Adhesion to fibronectin maintains regenerative capacity during ex vivo culture and transduction of human hematopoietic stem and progenitor cells

Blood

Volumn 92, Issue 12, 1998, Pages 4612-4621

  Dao, M A ^c   Hashino, K ^c   Kato, I ^c   Nolta, J A ^a,b  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

FIBRONECTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL ADHESION; CELL LINEAGE; CELL PROLIFERATION; CLONOGENESIS; CONTROLLED STUDY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPLEEN CELL; XENOTRANSPLANTATION;

EID: 0032535694     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.12.4612.424k04_4612_4621     Document Type: Article

References (17)

1. Miller DG, Adam MA, Miller AD: Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Mol Cell Biol 10:4239, 1990
2. Lewis PF, Emerman M: Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus. J Virol 68:510, 1994
3. Moore KA, Deisseroth AB, Reading CL, Williams DE, Belmont JW: Stromal support enhances cell-free retroviral vector transduction of human bone marrow long-term culture-initiating cells. Blood 79:1393, 1992
4. Cassel A, Cottler-Fox M, Doren S, Dunbar CE: Retroviral-mediated gene transfer into CD34-enriched human peripheral blood stem cells. Exp Hematol 21:585, 1993
5. Wells S, Malik P, Pensiero M, Kohn DB, Nolta JA: The presence of an autologous marrow stromal cell layer increases glucocerebrosidase gene transduction of long-term culture initiating cells (LTCICs) from the bone marrow of a patient with Gaucher disease. Gene Ther 2:512, 1995
6. + cells from Gaucher patients. Blood 86:141, 1995
7. Nolta JA, Smogorzewska EM, Kohn DB: Analysis of optimal conditions for retroviral-mediated transduction of primitive human hematopoietic cells. Blood 86:101, 1995
8. Moritz T, Patel VP, and Williams DA: Bone marrow extracellular matrix molecules improve gene transfer into human hematopoietic cells via retroviral vectors. J Clin Invest 93:1451, 1994
9. Hanenberg H, Xiao XL, Dilloo D, Hashino K, Kato I, Williams DA: Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells. Nat Med 2:876, 1996
10. Moritz T, Dutt P, Xiao XL, Carstnjen D, Vic T, Hanenberg H, Williams DA: Fibronectin improves transduction of reconstituting hematopoietic stem cells by retroviral vectors: Evidence of direct viral binding to chymotryptic carboxy-terminal fragments. Blood 88:855, 1996
11. Kimizuka F, Taguchi Y, Ohdate Y, Kawasw Y, Shimojo T, Hashino K, Kato I, Sekiguchi K, Titani K: Production and characterization of functional domains of human fibronectin expressed in Escherichia coli. J Biochem 110:284, 1991
12. + progenitors to sustain long-term hematopoiesis in immune-deficient mice after ex vivo retroviral-mediated transduction. Blood 89:446, 1997
13. Broxmeyer HE, Lu L, Cooper S, Ruggiere L, Li ZH, Lyman SD: Flt3 ligand stimulates/costimulates the growth of myeloid stem/progenitor cells. Exp Hematol 23:1121, 1995
14. Gabbianelli M, Pelosi E, Montesoro E, Valtieri M, Luchetti L, Samoggia P, Vitelli L, Barberi T, Testa U, Lyman S, Peschle C: Multi-level effects of flt3 ligand on human hematopoiesis: Expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors. Blood 86:1661, 1995
15. Mckenna HJ, de Vries P, Brasel P, Lyman SD, Williams DE: Effect of flt3 ligand on the ex vivo expansion of human CD34+ hematopoietic progenitor cells. Blood 86:3413, 1995
16. Petzer AL, Zandstra PW, Piret JM, Eaves CJ: Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: Novel responses to flt-3 ligand and thrombopoietin. J Exp Med 183:2551, 1996
17. Shah AJ, Smogorzewska EM, Hannum C, Crooks GM: Flt3 ligand induces proliferation of quiescent human bone marrow CD34+CD38-cells and maintains progenitor cells in vitro. Blood 87:3563, 1996