HPRT mutant T-cell lines from multiple sclerosis patiens recognize myelin proteolipid protein peptides

Journal of Neuroimmunology

Volumn 75, Issue 1-2, 1997, Pages 95-103

  Trotter, John L ^a   Damico, Cheryl A ^a   Cross, Anne H ^a   Pelfrey, Clara M ^b   Karr, Robert W ^c   Fu, Xin Ting ^c   McFarland, Henry F ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c PFIZER INC   (United States)

Author keywords

multiple sclerosis; myelin proteolipid protein; T cells

Indexed keywords

HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MYELIN BASIC PROTEIN; PROTEOLIPID PROTEIN;

ADULT; ARTICLE; CELL LINE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; MALE; MULTIPLE SCLEROSIS; MUTATION; PRIORITY JOURNAL; T LYMPHOCYTE;

ADULT; ANTIGENS; CELL LINE; FEMALE; GENES; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; MUTATION; MYELIN PROTEOLIPID PROTEIN; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES;

EID: 0030890461     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(97)00007-6     Document Type: Article

References (48)

1. Acha-Orbea, H., Mitchell, D.J., Timmerman, L., Wraith, D.C., Tausch, G.S., Waldor, M.K., Zamvil, S.S., McDevitt, H.O. and Steinman, L. (1988) Limited heterogeneity of T-cell receptors from T-lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 54, 263-273.
2. Allegretta, M., Nicklas, J.A., Sriram, S., and Albertini, R.J. (1990) T-cells responsive to myelin basic protein in patients with multiple sclerosis. Science 247, 718-721.
3. Amor, S., Baker, D., Groome, N. and Turk, J.L. (1993) Identification of a major encephalitogenic epitope of proteolipid protein (residues 56-70) for the induction of experimental allergic encephalomyelitis in Biozzi AB/H and non-obese diabetic mice. J. Immunol. 150, 5666-5672.
4. Chou, Y.K., Bourdette, D.N., Offner, H., Whitham, R., Wang, R.Y., Hashim, G.A. and Vandenbark, A.A. (1992) Frequency of T-cells specific for myelin basic protein and myelin proteolipid protein in blood and CSF in MS. J. Neuroimmunol. 38, 105-113.
5. Dawisha, S.M., Gmelig-Meyling, F. and Steinberg, A.D. (1994) Assessment of clinical parameters associated with increased frequency of mutant T-cells in patient with systemic lupus erythematosis. Arth. Rheum. 37, 270-277.
6. de Rosbo, N.K., Milo R., Lees, M.B., Burger, D., Bernard, C.C.A. and Ben-Nun, A. (1993) Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein. J. Clin. Invest. 92, 2602-2608.
7. Deibler, G.E., Martenson, R.E. and Kies, M.W. (1972) Large scale preparation of myelin basic protein from central nervous system tissues of myelin basic protein from central nervous system tissues of several mammalian species. Prep. Biochem. 2, 139-165.
8. Diehl, H-J, Schaich, M., Budzinski, R-M. and Stoffel, W. (1986) Individual exons encode the integral membrane domains of human myelin proteolipid protein. Proc. Natl. Acad. Sci. USA 83, 9807-9811.
9. Gaur, A., Wiers, B., Liu, A., Rothbard, J. and Fathman, C.G. (1992) Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy. Science 258, 1491-1494.
10. Gmelig-Meyling, F., Dawisha, S. and Steinberg, A.D. (1992) Assessment of in vivo frequency of mutated T-cells in patients with systemic lupus erythematosus. J. Exp. Med. 175, 297-300.
11. Greer, J.M., Kuchroo, V.K., Sobel, R.A. and Lees, M.B. (1992) Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178-191) for SJL mice. J. Immunol. 149, 783-788.
12. Hashim, G.A., Vandenbark, A., Galang, A.B., Diamanduros, T., Carvalho, E., Srinivasan, J., Jones, R., Vainiene, M., Morrison, W.J. and Offner, H. (1990) Antibodies specific for Vβ8 receptor peptide suppress experimental autoimmune encephalomyelitis. J. Immunol. 144, 4621-4627.
