Immune-deficient SCID and NOD/SCID mice models as functional assays for studying normal and malignant human hematopoiesis

Journal of Molecular Medicine

Volumn 75, Issue 9, 1997, Pages 664-673

  Lapidot, Tsvee ^b,c   Fajerman, Yfat ^b   Kollet, Orit ^a,b  

^a TEL AVIV UNIVERSITY   (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Human stem cells; Immune deficient SCID and NOD SCID mice; Leukemic stem cells

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL MODEL; CHRONIC MYELOID LEUKEMIA; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMOGENESIS; MOUSE; NONHUMAN; REVIEW; SCID MOUSE;

ANIMALS; ANTIGENS, CD34; BONE MARROW TRANSPLANTATION; CELL TRANSPLANTATION; CYTOKINES; DISEASE MODELS, ANIMAL; HEMATOPOIESIS; HUMANS; LEUKEMIA; MICE; MICE, INBRED NOD; MICE, SCID; ORGAN TRANSPLANTATION; SHEEP; STEM CELLS;

EID: 0030863757     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090050150     Document Type: Review

References (65)

1. Ogawa M (1993) Differentiation and proliferation of hematopoietic stem cells. Blood 81:2844-2853
2. Morrison S, Uchida N, Weissman IL (1995) The biology of hematopoietic stem cells. Annu Rev Cell Dev Biol 11:35-71
3. Pluznik D, Sachs L (1965) The cloning of normal mast cells in tissue culture. J Cell Physiol 66:319
4. Suda T, Suda J, Ogawa M (1984) Analysis of differentiaon of mouse hemopoietic stem cells in culture by sequential replating of paired progenitors. Blood 64:393
5. Tsuji K, Zsebo K, Ogawa M (1991) Enhancement of murine blast cell colony formation in culture by recombinant rat stem cell factor, ligand for c-kit. Blood 78:1223
6. + CD38 progenitor cells. Blood 77:1218
7. Baum C, Weissman L, Tsukamoto A, Buckle A, Peault B (1992) Isolation of a candidate human hematopoietic stem-cell population. Proc Natl Acad Sci USA 89:2804
8. Eaves C, Hogge, D et al (1991) Regulation of primitive human hematopoietic cells in long term marrow culture. Semin Hematol 28:126-131
9. +/CD38 cells in cord blood and bone marrow. Blood 77:1218-1227
10. Hao QL, Thiemann FT, Peterson D, Smogorzewska EM, Crooks GM (1996) Extended long-term culture reveals a highly quiescent and primitive human hematopoietic progenitor population. Blood 88:3306-3313
11. Frazer C, Humphries K et al (1992) Proliferation of totipotent hematopoietic stem cells in vitro with retention of long-term competitive in vivo reconstituting ability. Proc Natl Acad Sci USA, 89:1968-1972
12. Sluijs J, Ploemacher R et al (1993) Loss of long term repopulating ability in long-term bone marrow culture. Leukemia 7:725-732
13. Muench M, Fipro M, Moore MAS (1993) Bone marrow transplantation with Interleukin-1 plus kit ligand ex vivo expanded bone marrow accelerates hematopoietic reconstitution in mice without the loss of stem cell lineage and proliferative potential Blood 81:3463-3473
14. Osawa M, Hanada K, Hamada H, Nakauchi H (1996) Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 273:242-245
15. Goodell MA, Brose K, Paradis G, Conner AS, Mulligan RC (1996) Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med 183:1797-1806
16. Goodell MA, Rosenzweig M, Johnson PR, Mulligan RC (1996) Potential new target cell population for hematopoietic stem cell gene transfer. Cold Spring Harbor Meeting on Gene Therapy, 24-25 September, p 6
17. Berardi AC, Wang A, Levine JD, Lopez, P, Scadden DT (1995) Functional isolation and characterization of human hematopoietic stem cells. Science 267:104-108
18. Mathews WJ, Jordan CT, Wiegand GW, Pardoll D, Lemischka IR (1991) A receptor tyrosin kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell 65:1143
19. Hirayama F, Lyman SD, Clark SC, Ogawa M (1994) The flt3 ligand supports proliferation of lymphohematopoietic progenitors and early B-lymphoid progenitors. Blood 85:1762
20. + human hone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proc Natl Acad Sci USA 91:459
21. + cells and maintains progenitor cells in vitro. Blood 87:3563-3570
22. +/CD38) human hematopoietic cells: novel responses to FLT3-ligand and thrombopoietin. J Exp Med 183:2551-2558
