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Volumn 49, Issue 4, 1997, Pages 1116-1126

Human T-cell response to myelin basic protein peptide (83-99): Extensive heterogeneity in antigen recognition, function, and phenotype

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HLA ANTIGEN CLASS 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELIN BASIC PROTEIN; T LYMPHOCYTE RECEPTOR;

EID: 0030701864     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.49.4.1116     Document Type: Article
Times cited : (38)

References (56)
  • 2
    • 0025246367 scopus 로고
    • The T lymphocyte in experimental allergic encephalomyelitis
    • Zamvil SS, Steinman L. The T lymphocyte in experimental allergic encephalomyelitis. Annu Rev Immunol 1990;8:579-621.
    • (1990) Annu Rev Immunol , vol.8 , pp. 579-621
    • Zamvil, S.S.1    Steinman, L.2
  • 3
    • 0024334453 scopus 로고
    • Response of human T lymphocyte lines to myelin basic protein: Association of dominant epitopes with HLA-class II restriction molecules
    • Chou YK, Vainiene M, Whitham R, et al. Response of human T lymphocyte lines to myelin basic protein: association of dominant epitopes with HLA-class II restriction molecules. J Neurol Sci 1989;23:207-216.
    • (1989) J Neurol Sci , vol.23 , pp. 207-216
    • Chou, Y.K.1    Vainiene, M.2    Whitham, R.3
  • 4
    • 0025370870 scopus 로고
    • T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis
    • Ota K, Matsui M, Milford EL, Mackin GA, Weiner HL, Hafler DA. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 1990;346:183-187.
    • (1990) Nature , vol.346 , pp. 183-187
    • Ota, K.1    Matsui, M.2    Milford, E.L.3    Mackin, G.A.4    Weiner, H.L.5    Hafler, D.A.6
  • 5
    • 0025155486 scopus 로고
    • Myelin autoreactivity in multiple sclerosis: Recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple sclerosis patients and healthy donors
    • Pette, M, Fujita K, Wilkinson D, et al. Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple sclerosis patients and healthy donors. Proc Natl Acad Sci USA 1990;87:7968-7972.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 7968-7972
    • Pette, M.1    Fujita, K.2    Wilkinson, D.3
  • 6
    • 0026512105 scopus 로고
    • Diversity in fine specificity and T cell receptor usage of the human CD4+ cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106
    • Martin R, Utz U, Coligan JE, et al. Diversity in fine specificity and T cell receptor usage of the human CD4+ cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106. J Immunol 1992;148:1359-1366.
    • (1992) J Immunol , vol.148 , pp. 1359-1366
    • Martin, R.1    Utz, U.2    Coligan, J.E.3
  • 7
    • 0024368359 scopus 로고
    • Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype
    • Ando DG, Clayton J, Kono D, Urban JL, Sercarz EE. Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. Cell Immunol 1989;124:132-143.
    • (1989) Cell Immunol , vol.124 , pp. 132-143
    • Ando, D.G.1    Clayton, J.2    Kono, D.3    Urban, J.L.4    Sercarz, E.E.5
  • 8
    • 0027990803 scopus 로고
    • Experimental autoimmune panencephalitis and uveoretinitis transferred to the Lewis rat by T lymphocytes specific for the S100β molecule, a calcium binding protein of astroglia
    • Kojima K, Berger T, Lassmann H, et al. Experimental autoimmune panencephalitis and uveoretinitis transferred to the Lewis rat by T lymphocytes specific for the S100β molecule, a calcium binding protein of astroglia. J Exp Med 1994;180:817-829.
    • (1994) J Exp Med , vol.180 , pp. 817-829
    • Kojima, K.1    Berger, T.2    Lassmann, H.3
  • 9
    • 0026506799 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1 integrin
    • Yednock TA, Cannon C, Fritz LC, Sanchez-Madrid F, Steinman L, Karin N. Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1 integrin. Nature 1992;356:63-66.
