Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor

EMBO Journal

Volumn 17, Issue 1, 1998, Pages 232-243

  Kalkhoven, Eric ^a   Valentine, Janet E ^a   Heery, David M ^a   Parker, Malcolm G ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Activation function; Co activator; Oestrogen receptor; SRC1

Indexed keywords

CELL NUCLEUS RECEPTOR; DIMER; ESTROGEN RECEPTOR; STEROID RECEPTOR;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; RECEPTOR BINDING; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; COS CELLS; HISTONE ACETYLTRANSFERASES; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RECEPTORS, ESTROGEN; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0032472408     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.1.232     Document Type: Article

References (68)

1. Adan, R.A.H., Cox, J.J., van Kats, J.P. and Burbach, J.P.H. (1992) Thyroid hormone regulates the oxytocin gene. J. Biol. Chem., 267, 3771-3777.
2. Anzick, S.L. et al. (1997) AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science, 277, 965-968.
3. Bannister, A.J. and Kouzarides, T. (1996) The CBP co-activator is a histone acetyltransferase. Nature, 384, 641-643.
4. Barettino, D., Ruiz, M.D.M.V. and Stunnenberg, H.G. (1994) Characterization of the ligand-dependent transactivation domain of thyroid-hormone receptor. EMBO J., 13, 3039-3049.
5. Beato, M., Herrlich, P. and Schutz, G. (1995) Steroid-hormone receptors -many actors in search of a plot. Cell, 83, 851-857.
6. Bourguet, W., Ruff, M., Chambon, P., Gronemeyer, H. and Moras, D. (1995) Crystal-structure of the ligand-binding domain of the human nuclear receptor RXR-alpha. Nature, 375, 377-382.
7. Brzozowski, A.M. et al. (1997) Molecular basis of agonism and antagonism in the oestrogen receptor. Nature, 389, 753-758.
8. Bunone, G., Briand, P.-A., Miksicek, R.J. and Picard, D. (1996) Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO J., 15, 2174-2183.
9. Cavaillès, V., Dauvois, S., Danielian, P.S. and Parker, M.G. (1994) Interaction of proteins with transcriptionally active estrogen receptors. Proc. Natl Acad. Sci. USA, 91, 10009-10013.
10. Cavaíllès, V., Dauvois, S., L'Horset, F., Lopez, G., Hoare, S., Kushner, P.J. and Parker, M.G. (1995) Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. EMBO J., 14, 3741-3751.
11. Chakravarti, D., LaMorte, V.J., Nelson, M.C., Nakajima, T., Schulman, I.G., Juguilon, H., Montminy, M. and Evans, R.M. (1996) Role of CBP/P300 in nuclear receptor signalling. Nature, 383, 99-103.
12. Chambon, P. (1996) A decade of molecular biology of retinoic acid receptors. FASEB J., 10, 940-954.
13. Chang, K.-H. et al. (1997) A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein. Proc. Natl Acad. Sci. USA, 94, 9040-9045.
14. Chen, H., Lin, R.J., Schiltz, R.L., Chakravarti, D., Nash, A., Nagy, L., Privalsky, M.L., Nakatani, Y. and Evans, R.M. (1997) Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with p/CAF and CBP/p300. Cell, 90, 569-580.
15. Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
16. Danielian, P.S., White, R., Lees, J.A. and Parker, M.G. (1992) Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. EMBO J., 11, 1025-1033.
17. Danielian, P.S., White, R., Hoare, S.A., Fawell, S.E. and Parker, M.G. (1993) Identification of residues in the estrogen receptor which confer differential sensitivity to estrogen and hydroxytamoxifen. Mol. Endocrinol., 7, 232-240.
18. DiRenzo, J., Söderström, M., Kurokawa, R., Ogliastro, M.-H., Ricote, M., Ingrey, S., Hörlein, A., Rosenfeld, M.G. and Glass, C.K. (1997) Peroxisome proliferator-activated receptors and retinoic acid receptors differentially control the interactions of retinoid X receptor heterodimers with ligands, coactivators, and corepressors. Mol. Cell. Biol., 17, 2166-2176.
19. Durand, B., Saunder, M., Gaudon, C., Roy, B., Losson, R. and Chambon, P. (1994) Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity. EMBO J., 13, 5370-5382.
20. Fawell, S.E., Lees, J.A., White, R. and Parker, M.G. (1990) Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor. Cell, 60, 953-962.