23. Spangrude GJ, Brooks DM, Tumas DB (1995) Long-term repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: in vivo expansion of stem cell phenotype but not function. Blood 85:1006-1016
24. Pantelouris E (1971) Observations on the immunobiology of nude mice. Immunol 20:247
25. Andreiole G, Mule J, Hansen C, Linehan W, Rosenberg S (1985) Evidence that lymphokine-activated killer cells and natural killer cells are distinct based on analysis of congenitally immunodeficient mice. J Immunol 135:2911
26. Bosnia M, Carroll M (1991) The SCID mouse mutant: definitions, characterization, and potential uses. Annu Rev Immunol 9:323
27. Dick J, Lapidot T, Pflumio F (1991) Transplantation of normal and leukemic human bone marrow into immune-deficient mice: development of animal models for human hematopoiesis. Immunol Rev 124:25-43
28. Lapidot T, Cashman JD, Wang J, Doedens M, Schultz LD, Lansdorp P, Dick JE, Eaves CJ (1997) Kinetic evidence of the regeneration of multi-lineage hematopoiesis from primitive cells in normal human bone marrow transplanted immunodeficient mice. Blood (in press)
29. Shultz L, Schweltzar P, Christianson S, Goll B, Schweltzer I, Tennent B, McKenna S, Mobraaton L, Rajan T, Greiner D, Leiter E (1995) Multiple defects in innate and adaptive immunological function in NOD/LtSz-scid mice. J Immunol 154:180-191
30. Lowary P, Schultz L, Quesenberry P (1994) Multiple immune defects in the NOD/SCID mouse facilitate human hematopoietic engraftment. Blood 84 [Supp 1]:346a
31. Dick J (1996) Normal and leukemic human stem cells assayed in SCID mice. Semin Immunol 3:367-378
32. Mosier D, Gulizia R, Baird S, Wilson DB (1988) Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 335:256-259
33. Pflumio F, Lapidot T, Murdoch B, Patterson B, Dick J (1993) Engraftment of human lymphoid cells into newborn SCID mice leads to graft versus host disease. Int Immunol 5:1509-1522
34. Torbett B, Picchio G, Mosier D (1991) Hu-PBLSCID mice: a model for human immune function. AIDS, and lymphomagenesis. Immunol Rev 124:139-164
35. Lubin I, Faktorowich I, Lapidot T, Gan Y, Eshhar Z, Gazit E, Levite M, Reisner Y (1991) Engraftment and development of human T and B cells in mice after bone marrow transplantation. Science 252:427-431
36. Sawyers C, Gishizky M, Quail S, Golde D, Witte O (1992) Propagation of human blastic myeloid leukemias in the SCID mouse. Blood 79:2089-2098
37. Fraser CC, Kaneshama H, Hansteen G, Kilpatrick M, Hoffman R, Chen BP (1995) Human allogeneic stem cell maintenance and differentiation in a lone-term multilineage SCID-hu graft. Blood 86:1680-1693
38. Chen BP, Galy A, Kyoizumi S, Namikawa R, Scarborough J, Webb S, Ford B, Cen DZ, Chen SC (1994) Engraftment of human hematopoietic precursor cells with secondary transfer potential in SCID-hu mice. Blood 84:2497-2505
39. Namikawa R, Ueda R, Kyoizumi S (1993) Growth of human myeloid leukemias in the human marrow environment of SCID-hu mice. Blood 82:2526
40. Civin CI, Porada GA, Lee MJ, Terstappen L Zanjani ED (1996) Sustained, retransplantable, multilineage engraftment of highly purified adult human bone marrow stem cells in vivo. Blood 88:4102-4109
41. Dick J, Lapidot T, Pflumio F (1991) Transplantation of normal and leukemic human bone marrow into immune-deficient mice: development of animal models for human hematopoiesis. Immunol Rev 124:25-43
42. Lapidot T, Pflumio F, Doedens M, Murdoch B, Williams D, Dick J (1992) Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice. Science 255:1137-1141
43. Vormoor J, Lapidot T, Pflumio F, Risdon G, Patterson B, Broxmeyer H, Dick J (1994) Immature human cord blood progenitors engraft and proliferate to high levels in severe combined immunodeficient mice. Blood 83:2489-2497
44. Kollmann T, Kim A, Zhuang X, Hachamovitch M, Goldstein H (1994) Reconstitution of SCID mice with human lymphoid and myeloid cells after transplantation with human fetal bone marrow without the requirement for exogenous human cytokines. Proc Natl Acad Sci USA 91:8032-8036
