메뉴 건너뛰기




Volumn 47, Issue 10, 1998, Pages 1274-1280

Intracerebroventricular administration of leptin markedly enhances insulin sensitivity and systemic glucose utilization in conscious rats

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; LEPTIN;

EID: 0008466784     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(98)90336-5     Document Type: Article
Times cited : (52)

References (38)
  • 1
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang Y, Proenca R, Maffei M, et al: Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-431, 1994
    • (1994) Nature , vol.372 , pp. 425-431
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3
  • 2
    • 0029066265 scopus 로고
    • Effects of the obese gene product on body weight regulation in ob/ob mice
    • Pelleymounter M, Cullen M, Baker M, et al: Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543, 1995
    • (1995) Science , vol.269 , pp. 540-543
    • Pelleymounter, M.1    Cullen, M.2    Baker, M.3
  • 3
    • 0029073613 scopus 로고
    • Weight-reducing effects of the plasma protein encoded by the obese gene
    • Halaas JL, Gajiwala KS, Maffei M, et al: Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:542-546, 1995
    • (1995) Science , vol.269 , pp. 542-546
    • Halaas, J.L.1    Gajiwala, K.S.2    Maffei, M.3
  • 4
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
    • Campfield LA, Smith FJ, Guisez Y, et al: Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549, 1995
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3
  • 5
    • 0029939065 scopus 로고    scopus 로고
    • Decreased food intake does not completely account for adiposity reduction after ob protein infusion
    • Levin N, Nelson C, Gurney A, et al: Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proc Natl Acad Sci USA 93:1726-1739, 1996
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1726-1739
    • Levin, N.1    Nelson, C.2    Gurney, A.3
  • 6
    • 13144291126 scopus 로고    scopus 로고
    • Leptin acutely modulates hepatic gene-expression, glucose fluxes, and insulin action
    • abstr
    • Barzilai N, Massilon D, Vuguin P, et al: Leptin acutely modulates hepatic gene-expression, glucose fluxes, and insulin action. Diabetes 46:256,1997 (suppl 1, abstr)
    • (1997) Diabetes , vol.46 , Issue.1 SUPPL. , pp. 256
    • Barzilai, N.1    Massilon, D.2    Vuguin, P.3
  • 7
    • 0031439778 scopus 로고    scopus 로고
    • Leptin selectively decreases visceral adiposity and enhances insulin action
    • Barzilai N, Wang J, Massilon D, et al: Leptin selectively decreases visceral adiposity and enhances insulin action. J Clin Invest 100: 3105-3110, 1997
    • (1997) J Clin Invest , vol.100 , pp. 3105-3110
    • Barzilai, N.1    Wang, J.2    Massilon, D.3
  • 8
    • 0030784253 scopus 로고    scopus 로고
    • Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action
    • Rossetti L, Massilon D, Barzilai N, et al: Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J Biol Chem 272:27758-27763, 1997
    • (1997) J Biol Chem , vol.272 , pp. 27758-27763
    • Rossetti, L.1    Massilon, D.2    Barzilai, N.3
  • 9
    • 0030895726 scopus 로고    scopus 로고
    • 12 myotubules: Evidence for a PI3-kinase mediated effect
    • 12 myotubules: Evidence for a PI3-kinase mediated effect. Diabetologia 40:606-609, 1997
    • (1997) Diabetologia , vol.40 , pp. 606-609
    • Berti, L.1    Kellerer, M.2    Capp, E.3
  • 10
    • 0030737953 scopus 로고    scopus 로고
    • Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
    • Halaas JL, Boozer C, Blair-West J, et al: Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci USA 94:8878-8883, 1997
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8878-8883
    • Halaas, J.L.1    Boozer, C.2    Blair-West, J.3
  • 11
    • 0030934725 scopus 로고    scopus 로고
    • Serum leptin in relation to resting energy expenditure and fuel metabolism in obese subjects
    • Niskanen L, Haffner S, Karhumen LJ, et al: Serum leptin in relation to resting energy expenditure and fuel metabolism in obese subjects. Int J Obes 21:309-313, 1997
    • (1997) Int J Obes , vol.21 , pp. 309-313
    • Niskanen, L.1    Haffner, S.2    Karhumen, L.J.3
  • 12
    • 0029050937 scopus 로고
    • Overexpression of the obese (ob) gene in adipose tissue of human obese subjects
    • Lonnqvist F, Arner P, Nordfors L, et al: Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med 1:950-953, 1995
    • (1995) Nat Med , vol.1 , pp. 950-953