    • (1992) Nature , vol.356 , pp. 63-66
    • Yednock, T.A.1    Cannon, C.2    Fritz, L.C.3    Sanchez-Madrid, F.4    Steinman, L.5    Karin, N.6
  • 10
    • 0021924965 scopus 로고
    • Major histocompatibility complex-linked control of the murine immune response to myelin basic protein
    • Fritz RB, Skeen MJ, Jen-Chou CH, Garda M, Egorov IK. Major histocompatibility complex-linked control of the murine immune response to myelin basic protein. J Immunol 1985; 134:2328-2332.
    • (1985) J Immunol , vol.134 , pp. 2328-2332
    • Fritz, R.B.1    Skeen, M.J.2    Jen-Chou, C.H.3    Garda, M.4    Egorov, I.K.5
  • 11
    • 0029034068 scopus 로고
    • Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis
    • Martin R, McFarland HF. Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis. Crit Rev Clin Lab Sci 1995;32:121-182.
    • (1995) Crit Rev Clin Lab Sci , vol.32 , pp. 121-182
    • Martin, R.1    McFarland, H.F.2
  • 12
    • 0023753713 scopus 로고
    • Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention
    • Acha-Orbae H, Mitchell L, Timmermann L, et al. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 1988;54:263-273.
    • (1988) Cell , vol.54 , pp. 263-273
    • Acha-Orbae, H.1    Mitchell, L.2    Timmermann, L.3
  • 13
    • 0023751365 scopus 로고
    • Restricted use of the T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy
    • Urban JL, Kumar V, Kono DH, et al. Restricted use of the T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell 1988;54:577-592.
    • (1988) Cell , vol.54 , pp. 577-592
    • Urban, J.L.1    Kumar, V.2    Kono, D.H.3
  • 14
    • 0023886637 scopus 로고
    • Predominant expression of a T cell receptor Vβ gene subfamily in autoimmune encephalomyelitis
    • Zamvil SS, Mitchell DJ, Lee NE, et al. Predominant expression of a T cell receptor Vβ gene subfamily in autoimmune encephalomyelitis. J Exp Med 1988;167:1586-1596.
    • (1988) J Exp Med , vol.167 , pp. 1586-1596
    • Zamvil, S.S.1    Mitchell, D.J.2    Lee, N.E.3
  • 15
    • 0024530958 scopus 로고
    • Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar Vα and Vβ chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different
    • Burns FR, Li X, Shen N, et al. Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar Vα and Vβ chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different. J Exp Med 1989;169:27-39.
    • (1989) J Exp Med , vol.169 , pp. 27-39
    • Burns, F.R.1    Li, X.2    Shen, N.3
  • 16
    • 0024603242 scopus 로고
    • T cell receptor β chain usage in myelin basic protein-specific rat T lymphocytes
    • Chluba J, Steeg C, Becker A, Wekerle H, Epplen JT. T cell receptor β chain usage in myelin basic protein-specific rat T lymphocytes. Eur J Immunol 1989;19:279-284.
    • (1989) Eur J Immunol , vol.19 , pp. 279-284
    • Chluba, J.1    Steeg, C.2    Becker, A.3    Wekerle, H.4    Epplen, J.T.5
  • 17
    • 0024367051 scopus 로고
    • Autoimmune T cells: Immune recognition of normal and variant peptide epitopes and peptide-based therapy
    • Urban JL, Horvath SJ, Hood L. Autoimmune T cells: immune recognition of normal and variant peptide epitopes and peptide-based therapy. Cell 1989;59:257-271.
    • (1989) Cell , vol.59 , pp. 257-271
    • Urban, J.L.1    Horvath, S.J.2    Hood, L.3
  • 18
    • 0024325672 scopus 로고
    • Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy
    • Wraith DC, Smilek DE, Mitchell DJ, Steinman L, McDevitt HO. Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy. Cell 1989;59:247-255.
