Laureate ESCI award for excellence in clinical science 1999. Cytokines and the human immunodeficiency virus: From bench to bedside

European Journal of Clinical Investigation

Volumn 29, Issue 8, 1999, Pages 723-732

  Poli, G ^a,b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b P2 P3 Laboratories   (Italy)

Author keywords

Chemokines; Cytokines; Human immunodeficiency virus; Interleukin 2; Therapy

Indexed keywords

ANTIINFLAMMATORY AGENT; CELL SURFACE RECEPTOR; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; CLINICAL TRIAL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; META ANALYSIS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SUBCUTANEOUS DRUG ADMINISTRATION; VIRION; VIRUS EXPRESSION; VIRUS REPLICATION;

AWARDS AND PRIZES; CD4-POSITIVE T-LYMPHOCYTES; CHEMOKINES; CLINICAL MEDICINE; CYTOKINES; EUROPE; HIV; HIV INFECTIONS; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-2; SOCIETIES, SCIENTIFIC; VIRUS REPLICATION;

EID: 0032810908     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.1999.00525.x     Document Type: Review

References (126)

1. 1 Mellors JW, Rinaldo CR, Gupta P, White RM, Todd JA, Kingsley LA. Prognosis in HIV-1 infection predicted by the quantity of virus in the plasma. Science, 1996;272:1167-70.
2. 2 Palella FJ Jr, Delaney KM, Moorman AC, Lovelss MO, Fuhrer J, Satten GA, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med, 1998;338:853-60.
3. 3 Wong JK, Hezareh M, Gunthard HF, Havlir DV, Ignacio CC, Spina CA, et al. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science, 1997;278:1291-5.
4. 4 Chun TW, Stuyver L, Mizell SB, Ehler LA, Mican JA, Baeler M, et al. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc Natl Acad Sci USA, 1997;94:13193-7.
5. 5 Finzi D, Hermankova M, Pierson T, Carruth LM, Buck C, Chaisson RE, et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science, 1997;278:1295-300.
6. + T cell homeostasis and function in advanced HIV disease. Science, 1997;277:112-6.
7. 7 Fauci AS, Schnittman SM, Poli G, Koenig S, Pantaleo GNIH, conference. Immunopathogenic mechanisms in human immunodeficiency virus (HIV) infection. Ann Intern Med, 1991;114:678-93.
8. 8 Kovacs JA, Baseler M, Dewar RJ, Vogel S, Davey RT Jr, Falloon J, et al. Increases in CD 4 T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection. A preliminary study. N Engl J Med, 1995;332:567-75.
9. 9 Kovacs JA, Vogel S, Albert JM, Falloon J, Davey RT Jr, Walker RE, et al. Controlled trial of interleukin-2 infusions in patients infected with the human immunodeficiency virus. N Engl J Med, 1996;335:1350-6.
10. 10 Barre-Sinoussi F, Chermann JC, Rey F, Nugeyre MT, Chamaret S, Gruest J, et al. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science, 1983;220:868-71.
11. 11 Gallo RC, Sarin PS, Gelmann EP, Roben-Guroff M, Richardson E, Kalyanaraman VS, et al. Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS). Science, 1983;220:865-7.
12. 12 Suzuki Y, Gojobori T. The origin and evolution of human T-cell lymphotropic virus types I and II. Virus Genes, 1998;16:69-84.
13. 13 Watanabe T. HTLV-1-associated diseases. Int J Hematol, 1997;66:257-78.
14. 14 Folks T, Benn S, Rabson A, Theodore T, Hoggan MD, Martin M, et al. Characterization of a continuous T-cell line susceptible to the cytopathic effects of the acquired immunodeficiency syndrome (AIDS)-associated retrovirus. Proc Natl Acad Sci USA 1985;82:4539-43.
15. 15 Folks TM, Powell D, Lightfoote M, Koenig S, Fauci AS, Benn S, et al. Biological and biochemical characterization of a cloned Leu-3-cell surviving infection with the acquired immune deficiency syndrome retrovirus. J Exp Med, 1986;164:280-90.
16. 16 Folks T, Powell DM, Lightfoote MM, Benn S, Martin MA, Fauci AS. Induction of HTLV-III/LAV from a nonvirus-producing T-cell line: implications for latency. Science, 1986;231:600-2.