13. Howell, M.D., Winters, S.T., Olee, T., Powell, H.C., Carlo, D.J. and Brostoff, S.W. (1989) Vaccination against experimental allergic encephalomyelitis with T-cell receptor peptides. Science 246, 668-670.
14. Kennedy, M.K., Tan, L.J., Dal Canto, M.C. and Miller, S.D. (1990) Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptide. J. Immunol. 144, 909-915.
15. Lehmann, P.V., Forsthuber, T., Miller, A. and Sercarz, E.E. (1992) Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 358, 155-157.
16. Lipham, W.J., Redmond, T.M., Takahashi, H., Berzofsky, J.A., Wiggert, B., Chader, G.J. and Gery, I. (1991) Recognition of peptides that are immunopathogenic but cryptic. J. Immunol. 146, 3757-3762.
17. Linington, C., Gunn, C.A. and Lassmann, L. (1990) Identification of an encephalitogenic determinant of myelin proteolipid protein for the rabbit. J. Neuroimmunol. 30, 135-144.
18. Lodge, P.A., Allegretta, M., Steinman, L. and Sriram, S. (1994) Myelin basic protein peptide specificity and T-cell receptor gene usage of HPRT mutant T-cell clones in patients with multiple sclerosis. Ann. Neurol. 36, 734-740.
19. Lodge, P.A., Johnson, C. and Sriram, S. (1996) Frequency of MBP and MBP peptide-reactive T-cells in the HPRT mutant T-cell population of MS patients. Neurology 46, 1410-1415.
20. Markovic-Plese, S., Fukaura, H., Zhang, J., Sabbaugh, A., Southwood, S., Sette, A., Kuchroo, V.K. and Hafler D.A. (1995) T-cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans. J. Immunol. 155, 982-992.
21. Martin, R., Jaraquemada, D., Flerlage, M., Richert, J., Brostoff, S., Long, E.O., McFarlin, D.E. and McFarland, H.F. (1990) Fine specificity and HLA restriction of myelin basic protein specific cytotoxic T-cell lines from multiple sclerosis patients and healthy individuals. J. Immunol. 145, 540-548.
22. Owhashi, M. and Heber-Katz, E. (1988) Protection from experimental allergic encephalomyelitis conferred by a monoclonal antibody directed against a shared idiotype on rat T-cell receptors specific for myelin basic protein. J. Exp. Med. 168, 2153-2164.
23. Ohashi, T., Yamamura, T., Inobe, J., Kondo, T., Kunishita, T. and Tabira, T. (1995) Analysis of proteolipid protein (PLP)-specific T-cells in multiple sclerosis: Identification of PLP 95-116 as an HLA-DR2, w15-associated determinant. Int. Immunol. 7, 1771-1778.
24. Pelfrey, C.M., Trotter, J.L., Tranquill, L.R. and McFarland, H.F. (1993) Identification of a novel T-cell epitope of human proteolipid protein (residues 40-60) recognized by proliferative and cytolytic CD4 + T-cells from MS patients. J. Neuroimmunol. 46, 33-42.
25. Pelfrey, C.M., Trotter, J.L., Tranquill, L.R. and McFarland, H.F. (1994) Identification of a second T-cell epitope of human proteolipid protein (residues 89-106) recognized by proliferative and cytolytic CD4 + T-cells from multiple sclerosis patients. J. Neuroimmunol. 53, 153-161.
26. Prineas, J.W. (1985). The neuropathology of MS. Handb. Clin. Neurol. 3, 213-257.
27. Richert, J.R., Robinson, E.D., Deibler, G.E., Martenson, R.E., Dragovic, L.J. and Kies, M.W. (1989) Evidence for multiple human T-cell recognition sites on myelin basic protein. J. Neuroimmunol. 23, 55-66.
28. Sakai, K., Zamvil, S.S., Mitchell, D.J., Hodgkinson, S., Rothbard, J.B. and Steinman, L. (1989) Prevention of experimental encephalomyelitis with peptides that block interaction of T-cells with major histocompatibility complex proteins. Proc. Natl. Acad. Sci. 86, 9470-9474.
29. Sfikakis, P.P., Tesar, J., Theocharis, S., Klipple, G.L. and Tsokos, G.C. (1994) Increased frequency of in vivo hprt gene-mutated T-cells in the peripheral blood of patients with systemic sclerosis. Ann. Rheum. Dis. 53, 122-127.
30. Smilek, D.E., Wraith, D.C., Hodgkinson, S., Dwivedy, S., Steinman, L. and McDevitt, H.O. (1991) A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. 88, 9633-9637.