21. Folkers, G.E. and van der Saag, P.T. (1995) Adenovirus E1A functions as a cofactor for retinoic acid receptor beta (RAR beta) through direct interaction with RAR beta. Mol. Cell. Biol. 15, 5868-5878.
22. Glynne, R., Kerr, L.-A., Mockridge, I., Beck, S., Kelly, A. and Trowsdale, J. (1993) The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing. Eur. J. Immunol., 23, 860-866.
23. Green, S., Isseman, I. and Sheer, E. (1988) A versatile in vivo and in vitro eukaryotic expression vector for protein engineering. Nucleic Acids Res., 16, 369.
24. Halachmi, S., Marden, E., Martin, G., MacKay, H., Abbondanza, C. and Brown, M. (1994) Estrogen receptor-associated proteins-possible mediators of hormone-induced transcription. Science, 264, 1455-1458.
25. Hanstein, B., Eckner, R., DiRenzo, J., Halachmi, S., Liu, H., Searcy, B., Kurokawa, R. and Brown, M. (1996) p300 is a component of an estrogen receptor coactivator complex. Proc. Natl Acad. Sci. USA, 93, 11540-11545.
26. Heery, D.M., Kalkhoven, E., Hoare, S. and Parker, M.G. (1997) A signature motif in coactivators mediates binding to nuclear receptors. Nature, 387, 733-736.
27. Henttu, P.M.A., Kalkhoven, E. and Parker, M.G. (1997) AF-2 activity and recruitment of steroid receptor coactivator 1 to the estrogen receptor depend on a lysine residue conserved in nuclear receptors. Mol. Cell. Biol., 17, 1832-1839.
28. Hong, H., Kohli, K., Garabedian, M.J. and Stallcup, M.R. (1997) GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. Mol. Cell. Biol., 17, 2735-2744.
29. Ing, N.H., Beekman, J.M., Tsai, S.Y., Tsai, M.-J. and O'Malley, B.W. (1992) Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II). J. Biol. Chem., 267, 17617-17623.
30. II30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor. Cell, 79, 107-117.
31. Jones, T., Sheer, D., Bevec, D., Kappel, B., Hauber, J. and Steinkasserer, A. (1997) The human HIV-1 Rev binding-protein (HRP) maps to chromosome 2q36. Genomics, 40, 198-199.
32. Kalkhoven, E., Roelen, B.A.J., de Winter, J.P., Mummery, C.L., van den Eijnden-van Raaij, A.J.M., van der Saag, P.T. and van der Burg, B. (1995) Resistance to TGF-β and activin due to reduced receptor expression in human breast tumor cell lines. Cell Growth Diff., 6, 1151-1161.
33. Kamei, Y. et al. (1996) A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell, 85, 403-414.
34. Kato, S. et al. (1995) Activation of the estrogen-receptor through phosphorylation by mitogen-activated protein-kinase. Science, 270, 1491-1494.
35. Kurokawa, R., Soderstrom, M., Horlein, A., Halachmi, S., Brown, M., Rosenfeld, M.G. and Glass, C.K. (1995) Polarity-specific activities of retinoic acid receptors determined by a co-repressor. Nature, 377, 451-454.
36. Lahooti, H., White, R., Danielian, P.S. and Parker, M.G. (1994) Characterization of ligand-dependent phosphorylation of the estrogen receptor. Mol. Endocrinol., 8, 182-188.
37. Le Douarin, B. et al. (1995) The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18. EMBO J., 14, 2020-2033.
38. Lee, J.W., Ryan, F., Swaffield, J.C., Johnston, S.A. and Moore, D.D. (1995) Interaction of thyroid-hormone receptor with a conserved transcriptional mediator. Nature, 374, 91-94.
39. Lees, J.A., Fawell, S.E. and Parker, M.G. (1989) Identification of two transactivation domains in the mouse oestrogen receptor. Nucleic Acids Res., 17, 5477-5488.
40. L'Horset, F., Dauvois, S., Heery, D.M., Cavaillès, V. and Parker, M.G. (1996) RIP-140 interacts with multiple nuclear receptors by means of two distinct sites. Mol. Cell. Biol., 16, 6029-6036.
41. Li, H., Gomes, P.J. and Chen, J.D. (1997) RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2. Proc. Natl Acad. Sci. USA, 94, 8479-8484.
42. Lillie, J.W. and Green, M.R. (1989) Transcription activation by the adenovirus Ela protein. Nature, 338, 39-44.
43. Mangelsdorf, D.J., Umesono, K., Kliewer, S.A., Borgmeyer, U., Ong, E.S. and Evans, R.M. (1991) A direct repeat of the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR. Cell, 66, 555-561.
