Cytokine treatment or accessory cells are required to initiate engraftment of purified primitive human hematopoietic cells transplanted at limiting doses into NOD/SCID mice

Bone Marrow Transplantation

Volumn 23, Issue 3, 1999, Pages 203-209

  Bonnet, D ^a,b   Bhatia, M ^a,c   Wang, J C Y ^a   Kapp, U ^a   Dick, J E ^a,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b Coriell Inst for Medical Research ^*  (United States)

^c ROBARTS RESEARCH INSTITUTE   (Canada)

^d HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

Author keywords

NOD SCID mice; Stem cells; Xenotransplant

Indexed keywords

CD34 ANTIGEN; CD38 ANTIGEN; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; STEM CELL FACTOR;

ACCESSORY CELL; ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL EXPERIMENT; ARTICLE; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; UMBILICAL CORD BLOOD; XENOGRAFT;

EID: 0032994401     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1701564     Document Type: Article

References (25)

1. Ogawa M. Differentiation and proliferation of hematopoietic stem cells. Blood 1993; 81: 2844-2853.
2. Phillips R. Hematopoietic stem cells: concepts, assays, and controversies. Semin Immunol 1991; 3: 337-347.
3. Dick JE. Normal and leukemic human stem cells assayed in SCID mice. Semin Immunol 1996; 8: 197-206.
4. Larochelle A, Vormoor J, Hanenberg H et al. Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy. Nature Med 1996; 2: 1329-1337.
5. Cashman JD, Lapidot T, Wang JC et al. Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice. Blood 1997; 89: 4307-4316.
6. Bhatia M, Wang JCY, Kapp U et al. Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. Proc Natl Acad Sci USA 1997; 94: 5320-5325.
7. Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nature Med 1997; 3: 730-737.
8. Lapidot T, Sirard C, Vormoor J et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994; 367: 645-648.
9. Sykes M, Sheard M, Sachs DH. Effects of T cell depletion in radiation bone marrow chimeras. I. Evidence for a donor cell population which increases allogeneic chimerism but which lacks the potential to produce GVHD. J Immunol 1988; 141: 2282-2288.
10. Kaufman CL, Colson YL, Wren SM et al. Phenotypic characterization of a novel bone marrow-derived cell that facilitates engraftment of allogeneic bone marrow stem cells. Blood 1994; 84: 2436-2446.
11. Morrison SJ, Uchida N, Weissman IL. The biology of hematopoietic stem cells. Ann Rev Cell Dev Biol 1995; 11: 35-71.
12. Berenson RJ, Bensinger WI, Hill RS et al. Engraftment after infusion of CD34 marrow cells in patients with breast cancer or neuroblastoma. Blood 1991; 77: 1717-1722.
13. + stem cells do not contain clonal myeloma cells. Blood 1995; 86: 381-389.
14. Vormoor J, Lapidot T, Pflumio F et al. Immature human cord blood progenitors engraft and proliferate to high levels in immune-deficient SCID mice. Blood 1994; 83: 2489-2497.
15. Lapidot T, Pflumio F, Doedens M et al. Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in scid mice. Science 1992; 255: 1137-1141.
16. Wang JC, Doedens M, Dick JE. Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay. Blood 1997; 89: 3919-3924.
17. Bhatia M, Bonnet D. Kapp U et al. Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture. J Exp Med 1997; 186: 619-624.
18. Takamatsu Y, Akashi K, Harada M et al. Cytokine production by peripheral blood monocytes and T cells during hematopoietic recovery after intensive chemotherapy. Br J Haematol 1993; 83: 21-27.
19. Hardy CL. The homing of hematopoietic stem cells to the bone marrow. Am J Med Sci 1995; 309: 260-266.
20. Shultz L, Schweitzer P, Christianson S et al. Multiple defects in innate and adaptive immunological function in NOD/LtSz-scid mice. J Immunol 1995; 154: 180-191.
21. Gan OI, Murdoch B, Larochelle A, Dick JE. Differential maintenance of primitive human SCID-repopulating cells, clonogenic progenitors, and long-term culture-initiating cells after incubation on human bone marrow stromal cells. Blood 1997; 90: 641-650.
22. O'Reilly RJ. Allogenic bone marrow transplantation: current status and future directions. Blood 1983; 62: 941-964.
23. Vallera DA, Soderling CC, Kersey JH. Bone marrow transplantation across major histocompatibility barriers in mice. III. Treatment of donor grafts with monoclonal antibodies directed against Lyt determinants. J Immunol 1982; 128: 871-875.
24. Vallera DA, Soderling CC, Carlson GJ, Kersey JH. Bone marrow transplantation across major histocompatibility barriers in mice. Effect of elimination of T cells from donor grafts by treatment with monoclonal Thy-1.2 plus complement or antibody alone. Transplantation 1981; 31: 218-222.
25. +CD38 cells. Blood 1998; 91: 1966-1976.