Mutations of the DPC4/Smad4 gene in biliary tract carcinoma

Cancer Research

Volumn 58, Issue 6, 1998, Pages 1124-1126

  Hahn, Stephan A ^a   Bartsch, Detlef ^b   Schroers, Anja ^a   Galehdari, Hamid ^a   Becker, Matthias ^a   Ramaswamy, Annette ^b   Schwarte Waldhoff, Irmgard ^a   Maschek, Hansjörg ^c   Schmiegel, Wolff ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT;

ARTICLE; BILE DUCT CARCINOMA; CARCINOGENESIS; CHROMOSOME 18Q; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN TISSUE; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN DOMAIN; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

AMINO ACID SEQUENCE; BILIARY TRACT NEOPLASMS; CARCINOMA; DNA, NEOPLASM; DNA-BINDING PROTEINS; GENES, TUMOR SUPPRESSOR; HUMANS; MOLECULAR SEQUENCE DATA; POINT MUTATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SMAD4 PROTEIN; TRANS-ACTIVATORS;

EID: 0032520915     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Rozenblum, E., Schutte, M., Goggins, M., Hahn, S. A., Panzer, S., Zahurak, M., Goodman, S. N., Sohn, T. A., Hruban, R. H., Yeo, C. J., and Kern, S. E. Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res., 57: 1731-1734, 1997.
2. Levi, S., Urbano-Spizua, A., Gill, R., Thomas, D. M., Gilbertson, J., Foster, C., and Marshall, C. J. Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique. Cancer Res., 51: 3497-3502, 1991.
3. Ink4b/MTS2 Genes in biliary tract cancers. Cancer Res., 55: 2756-2760, 1995.
4. Watanabe, M., Asaka, M., Tanaka, J., Kurosawa, M., Kasai, M., and Miyazaki, T. Point mutations of K-ras gene codon 12 in biliary tract tumors. Gastroenterology, 107: 1147-1153, 1995.
5. Hahn, S. A., Schutte, M., Hoque, A. T. M., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., and Kern, S. E. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science (Washington DC), 271: 350-353, 1996.
6. Massagué, J. TGFβ signaling: receptors, transducers, and Mad proteins. Cell, 85: 947-950, 1996.
7. Hahn, S. A., Hoque, A. T. M., Moskaluk, C. A., da Costa, L. T., Schutte, M., Rozenblum, E., Seymour, A. B., Weinstein, C. L., Yeo, C. J., Hruban, R. H., and Kern, S. E. Homozygous deletion map at 18q21.1 in pancreatic cancer. Cancer Res., 56: 490-494, 1996.
8. Schutte, M., Hruban, R. H., Hedrick, L., Cho, K. R., Molnar, G., Weinstein, G., Bova, S., Isaacs, W. B., Cairns, P., Nawroz, H., Sidransky, D., Casero, B., Meltzer, P. S., Hahn, S. A., and Kern, S. E. DPC4 gene in various tumor types. Cancer Res., 56: 2527-2530, 1996.
9. Hahn, S. A., Seymour, A. B., Hoque, A. T. M. S., Schutte, M., da Costa, L. T., Redston, M. S., Caldas, C., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., and Kern, S. E. Allelotype of pancreatic adenocarcinoma using xenograft enrichment. Cancer Res., 55: 4670-4675, 1995.
10. Mutter, G. L., and Boynton, K. A. PCR bias in amplification of androgen receptor alleles, a trinucleotide repeat marker used in clonality studies. Nucleic Acids Res., 23: 1411-1418, 1995.
11. Caldas, C., Hahn, S. A., da Costa, L. T., Redston, M. S., Schutte, M., Seymour, A. B., Weinstein, C. L., Hruban, R. H., Yeo, C. J., and Kern, S. E. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat. Genet., 8: 27-32, 1994.
12. Thiagalingam, S., Lengauer, C., Leach, F. S., Schutte, M., Hahn, S. A., Overhauser, J., Willson, J. K. V., Markowitz, S., Hamilton, S. R., Kern, S. E., Kinzler, K. W., and Vogelstein, B. Evaluation of candidate tumor suppressor genes on chromosome 18 in colorectal cancers. Nat. Genet., 13: 342-346, 1996.
13. Takagi, Y., Kohmura, H., Futamura, M., Kida, H., Tanemura, H., Shimokawa, K., and Saji, S. Somatic alterations of the DPC4 gene in human colorectal cancers in vivo. Gastroenterology, 111: 1369-1372, 1996.
14. Nagatake, M., Takagi, Y., Osada, H., Uchida, K., Mitsudomi, T., Saji, S., Shimokata, K., Takahashi, T., and Takahashi, T. Somatic in vivo alterations of the DPC4 gene at 18q21 in human lung cancers. Cancer Res., 56: 2718-2720, 1996.
15. Hoque, A. T. M. S., Hahn, S. A., and Kern, S. E. DPC4 gene mutation in colitis associated neoplasia. Gut. 40: 120-122, 1997.
16. Kim, S. K., Fan, Y., Papadimitrakopoulou, V., Clayman, G., Hittelman, W. N., Hong, W. K., Lotan, R., and Mao, L. DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma. Cancer Res., 56: 2519-2521, 1996.
17. Barrett, M. T., Schutte, M., Kern, S. E., and Reid, B. J. Allelic loss and mutational analysis of the DPC4 gene in esophageal adenocarcinoma. Cancer Res., 56: 4351-4353, 1996.
18. Lei, J., Zou, T-T., Shi, Y-Q., Zhou, X., Smolinski, K. N., Yin, J., Souza, R. F., Appel, R., Wang, S., Cymes, K., Chan, O., Abraham, J., M., Harpaz, N., and Meltzer, S. J. Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms. Oncogene, 13: 2459-2462, 1996.
19. Kong, X. T., Choi, S. H., Inoue, A., Xu, F., Chen, T., Takita, J., Yokota, J., Bessho, F., Yanagisawa, M., Hanada, R., Yamamoto, K., and Hayashi, Y. Expression and mutational analysis of the DCC, DPC4, and MADR2/JV18-1 genes in neuroblastoma. Cancer Res., 57: 3772-3778, 1997.
20. McGrogan, D., Pegram, M., Slamon, D., and Bookstein, R. Comparative mutational analysis of DPC4 (Smad4) in prostatic and colorectal carcinomas. Oncogene, 15: 1111-1114, 1997.