, F.9    Annett, G.10
  • 32
    • 0028597094 scopus 로고
    • Umbilical cord blood cell transduction by retroviral vectors: Preclinical studies to optimize gene transfer
    • Hanley ME, Nolta JA, Parkman R, Kohn DB Umbilical cord blood cell transduction by retroviral vectors: preclinical studies to optimize gene transfer. Blood Cells. 20:1994;539-543.
    • (1994) Blood Cells , vol.20 , pp. 539-543
    • Hanley, M.E.1    Nolta, J.A.2    Parkman, R.3    Kohn, D.B.4
  • 33
    • 0032056367 scopus 로고    scopus 로고
    • Efficient retroviral-mediated gene transfer to human cord blood stem cells with in vivo repopulating potential
    • Conneally E, Eaves CJ, Humphries RK Efficient retroviral-mediated gene transfer to human cord blood stem cells with in vivo repopulating potential. Blood. 91:1998;3487-3493.
    • (1998) Blood , vol.91 , pp. 3487-3493
    • Conneally, E.1    Eaves, C.J.2    Humphries, R.K.3
  • 34
    • 0029839240 scopus 로고    scopus 로고
    • Cytokine regulation of proliferation and cell adhesion are correlated events in human CD34+ hemopoietic progenitors
    • Levesque JP, Haylock DN, Simmons PJ Cytokine regulation of proliferation and cell adhesion are correlated events in human CD34+ hemopoietic progenitors. Blood. 88:1996;1168-1176.
    • (1996) Blood , vol.88 , pp. 1168-1176
    • Levesque, J.P.1    Haylock, D.N.2    Simmons, P.J.3
  • 37
    • 0033613827 scopus 로고    scopus 로고
    • Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors
    • The authors demonstrate that lentiviral vectors, based on HIV-1, can mediate transduction of a significant portion of NOD/SCID-engrafting cells from human cord blood in the absence of cytokine stimulation.
    • Miyoshi H, Smith KA, Mosier DE, Verma IM, Torbett BE Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors. Science. 283:1999;682-686. The authors demonstrate that lentiviral vectors, based on HIV-1, can mediate transduction of a significant portion of NOD/SCID-engrafting cells from human cord blood in the absence of cytokine stimulation.
    • (1999) Science , vol.283 , pp. 682-686
    • Miyoshi, H.1    Smith, K.A.2    Mosier, D.E.3    Verma, I.M.4    Torbett, B.E.5
  • 39
    • 0032532361 scopus 로고    scopus 로고
    • Cell cycle-related changes in repopulating capacity of human mobilized peripheral blood CD34(+) cells in non-obese diabetic/severe combined immune-deficient mice
    • The authors demonstrate that hematopoietic stem cells that have been driven out of their quiescent state into cell cycle do not engraft as well as resting stem cells. Discussion of these findings, and their implications, is provided in the text of the review.
    • Gothot A, van der Loo JC, Clapp DW, Srour EF Cell cycle-related changes in repopulating capacity of human mobilized peripheral blood CD34(+) cells in non-obese diabetic/severe combined immune-deficient mice. Blood. 92:1998;2641-2649. The authors demonstrate that hematopoietic stem cells that have been driven out of their quiescent state into cell cycle do not engraft as well as resting stem cells. Discussion of these findings, and their implications, is provided in the text of the review.
    • (1998) Blood , vol.92 , pp. 2641-2649
    • Gothot, A.1    Van Der Loo, J.C.2    Clapp, D.W.3    Srour, E.F.4
  • 41
    • 0029055941 scopus 로고
    • Analysis of optimal conditions for retroviral-mediated transduction of primitive human hematopoietic cells
    • Nolta JA, Smogorzewska EM, Kohn DB Analysis of optimal conditions for retroviral-mediated transduction of primitive human hematopoietic cells. Blood. 86:1995;101-110.
    • (1995) Blood , vol.86 , pp. 101-110
    • Nolta, J.A.1    Smogorzewska, E.M.2    Kohn, D.B.3
  • 42
    • 0033054279 scopus 로고    scopus 로고
    • Adhesion receptor expression by hematopoietic cell lines and murine progenitors: Modulation by cytokines and cell cycle status
    • Cells cultured in suspension with cytokines have reduced expression of VLA-4 and other integrins. The reduction in integrin levels correlated with poor engraftment.
    • Becker PS, Nilsson SK, Li Z, Berrios VM, Dooner MS, Cooper CL, Hsieh CC, Quesenberry PJ Adhesion receptor expression by hematopoietic cell lines and murine progenitors: modulation by cytokines and cell cycle status. Exp Hematol. 27:1999;533-541. Cells cultured in suspension with cytokines have reduced expression of VLA-4 and other integrins. The reduction in integrin levels correlated with poor engraftment.