17. 17 Zagury D, Bernard J, Leonard R. Long-term cultures of HTLV-III - infected T cells: a model of cytopathology of T-cell depletion in AIDS. Science, 1986;231:850-3.
18. 18 Mikovits JA, Raziuddin, Gonda M, Ruta M, Lohrey NC, Kung HF, et al. Negative regulation of human immune deficiency virus replication in monocytes. Distinctions between restricted and latent expression in THP-1 cells. J Exp Med, 1990;171:1705-20.
19. 19 De Maria A, Pantaleo G, Schnittman SM, Greenhouse JJ, Baseler M, Orenstein JM, et al. Infection of CD8+ T lymphocytes with HIV. Requirement for interaction with infected CD4+ cells and induction of infectious virus from chronically infected CD8+ cells. J Immunol, 1991;146:2220-6.
20. 20 Dalgleish AG, Beverley PC, Clapham PR, Crawford DH, Greaves MF, Weiss RA, et al. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312:763-7.
21. 21 Hildreth JE, Orentas RJ. Involvement of a leukocyte adhesion receptor (LFA-1) in HIV-induced syncytium formation. Science, 1989;244:1075-8.
22. 22 Pantaleo G, Butini L, Graziosi C, Poli G, Schnittman SM, Gallin JI, et al. LFA-1 is required for HIV-mediated cell fusion, but not viral spreading, in CD4+ T lymphocytes. J Exp Med, 1991;173:511-4.
23. 23 Moran PA, Diegel ML, Sias JC, Ledbetter JA, Zarling JM. Regulation of HIV production by blood mononuclear cells from HIV-infected donors: I. Lack of correlation between HIV-1 production and T cell activation. AIDS Res Hum Retroviruses, 1993;9:455-64.
24. 24 Folks TM, Clouse KA, Justement J, Rabson A, Duh E, Kehrl JH, et al. Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone. Proc Natl Acad Sci USA, 1989;86:2365-8.
25. 25 Clouse KA, Powell D, Washington I, Poli G, Strebel K, Farrar W, et al. Monokine regulation of human immunodeficiency virus-1 expression in a chronically infected human T cell clone. J Immunol, 1989;142:431-8.
26. 26 Osborn L, Kunkel S, Nabel GJ. Tumor necrosis factor a and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kB. Proc Natl Acad Sci USA, 1989;86:2336-40.
27. 27 Duh EJ, Maury WJ, Folks TM, Fauci AS, Rabson AB. Tumor necrosis factor a activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kB sites in the long terminal repeat. Proc Natl Acad Sci USA, 1989;86:5974-8.
28. 28 Griffin GE, Leung K, Folks TM, Kunkel S, Nabel GJ. Activation of HIV gene expression during monocyte differentiation by induction of NF-kappa B. Nature, 1989;339:70-3.
29. 29 Franzoso G, Biswas P, Poli G, Carlson LM, Brown KD, Tomita-Yamaguchi M, et al. A family of serine proteases expressed exclusively in myelo-monocytic cells specifically processes the nuclear factor-kappa B subunit p65 in vitro and may impair human immunodeficiency virus replication in these cells. J Exp Med, 1994;180:1445-56.
30. 30 Siebenlist U, Franzoso G, Brown K. Structure, regulation and function of NF-kB. Annu Rev Cell Biol, 1994;10;405-55.
31. 31 Poli G, Kinter A, Justement JS, Kehrl JH, Bressler P, Stanely S, et al. Tumor necrosis factor alpha functions in an autocrine manner in the induction of human immunodeficiency virus expression. Proc Natl Acad Sci USA, 1990;87:782-5.
32. 32 Vyakarnam A, McKeating J, Meager A, Beverley PC. Tumour necrosis factors (α, β) induced by HIV-1 in peripheral blood mononuclear cells potentiate virus replication. AIDS, 1990;4:21-7.
33. 33 Kinter AL, Poli G, Fox L, Hardy E, Fauci AS. HIV replication in IL-2-stimulated peripheral blood mononuclear cells is driven in an autocrine/paracrine manner by endogenous cytokines. J Immunol, 1995;154:2448-59.
34. 34 Weissman D, Poli G, Fauci AS. Interleukin 10 blocks HIV replication in macrophages by inhibiting the autocrine loop of tumor necrosis factor alpha and interleukin 6 induction of virus. AIDS Res Hum Retroviruses, 1994;10:1199-206.