    • (1989) Cell , vol.59 , pp. 247-255
    • Wraith, D.C.1    Smilek, D.E.2    Mitchell, D.J.3    Steinman, L.4    McDevitt, H.O.5
  • 19
    • 0024380896 scopus 로고
    • Prevention of experimental encephalomyelitis with peptides that block interaction of T cells with major histocompatibility complex proteins
    • Sakai K, Zamvil SS, Mitchell DJ, Hodgkinson S, Rothbard JB, Steinman L. Prevention of experimental encephalomyelitis with peptides that block interaction of T cells with major histocompatibility complex proteins. Proc Natl Acad Sei USA 1989;86:9470-9474.
    • (1989) Proc Natl Acad Sei USA , vol.86 , pp. 9470-9474
    • Sakai, K.1    Zamvil, S.S.2    Mitchell, D.J.3    Hodgkinson, S.4    Rothbard, J.B.5    Steinman, L.6
  • 20
    • 0025780265 scopus 로고
    • Immunomodulation of experimental allergic encephalomyelitis by antibodies to the antigen-Ia complex
    • Aharoni R, Teitelbaum D, Arnon R, Puri J. Immunomodulation of experimental allergic encephalomyelitis by antibodies to the antigen-Ia complex. Nature 1991;351:147-150.
    • (1991) Nature , vol.351 , pp. 147-150
    • Aharoni, R.1    Teitelbaum, D.2    Arnon, R.3    Puri, J.4
  • 21
    • 0024425273 scopus 로고
    • Immunization with a synthetic T-cell receptor V-region peptide against experimental autoimmune encephalomyelitis
    • Vandenbark AA, Hashim G, Offner H. Immunization with a synthetic T-cell receptor V-region peptide against experimental autoimmune encephalomyelitis. Nature 1989;341:541-544.
    • (1989) Nature , vol.341 , pp. 541-544
    • Vandenbark, A.A.1    Hashim, G.2    Offner, H.3
  • 22
    • 0024468234 scopus 로고
    • Vaccination against experimental allergic autoimmune encephalomyelitis with T cell receptor peptides
    • Howell MD, Winters ST, Olee T, Powell HC, Carlo DJ, Brostoff SW. Vaccination against experimental allergic autoimmune encephalomyelitis with T cell receptor peptides. Science 1989;246:668-670.
    • (1989) Science , vol.246 , pp. 668-670
    • Howell, M.D.1    Winters, S.T.2    Olee, T.3    Powell, H.C.4    Carlo, D.J.5    Brostoff, S.W.6
  • 23
    • 0023858086 scopus 로고
    • Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments
    • Higgins PJ, Weiner HL. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments. J Immunol 1988;140:440-445.
    • (1988) J Immunol , vol.140 , pp. 440-445
    • Higgins, P.J.1    Weiner, H.L.2
  • 24
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
    • Chen Y, Kuchroo VK, Inobe J-I, Hafler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994;265:1237-1240.
    • (1994) Science , vol.265 , pp. 1237-1240
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.-I.3    Hafler, D.A.4    Weiner, H.L.5
  • 26
    • 0027964523 scopus 로고
    • A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire
    • Kuchroo VK, Greer JM, Kaul D, et al. A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire. J Immunol 1994;153: 3326-3336.
    • (1994) J Immunol , vol.153 , pp. 3326-3336
    • Kuchroo, V.K.1    Greer, J.M.2    Kaul, D.3
  • 27
    • 0028148199 scopus 로고
    • Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon γ and tumor necrosis factor a production
    • Karin N, Mitchell DJ, Brocke S, Ling N, Steinman L. Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon γ and tumor necrosis factor a production. J Exp Med 1994;180:2227-2237.
    • (1994) J Exp Med , vol.180 , pp. 2227-2237
    • Karin, N.1    Mitchell, D.J.2    Brocke, S.3    Ling, N.4    Steinman, L.5
  • 28
    • 0028866978 scopus 로고
    • An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis
    • Nicholson LB, Greer JM, Sobel RA, Lees MB, Kuchroo VK. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity 1995;3:397-405.
