Multiple sclerosis: Altered expression of 70- and 27-kDa heat shock proteins in lesions and myelin

Journal of Neuropathology and Experimental Neurology

Volumn 56, Issue 6, 1997, Pages 664-672

  Aquino, Dennis A ^a   Capello, Elisabetta ^a   Weisstein, Jason ^a   Sanders, Virginia ^b   Lopez, Carmen ^a   Tourtellotte, Wallace W ^c   Brosnan, Celia F ^a   Raine, Cedric S ^a   Norton, William T ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; MYELIN BASIC PROTEIN;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEMYELINATING DISEASE; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; NEUROPATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; WHITE MATTER;

EID: 0030732754     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199706000-00004     Document Type: Article

References (46)

1. Aquino DA, Brosnan CF. Heat-shock proteins and immunopathology: An overview. Chem Immunol 1992;53:1-16
2. Brown CR, Martin RL, Hansen WJ, Beckmann RP, Welch WJ. The constitutive and stress inducible forms of hsp 70 exhibit functional similarities and interact with one another in an ATP-dependent fashion. J Cell Biol 1993;120:1101-12
3. Aquino DA, Klipfel AA, Brosnan CF, Norton WT. The 70-kDa heat shock cognate protein (HSC70) is a major constituent of the central nervous system and is up-regulated only at the mRNA level in acute experimental autoimmune encephalomyelitis. J Neurochem 1993;61:1340-48
4. Kawagoe J, Abe K, Sato S, Nagano I, Nakamura S, Kogure K. Distributions of heat shock protein (HSP) 70 and heat shock cognate protein (HSC) 70 mRNAs after transient focal ischemia in rat brain. Brain Res 1992;587:195-202
5. Miller EK, Raese JD, Morrison-Bogorad M. Expression of heat shock protein 70 and heat shock cognate 70 messenger RNAs in rat cortex and cerebellum after heat shock or amphetamine treatment. J Neurochem 1991;56:2060-71
6. Cohen IR. Autoimmunity to chaperonins in the pathogenesis of arthritis and diabetes. Annu Rev Immunol 1991;9:567-89
7. Yang XD, Feige U. The 65 kD heat shock protein: A key molecule mediating the development of autoimmune arthritis? Autoimmunity 1991;9:83-88
8. Anderton SM, van der Zee R, Prakken B, Noordzij A, van Eden W. Activation of T cells recognizing 60 kD heat shock protein can protect against experimental arthritis. J Exp Med 1995;181:943-52
9. Boog CJP, de Graeff-Meeder ER, Lucassen MA, et al. Two monoclonal antibodies generated against human hsp60 show reactivity with synovial membranes of patients with juvenile chronic arthritis. J Exp Med 1992;175:1805-10
10. Brudzynski K, Martinez V, Gupta RS. Immunocytochemical localization of heat-shock protein 60-related protein in β-cell secretory granules and its altered distribution in non-obese diabetic mice. Diabetologia 1992;35:316-24
11. Elias D, Reshef T, Birk OS, van der Zee R, Walker MD, Cohen IR. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc Natl Acad Sci USA 1991;88:3088-91
12. Battistini L, Salvetti M, Ristori G, Falcone M, Raine CS, Brosnan CF. γδ T cell receptor analysis supports a role for HSP 70 selection of lymphocytes in multiple sclerosis lesions. Mol Med 1995;1:554-62
13. Stinissen P, Vandevyver C, Medaer R, et al. Increased frequency of γδ T cells in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis. Reactivity, cytotoxicity, and T cell receptor V gene rearrangements. J Immunol 1995;154:4883-94
14. Salvetti M, Ristori G, Buttinelli C, et al. The immune response to mycobacterial 70-kDa heat shock proteins frequently involves autoreactive T cells and is quantitatively disregulated in multiple sclerosis. J Neuroimmunol 1996;65:143-53
15. Brosnan CF, Battistini L, Gao Y-L, Raine CS, Aquino DA. Heat shock proteins and multiple sclerosis: A review. J Neuropathol Exp Neurol 1996;55:389-402
16. van Noort JM, van Sechel AC, Bajramovic JJ, et al. The small heat-shock protein αB-crystallin as candidate autoantigen in multiple sclerosis. Nature 1995;375:798-801
17. Aquino DA, Lopez C, Farooq M. Antisense oligonucleotide to the 70-kDa heat shock cognate protein inhibits synthesis of myelin basic protein. Neurochem Res 1996;21:417-22
18. Ciocca DR, Oesterreich S, Chamness GC, McGuire WL, Fuqua SAW. Biological and clinical implications of heat shock protein 27000 (Hsp27): A review. J Natl Cancer Inst 1993;85:1558-70
19. Arrtgo A-P, Mehlen P. Expression, cellular location and function of low molecular weight heat shock proteins (Hsp20s) during development of the nervous system. In: Mayer RJ, Brown IR, eds. Heat shock proteins in the nervous system. San Diego: Academic Press Inc., 1994:145-67
20. Aquino DA, Padin C, Perez JM, Peng D, Lyman WD, Chiu F-C. Analysis of glial fibrillary acidic protein, neurofilament protein, actin and heat shock proteins in human fetal brain during the second trimester. Develop Brain Res 1996;91:1-10
