Delayed engraftment of nonobese diabetic/severe combined immunodeficient mice transplanted with ex vivo-expanded human CD34+ cord blood cells

Blood

Volumn 93, Issue 3, 1999, Pages 1097-1105

  Guenechea G ^a   Segovia, J C ^a   Albella, B ^a   Lamana, M ^a   Ramirez M ^a   Regidor, C ^a   Fernandez M N ^a   Bueren, J A ^a  

^a CIEMAT   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CD45 ANTIGEN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; GRAFT SURVIVAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; NONHUMAN; PERIPHERAL BLOOD STEM CELL; PRIORITY JOURNAL; SCID MOUSE; UMBILICAL CORD BLOOD;

EID: 0345196594     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.3.1097     Document Type: Article

References (46)

1. Muench MO, Firpo MT, Moore MAS: Bone marrow transplantation with interleukin-1 plus kit-ligand ex vivo expanded bone marrow accelerates hematopoietic reconstitution in mice without the loss of stem cell lineage and proliferative potential. Blood 81:3463, 1993
2. Serrano F, Varas F, Bernad A, Bueren JA: Accelerated and long-term hematopoietic engraftment in mice transplanted with ex vivo expanded bone marrow. Bone Marrow Transplant 14:855, 1994
3. Holyoake TL, Freshney MG, McNair L, Parker AN, McKay PJ, Steward WP, Fitzsimons E, Graham J, Pragnell IB: Ex vivo expansion with stem cell factor and interleukin-11 augments both short-term recovery posttransplant and the ability to serially transplant marrow. Blood 87:4589, 1996
4. Szilvassy SJ, Weller KP, Chen B, Juttner CA, Tsukamoto A, Hoffman R: Partially differentiated ex vivo expanded cells accelerate hematologic recovery in myeloablated mice transplanted with highly enriched long-term repopulating stem cells. Blood 88:3642, 1996
5. Ratajczak MZ, Ratajczak J, Machalinski B, Gewirtz AM: In vitro and in vivo evidence that ex vivo cytokine priming of donor marrow cells may ameliorate posttransplant thrombocytopenia. Blood 91:353, 1998
6. Albella B, Segovia JC, Bueren JA: Does the granulocyte-macrophage colony-forming unit content in ex vivo-expanded grafts predict the recovery of the recipient leukocytes? Blood 90:464, 1997
7. Brugger W, Heimfeld S, Berenson RJ, Mertelsman R, Kanz L: Reconstitution of hematopoiesis after high-dose chemotherapy by autologous progenitors cells generated ex vivo. N Engl J Med 333:283, 1995
8. Alcorn MJ, Holyoake TL, Richmond L, Pearson C, Farrell E, Kyle B, Dunlop DJ, Fitzsimons E, Steward WP, Pragnell IB, Franklin IM: CD34-positive cells isolated from cryopreserved peripheral-blood progenitor cells can be expanded ex vivo and used for transplantation with little or no toxicity. J Clin Oncol 14:1839, 1996
9. Bertolini F, Battaglia M, Pedrazzoli P, Da Prada GA, Lanza A, Soligo D, Caneva L, Sarina B, Murphy S, Thomas T, della Cuna GR: Megakaryocytic progenitors can be generated ex vivo and safely administered to autologous peripheral blood progenitor cell transplant recipients. Blood 89:2679, 1997
10. Williams SF, Lee WJ, Bender JG, Zimmerman T, Swinney P, Blake M, Carreon J, Schilling M, Smith S, Williams DE, Oldham F, Van Epps D: Selection and expansion of peripheral blood CD34+ cells in autologous stem cell transplantation for breast cancer. Blood 87:1687, 1996
11. Holyoake TL, Alcorn MJ, Richmond L, Farrell E, Pearson C, Green R, Dunlop DJ, Fitzsimons E, Pragnell IB, Franklin IM: CD34 positive PBPC expanded ex vivo may not provide durable engraftment following myeloablative chemoradiotherapy regimens. Bone Marrow Transplant 19:1095, 1997
12. + hematopoietic progenitor cells with recombinant immunotoxins. Blood 91:1820, 1998
