CD34+AC133+ cells isolated from cord blood are highly enriched in long-term culture-initiating cells, NOD/SCID-repopulating cells and dendritic cell progenitors

Stem Cells

Volumn 16, Issue 6, 1998, Pages 387-396

  De Wynter, E A ^a   Buck, D ^d   Hart, C ^a   Heywood, R ^a   Coutinho, L H ^a   Clayton, A ^c   Rafferty, J A ^a   Burt, D ^c   Guenechea, G ^b   Bueren, J A ^b   Gagen, D ^a   Fairbairn, L J ^a   Lord, B I ^a   Testa, N G ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b CIEMAT   (Spain)

^c Paterson Institute

^d AmCell Corporation   (United States)

Author keywords

AC133+; CD34+ cell; Dendritic cells; LTC IC; NOD SCID mice

Indexed keywords

CD34 ANTIGEN;

ANTIGEN EXPRESSION; ARTICLE; BONE MARROW CELL; CELL ISOLATION; CLONOGENESIS; CONTROLLED STUDY; DENDRITIC CELL; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; NORMAL HUMAN; UMBILICAL CORD BLOOD;

EID: 14444282451     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.160387     Document Type: Article

References (33)

1. Morrison S, Weissman I. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity 1994;1:661-673.
2. Randall T, Weissman I. Characterization of a population of cells in the bone marrow that phenotypically mimics hematopoietic stem cells: resting stem cells or mystery population? STEM CELLS 1998;16:38-48.
3. Civin CI, Loken MR. Cell surface antigens on human marrow cells: dissection of hematopoietic development using monoclonal antibodies and multiparameter flow cytometry. Int J Cell Cloning 1987;5:267-288.
4. Civin CI, Gore SD. Antigenic analysis of hematopoiesis: a review. J Hematother 1993;2:137-144.
5. Sutherland D, Keating A. The CD34 antigen: structure, biology and potential clinical applications. J Hematother 1992;1:115-129.
6. + marrow cells in patients with breast cancer or neuroblastoma. Blood 1991;77:1717-1722.
7. - subpopulation from mobilized peripheral blood. Blood 1995;85:368-378.
8. + cells. Blood 1996;87:949-955.
9. Sutherland H, Eaves C, Eaves A. Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro. Blood 1989;74:1563-1569.
10. + cord blood cells in serum-free long-term cultures supplemented with hematopoietic cytokines. Blood 1993;82:2664-2672.
11. + subpopulations in umbilical cord blood and identification of long-term culture-initiating cells present in two subsets. STEM CELLS 1996;14:566-576.
12. Baum CM, Weissman IL, Tsukamoto AS et al. Isolation of a candidate human hematopoietic stem cell population. Proc Natl Acad Sci USA 1992;89:2804-2808.
13. Traycoff C, Abboud M, Laver J et al. Evaluation of the in vitro behavior of phenotypically defined populations of umbilical cord blood and estimation of its potential for transplantation in adults. Proc Natl Acad Sci USA 1994;22:215-222.
14. Petzer A, Hogge D, Lansdorp P et al. Self-renewal of primitive human hematopoietic cells (long-term culture initiating cells) in vitro and their expansion in defined medium. Proc Natl Acad Sci USA 1996;3:1470-1474.
15. Larochelle A, Vormoor J, Hanenberg H. Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy. Nat Med 1996;2:1329-1337.
16. Miraglia S, Godfrey W, Yin A et al. A novel five-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning. Blood 1997;90:5013-5021.
17. Yin A, Miraglia S, Zanjani E et al. AC133, a novel marker for human hematopoietic stem and progenitor cells. Blood 1997;90:5002-5012.
18. + cell determination by flow cytometry. J Hematother 1996;5:213-226.
19. Coutinho LH, Gilleece MH, de Wynter E et al. Clonal and long-term cultures using human bone marrow. In: Testa NG, Molineux G, eds. Haemopoiesis: A Practical Approach. Oxford: Oxford University Press, 1993:75-106.
20. Lord BI, Hendry JH, Keene JP et al. A comparison of low and high dose-rate radiation for recipient mice in spleen-colony studies. Cell Tissue Kinet 1984;17:323-334.
21. Drize N, Chertkov J, Sadovnikova E et al. Long-term maintenance of hematopoiesis in irradiated mice by retrovirally transduced peripheral blood stem cells. Blood 1997;89:1811-1817.
22. Strobl H, Bello Fernandez C, Riedl E et al. flt3 ligand in cooperation with transforming growth factor-beta 1 potentiates in vitro development of Langerhans-type dendritic cells and allows single-cell dendritic cell cluster formation under serum-free conditions. Blood 1997;90:1425-1434.
23. + hemopoietic progenitors. J Immunol 1996;157:1499-1507.
24. + cells in peripheral and cord blood by flow cytometry. Exp Hematol 1994;22:1003-1010.
25. Sutherland HJ, Lansdorp PM, Henkelman DH et al. Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers. Proc Natl Acad Sci USA 1990;87:3584-3588.
26. Pettengell R, Luft T, Henschler R et al. Direct comparison by limiting dilution analysis of long-term culture initiating cells for human bone marrow, umbilical cord blood and blood stem cells. Blood 1994;84:3653-3659.
27. Bhatia M, Wang JCY, Kapp U et al. Purification of primitive human hematopoietic cells capable of repopulating immunedeficient mice. Proc Natl Acad Sci USA 1997;94:5320-5325.
28. Testa NG, Lord BI, Shore NA. The in vivo seeding of hemopoietic colony forming cells in irradiated mice. Blood 1972;40:654-661.
29. Wang JCY, Doedens M, Dick JE. Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay. Blood 1997;11:3919-3924.
30. Greiner DL, Hazeldene RA, Shultz LD. SCID mouse models of human stem cell engraftment. STEM CELLS 1998;16:166-177.
31. Caux C, Dezutter-Dambuyant C, Shmitt D et al. GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells. Nature 1992;360:258-261.
32. Inaba T, Shimazaki C, Hirata T et al. Phenotypic differences of CD34-positive stem cells harvested from peripheral blood and bone marrow obtained before and after peripheral blood stem cell collection. Bone Marrow Transplant 1994;13:527-532.
33. + progenitors in human bone marrow. J Immunol 1992;149:2681-2688.