메뉴 건너뛰기




Volumn 48, Issue 8, 1999, Pages 1615-1622

Glucose metabolism and insulin sensitivity in transgenic mice overexpressing leptin with lethal yellow agouti mutation: Usefulness of leptin for the treatment of obesity-associated diabetes

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; LEPTIN;

EID: 0032768291     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.8.1615     Document Type: Article
Times cited : (83)

References (43)
  • 1
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang Y, Proenca R, Maffei M, Barone, M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432, 1994
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Leopold, L.4    Friedman, J.M.5
  • 4
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
    • Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P: Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549, 1995
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 6
    • 0028793697 scopus 로고
    • Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
    • Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB, Flier JS: Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nature Med 1:1311-1314, 1995
    • (1995) Nature Med , vol.1 , pp. 1311-1314
    • Frederich, R.C.1    Hamann, A.2    Anderson, S.3    Lollmann, B.4    Lowell, B.B.5    Flier, J.S.6
  • 10
    • 0029881125 scopus 로고    scopus 로고
    • Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
    • Schwartz MW, Peskind E, Raskind M, Boyko EJ, Porte DJ: Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nature Med 2:589-593, 1996
    • (1996) Nature Med , vol.2 , pp. 589-593
    • Schwartz, M.W.1    Peskind, E.2    Raskind, M.3    Boyko, E.J.4    Porte, D.J.5
  • 14
    • 0031748933 scopus 로고    scopus 로고
    • Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins
    • Cusin I, Zakrzewska KE, Boss O, Muzzin P, Giacobino JP, Ricquier D, Jeanrenaud B, Jeanrenaud FR: Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins. Diabetes 47:1014-1019, 1998
    • (1998) Diabetes , vol.47 , pp. 1014-1019
    • Cusin, I.1    Zakrzewska, K.E.2    Boss, O.3    Muzzin, P.4    Giacobino, J.P.5    Ricquier, D.6    Jeanrenaud, B.7    Jeanrenaud, F.R.8
  • 15
    • 0008466784 scopus 로고    scopus 로고
    • Intracerebroventricular administration of leptin markedly enhances insulin sensitivity and systemic glucose utilization in conscious rats
    • Shi ZQ, Nelson A, Whitcomb L, Wang J, Cohen AM: Intracerebroventricular administration of leptin markedly enhances insulin sensitivity and systemic glucose utilization in conscious rats. Metabolism 47:1274-1280, 1998
    • (1998) Metabolism , vol.47 , pp. 1274-1280
    • Shi, Z.Q.1    Nelson, A.2    Whitcomb, L.3    Wang, J.4    Cohen, A.M.5
  • 16
    • 0030678119 scopus 로고    scopus 로고
    • Independent and additive effects of central POMC and leptin pathways on murine obesity
    • Boston BA, Blaydon KM, Varnerin J, Cone RD: Independent and additive effects of central POMC and leptin pathways on murine obesity. Science 278: 1641-1644, 1997
    • (1997) Science , vol.278 , pp. 1641-1644
    • Boston, B.A.1    Blaydon, K.M.2    Varnerin, J.3    Cone, R.D.4
  • 17
    • 0031471130 scopus 로고    scopus 로고
    • Long-term correction of obesity and diabetes in genetically obese mice by a single intra-muscular injection of recombinant adeno-associated virus encoding mouse leptin
    • Murphy JE, Zhou S, Giese K, Williams LT, Escobedo JA, Dwadki VJ: Long-term correction of obesity and diabetes in genetically obese mice by a single intra-muscular injection of recombinant adeno-associated virus encoding mouse leptin. Proc Natl Acad Sci U S A 94:13921-13926, 1997
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 13921-13926
    • Murphy, J.E.1    Zhou, S.2    Giese, K.3    Williams, L.T.4    Escobedo, J.A.5    Dwadki, V.J.6
  • 18
    • 0032578453 scopus 로고    scopus 로고
    • Abnormal regulation of the leptin gene in the pathogenesis of obesity
    • Ioffe E, Moon B, Connolly E, Friedman JM: Abnormal regulation of the leptin gene in the pathogenesis of obesity. Proc Natl Acad Sci U S A 95: 11852-11857, 1998
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 11852-11857
    • Ioffe, E.1    Moon, B.2    Connolly, E.3    Friedman, J.M.4
  • 19
    • 0023888908 scopus 로고
    • The safety and efficacy of a controlled low-energy (very-low-calorie) diet in the treatment of non-insulin-dependent diabetes and obesity
    • Amatruda JM, Richeson JF, Welle SL, Brodows RG, Lockwood DH: The safety and efficacy of a controlled low-energy (very-low-calorie) diet in the treatment of non-insulin-dependent diabetes and obesity. Arch Intern Med 148:873-877, 1988
    • (1988) Arch Intern Med , vol.148 , pp. 873-877
    • Amatruda, J.M.1    Richeson, J.F.2    Welle, S.L.3    Brodows, R.G.4    Lockwood, D.H.5
  • 20
    • 0032577350 scopus 로고    scopus 로고