13. Garbe A, Spyridonidis A, Mobest D, Schmoor C, Mertelsmann R, Henschler R: Transforming growth factor-beta 1 delays formation of granulocyte-macrophage colony-forming cells, but spares more primitive progenitors during ex vivo expansion of CD34+ haemopoietic cells. Br J Haematol 99:951, 1998
14. Widmer L, Pichert G, Jost LM, Stahel RA: Fate of contaminating t(14;18)+ lymphoma cells during ex vivo expansion of CD34-selected hematopoietic progenitor cells. Blood 88:3166, 1998
15. Garcia-Sanchez F, Pizzorno G, Fu SQ, Nanakorn T, Krause DS, Liang J, Adams E, Leffert JJ, Yin LH, Cooperberg MR, Hanania E, Wang WL, Won JH, Peng XY, Cote R, Brown R, Burtness B, Giles R, Crystal R, Deisseroth AB: Cytosine deaminase adenoviral vector and 5-fluorocytosine selectively reduce breast cancer cells 1 million-fold when they contaminate hematopoietic cells: A potential purging method for autologous transplantation. Blood 92:672, 1998
16. Bernad A, Varas F, Gallego JM, Almendral JM, Bueren JA: Ex vivo expansion and selection of retrovirally transduced bone marrow and efficient methodology for gene-transfer to murine lymphohaemopoietic stem cells. Br J Haematol 87:6, 1994
17. + peripheral blood progenitor cells after introduction of a mutated dihydrofolate reductase cDNA via retroviral gene therapy. Blood 85:566, 1995
18. Conneally E, Eaves CJ, Humphries RK: Efficient retroviral-mediated gene transfer to human cord blood stem cells with in vivo repopulating potential. Blood 91:3487, 1998
19. Dunbar CE, Cottler-Fox M, O'Shaughnessy JA, Doren S, Carter C, Berenson R, Brown S, Moen RC, Greenblatt J, Stewart FM, Leitman SF, Wilson WH, Cowan K, Young NS, Nienhuis AW: Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation. Blood 85:3048, 1995
20. Larochelle A, Vormoor J, Hanenberg H, Wang J, Bathia M, Lapidot T, Moritz T, Murdoch B, Xiao XL, Kato I, Williams DA, Dick J: Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy. Nature Med 2:1329, 1996
21. Gluckman E, Rocha V, Boyer-Chammard A, Locatelli F, Arcese W, Pasquini R, Ortega J, Souillet G, Ferreira E, Laporte JP, Fernandez M, Chastang C: Outcome of cord-blood transplantation from related and unrelated donors. Eurocord Transplant Group and the European Blood and Marrow Transplantation Group. N Engl J Med 337:373, 1997
22. Wagner JE, Kernan NA, Steinbuch M, Broxmeyer HE, Gluckman E: Allogeneic sibling umbilical-cord-blood transplantation in children with malignant and non-malignant disease. Lancet 346:214, 1995
23. Kurtzberg J, Laughlin M, Graham ML, Smith C, Olson JF, Halperin EC, Ciocci G, Carrier C, Stevens CE, Rubinstein P: Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. N Engl J Med 335:157, 1996
24. Wagner JE, Rosenthal J, Sweetman R, Shu XO, Davies SM, Ramsay NK, McGlave PB, Sender L, Cairo MS: Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: Analysis of engraftment and acute graft-versus-host disease. Blood 88:795, 1996
25. Varas F, Bernad A, Bueren JA: Restrictions in the stem cell function of murine bone marrow grafts after ex vivo expansion of short-term repopulating progenitors. Exp Hematol 26:100, 1998
26. Peters SO, Kittler LW, Ramshaw HS, Quesenberry PJ: Ex vivo expansion of murine marrow cells with interleukin-3 (IL-3), IL-6, IL-11, and stem cell factor leads to impaired engraftment in irradiated hosts. Blood 87:30, 1996
27. Traycoff CM, Cornetta K, Yoder MC, Davidson A, Srour EF: Ex vivo expansion of murine hematopoietic progenitor cells generates classes of expanded cells possessing different levels of bone marrow repopulating potential. Exp Hematol 24:299, 1996