35. 35 Goletti D, Kinter AL, Hardy EC, Poli G, Fauci AS. Modulation of endogenous IL-1 beta and IL-1 receptor antagonist results in opposing effects on HIV expression in chronically infected monocytic cells. J Immunol, 1996;156:3501-8.
36. 36 Peterson PK, Gekker G, Chao CC, Schut R, Molitor TW, Balfour HH Jr Cocaine potentiates HIV-1 replication in human peripheral blood mononuclear cell cocultures. Involvement of transforming growth factor-beta. J Immunol, 1991;146:81-4.
37. 37 Peterson PK, Gekker G, Chao CC, Schut R, Verhoef J, Edelman CK, et al. Cocaine amplifies HIV-1 replication in cytomegalovirus-stimulated peripheral blood mononuclear cell cocultures. J Immunol, 1992;149:676-80.
38. 38 Kinter AL, Ostrowski M, Goletti D, Oliva A, Weissman D, Gantt K, et al. HIV replication in CD4+ T cells of HIV-infected individuals is regulated by a balance between the viral suppressive effects of endogenous beta-chemokines and the viral inductive effects of other endogenous cytokines. Proc Natl Acad Sci USA, 1996;93:14076-81.
39. 39 Lazdins JK, Klimkait T, Woods-Cook K, Walker M, Alteri E, Cox D, et al. In vitro effect of transforming growth factor-β on progression of HIV-1 infection in primary mononuclear phagocytes. J Immunol, 1991;147:1201-7.
40. 40 Schuitemaker H, Kootstra NA, Koppelman MH, Bruisten SM, Huisman HG, Tersmette M, et al. Proliferation-dependent HIV-1 infection of monocytes occurs during differentiation into macrophages. J Clin Invest, 1992;89;1154-60.
41. 41 Weissman D, Poli G, Fauci AS. IL-10 synergizes with multiple cytokines in enhancing HIV production in cells of monocytic lineage. J Acquir Immune Defic Syndr Hum Retrovirol, 1995;9:442-9.
42. 42 Vicenzi E, Biswas P, Mengozzi M, Poli G. Role of proinflammatory cytokines and beta-chemokines in controlling HIV replication. J Leukoc Biol, 1997;62:34-40.
43. 43 Herbein G, Montaner LJ, Gordon S. Tumor necrosis factor alpha inhibits entry of human immunodeficiency virus type 1 into primary human macrophages: a selective role for the 75-kilodalton receptor. J Virol, 1996;70:7388-97.
44. 44 Walker CM, Moody DJ, Stites DP, Levy JA. CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication. Science, 1986;234:1563-6.
45. 45 Blackbourn DJ, Mackewicz C, Barker E, Levy JA. Human CD8+ cell non-cytolytic anti-HIV activity mediated by a novel cytokine. Res Immunol, 1994;145:653-9.
46. 46 Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science, 1995;270:1811-5.
47. 47 Baier M, Werner A, Bannert N, Metzner K, Kurth R. HIV suppression by interleukin-16. Nature, 1995;378:563.
48. 48 Maciaszek JW, Parada NA, Cruikshank WW, Center DM, Kornfeld H, Viglianti GA. IL-16 represses HIV-1 promoter activity. J Immunol, 1997;158:5-8.
49. 49 Feng Y, Broder CC, Kennedy PE, Berger EA. HIV-1 entry cofactor: cloning of a seven-transmembrane G protein-coupled receptor. Science, 1996;272:872-7.
50. 50 Scarlatti G, Tresoldi E, Bjorndal A, Fredriksson R, Colognesi C, Deng HK, et al. In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression. Nat Med, 1997;3:1259-65.
51. 51 Alkhatib G, Combadiere C, Broder CC, Feng Y, Kennedy PE, Murphy PM, et al. CC CKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science, 1996;272:1955-8.
52. 52 Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, et al. The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV isolates. Cell, 1996;85:1135-48.
53. 53 He J, Chen Y, Farzan M, Choe H, Ohangen A, Gartner S, et al. CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature, 1997;385:645-9.