    • (1995) Immunity , vol.3 , pp. 397-405
    • Nicholson, L.B.1    Greer, J.M.2    Sobel, R.A.3    Lees, M.B.4    Kuchroo, V.K.5
  • 29
    • 0030069797 scopus 로고    scopus 로고
    • Dynamics of autoimmune T cell infiltration: Reversal of paralysis and disappearance of inflammation following treatment of experimental encephalomyelitis with a myelin basic protein peptide analog
    • Brocke S, Gijbels K, Allegretta M, et al. Dynamics of autoimmune T cell infiltration: reversal of paralysis and disappearance of inflammation following treatment of experimental encephalomyelitis with a myelin basic protein peptide analog. Nature 1996;379:343-346.
    • (1996) Nature , vol.379 , pp. 343-346
    • Brocke, S.1    Gijbels, K.2    Allegretta, M.3
  • 30
    • 0025966510 scopus 로고
    • A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis
    • Martin R, Howell MD, Jaraquemada D, et al. A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis. J Exp Med 1991;173:19-24.
    • (1991) J Exp Med , vol.173 , pp. 19-24
    • Martin, R.1    Howell, M.D.2    Jaraquemada, D.3
  • 31
    • 0015264390 scopus 로고
    • Large scale preparation of myelin basic protein from central nervous system tissue of several mammalian species
    • Deibler GE, Martenson RE, Kies MW. Large scale preparation of myelin basic protein from central nervous system tissue of several mammalian species. Prep Biochem 1972;2:139-165.
    • (1972) Prep Biochem , vol.2 , pp. 139-165
    • Deibler, G.E.1    Martenson, R.E.2    Kies, M.W.3
  • 32
    • 0344650195 scopus 로고
    • Isolation, primary structure, and synthesis of human hypothalamic somatocrinin: Growth hormone-releasing factor
    • Ling N, Esch F, Böhlen P, Brazeau P, Wehrenberg WB, Guillemin R. Isolation, primary structure, and synthesis of human hypothalamic somatocrinin: growth hormone-releasing factor. Proc Natl Acad Sci USA 1984;81:4302-4306.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 4302-4306
    • Ling, N.1    Esch, F.2    Böhlen, P.3    Brazeau, P.4    Wehrenberg, W.B.5    Guillemin, R.6
  • 33
    • 0025044023 scopus 로고
    • HLA-DR2a is the dominant restriction molecule for the cytotoxic T cell response to myelin basic protein in DR2Dw2 individuals
    • Jaraquemada D, Martin R, Rosen-Bronson S, Flerlage M, McFarland HF, Long EO. HLA-DR2a is the dominant restriction molecule for the cytotoxic T cell response to myelin basic protein in DR2Dw2 individuals. J Immunol 1990;145:2880-2885.
    • (1990) J Immunol , vol.145 , pp. 2880-2885
    • Jaraquemada, D.1    Martin, R.2    Rosen-Bronson, S.3    Flerlage, M.4    McFarland, H.F.5    Long, E.O.6
  • 34
    • 0027170328 scopus 로고
    • Skewed T cell receptor repertoire in genetically identical twins with multiple sclerosis correlates with disease
    • Utz U, Biddison WE, McFarland HF, McFarlin DE, Flerlage M, Martin R. Skewed T cell receptor repertoire in genetically identical twins with multiple sclerosis correlates with disease. Nature 1993;364:243-247.
    • (1993) Nature , vol.364 , pp. 243-247
    • Utz, U.1    Biddison, W.E.2    McFarland, H.F.3    McFarlin, D.E.4    Flerlage, M.5    Martin, R.6
  • 35
    • 0028068083 scopus 로고
    • Ligand motifs of HLA-DRB5*0101 and DRB1*1501 molecules delineated from self-peptides
    • Vogt AB, Kropshofer H, Kalbacher H, et al. Ligand motifs of HLA-DRB5*0101 and DRB1*1501 molecules delineated from self-peptides. J Immunol 1994;153:1665-1673.