    • Lonnqvist, F.1    Arner, P.2    Nordfors, L.3
  • 13
    • 0029083859 scopus 로고
    • Increased obese mRNA expression in omental fat cells from massively obese humans
    • Hamilton BS, Paglia D, Kwan AYM, et al: Increased obese mRNA expression in omental fat cells from massively obese humans. Nat Med 1:953-956, 1995
    • (1995) Nat Med , vol.1 , pp. 953-956
    • Hamilton, B.S.1    Paglia, D.2    Kwan, A.Y.M.3
  • 14
    • 0029165409 scopus 로고
    • Glucose metabolism in obese subjects: Lessons from OGTT, IVGTT and clamp studies
    • Scheen AJ, Paquot N, Letiexhe MR, et al: Glucose metabolism in obese subjects: Lessons from OGTT, IVGTT and clamp studies. Int J Obes 19:14-20, 1995 (suppl 3)
    • (1995) Int J Obes , vol.19 , Issue.3 SUPPL. , pp. 14-20
    • Scheen, A.J.1    Paquot, N.2    Letiexhe, M.R.3
  • 17
    • 0029937016 scopus 로고    scopus 로고
    • Glucagon response to hypoglycemia is improved by insulin-independent restoration of normoglycemia in diabetic rats
    • Shi ZQ, Rastogi KS, Lekas M, et al: Glucagon response to hypoglycemia is improved by insulin-independent restoration of normoglycemia in diabetic rats. Endocrinology 137:3193-3199, 1996
    • (1996) Endocrinology , vol.137 , pp. 3193-3199
    • Shi, Z.Q.1    Rastogi, K.S.2    Lekas, M.3
  • 18
    • 0018833223 scopus 로고
    • Somatostatin analog:plasma catecholamine suppression mediated by the central nervous system
    • Fisher DA, Brown MR: Somatostatin analog:plasma catecholamine suppression mediated by the central nervous system. Endocrinology 107:714-718, 1980
    • (1980) Endocrinology , vol.107 , pp. 714-718
    • Fisher, D.A.1    Brown, M.R.2
  • 19
    • 0026100430 scopus 로고
    • Mechanism of glucoregulatory responses to stress and their deficiency in diabetes
    • Miles PD, Yamatani K, Lickley HLA, et al: Mechanism of glucoregulatory responses to stress and their deficiency in diabetes. Proc Natl Acad Sci USA 88:1296-1300, 1991
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 1296-1300
    • Miles, P.D.1    Yamatani, K.2    Lickley, H.L.A.3
  • 20
    • 0030884698 scopus 로고    scopus 로고
    • Insulin resistance and hypersecretion in obesity
    • Ferrannini E, Natali A, Bell P, et al: Insulin resistance and hypersecretion in obesity. J Clin Endocrinol Metab 100:1166-1173, 1997
    • (1997) J Clin Endocrinol Metab , vol.100 , pp. 1166-1173
    • Ferrannini, E.1    Natali, A.2    Bell, P.3
  • 21
    • 77049274176 scopus 로고
    • Measurement of size and turnover rate of body glucose pool by isotope dilution method
    • Steele R, Wall JS, deBodo RC, et al: Measurement of size and turnover rate of body glucose pool by isotope dilution method. Am J Physiol 187:15-24, 1956
    • (1956) Am J Physiol , vol.187 , pp. 15-24
    • Steele, R.1    Wall, J.S.2    DeBodo, R.C.3
  • 22
    • 0018242291 scopus 로고
    • Experimental validation of measurements of glucose turnover in nonsteady state
    • Radziuk J, Norwich KH, Vranic M: Experimental validation of measurements of glucose turnover in nonsteady state. Am J Physiol 234:E84-E93, 1978 (suppl)
    • (1978) Am J Physiol , vol.234 , Issue.SUPPL.
    • Radziuk, J.1    Norwich, K.H.2    Vranic, M.3
  • 23
    • 0020757484 scopus 로고
    • Optimal segments. A method for smoothing tracer data to calculate metabolic fluxes
    • Finegood DT, Bergman RN: Optimal segments. A method for smoothing tracer data to calculate metabolic fluxes. Am J Physiol 244:E472-E479, 1983 (suppl)
    • (1983) Am J Physiol , vol.244 , Issue.SUPPL.
    • Finegood, D.T.1    Bergman, R.N.2
  • 24
    • 0031046730 scopus 로고    scopus 로고
    • Phenotype of the obese Koletsky (f) rat due to Tyr763 stop mutation in the extracellular domain of the leptin receptor (Lepr.)
    • Wu-Peng XS, Chua SC, Okada N, et al: Phenotype of the obese Koletsky (f) rat due to Tyr763 stop mutation in the extracellular domain of the leptin receptor (Lepr.). Diabetes 46:513-518, 1997
    • (1997) Diabetes , vol.46 , pp. 513-518
    • Wu-Peng, X.S.1    Chua, S.C.2    Okada, N.3
  • 25
    • 1842405349 scopus 로고    scopus 로고
    • Leptin directly alters lipid partitioning in skeletal muscle
    • Muoio DM, Dohm GL, Fiedorek FT, et al: Leptin directly alters lipid partitioning in skeletal muscle. Diabetes 46:1360-1363, 1997
    • (1997) Diabetes , vol.46 , pp. 1360-1363
    • Muoio, D.M.1    Dohm, G.L.2    Fiedorek, F.T.3
  • 26
    • 0030898516 scopus 로고    scopus 로고
