A pathogenic role for γδ T cells in relapsing-remitting experimental allergic encephalomyelitis in the SJL mouse

Journal of Immunology

Volumn 157, Issue 2, 1996, Pages 941-949

  Rajan, Alice J ^a   Gao, Yan Ling ^a   Raine, Cedric S ^a   Brosnan, Celia F ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN;

ACUTE PHASE RESPONSE; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEMYELINATION; FEMALE; FLUORESCENCE ACTIVATED CELL SORTER; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RELAPSE; REMISSION; SPLEEN CELL; T LYMPHOCYTE;

ACUTE DISEASE; ANIMALS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; LYMPHOCYTE COUNT; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED STRAINS; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RECURRENCE; SPINAL CORD; T-LYMPHOCYTE SUBSETS;

EID: 0029901881     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Alvord, E. C., M. W. Kies, and A. J. Suckling. 1984. Experimental allergic encephalomyelitis: a useful model for multiple sclerosis. Prog. Clin. Biol. Res. 146:1.
2. Wekerle, H., K. Kojima, J. Lannes-Vieira, H. Lassmann, and C. Linington. 1994. Animal models (review). Ann. Neurol. 36:S47.
3. Miller, S. D., and W. J. Karpus. 1994. The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases. Immunol. Today. 15:356.
4. Cross, A. H. 1992. Immune traffic control and the central nervous system. Semin. Immunol. 4:213.
5. Hickey, W. F., B. L. Hsu, and H. Kimura. 1991. T-lymphocyte entry into the central nervous system. J. Neurosci. Res. 28:254.
6. Selmaj, K. W. 1992. The role of cytokines in inflammatory conditions of the central nervous system. Semin. Neurosci. 4:221.
7. Brosnan, C. F., M. B. Bornstein, and B. R. Bloom. 1981. The effects of macrophage depletion on the clinical and pathological expression of experimental allergic encephalomyelitis. J. Immunol. 130:1503.
8. Huitinga, I., N. van Rooijen, C. J. A. deGroot, B. M. J. Uitdehaag, and C. D. Dijkstra. 1990. Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages. J. Exp. Med. 172:1025.
9. Freedman, M. S., T. C. Ruijs, L. K. Selin, and J. P. Antel. 1991. Peripheral blood γδT cells lyse fresh human brain derived oligodendrocytes. Ann. Neurol. 30:794.
10. Christmas, S. E. 1992. Cytokine production by T lymphocytes bearing the γδ T cell antigen receptor. In Heat Shock Proteins and Gamma-Delta T Cells, Vol 53. C. F. Brosnan, ed. Karger, Basel, Switzerland, pp. 32-46.
11. Follows, G. A., M. E. Munk., A. J. Gatrill., P. Convadt., and S. H. Kaufmann. 1992. Gamma interferon and interleukin 2, but not interleukin-4, are detectable in γδ T cell cultures after activation with bacteria. Infect. Immun. 60:1229.
12. Lundqvist, C., V. Baranov, S. Teglund, S. Hammarstrom, and M. L. Hammarstrom. 1994. Cytokine profile and ultrastructure of intraepithelial γδ T cells in chronically inflamed human gingiva suggest a cytotoxic effector function. J. Immunol. 153:2302.
13. Ferrick, D. A., M. D. Schrenzel, T. Mulvania, B. Haiech, W. G. Ferlin, and H. Lepper. 1995. Differential production of interferon-gamma and interleukin 4 in response to Th1 and Th2-stimulaling pathogens by γδ T cells in vivo. Nature 373:255.
14. Strominger, J. L. 1989. The γδ T cell receptor and class 1b MHC-related proteins: enigmatic molecules for immune recognition. Cell 57:895.
15. Pfeffer, K., B. Schoel, H. Gulle, S. H. E. Kaufmann, and H. Wagner. 1990. Primary responses of human T cells to mycobacteria: a frequent set of γδ T cells are stimulated by protease resistant ligands. Eur. J. Immunol. 20:1175.
16. Tanaka, Y., S. Sano, E. Nieves, G. DeLibero, D. Rosa, R. L. Modlin, M. B. Brenner, B. R. Bloom, and C. T. Morita. 1994. Non-peptide ligands for γδ T cells. Proc. Natl. Acad. Sci. USA 91:8175.
17. Tanaka, Y., C. T. Morita, Y. Tanaka, E. Nieves, M. B. Brenner, and B. R. Bloom. 1995. Natural and synthetic non-peptide antigens recognized by human gamma-delta T cells. Nature 375:155.