31. Sriram, S. (1994) Longitudinal study of frequency of HPRT mutant T-cells in patients with multiple sclerosis. Neurology 44, 311-315.
32. Sun, J.B., Olsson, T., Wang, W.Z., Xiao, B.G., Kostulas, V., Fredrikson, S., Ekre, H.P. and Link, H. (1991) Autoreactive T- and B-cells responding to myelin proteolipid protein in multiple sclerosis and controls. Eur. J. Immunol. 21, 1461-1468.
33. Traugott, U., Shevach, E., Chiba, J., Stone, H.J. and Raine, C.S. (1981) Autoimmune encephalomyelitis: Simultaneous identification of T-and B-cells in the target organ. Science 214, 1251-1253.
34. Traugott, U., Reinherz, E.L. and Raine, C.S. (1983) Multiple sclerosis. Distribution of T-cell subsets within active chronic lesions. Science 219, 308-310.
35. Trotter, J.L., Clark, H.B., Collins, K.G., Wegeschiede, C.L. and Scarpellini, J.D. (1987) Myelin proteolipid protein induces demyelinating disease in mice. J. Neurol. Sci. 79, 173-188.
36. Trotter, J.L., Hickey, W.F., van der Veen, R.C. and Sulze L. (1991) Peripheral blood mononuclear cells from multiple sclerosis patients recognize myelin proteolipid protein and selected peptides. J. Neuroimmunol. 33, 55-62.
37. Trotter, J.L., Lieberman, L., Margolis, F.L. and Agrawal, H.C. (1981) Radioimmunoassay for central nervous system myelin specific proteolipid protein. J. Neurochem. 36, 1256-1262.
38. Tuohy, V.K., Lu, Z., Sobel, R.A., Laursen, R.A. and Lees, M.B. (1988) A synthetic peptide from myelin proteolipid protein induces experimental allergic encephalomyelitis. J. Immunol. 141, 1126-1130.
39. Tuohy, V.K., Lu, Z., Sobel, R.A., Laursen, R.A. and Lees, M.B. (1989) Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J. Immunol. 142, 1523-1526.
40. Tuohy, V.K. and Thomas, D.M. (1995) Sequence 104-117 of myelin proteolipid protein is a cryptic encephalitogenic T-cell determinant for SJL/J mice. J. Neuroimmunol. 56, 161-170.
41. Van den Berg, L.H., Mollee, I., Wokke, J.H.J. and Logtenberg, T. (1995) Increased frequencies of HPRT mutant T-lymphocytes in patients with Guillain-Barre' syndrome and chronic inflammatory demyelinating polyneuropathy: further evidence for a role of T-cells in the etiopathogenesis of peripheral demyelinating diseases. J. Neuroimmunol. 58, 37-42.
42. van der Veen, R.C., Trotter, J.L. and Kapp, J.A. (1992) Immune processing of proteolipid protein by subsets of antigen-presenting spleen cells. J. Neuroimmunol. 38, 139-146.
43. van der Veen, R.C., Trotter, J.L., Hickey, W.F. and Kapp JA. (1990) The development and characterization of encephalitogenic cloned T-cells specific for myelin proteolipid protein. J. Neuroimmunol. 26, 139-145.
44. Vandenbark, A., Hashim, G. and Offner, H. (1989) Immunization with a synthetic T-cell receptor V-region protects against experimental autoimmune encephalomyelitis. Nature 341, 541-544.
45. Whitham, R.H., Jones, R.E., Hashim, G.A., Hoy, C.M., Wang, R.Y., Vandenbark, A.A. and Offner, H. (1991) Location of a new encephalitogenic epitope (residues 43 to 64) in proteolipid protein that induces relapsing experimental autoimmune encephalomyelitis in PL/J and (SJL X PL)F1 mice. J. Immunol. 147, 3803-3808.
46. Yamamura, T., Namikawa, T., Endoh, M., Kunishita, T. and Tabira, T. (1986) Experimental allergic encephalomyelitis induced by proteolipid apoprotein in Lewis rats. J. Neuroimmunol. 12, 143-153.
47. Zamvil, S., Nelson, P., Trotter, J., Mitchell, D., Knobler, R., Fritz, T. and Steinman, L. (1985) T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination. Nature 317, 355-358.
48. Zhang, J., Markovic-Plese, S., Lacet, B., Raus, J., Weiner, H.L. and Hafler, D.A. (1994) Increased frequency of interleukin 2-responsive T-cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J. Exp. Med. 179, 973-984.