21. Miron T, Wilchek M, Geiger B. Characterization of an inhibitor of actin polymerization in vinculin-rich fraction of turkey gizzard smooth muscle. Eur J Biochem 1988;178:543-53
22. Miron T, Vancompernolle K, Vandekerckhove J, Wilchek M, Geiger B. A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein. J Cell Biol 1991;114:255-61
23. Oksenberg JR, Panzara MA, Begovich AB, et al. Selection for T-cell receptor Vβ-Dβ-Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature 1993;362:68-70
24. Warren KG, Catz I, Johnson E, Mielke B. Anti-myelin basic protein and anti-proteolipid protein specific forms of multiple sclerosis. Ann Neurol 1994;35:280-89
25. Zhang J, Markovic-Plese S, Lacet B, Raus J, Weiner HL, Hafler DA. Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J Exp Med 1994;179:973-84
26. Raine CS, Wu E, Ivanyi J, Katz D, Brosnan CF. Multiple sclerosis: A protective or a pathogenic role for heat shock protein 60 in the central nervous system? Lab Invest 1996;75:109-23
27. Renkawek K, Bosman GJCGM, de Jong WW. Expression of small heat-shock protein hsp 27 in reactive gliosis in Alzheimer disease and other types of dementia. Acta Neuropathol 1994;87:511-19
28. Gao YL, Raine CS, Brosnan CE Humoral response to hsp 65 in multiple sclerosis and other neurologic conditions. Neurology 1994;44:941-46
29. Hamos JE, Oblas B, Pulaski-Salo D, Welch WJ, Bole DG, Drachman DA. Expression of heat shock proteins in Alzheimer's disease. Neurology 1991;41:345-50
30. Harrison PJ, Procter AW, Exworthy T, et al. Heat shock protein (hsx70) mRNA expression in human brain: Effects of neurodegenerative disease and agonal state. Neuropathol Appl Neurobiol 1993;19:10-21
31. Tourtellotte WW, Rosario IP, Riehl J, Sanders V, Syndulko K. National neurological research specimen bank. A model for human frozen neurospecimen banking. In: Adelman G, Smith BH, eds. Encyclopedia of neuroscience. Amsterdam: Elsevier, 1997. Forthcoming.
32. Sanders V, Conrad AJ, Tourtellotte WW. On classification of postmortem multiple sclerosis plaques for neuroscientists. J Neuroimmunol 1993;46:207-16
33. Adams DJ, Hajj H, Edwards DP, Bjercke RJ, McGuire WL. Detection of a Mr 24,000 estrogen-regulated protein in human breast cancer by monoclonal antibodies. Cancer Res 1983;43:4297-4301
34. Nadler SG, Tepper MA, Schacter B, Mazzucco CE. Interaction of the immunosuppressant deoxyspergualin with a member of the Hsp70 family of heat shock proteins. Science 1992;258:484-86
35. Aquino DA, Chiu F-C, Brosnan CF, Norton WT. Glial fibrillary acidic protein increases in the spinal cord of Lewis rats with acute experimental autoimmune encephalomyelitis. J Neurochem 1988;51:1085-96
36. Norton WT, Poduslo SE. Myelination in rat brain: Method of myelin isolation. J Neurochem 1973;21:749-57
37. Morimoto RI, Tissières A, Georgopoulos C. Progress and perspectives on the biology of heat shock proteins and molecular chaperones. In: Morimoto RI, Tissières A, Georgopoulos C, eds. The biology of heat shock proteins and molecular chaperones. Plainview: Cold Spring Harbor Laboratory Press, 1994:1-30
38. Jakob U, Gaestel M, Engel K, Buchner J. Small heat shock proteins are molecular chaperones. J Biol Chem 1993;268:1517-20
39. Brown IR. Induction of heat shock genes in the mammalian brain by hyperthermia and tissue injury. In: Mayer RJ, Brown IR, eds. Heat shock proteins in the nervous system. San Diego: Academic Press Inc., 1994:31-53
40. Haass C, Klein U, Kloetzel P-M. Developmental expression of Drosophila melanogaster small heat-shock proteins. J Cell Sci 1990;96: 413-18
41. Voskuhl RR, Robinson ED, Segal BM, et al. HLA restriction and TCR usage of T lymphocytes specific for a novel candidate autoantigen, X2 MBP, in multiple sclerosis. J Immunol 1994;153: 4834-44
42. Voskuhl RR, McFarlin DE, Stone R, McFarland HF. T-lymphocyte recognition of a portion of myelin basic protein encoded by an exon expressed during myelination. J Neuroimmunol 1993;42:187-92
43. Capello E, Voskuhl RR, McFarland HF, Raine CS. Multiple sclerosis: Implications of re-expression of a developmental gene (X2 MBP) for repair of chronic lesions. Ann Neurol 1997. Forthcoming.
44. Hofman FM, von Hanwehr RI, Dinarello CA, Mizel SB, Hinton D, Merrill JE. Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain. J Immunol 1986; 136:3239-45
45. Hofman FM, Hinton DR, Johnson K, Merrill JE. Tumor necrosis factor identified in multiple sclerosis brain. J Exp Med 1989;170: 607-12
46. D'Souza SD, Antel JP, Freedman MS. Cytokine induction of heat shock protein expression in human oligodendrocytes: An interleukin-1 mediated mechanism. J Neuroimmunol 1994;50: 17-24