18. + T cell receptor γδ T lymphocyte clone specific for herpes simplex virus glycoprotein 1. J. Immunol. 148:983.
19. Born, W., L. Hall, A. Dallas, J. Boymel, T. Shinnick, D. Young, P. Brennan, and R. O'Brien. 1990. Recognition of a peptide antigen by heat shock reactive γδ T lymphocytes. Science 249:67.
20. O'Brien, R. L., Y. X. Fu, R. Cranfill, A. Dallas, C. Ellis, C. Reardon, J. Lang, S. R. Carding, R. Kubo, and W. Born. 1992. Heat shock protein 60-reactive γδ cells: a large, diversified T-lymphocyte subset with highly focused specificity. Proc. Natl. Acad. Sci. USA 89:4348.
21. + T cells respond to mycobacterial heat shock protein. Nature 340:309.
22. Modlin, R. L., C. Pirmez, F. M. Horman, V. Torigan, K. Uyemura, T. H. Rea, B. R. Bloom, and M. B. Brenner. 1989. Lymphocytes bearing antigen-specific γδ T cell receptors accumulate in human infectious disease lesions. Nature 339:544.
23. Inoue, T., Y. Yoshikai, G. Matsuzaki, and K. Nomoto. 1991. Early appearing γ/δ bearing T cells during infection with Calmette-Guérin bacillus. J. Immunol. 146:2754.
24. Ohga, S., Y. Yoshikai, Y. Takeda, K. Hiromatsu, and K. Nomoto. 1990. Sequential appearance of γδ and αβ bearing T cells in the peritoneal cavity during an i.p. infection with Listeria monocytogenes. Eur. J. Immunol. 20:533.
25. + T cells. J. Exp. Med. 172:1225.
26. Hou, S., J. M. Katz, P. C. Doherty, and S. R. Carding. 1992. Extent of γδ T cell involvement in the pneumonia caused by Sendai virus. Cell. Immunol. 143:183.
27. Jones-Carson, J., A. Vazquez-Torres, H. C. van der Heyde, T. Warner, R. D. Wagner, and E. Balish. 1995. γδ T cell induced nitric oxide production enhances resistance to mucosal candidiasis. Nature Med. 1:552.
28. Sandor, M., A. I. Sperling, G. A. Cook, J. V. Weinstock, R. G. Lynch, and J. A. Bluestone. 1995. Two waves of γδ T cells expressing different Vδ genes are recruited into schistosome induced liver granulomas. J. Immunol. 155:275.
29. Uyemura, K., J. Klotz, C. Pirmez, J. Ohmen, X. H. Wang, C. Ho, W. L. Hoffman, and R. L. Modlin. 1992. Microanatomic clonality of γδ T cells in human leishmaniasis lesions. J. Immunol. 148:1205.
30. - T cells in the polyclonal lymphocyte responses to murine T. cruzi infection. Int. Immunol. 1:176.
31. Peterman, G. M., C. Spencer, A. I. Sperling, and J. A. Bluestone. 1993. Role of γδ T cells in murine collagen-induced authritis. J. Immunol. 151:6546.
32. Huber, S. A., A. Moraska, and M. Choate. 1992. T cells expressing γδ T cells receptor potentiate coxsackie virus B3-induced myocarditis. J. Virol. 66:6541.
33. + oligodendrocytes in multiple sclerosis. Proc. Natl. Acad. Sci. USA 88:6452.
34. Wucherpfennig, K. W., J. Newcombe, C. Kebby, M. L. Cuzner, and D. A. Hafler. 1992. γδ T cell receptor repertoire in acute demyelinating multiple sclerosis lesions. Proc. Natl. Acad. Sci. USA 89:4588.
35. Hvas, J., J. R. Oksenberg, R. Fernando, L. Steinman, and C. C. A. Bernard. 1993. γδ T cell receptor repertoire in brain lesions of patients with multiple sclerosis. J. Neuroimmunol. 46:225.
36. Battistini, L., K. Selmaj, C. Kowal, J. Ohmen, R. L. Modlin, C. S. Raine, and C. F. Brosnan. 1995. Multiple sclerosis: limited diversity of the Vδ2-Jδ3 T cell receptor in chronic active lesions. Ann. Neurol. 37:198.
37. Shimonkevitz, R., C. Colburn, J. Burnham, R. S. Murray, and B. L. Kotzin. 1993. Clonal expansion of activated γδ T cells in recent onset multiple sclerosis. Proc. Natl. Acad. Sci. USA 90:923.
38. Sobel, R. A., and V. K. Kuchroo. 1992. The immunopathology of acute experimental allergic encephalomyelitis induced with myelin proteolipid protein. T cell receptors in inflammatory lesions. J. Immunol. 149:1444.
39. Gao, Y. L., C. F. Brosnan, and C. S. Raine. 1995. Experimental autoimmune encephalomyelitis: quantitative and semiquantitative differences in heat shock protein 60 expression in the central nervous system. J. Immunol. 154:3548.