    • Direct antidiabetic effect of leptin through triglyceride depletion of tissues
    • Shimabukuro M, Koyama K, Chen G, et al: Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci USA 94:4637-4641, 1997
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4637-4641
    • Shimabukuro, M.1    Koyama, K.2    Chen, G.3
  • 27
    • 0344901286 scopus 로고    scopus 로고
    • Acute intravenous and intracerebroventricular leptin infusion increases glucose uptake in insulin sensitive tissues and glucose turnover by an insulin independent pathway
    • Charron ML, Friedman J: Acute intravenous and intracerebroventricular leptin infusion increases glucose uptake in insulin sensitive tissues and glucose turnover by an insulin independent pathway. J Physiol 389:374-377, 1997
    • (1997) J Physiol , vol.389 , pp. 374-377
    • Charron, M.L.1    Friedman, J.2
  • 28
    • 0030737573 scopus 로고    scopus 로고
    • Effects of leptin on insulin sensitivity in normal rats
    • Sivitz WI, Walsh SA, Morgan DA, et al: Effects of leptin on insulin sensitivity in normal rats. Neuroendocrinology 138:3395-3401, 1997
    • (1997) Neuroendocrinology , vol.138 , pp. 3395-3401
    • Sivitz, W.I.1    Walsh, S.A.2    Morgan, D.A.3
  • 29
    • 0024997322 scopus 로고
    • Decreased glucose utilization during prolonged anesthesis and surgery
    • Tsubo T, Kudo T, Matsuki A, et al: Decreased glucose utilization during prolonged anesthesis and surgery. Can J Anaesth 37:645-649, 1990
    • (1990) Can J Anaesth , vol.37 , pp. 645-649
    • Tsubo, T.1    Kudo, T.2    Matsuki, A.3
  • 31
    • 0030852506 scopus 로고    scopus 로고
    • Is leptin a stress related peptide?
    • Bornstein SR: Is leptin a stress related peptide? Nat Med 3:937, 1997
    • (1997) Nat Med , vol.3 , pp. 937
    • Bornstein, S.R.1
  • 32
    • 0029860791 scopus 로고    scopus 로고
    • Modulation of insulin activities by leptin
    • Cohen B, Novick D, Rubinstein M: Modulation of insulin activities by leptin. Science 274:1185-1188, 1996
    • (1996) Science , vol.274 , pp. 1185-1188
    • Cohen, B.1    Novick, D.2    Rubinstein, M.3
  • 33
    • 0040381066 scopus 로고    scopus 로고
    • Leptin impairs metabolic actions of insulin in isolated rat adipocytes
    • Muller G, Ertl J, Gerl M, et al: Leptin impairs metabolic actions of insulin in isolated rat adipocytes. Science 272:10585-10593, 1997
    • (1997) Science , vol.272 , pp. 10585-10593
    • Muller, G.1    Ertl, J.2    Gerl, M.3
  • 34
    • 0030847432 scopus 로고    scopus 로고
    • Acute stimulation of glucose metabolism in mice by leptin treatment
    • Kamohara S, Burcelin R, Halaas JL, et al: Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 389:374-377, 1997
    • (1997) Nature , vol.389 , pp. 374-377
    • Kamohara, S.1    Burcelin, R.2    Halaas, J.L.3
  • 35
    • 0030806382 scopus 로고    scopus 로고
    • Localization of leptin receptor in the human brain
    • Couce ME, Burguera E, Parisi JE, et al: Localization of leptin receptor in the human brain. Neuroendocrinology 66:145-150, 1997
    • (1997) Neuroendocrinology , vol.66 , pp. 145-150
    • Couce, M.E.1    Burguera, E.2    Parisi, J.E.3
  • 36
    • 0025942149 scopus 로고
    • Ventromedial hypothalamic stimulation enhances peripheral glucose uptake in anesthetized rats
    • Sudo M, Minokoshi Y, Shimazu T: Ventromedial hypothalamic stimulation enhances peripheral glucose uptake in anesthetized rats. Am J Physiol 261:E298-E303, 1991 (suppl)
    • (1991) Am J Physiol , vol.261 , Issue.SUPPL.
    • Sudo, M.1    Minokoshi, Y.2    Shimazu, T.3
  • 37
    • 0024315055 scopus 로고
    • Cold exposure reverses inhibitory effects of fasting on peripheral glucose uptake in rats
    • Shibata H, Perusse F, Vallerand A, et al: Cold exposure reverses inhibitory effects of fasting on peripheral glucose uptake in rats. Am J Physiol 257:R96-R101, 1989 (suppl)
    • (1989) Am J Physiol , vol.257 , Issue.SUPPL.
    • Shibata, H.1    Perusse, F.2    Vallerand, A.3
  • 38
    • 0022149779 scopus 로고
    • Insulin action during fasting and refeeding in rat determined by euglycemic clamp
    • Penicaud L, Kande JK, Le Magnen J, et al: Insulin action during fasting and refeeding in rat determined by euglycemic clamp. Am J Physiol 249:E514-E518, 1985 (suppl)
    • (1985) Am J Physiol , vol.249 , Issue.SUPPL.
    • Penicaud, L.1    Kande, J.K.2    Le Magnen, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.