    • Strategies and potential molecular targets for obesity treatment
    • Campfield LA, Smith FJ, Burn P: Strategies and potential molecular targets for obesity treatment. Science 280:1383-1387, 1998
    • (1998) Science , vol.280 , pp. 1383-1387
    • Campfield, L.A.1    Smith, F.J.2    Burn, P.3
  • 22
    • 0030297919 scopus 로고    scopus 로고
    • Adipogenesis and obesity: Rounding out the big picture
    • Spiegelman BM, Flier JS: Adipogenesis and obesity: rounding out the big picture. Cell 87:377-389, 1996
    • (1996) Cell , vol.87 , pp. 377-389
    • Spiegelman, B.M.1    Flier, J.S.2
  • 24
    • 0031436635 scopus 로고    scopus 로고
    • The molecular genetics of rodent single gene obesities
    • Leibel RL, Chung WK, Chua SC: The molecular genetics of rodent single gene obesities. J Biol Chem 272:31937-31940, 1997
    • (1997) J Biol Chem , vol.272 , pp. 31937-31940
    • Leibel, R.L.1    Chung, W.K.2    Chua, S.C.3
  • 25
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
    • Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD: Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385: 165-168, 1997
    • (1997) Nature , vol.385 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 26
  • 27
    • 0017349397 scopus 로고    scopus 로고
    • Laboratory animals exhibiting obesity and diabetes syndromes
    • Herberg L, Coleman DL: Laboratory animals exhibiting obesity and diabetes syndromes. Metabolism 26:59-87, 1997
    • (1997) Metabolism , vol.26 , pp. 59-87
    • Herberg, L.1    Coleman, D.L.2
  • 30
    • 0029804743 scopus 로고    scopus 로고
    • Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y
    • Erickson JC, Hollopeter G, Palmiter RD: Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274:1704-1707, 1996
    • (1996) Science , vol.274 , pp. 1704-1707
    • Erickson, J.C.1    Hollopeter, G.2    Palmiter, R.D.3
  • 31
    • 0030961962 scopus 로고    scopus 로고
    • Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and β-cell glucokinase genes: Genetic reconstitution of diabetes as apolygenic disease
    • Terauchi Y, Iwamoto K, Tamemoto H, Komeda K, Ishii C, Kanazawa Y, Asanuma N, Aizawa T, Akanuma Y, Yasuda K, Kodama T, Tobe K, Yazaki Y, Kadowaki T: Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and β-cell glucokinase genes: genetic reconstitution of diabetes as apolygenic disease. J Clin Invest 99:861-866, 1997
    • (1997) J Clin Invest , vol.99 , pp. 861-866
    • Terauchi, Y.1    Iwamoto, K.2    Tamemoto, H.3    Komeda, K.4    Ishii, C.5    Kanazawa, Y.6    Asanuma, N.7    Aizawa, T.8    Akanuma, Y.9    Yasuda, K.10    Kodama, T.11    Tobe, K.12    Yazaki, Y.13    Kadowaki, T.14
  • 32
    • 0027256438 scopus 로고
    • Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation
    • Miller MW, Duhl DMJ, Vrieling H, Cordes SP, Ollmann MM, Winkes BM, Barsh GS: Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Gene Dev 7:454-467, 1993
    • (1993) Gene Dev , vol.7 , pp. 454-467
    • Miller, M.W.1    Duhl, D.M.J.2    Vrieling, H.3    Cordes, S.P.4    Ollmann, M.M.5    Winkes, B.M.6    Barsh, G.S.7
  • 34
    • 0028785081 scopus 로고
    • Expression and transgenic studies of the mouse agouti gene provide insight into the mechanisms by which mammalian coat color patterns are generated
    • Millar SE, Miller MW, Stevens ME, Barsh GS: Expression and transgenic studies of the mouse agouti gene provide insight into the mechanisms by which mammalian coat color patterns are generated. Development 121:3223-3232, 1995
    • (1995) Development , vol.121 , pp. 3223-3232
    • Millar, S.E.1    Miller, M.W.2    Stevens, M.E.3    Barsh, G.S.4
  • 38
    • 0032547042 scopus 로고    scopus 로고
    • Satiety effect of and sympathetic activation of leptin are mediated by hypothalamic melanocortin system
    • Satoh N, Ogawa Y, Katsuura G, Numata Y, Masuzaki H, Yoshimasa Y, Nakao K: Satiety effect of and sympathetic activation of leptin are mediated by hypothalamic melanocortin system. Neurosci Lett 249:107-110, 1998
    • (1998) Neurosci Lett , vol.249 , pp. 107-110
    • Satoh, N.1    Ogawa, Y.2    Katsuura, G.3    Numata, Y.4    Masuzaki, H.5    Yoshimasa, Y.6    Nakao, K.7
  • 42
    • 0032572722 scopus 로고    scopus 로고
    • Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
    • Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI: Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394:897-901, 1998
    • (1998) Nature , vol.394 , pp. 897-901
    • Lord, G.M.1    Matarese, G.2    Howard, J.K.3    Baker, R.J.4    Bloom, S.R.5    Lechler, R.I.6
  • 43
    • 0014640981 scopus 로고
    • Obesity and insulin resistance in the obese-hyperglycemic mouse (ob/ob)
    • Chlouverakis C, White PA: Obesity and insulin resistance in the obese-hyperglycemic mouse (ob/ob). Metabolism 18:998-1006, 1969
    • (1969) Metabolism , vol.18 , pp. 998-1006
    • Chlouverakis, C.1    White, P.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.