    • (1994) J Immunol , vol.153 , pp. 1665-1673
    • Vogt, A.B.1    Kropshofer, H.2    Kalbacher, H.3
  • 36
    • 0028120895 scopus 로고
    • Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones
    • Wucherpfennig KW, Sette A, Southwood S, Oseroff C, Matsui M, Strominger JL, Hafler DA. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J Exp Med 1994;179:279-290.
    • (1994) J Exp Med , vol.179 , pp. 279-290
    • Wucherpfennig, K.W.1    Sette, A.2    Southwood, S.3    Oseroff, C.4    Matsui, M.5    Strominger, J.L.6    Hafler, D.A.7
  • 37
    • 0029743819 scopus 로고    scopus 로고
    • Cytokine phenotype of human autoreactive T cell clones specific for the immunodominant myelin basic protein peptide (83-99)
    • Hemmer B, Vergelli M, Calabresi P, Huang T, McFarland HF, Martin R. Cytokine phenotype of human autoreactive T cell clones specific for the immunodominant myelin basic protein peptide (83-99). J Neurosci Res 1996;45:852-862.
    • (1996) J Neurosci Res , vol.45 , pp. 852-862
    • Hemmer, B.1    Vergelli, M.2    Calabresi, P.3    Huang, T.4    McFarland, H.F.5    Martin, R.6
  • 39
    • 0031569102 scopus 로고    scopus 로고
    • Human autoreactive CD4+ T cell clones use perforin- or Fas/Fas ligand-mediated pathways for target cell lysis
    • Vergelli M, Hemmer B, Muraro PA, et al. Human autoreactive CD4+ T cell clones use perforin- or Fas/Fas ligand-mediated pathways for target cell lysis. J Immunol 1997;158:2756-2761.
    • (1997) J Immunol , vol.158 , pp. 2756-2761
    • Vergelli, M.1    Hemmer, B.2    Muraro, P.A.3
  • 40
    • 0028887624 scopus 로고
    • Preferential expression of CD30 by human CD4+ T cells producing Th2-type cytokines
    • Del Prete G, De Carli M, Almerigogna F, et al. Preferential expression of CD30 by human CD4+ T cells producing Th2-type cytokines. FASEB J 1995;9:81-86.
    • (1995) FASEB J , vol.9 , pp. 81-86
    • Del Prete, G.1    De Carli, M.2    Almerigogna, F.3
  • 41
    • 0024997357 scopus 로고
    • Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals
    • Martin R, Jaraquemada D, Flerlage MJ, et al. Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals. J Immunol 1990;145:540-548.
    • (1990) J Immunol , vol.145 , pp. 540-548
    • Martin, R.1    Jaraquemada, D.2    Flerlage, M.J.3
  • 45
    • 0028293862 scopus 로고
    • Failure to demonstrate long-lived MHC saturation both in vitro and in vivo
    • Ishioka GY, Adorini A, Guery J-C, et al. Failure to demonstrate long-lived MHC saturation both in vitro and in vivo. J Immunol 1994;152:4310-4319.
    • (1994) J Immunol , vol.152 , pp. 4310-4319
    • Ishioka, G.Y.1    Adorini, A.2    Guery, J.-C.3
  • 46
    • 0027333348 scopus 로고
    • Tickling the TCR: Selective T-cell functions stimulated by altered peptide ligands
    • Evavold BD, Sloan-Lancaster J, Allen PM. Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands. Immunol Today 1993;14:602-609.
    • (1993) Immunol Today , vol.14 , pp. 602-609
    • Evavold, B.D.1    Sloan-Lancaster, J.2    Allen, P.M.3
  • 47
    • 0028345391 scopus 로고
    • Antigen analogs/MHC complexes as specific T cell receptor antagonists
    • Sette A, Alexander J, Rupert J, et al. Antigen analogs/MHC complexes as specific T cell receptor antagonists. Annu Rev Immunol 1994;12:413-431.