54. 54 Gong W, Howard OM, Turpin JA, Grimm MC, Ueda H, Gray PW, et al. Monocyte chemotactic protein-2 activates CCR5 and blocks CD4/CCR5-mediated HIV-1 entry/ replication. J Biol Chem, 1998;273:4289-92.
55. 55 Dimitrov DS. How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity. Cell, 1997;91:721-30.
56. 56 Littman DR. Chemokine receptors - keys to AIDS pathogenesis. Cell, 1998;93:677-80.
57. 57 Huang Y, Paxton WA, Wolinsky SM, Neumann AU, Zhang L, He T, et al. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nature Med, 1996;2:1240-3.
58. 58 Dean M, Carrington M, Winkler C, Huttley GA, Smith MW, Allikmets R, et al. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Science, 1996;273:1856-62.
59. 59 Liu R, Paxton WA, Choe S, Ceradini D, Martin SR, Horuk R, et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell, 1996;86:367-77.
60. 60 Morawetz RA, Rizzardi GP, Glauser D, Rutscmann O, Hirschel B, Perrin L, et al. Genetic polymorphism of CCR5 gene and HIV disease: the heterozygous (CCR5/delta ccr5) genotype is neither essential nor sufficient for protection against disease progression. Eur J Immunol, 1997;27: 3223-7.
61. 61 Pal R, Garzino-Demo A, Markham PD, Burns J, Brown M, Gallo RC, et al. Inhibition of HIV-1 infection by the b-chemokine MDC. Science, 1997;278:695-8.
62. 62 Lee B, Rucker J, Doms RW, Tsang M, Hu X, Dietz M, et al. β-Chemokine MDC and HIV-1 infection. Science, 1998;281:487-a.
63. 63 Arenzana-Seisdedos F, Amara A, Thomas D, Virelizier JL. β-Chemokine MDC and HIV-1 infection. Science, 1998;281:487-a.
64. 64 Struyf S, Proost P, Sozzani S, Mantovani A, Wuyts A, De Clerq E, et al. Enhanced anti-HIV-1 activity and altered chemotactic potency of NH2-terminally processed macrophage-derived chemokine (MDC) imply an additional MDC receptor. J Immunol, 1998;161:2672-5.
65. 65 Bleul C, Farzan M, Choe H, Parolin C, Clark-Lewis I, Sodroski J, et al. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature, 1996;382:829-33.
66. 66 Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S, Kitamura Y, et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature, 1996;382:635-8.
67. 67 Aiuti A, Webb IJ, Bleul C, Springer T, Gutierrez-Ramos JC. The chemokine SDF-1 is a chemoattractant for human. CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. J Exp Med, 1997;185:111-20.
68. 68 Aiuti A, Turchetto L, Cota M, Cipponi A, Brambilla A, Arcelloni C, et al. Human CD34+ cells express CXCR4 and its ligand stromal cell derived factor-I. Implications for infection by T-cell tropic human immunodeficiency virus. Blood 1999 (in press).
69. 69 Biswas P, Mengozzi M, Mantelli B, Delfanti F, Brambilla A, Vicenzi E, et al. 1,25-Dihydroxyvitamin D3 upregulates functional CXCR4 human immunodeficiency virus type 1 coreceptors in U937 minus clones: NF-kappaB independent enhancement of viral replication. J Virol, 1998;72:8380-3.
70. 70 Schmidtmayerova H, Sherry B, Bukrinsky M. Chemokines and HIV replication. Nature, 1996;382:767.
71. 71 Dolei A, Biolchini A, Serra C, Curreli S, Gomes E, Dianzani F. Increased replication of T-cell-tropic HIV strains and CXC-chemokine receptor-4 induction in T cells treated with macrophage inflammatory protein (MIP)-1alpha, MIP-1beta and RANTES beta-chemokines. AIDS, 1998;12:183-90.
72. 72 Kinter A, Catanzaro A, Monaco J, Ruiz M, Justement J, Moir S, et al. CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4 (+) T cells: role of signal transduction. Proc Natl Acad Sci USA 1998;95:11880-5.
73. 73 Kelly MD, Naif HM, Adams SL, Cunningham AL, Lloyd AR. Dichotomous effects of beta-chemokines on HIV replication in monocytes and monocyte-derived macrophages. J Immunol, 1998;160:3091-5.