40. Birnbaum, G., L. Kotilinek, and L. Albrecht. 1993. Spinal fluid lymphocytes from a group of multiple sclerosis patients respond to mycobacterial antigens. Ann. Neurol. 34:18.
41. Salvetti, M., C. Buttinelli, G. Ristori, M. Carbonari, M. Cherchi, M. Fiorelli, M. G. Grasso, L. Thoma, and C. Pazzilli. 1992. T-lymphocyte reactivity to the recombinant 65 and 70 KDa heat shock proteins in multiple sclerosis. J. Autoimmun. 5:691.
42. Stinissen, P., C. Vanbevyvrel, R. Medaer, L. Vanvegaer, J. Nies, L. Tuyls, D. A. Hafler, J. Raus, and J. Zhang. 1995. Increased frequency of γδ T cells in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis: reactivity, cytotoxicity, and T cell receptor V gene rearrangement. J. Immunol. 154:4883.
43. van Noort, J. M., A. C. van Sechel, J. J. Bajramovic, M. EL Ouagmiri, C. H. Paulman, H. Lassmann, and R. Ravid. 1995. The small heat-shock protein αB-crystallin as a candidate autoantigen in multiple sclerosis. Nature 375:798.
44. Goodman, T., and L. Lefrancois. 1989. Intraepithelial lymphocytes: anatomical site, not T cell receptor form, dictates phenotype and function. J. Exp. Med. 170:1569.
45. Tsuji, M., P. Mombaerts, L. Lefrancois, R. S. Nussenzweig, F. Zavala, and S. Tonegawa. 1994. γδ T cells contribute to immunity against the liver stages of malaria in αβ T-cell-deficient mice. Proc. Natl. Acad. Sci. USA 91:345.
46. Pettinelli, C. B., and D. E. McFarlin. 1981. Adoptive tranfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein requirement for Lyt 1-2-T lymphocytes. J. Immunol. 127:1420.
47. Mokhtarian, F., D. E. McFarlin, and C. S. Raine. 1984. Adoptive transfer of myelin basic protein sensitized T cells produces chronic relapsing demyelinating disease in mice. Nature 309:356.
48. Selmaj, K., C. S. Raine, and A. H. Cross. 1991. Anti-tumor necrosis factor therapy abrogates autoimmune demyelination. Ann. Neurol. 30:694.
49. + T cells as a mechanism for remission from experimental allergic encephalomyelitis. J. Neuroimmunol. 44:1993.
50. Olive, C. 1995. γδ T-cell receptor variable region usage during the development of experimental allergic encephalomyelitis. J. Neuroimmunol. 65:1.
51. Mor, F., and I. R. Cohen. 1992. T cells in the lesion of experimental autoimmune encephalomyelitis. J. Clin. Invest. 90:2447.
52. Battistini, L., M. Salvetti, G. Ristori, M. Falcone, C. S. Raine, and C. F. Brosnan. 1995. γδ T cell receptor analysis supports a role for HSP 70 selection of lymphocytes in multiple sclerosis lesions. Mol. Med. 1:554.
53. Porcelli, A. 1995. The CD1 family: a third lineage of antigen presenting molecules. Adv. Immunol. 59:1.
54. MacMicking, J. D., D. O. Willenborg, M. J. Weidemann, K. A. Rockett, and W. B. Cowden. 1992. Elevated secretion of reactive nitrogen and oxygen intermediates by inflammatory leukocytes in hyperacute EAE: enhancement by the soluble products of encephalitogenic T cells. J. Exp. Med. 176:330.
55. Lin, R. F., T. S. Lin, R. G. Tilton, and A. H. Cross. 1993. Nitric oxide localized to spinal cords of mice with experimental allergic encephalomyelitis: an electron paramagnetic resonance study. J. Exp. Med. 178:643.
56. Koprowski, H., Y. M. Zheng, E. Heber-Katz, N. Fraser, L. Rorke, Z. F. Fu, C. Hanlon, and B. Dietzschold. 1993. In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic disease. Proc. Natl. Acad. Sci. USA 90:3024.
57. Cross, A. H., T. P. Misko, R. F. Lin, W. F. Hickey, J. L. Trotter, and R. G. Tilton. 1994. Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice. J. Clin. Invest. 93:2684.
58. Hiromatsu, K., Y. Yoshikai, G. Matsuzaki, S. Ohga, K. Muramori, K. Matsumoto, J. A. Bluestone, and K. Nomoto. 1992. A protective role of γδ T cells in primary infection with Listeria monocytogenes in mice. J. Exp. Med. 175:49.