    • (1999) Exp Hematol , vol.27 , pp. 533-541
    • Becker, P.S.1    Nilsson, S.K.2    Li, Z.3    Berrios, V.M.4    Dooner, M.S.5    Cooper, C.L.6    Hsieh, C.C.7    Quesenberry, P.J.8
  • 43
    • 15144339719 scopus 로고    scopus 로고
    • Homing and trafficking of hemopoietic progenitor cells
    • Papayannopoulou T, Craddock C Homing and trafficking of hemopoietic progenitor cells. Acta Haematol. 97:1997;97-104.
    • (1997) Acta Haematol , vol.97 , pp. 97-104
    • Papayannopoulou, T.1    Craddock, C.2
  • 44
    • 0028971211 scopus 로고
    • The VLA4/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen
    • Papayannopoulou T, Craddock C, Nakamoto B, Priestley GV, Wolf NS The VLA4/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen. Proc Natl Acad Sci USA. 92:1995;9647-9651.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9647-9651
    • Papayannopoulou, T.1    Craddock, C.2    Nakamoto, B.3    Priestley, G.V.4    Wolf, N.S.5
  • 46
    • 0032402140 scopus 로고    scopus 로고
    • Highly efficient transduction of the green fluorescent protein gene in human umbilical cord blood stem cells capable of cobblestone formation in long-term cultures and multilineage engraftment of immunodeficient mice
    • The authors used the EGFP marker, detectable by FACS (flow-assisted cell sorting), to optimize vector promoters and transduction conditions that allow transgene expression in multilineage progeny of human umbilical cord blood progenitors in NOD/SCID mice.
    • Van Hennik PB, Verstegen MM, Bierhuizen MF, Limon A, Wognum AW, Cancelas JA, Barquinero J, Ploemacher RE, Wagemaker G Highly efficient transduction of the green fluorescent protein gene in human umbilical cord blood stem cells capable of cobblestone formation in long-term cultures and multilineage engraftment of immunodeficient mice. Blood. 92:1998;4013-4022. The authors used the EGFP marker, detectable by FACS (flow-assisted cell sorting), to optimize vector promoters and transduction conditions that allow transgene expression in multilineage progeny of human umbilical cord blood progenitors in NOD/SCID mice.
    • (1998) Blood , vol.92 , pp. 4013-4022
    • Van Hennik, P.B.1    Verstegen, M.M.2    Bierhuizen, M.F.3    Limon, A.4    Wognum, A.W.5    Cancelas, J.A.6    Barquinero, J.7    Ploemacher, R.E.8    Wagemaker, G.9
  • 47
    • 0031747105 scopus 로고    scopus 로고
    • Serial bone marrow sampling for long-term follow up of human hematopoiesis in NOD/SCID mice
    • The authors describe a method for collection of bone marrow samples from mice that does not require sacrificing the animals. Therefore serial analyses can be done on the same transplanted human hematopoietic cell populations.
    • Verlinden SF, van Es HH, van Bekkum DW Serial bone marrow sampling for long-term follow up of human hematopoiesis in NOD/SCID mice. Exp Hematol. 26:1998;627-630. The authors describe a method for collection of bone marrow samples from mice that does not require sacrificing the animals. Therefore serial analyses can be done on the same transplanted human hematopoietic cell populations.
    • (1998) Exp Hematol , vol.26 , pp. 627-630
    • Verlinden, S.F.1    Van Es, H.H.2    Van Bekkum, D.W.3
  • 48
    • 0029913896 scopus 로고    scopus 로고
    • Transduction of pluripotent human hematopoietic stem cells demonstrated by clonal analysis after engraftment in immune-deficient mice
    • Nolta JA, Dao MA, Wells S, Smogorzewska EM, Kohn DB Transduction of pluripotent human hematopoietic stem cells demonstrated by clonal analysis after engraftment in immune-deficient mice. Proc Natl Acad Sci USA. 93:1996;2414-2419.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2414-2419
    • Nolta, J.A.1    Dao, M.A.2    Wells, S.3    Smogorzewska, E.M.4    Kohn, D.B.5
  • 49
    • 0031438304 scopus 로고    scopus 로고
    • Clonal diversity of primitive human hematopoietic progenitors following retroviral marking and long-term engraftment in immune-deficient mice
    • Dao MA, Yu XJ, Nolta JA Clonal diversity of primitive human hematopoietic progenitors following retroviral marking and long-term engraftment in immune-deficient mice. Exp Hematol. 25:1997;1357-1366.
    • (1997) Exp Hematol , vol.25 , pp. 1357-1366
    • Dao, M.A.1    Yu, X.J.2    Nolta, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.