74. 74 Gordon CJ, Muesing MA, Proudfoot AE, Power CA, Moore JP, Trkola A. Enhancement of human immunodeficiency virus type I infection by the CC-chemokine RANTES is independent of the mechanism of virus-cell fusion. J Virol, 1999;73:684-94.
75. 75 Doranz BJ, Rucker J, Yi Y, Smyth RJ, Samson M, Peiper SC, et al. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell, 1996;85:1149-58.
76. 76 Smith MW, Dean M, Carrington M, Winkler C, Huttley GA, Lomb DA, et al. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study. Science, 1997;277:959-65.
77. 77 Rizzardi GP, Morawetz RA, Vicenzi E, Ghezzi S, Poli G, Lazzarin A, et al. CCR2 polymorphism and HIV disease. Swiss HIV Cohort. Nature Med, 1998;4:252-3.
78. 78 Frade JMR, Llorente M, Mellado M, Alcarni J, Gutierrez-Ramos JC, Zaballos A, et al. The amino-terminal domain of the CCR2 chemokine receptor acts as coreceptor for HIV-1 infection. J Clin Invest, 1997;100:497-502.
79. 79 Weiss L, Si-Mohamed A, Giral P, Castiel P, Ledur A, Blondin C, et al. Plasma levels of monocyte chemoattractant protein-1 but not those of macrophage inhibitory protein-1alpha and RANTES correlate with virus load in human immunodeficiency virus infection. J Infect Dis, 1997;176:1621-4.
80. 80 Bernasconi S, Cinque P, Peri G, Sozzani S, Crociata A, Torri W, et al. Selective elevation of monocyte chemotactic protein-1 in the cerebrospinal fluid of AIDS patients with cytomegalovirus encephalitis. J Infect Dis, 1996;174:1098-101.
81. 81 Conant K, Garzino-Demo A, Nath A, McArthur JC, Halliday W, Power C, et al. Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia. Proc Natl Acad Sci USA 1998;95:3117-21.
82. 82 Cinque P, Vago L, Mengozzi M, Torri V, Ceresa D, Vicenzi E, et al. Elevated cerebrospinal fluid levels of monocyte chemotactic protein-1 correlate with HIV-1 encephalitis and local viral replication. Aids, 1998;12:1327-32.
83. 83 Mengozzi M, De Filippi C, Transidico P, Biswas P, Cota M, Ghezzi S, et al. Human immunodeficiency virus replication induces monocyte chemotactic protein-1 in human macrophages and U937 promonocytic cells. Blood, 1999;93:1851-7.
84. 84 Schmidtmayerova H, Nottet HS, Nuovo G, Raabe T, Flanagan CR, Dubrovsky L, et al. Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes. Proc Natl Acad Sci USA 1996;93:700-4.
85. 85 Canque B, Rosenzwajg M, Gey A, Tartour E, Fridman WH, Gluckman JC. Macrophage inflammatory protein-1alpha is induced by human immunodeficiency virus infection of monocyte-derived macrophages. Blood, 1996;87:2011-9.
86. 86 Rubartelli A, Poggi A, Sitia R, Zocchi MR. HIV-I Tat: a polypeptide for all seasons. Immunol Today, 1998;19:543-5.
87. 87 Schnittman SM, Lane HC, Higgins SE, Folks T, Fauci AS. Direct polyclonal activation of human B lymphocytes by the acquired immune deficiency syndrome virus. Science, 1986;233:1084-6.
88. 88 Emilie D, Peuchmaur MC, Maillot MC, Crevon N, Brousee JF, Delfraissy J, et al. Production of interleukins in human immunodeficiency virus-1-replicating lymphnodes. J Clin Invest, 1990,86:148-59.
89. 89 Graziosi C, Pantaleo G, Gantt KR, Fortin J-P, Demerest JF, Cohen OJ, et al. Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals. Science, 1994;265:248-52.
90. 90 Kekow J, Wachsman W, McCutchan JA, Cronin M, Carson DA, Lotz. M. Transforming growth factor beta and noncytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection. Proc Natl Acad Sci USA 1990;87:8321-5.
91. 91 Kekow J, Wachsman W, McCutchan JA, Gross WL, Zachariah M, Carson DA, et al. Transforming growth factor-beta and suppression of humoral immune responses in HIV infection. J Clin Invest, 1991;87:1010-6.
