Genetic polymorphism of CCR5 gene and HIV disease: The heterozygous (CCR5/Δccr5) genotype is neither essential nor sufficient for protection against disease progression

European Journal of Immunology

Volumn 27, Issue 12, 1997, Pages 3223-3227

  Morawetz, Renate A ^a   Rizzardi, G Paolo ^a   Glauser, Didier ^a   Rutschmann, Olivier ^b   Hirschel, Bernard ^b   Perrin, Luc ^b   Opravil, Milos ^c   Flepp, Markus ^c   Von Overbeck, Jan ^a   Glauser, Michel P ^a   Ghezzi, Silvia ^d   Vicenzi, Elisa ^d   Poli, Guido ^d   Lazzarin, Adriano ^d   Pantaleo, Giuseppe ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

CCR 5 polymorphism; HIV disease progression; Long term nonprogressor

Indexed keywords

CD4 ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; DISEASE COURSE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; T LYMPHOCYTE; VIREMIA;

HETEROZYGOTE; HIV INFECTIONS; HIV-1; HUMANS; POLYMORPHISM, GENETIC; PROGNOSIS; RECEPTORS, CCR5;

EID: 0031445262     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.1830271220     Document Type: Article

References (31)

1. Deng, H., Liu, R., Ellmeier, W., Choe, S., Unutmaz, D., Burkhart, M., Di Marzio, P., Marmon, S., Sutton, R. E., Hill, C. M., Davis, C. B., Peiper, S. C., Schall, T. J., Littman, D. R. and Landau, N. R., Nature 1996. 381: 661.
2. Dragic, T., Litwin, V, Allaway, G. P., Martin, S. R., Huang, Y., Nagashima, K. A., Cayanan, C., Maddon, P. J., Koup, R. A., Moore, J. P. and Paxton, W. A., Nature 1996. 381: 667.
3. Alkhatib, G., Combadiere, C., Broder, C. C., Feng, Y., Kennedy, P. E., Murphy, P. M. and Berger, E. A., Science 1996. 272: 1955.
4. Choe, H., Farzan, M., Sun, Y., Sullivan, N., Rollins, B., Ponath, P. D., Wu, L., Mackay, C. R., LaRosa, G., Newman, W., Gerard, N., Gerard, C. and Sodroski, J., Cell 1996. 85: 1135.
5. Doranz, B. J., Rucker, J., Yi, Y., Smyth, R. J., Samson, M., Peiper, S. C., Parmentier, M., Collman, R. G. and Doms, R. W., Cell 1996. 85: 1149.
6. Paxton, W. A., Martin, S. R., Tse, D., O'Brien, T. R., Skurnick, J., VanDevanter, N. L., Padian, N., Braun, J. F., Kotler, D. P., Wolinsky, S. M. and Koup, R. A., Nature Med. 1996. 2: 412.
7. Liu, R., Paxton, W. A., Choe, S., Ceradini, D., Martin, S. R., Horuk, R., MacDonald, M. E., Stuhlmann, H., Koup, R. A. and Landau, N. R., Cell 1996. 86: 367.
8. Samson, M., Libert, F., Doranz, B. J., Rucker, J., Liesnard, C., Farber, C. M., Saragosti, S., Lapoumeroulie, C., Cognaux, J., Forceille, C., Muyldermans, G., Verhofstede, C., Burtonboy, G., Georges, M., Imai, T., Rana, S., Yi, Y., Smyth, R. J., Collman, R. G., Doms, R. W., Vassart, G. and Parmentier, M., Nature 1996. 382: 722.
9. Biti, R., Ffrench, R., Young, J., Bennetts, B. and Stewart, G., Nature Med. 1997. 3: 252.
10. O'Brien, T. R., Winkler, C., Dean, M., Nelson, J. A. E., Carrington, M., Michael, N. L. and White II, G. C., Lancet 1997. 349: 1219.