44. Mangelsdorf, D.J. et al. (1995) The nuclear receptor superfamily: the second decade. Cell, 83, 835-839.
45. McInerney, E.M., Tsai, M.J., Omalley, B.W. and Katzenellenbogen, B.S. (1996) Analysis of estrogen-receptor transcriptional enhancement by a nuclear hormone-receptor coactivator. Proc. Natl Acad. Sci. USA, 93, 10069-10073.
46. Ogryzko, V.V., Schiltz, R.L., Russanova, V., Howard, B.H. and Nakatani, Y. (1996) The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell, 87, 953-959.
47. Oñate, S.A., Tsai, S.Y., Tsai, M.-J. and O'Malley, B.W. (1995) Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science, 270, 1354-1357.
48. Parker, M.G. (1993) Steroid and related receptors. Curr. Opin. Cell Biol., 5, 499-504.
49. Renaud, J.-P., Rochel, N., Ruff, M., Vivat, V., Chambon, P., Gronemeyer, H. and Moras, D. (1995) Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid. Nature, 378, 681-689.
50. Saatcioglu, F., Bartunek, P., Deng, T., Zenke, M. and Karin, M. (1993) A conserved C-terminal sequence that is deleted in v-ErbA is essential for the biological activities of c-ErbA (the thyroid hormone receptor). Mol. Cell. Biol., 13, 3675-3685.
51. Sadovsky, Y., Webb, P., Lopez, G., Baxter, J.D., Cavailles, V., Parker, M.G. and Kushner, P.J. (1995) Transcriptional activators differ in their responses to overexpression of TATA-box-binding protein. Mol. Cell. Biol., 15, 1554-1563.
52. Sadowski, I. and Ptashne, M. (1989) A vector for expressing GAL4(1-147) fusions in mammalian cells. Nucleic Acids Res., 17, 7539.
53. Sleigh, M.J. (1986) A nonchromatographic assay for expression of the chloramphenicol acetyltransferase gene in eucaryotic cells. Anal. Biochem., 156, 251-256.
54. Smith, C.L., Onate, S.A., Tsai, M.-J. and O'Malley, B.W. (1996) CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription. Proc. Natl Acad. Sci. USA, 93, 8884-8888.
55. Spencer, T.E. et al. (1997) Steroid receptor coactivator-1 is a histone acetyltransferase. Nature, 389, 194-198.
56. Tasset, D., Tora, L., Fromental, C., Scheer, E. and Chambon, P. (1990) Distinct classes of transcriptional activating domains function by different mechanisms. Cell, 62, 1177-1187.
57. Tone, Y., Collingwood, T.N., Adams, M. and Chatterjee, V.K. (1994) Functional analysis of a transactivation domain in the thyroid hormone β receptor. J. Biol. Chem., 269, 31157-31161.
58. Tora, L., White, J., Brou, C., Tasset, D., Webster, N., Scheer, E. and Chambon, P. (1989) The human estrogen receptor has two independent nonacidic transcriptional activation functions. Cell, 59, 477-487.
59. Torchia, J., Rose, D.W., Inostroza, J., Kamei, Y., Westin, S., Glass, C.K. and Rosenfeld, M.G. (1997) The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature, 387, 677-684.
60. Voegel, J.J., Heine, M.J.S., Zechel, C., Chambon, P. and Gronemeyer, H. (1996) TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J., 15, 101-108.
61. vom Baur, E. et al. (1996) Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. EMBO J., 15, 110-124.
62. Wade, P.A. and Wolffe, A.P. (1997) Chromatin: histone acetyltransferases in control. Curr. Biol., 7, 82-84.
63. Wagner, R.L., Apriletti, J.W., McGrath, M.E., West, B.L., Baxter, J.D. and Fletterick, R.J. (1995) A structural role for hormone in the thyroid hormone receptor. Nature, 378, 690-697.
64. White, R., Jobling, S., Hoare, S.A., Sumpter, J.P. and Parker, M.G. (1994) Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology, 135, 175-182.
65. Wurtz, J.-M., Bourguet, W., Renaud, J.-P., Vivat, V., Chambon, P., Moras, D. and Gronemeyer, H. (1996) A canonical structure for the ligand-binding domain of nuclear receptors. Nature Struct. Biol., 3, 87-94.
66. Yang, X.-J., Ogryzko, V.V., Nishikawa, J.-I., Howard, B.H. and Nakatani, Y. (1996) A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature, 382, 319-324.
67. Yao, T.-P., Ku, G., Zhou, N., Scully, R. and Livingston, D.M. (1996) The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proc. Natl Acad. Sci. USA, 93, 10626-10631.
68. 70, for the androgen receptor in human prostate cells. Proc. Natl Acad. Sci. USA, 93, 5517-5521.