92. 92 Wahl SM, Allen JB, McCartney-Francis N, Morganti-Kossmann MC, Kossmann T, Ellingsworth L, et al. Macrophage-and astrocyte-derived transforming growth factor beta as a mediator of central nervous system dysfunction in acquired immune deficiency syndrome. J Exp Med, 1991;173:981-91.
93. 93 Trimble LA, Lieberman J, Circulating CD 19984, 8 T. lymphocytes in human immunodeficiency virus-infected individuals have impaired function and downmodulate CD3 zeta, the signaling chain of the T-cell receptor complex. Blood 91:585-94.
94. 94 Leonard WJ, O'Shea JJ. Jaks and STATs: biological implications. Annu Rev Immunol, 1998;16:293-322.
95. 95 Bovolenta C, Lorini AL, Mantelli B, Camorali L, Novelli F, Biswas P, et al. A selective defect of IFN-gamma-but not of IFN-alpha-induced JAK/STAT pathway in a subset of U937 clones prevents the antiretroviral effect of IFN-gamma against HIV-1. J Immunol, 1999;162:323-30.
96. 96 Bovolenta C, Camorali L, Lorini AL, Poli G. HIV infection and signal transduction. J Biol Regul Homeost Agents, 1998;12:63-6.
97. 97 Pericle F, Pinto LA, Hicks S, Kirken RA, Sconocchia G, Rusnak J, et al. HIV-1 infection induces a selective reduction in STAT5 protein expression. J Immunol, 1998;160:28-31.
98. 98 Bovolenta C, Testolin L, Benussi L, Lievens PM, Liboi E. Positive selection of apoptosis-resistant cells correlates with activation of dominant-negative STAT5. J Biol Chem, 1998;273:20779-84.
99. 99 Rosenberg ES, Billingsley JM, Caliendo AM, Boswell SL, Sax PE, Kalmans SA, et al. Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia. Science, 1997;278:1447-50.
100. 100 Teppler H, Kaplan G, Smith K, Cameron P, Montana A, Meyn P, et al. Efficacy of low doses of the polyethylene glycol derivative of interleukin-2 in modulating the immune response of patients with human immunodeficiency virus type 1 infection. J Infect Dis, 1993;167:291-8.
101. 101 Jacobson EL, Pilaro F, Smith KA. Rational interleukin 2 therapy for HIV positive individuals: daily low doses enhance immune function without toxicity. Proc Natl Acad Sci USA 1996;93:10405-10.
102. 102 Davey RT Jr, Chaitt DG, Piscitelli SC, Wells M, Kovacs JA, Walker RE, et al. Subcutaneous administration of interleukin-2 in human immunodeficiency virus type 1-infected persons. J Infect Dis, 1997;175:781-9.
103. 103 Connors M, Kovacs JA, Krevat S, Gea-Banacloche JC, Sneller MC, Flanigan M, et al. HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies. Nature Med, 1997;3:533-40.
104. 104 De Paoli P, Zanussi S, Simonelli C, Bortolin MT, D'Andrea M, Crepaldi C, et al. Effects of subcutaneous interleukin-2 therapy on CD4 subsets and in vitro cytokine production in HIV+ subjects. J Clin Invest, 1997;100:2737-43.
105. 105 Barker E, Mackewicz CE, Levy JA, Effects of TH, 1 and TH 1995;2: cytokines on CD8+ cell response against human immunodeficiency virus: implications for long-term survival. Proc Natl Acad Sci USA 92:11135-9.
106. + T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy. Nat Med 1999;5:651-5.
107. 107 Poli G, Kinter AL, Fauci AS. Interleukin 1 induces expression of the human immunodeficiency virus alone and in synergy with interleukin 6 in chronically infected U, 1994;1: cells: inhibition of inductive effects by the interleukin 1 receptor antagonist. Proc Natl Acad Sci USA 91:108-12.
108. 108 Koyanagi Y, O'Brien WA, Zhao JQ, Golde DW, Gasson JC, Chen IS. Cytokines alter production of HIV-1 from primary mononuclear phagocytes. Science, 1988;241:1673-5.
109. 109 Poli G, Bressler P, Kinter A, Duh E, Timmer WC, Rabson A, et al. Interleukin 6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor alpha by transcriptional and post-transcriptional mechanisms. J Exp Med, 1990;172:151-8.