28. Kittler EL, Peters SO, Crittenden RB, Debatis ME, Ramshaw HS, Stewart FM, Quesenberry PJ: Cytokine-facilitated transduction leads to low-level engraftment in nonablated hosts. Blood 90:865, 1997
29. Trevisan M, Yan X-Q, Iscove MN: Cycle initiation and colony formation in culture by murine marrow cells with long-term reconstituting potential in vivo. Blood 88:4149, 1996
30. Yonemura Y, Ku H, Lyman SD, Ogawa M: In vitro expansion of hematopoietic progenitors and maintenance of stem cells: Comparison between FLT3/FLK-2 ligand and KIT ligand. Blood 89:1915, 1996
31. Miller CL, Eaves CJ: Expansion in vitro of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability. Proc Natl Acad Sci USA 94:13648, 1998
32. Bathia M, Bonnet D, Kapp U, Wang J, Murdoch B, Dick J: Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture. J Exp Med 186:619, 1997
33. Conneally E, Cashman J, Petzer A, Eaves CJ: Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice. Proc Natl Acad Sci USA 94:9836, 1997
34. Rubinstein P, Dobrila P, Rosenfield RE, Adamson JW, Migliaccio G, Migliaccio AR, Taylor PE, Stevens CE: Processing and cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution. Proc Natl Acad Sci USA 92:10119, 1995
35. Benito A, Grillot D, Nuñez G, Fernandez-Luna JL: Regulation and function of Bcl-2 during differentiation-induced cell death in HL-60 promyelocytic cells. Am J Pathol 146:481, 1995
36. Verlinden SF, van Es HH, van Bekkum DW: Serial bone marrow sampling for long-term follow up of human hematopoiesis in NOD/ SCID mice. Exp Hematol 26:627, 1998
37. Sekhar M, Yu JM, Soma T, Dunbar CE: Murine long-term repopulating ability is compromised by ex vivo culture in serum-free medium despite preservation of committed progenitors. J Hematother 6:543, 1997
38. Poloni A, Giarratana MC, Firat H, Kobari L, Gorin NC, Douay L: The ex vivo expansion capacity of normal human bone marrow cells is dependent on experimental conditions: Role of the cell concentration, serum and CD34+ cell selection in stroma-free cultures. Hematol Cell Ther 39:49, 1997
39. Abe T, Ito M, Okamoto Y, Kim HJ, Takaue Y, Yasutomo K, Makimoto A, Yamaue T, Kawano Y, Watanabe T, Shimada T, Kuroda Y: Transduction of retrovirus-mediated NeoR gene into CD34+ cells purified from granulocyte colony-stimulating factor (G-CSF)-mobilized infant and cord blood [see comments]. Exp Hematol 25:966, 1997
40. Veena P, Traycoff CM, Williams DA, McMahel J, Rice S, Cornetta K, Srour EF: Delayed targeting of cytokine-nonresponsive human bone marrow CD34(+) cells with retrovirus-mediated gene transfer enhances transduction efficiency and long-term expression of transduced genes. Blood 91:3693, 1998
41. Cashman J, Bockhold K, Hogge DE, Eaves AC, Eaves CJ: Sustained proliferation, multi-lineage differentiation and maintenance of primitive human haemopoietic cells in NOD/SCID mice transplanted with human cord blood. Br J Haematol 98:1026, 1997
42. Brandt JE, Bartholomew AM, Nelson MC, Chute JP, Turian JV, Chen L, Hoffman R: Rescue of lethally myeloablated baboons with ex vivo expanded grafts results in delayed engraftment. Exp Hematol 26:699, 1998 (abstr)
43. Reems JA, Mielcarek M, Torok-Storb B: Differential modulation of adhesion markers with ex vivo expansion of human umbilical CD34+ progenitor cells. Biol Blood Marrow Transplant 3:133, 1998
44. + hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor. Blood 91:4523, 1998
45. +)-enriched cells from umbilical cord blood in NOD/LtSz-scid/scid mice. Blood 90:85, 1997
46. Ramirez M, Rottman GA, Shultz LD, Civin CI: Mature human hematopoietic cells in donor bone marrow complicate interpretation of stem/progenitor cell assays in xenogeneic hematopoietic chimeras. Exp Hematol 26:332, 1998