    • (1994) Annu Rev Immunol , vol.12 , pp. 413-431
    • Sette, A.1    Alexander, J.2    Rupert, J.3
  • 48
    • 0028988331 scopus 로고
    • T cell receptor antagonists and partial agonists
    • Jameson SC, Bevan MJ. T cell receptor antagonists and partial agonists. Immunity 1995;2:1-11.
    • (1995) Immunity , vol.2 , pp. 1-11
    • Jameson, S.C.1    Bevan, M.J.2
  • 49
    • 0014201794 scopus 로고
    • Allergic encephalomyelitis: Passive transfer prevented by encephalitogen
    • Levine S, Hoenig EM, Kies MW. Allergic encephalomyelitis: passive transfer prevented by encephalitogen. Science 1968; 161:1155-1157.
    • (1968) Science , vol.161 , pp. 1155-1157
    • Levine, S.1    Hoenig, E.M.2    Kies, M.W.3
  • 50
    • 0030056468 scopus 로고    scopus 로고
    • Models of T cell anergy: Is there a common molecular mechanism?
    • Schwartz RH. Models of T cell anergy: is there a common molecular mechanism? J Exp Med 1996;184:19-29.
    • (1996) J Exp Med , vol.184 , pp. 19-29
    • Schwartz, R.H.1
  • 51
    • 10244247768 scopus 로고    scopus 로고
    • Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87-99)
    • Vergelli M, Hemmer B, Utz U, et al. Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87-99). Eur J Immunol 1996;26:2624-2634.
    • (1996) Eur J Immunol , vol.26 , pp. 2624-2634
    • Vergelli, M.1    Hemmer, B.2    Utz, U.3
  • 52
    • 0031569454 scopus 로고    scopus 로고
    • Modifications of peptide ligands enhancing T cell responsiveness imply large numbers of stimulatory ligands
    • Vergelli M, Hemmer B, Kalbus M, et al. Modifications of peptide ligands enhancing T cell responsiveness imply large numbers of stimulatory ligands. J Immunol 1997;158:3746-3752.
    • (1997) J Immunol , vol.158 , pp. 3746-3752
    • Vergelli, M.1    Hemmer, B.2    Kalbus, M.3
  • 53
    • 0030925578 scopus 로고    scopus 로고
    • Identification of high potency microbial and self ligands for a human autoreactive class II restricted T cell clone
    • Hemmer B, Fleckenstein B, Vergelli M, Jung G, McFarland HF, Martin R, Wiesmüller K-H. Identification of high potency microbial and self ligands for a human autoreactive class II restricted T cell clone. J Exp Med 1997;45:1651-1659.
    • (1997) J Exp Med , vol.45 , pp. 1651-1659
    • Hemmer, B.1    Fleckenstein, B.2    Vergelli, M.3    Jung, G.4    McFarland, H.F.5    Martin, R.6    Wiesmüller, K.-H.7
  • 54
    • 0028956146 scopus 로고
    • Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand
    • Windhagen A, Scholz C, Höllsberg P, Fukaura H, Sette A, Hafler DA. Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand. Immunity 1995;2:373-380.
    • (1995) Immunity , vol.2 , pp. 373-380
    • Windhagen, A.1    Scholz, C.2    Höllsberg, P.3    Fukaura, H.4    Sette, A.5    Hafler, D.A.6
  • 55
    • 0030452309 scopus 로고    scopus 로고
    • Late complications of immune deviation therapy in a nonhuman primate
    • Genain CPA, Abel K, Belmar N, et al. Late complications of immune deviation therapy in a nonhuman primate. Science 1996;274:2054-2057.
    • (1996) Science , vol.274 , pp. 2054-2057
    • Genain, C.P.A.1    Abel, K.2    Belmar, N.3
  • 56
    • 0028485743 scopus 로고    scopus 로고
    • The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice
    • Singer GG, Abbas AK. The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1996;5:365-371.
    • (1996) Immunity , vol.5 , pp. 365-371
    • Singer, G.G.1    Abbas, A.K.2


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