110. 110 Al-Harthi L, Roebuck KA, Landay A. Induction of HIV-1 replication by type 1-like cytokines, interleukin (IL) -12 and 1L-15: effect on viral transcriptional activation, cellular proliferation, and endogenous cytokine production. J Clin Immunol, 1998;18:124-31.
111. 111 Bayard-McNeeley M, Doo H, He S, Hafner A, Johnson WD Jr, Ho JL. Differential effects of interleukin-12, interleukin-15, and interleukin-2 on human immunodeficiency virus type 1 replication in vitro. Clin Diagn Lab Immunol, 1996;3:547-53.
112. 112 Shapiro L, Puren AJ, Barton HA, Novick D, Peskind RL, Shenkar R, et al. Interleukin 18 stimulates HIV type 1 in monocytic cells. Proc Natl Acad Sci USA 1998;95:12550-5.
113. 113 Gendelman HE, Orenstein JM, Martin MA, Ferrua C, Mitra R, Phipps T, et al. Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes. J Exp Med, 1988;167:1428-41.
114. 114 Folks TM, Justement J, Kinter A, Dinarello CA, Fauci AS. Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line. Science, 1987;238:800-2.
115. 115 Ho DD, Hartshorn KL, Rota TR, Andrews CA, Kaplan JC, Schooley RT, et al. Recombinant human interferon alpha-A suppresses HTLV-III replication in vitro. Lancet, 1985;i:602-4.
116. 116 Poli G, Orenstein JM, Kinter A, Folks TM, Fauci AS. Interferon-alpha but not AZT suppresses HIV expression in chronically infected cell lines. Science, 1989;244:575-7.
117. 117 Shirazi Y, Pitha PM. Interferon alpha-mediated inhibition of human immunodeficiency virus type 1 provirus synthesis in T-cells. Virology, 1993;193:303-12.
118. 118 Montaner LJ, Doyle AG, Collin M, Georges H, James W, Minty A, et al. Interleukin 13 inhibits human immunodeficiency virus type 1 production in primary blood-derived human macrophages in vitro. J Exp Med, 1993;178:743-7.
119. 119 Scala E, D'Offizi G, Rosso R, Tirriziani O, Ferrara R, Mazzone AM, et al. C-C chemokines, IL-16, and soluble antiviral factor activity are increased in cloned T cells from subjects with long-term nonprogressive HIV infection. J Immunol, 1997;158:4485-92.
120. 120 Kazazi F, Mathijs JM, Chang J, Malafiej P, Lopez A, Dowton D, et al. Recombinant interleukin 4 stimulates human immunodeficiency virus production by infected monocytes and macrophages. J Gen Virol, 1992;73: 941-9.
121. 121 Foli A, Saville MW, Baseler MW, Yarchoan R. Effects of the Th1 and Th2 stimulatory cytokines interleukin-12 and interleukin-4 on human immunodeficiency virus replication. Blood, 1995;85:2114-23.
122. 122 Akridge RE, Reed SG. Interleukin-12 decreases human immunodeficiency virus type 1 replication in human macrophage cultures reconstituted with autologous peripheral blood mononuclear cells. J Infect Dis, 1996;173:559-64.
123. 123 Poli G, Kinter AL, Justement JS, Bressler P, Kehrl JH, Fauci AS. Transforming growth factor beta suppresses human immunodeficiency virus expression and replication in infected cells of the monocyte/macrophage lineage. J Exp Med, 1991;173:589-97.
124. 124 Poli G, Kinter AL, Justement JS, Bressler P, Kehrl JH, Fauci AS. Retinoic acid mimics transforming growth factor beta in the regulation of human immunodeficiency virus expression in monocytic cells. Proc Natl Acad Sci USA 1992;89:2689-93.
125. 125 Biswas P, Poli G, Kinter AL, Justement JS, Stanley SK, Maury WJ, et al. Interferon gamma induces the expression of human immunodeficiency virus in persistently infected promonocytic cells (U1) and redirects the production of virions to intracytoplasmic vacuoles in phorbol myristate acetate-differentiated U1 cells. J Exp Med, 1992;176:739-50.
126. 126 Amara A, Gall SL, Schwartz O, Salamero J, Montes M, Loetscher P, et al. HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication. J Exp Med, 1997;186:139-46.