11. Theodorou, I., Meyer, L., Magierowska, M., Katlama, C., Rouzioux, C. and Group, S. S., Lancet 1997. 349: 1219.
12. Dean, M., Carrington, M., Winkler, C., Huttley G. A., Smith, M. W., Allikmets, R., Goedert, J. J., Buchbinder, S. P., Vittinghoff, E., Gomperts, E., Donfield, S., Vlahov, D., Kaslow, R., Saah, A., Rinaldo, C., Detels, R. and O'Brien, S. J., Science 1996. 273: 1856.
13. Huang, Y., Paxton, W. A., Wolinsky, S. M., Neumann, A. U., Zhang, L., He, T., Kang, S., Ceradini, D., Jin, Z., Yazdanbakhsh, K., Kunstman, K., Erickson, D., Dragon, E., Landau, N. R., Phair, J., Ho, D. D. and Koup, R. A., Nature Med. 1996. 2: 1240.
14. Michael, N. L., Chang, G., Louie, L. G., Mascola, J. R., Dondero, D., Birx, D. L. and Sheppard, H. W., Nature Med. 1997. 3: 338.
15. Rappaport, J., Cho, Y. Y., Hendel, H., Schwartz, E. J., Schachter, F. and Zagury, J. F., Lancet 1997. 349: 922.
16. Wu L., Paxton, W. A., Kassam, N., Ruffing, N., Rottman, J. B., Sullivan, N., Choe, H., Sodroski, J., Newman, W.,. Koup, R. A. and Mackay, C. R., J. Exp. Med. 1997. 185: 1681.
17. Samson, M., Labbe, O., Mollereau, C., Vassart, G. and Parmentier, M., Biochemistry 1996. 35: 3362.
18. Centers for Disease Control and Prevention, MMWR 1992. 41: 1.
19. Zimmerman, P. A., Buckler White, A., Alkhatib, G.., Spalding, T., Kubofcik, J., Combadiere, C., Weissman, D., Cohen, O., Rubbert, A., Lam, G., Vaccarezza, M., Kennedy, P. E., Kumaraswami, V., Giorgi, J. V., Detels, R., Hunter, J., Chopek, M., Berger, E. A., Fauci, A. S., Nutman, T. B. and Murphy, P. M., Mol. Medicine 1997. 3: 23.
20. Lifson, A. R., Buchbinder, S. P., Sheppard, H. W., Mawle, A. C., Wilber, J. C., Stanley, M., Hart, C. E., Hessol, N. A. and Holmberg, S. D., J. Infect. Dis. 1991. 163: 959.
21. Sheppard, H. W., Lang, W., Ascher, M. S., Vittinghoff, E. and Winkelstein, W., AIDS 1993. 7: 1159.
22. Levy, J. A., AIDS 1993. 7: 1401.
23. Buchbinder, S. P., Katz, M. H., Hessol, N. A., O'Malley, P. M. and Holmberg, S. D., AIDS 1994. 8: 1123.
24. Kaslow, R. A. and Mann, D. L., J. Infect. Dis. 1994. 169: 1332.
25. Cao Y., Qin, L., Zhang, L., Safrit, J. and Ho, D. D., N. Engl. J. Med. 1995. 332: 201.
26. Pantaleo, G., Menzo, S., Vaccarezza, M. et al., N. Engl. J. Med. 1995. 332: 209.
27. Kirchhoff, F., Greenough, T. C., Brettler, D. B., Sullivan, J. L. and Desrosiers, R. C., N. Engl. J. Med. 1995. 332: 228.
28. Deacon, N. J., Tsykin, A., Solomon, A. et al., Science 1995. 270: 988.
29. Moore, J. P., Science 1997. 276: 51.
30. Trkola, A.., Dragic, T., Arthos, J., Binley, J. M., Olson, W. C., Allaway, G. P., Cheng-Mayer, C., Robinson, J., Maddon, P. J. and Moore, J. P., Nature 1996. 384: 184.
31. Pantaleo, G., Demarest, J. F., Schacker, T., Vaccarezza M., Cohen, O. J., Daucher, M., Graziosi, C., Schnittman, S. S., Quinn, T. C., Shaw, G. M., Perrin, L., Tambussi, G., Lazzarin, A., Sekaly, R. P., Soudeyns, H., Corey, L. and Fauci, A. S., Proc. Natl. Acad. Sci. USA 1997. 94: 254.