45. Lansdorp PM, Dragowska W, Mayani H (1993) Ontogeny related changes in proliferative potential of human hematopoietic cells. J Exp Med 178:787-791
46. Nolta JA, Hanley MB, Kohn DB (1994) Sustained human hematopoiesis in immunodeficient mice by cotransplantation of marrow stroma expressing human interleukin-3. Analysis of gene transducion of long-lived progenitors. Blood 83:3041-3051
47. Larochelle A, Vormoor J, Lapidot T, Sher G, Furukawa T, Li Q, Schultz L, Olivieri N, Stamatoyannopoulos G, Dick J (1995) Engraftment of immune- deficient mice with primitive hematopoietic cells from β-thalassemia and sickle cell anemia patients: implications for evaluating human gene therapy protocols. Hum Mol Gen 4:163-172
48. Larochelle A, Vormoor J, Haneberg H, Wang J, Bhatia M, Lapidot T, Moritz T, Murdoch B, Xiao X, Williams D, Dick J (1996) Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mice using retroviral gene marking and cell purification. Nat Med 12:1329-1337
49. Sawyers C, Denny C, Witte O (1991) Leukemia and the disruption of normal hematopoiesis. Cell 64:337-350
50. Griffin J, Lowenberg B (1986) Clonogenic cells in acute myeloblastic leukemia. Blood 68. 1185-1195
51. Goldman J (1987) Chronic myeloproliferative syndrome. Baillieres Clin Hematol 1:671-725
52. Grier H, Civin C (1993) The concept of a leukemia stem cell with extensive self-renewal capacity and considerable differentiation. In: Nathan D, Oski F (eds) Hematology of infancy and childhood. Saunders, Philadelphia, pp 1288-1318
53. McCulloch E, Minden M, Miyauchi C, Kelleher A, Wang C (1988) Stem cell renewal and differentiation in acute myeloblastic leukemia. J Cell Sci Supp 10:267-281
54. Lowenber B, Touw I (1993) Hematopoietic growth factors and their receptors in acute leukemia. Blood 81:281-292
55. Coulombel L, Eaves C, Kalousek D, Gupta C, Eaves A (1985) Long- term marrow cultures of cells from patients with acute myelogenous leukemia. J Clin Invest 75:961-969
56. Udomsakdi C, Eaves C, Swolin B, Reid D, Barnet M, Eaves A (1992) Rapid decline of chronic myeloid leukemic cells in long term culture due to a defect at the leukemic stem cell level. Proc Natl Acad Sci USA 89:6192-6196
57. Kamel-Reid S, Letarte M, Doedens M, Lapidot T, Freedman M, Dick J (1991) Bone marrow from children in relapse with pre-B ALL proliferates and diseminates rapidly in SCID mice. Blood 78:2973-2981
58. Uckun FM, Sather H, Reaman G, Shuster J, Land V, Trigg M (1995) Leukemic cell growth in SCID mice as a predictor of relapse in high risk B-lineagw acute lymphoblastic leukemia. Blood 85:873-878
59. Uckun FM (1996) Severe combined immunodeficient mouse models of human leukemia. Blood 88:1135-1146
60. Meydan N, Grunberger T, Dadi H, Shahar M, Arpaia E, Lapidot T, Leader S, Freedmab M, Cohen A, Gazit A, Levitzki A, Roifman C (1996) Inhibition of acute lymphoblastic leukemia by a JAK-2 inhibitor. Nature 379:645-648
61. Lapidot T, Sirard C, Vormoor J, Cashman J, Doedens M, Murdoch B, Jamal N, Messner H, Addey L, Minden M, Laraya P, Keating A, Eaves A, Lansdorp P, Eaves C, Dick J (1996) Normal and leukemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase while leukemic SRC are detected in blast crisis Blood 87:1539-1548
62. Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Cortes J, Minden M, Paterson B, Caliguri M, Dick J (1994) A cell initiating human acute myeloid leukemia after transplantation into SCID mice. Nature 367:645-648
63. Bonnet D, Dick JE (1997) Primitive human hematopoietic cells are the target for transformation in acute myeloid leukemia. (submitted)
64. Freedman MH, Estrov Z, Chan HSL (1988) Juvenile chronic myelogenous leukemia. Am J Pediatr Hematol Oncol 10:261
65. Lapidot T, Grunberger T, Vormoor J, Estrov Z, Kollet O, Bunin N, Zaizov R, Williams D, Freedman M (1996) Identification of human juvenile chronic myelogenous leukemia stem cells capable of initiating the disease in primary and secondary SCID mice. Blood 88:2655-2664