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Volumn 1, Issue 5, 1999, Pages 565-572

Adenoviral vectors for liver-directed gene therapy

Author keywords

Adenoviral vector; Gene therapy; Gutless vectors; Helper virus; Hepatocyte; Transgene

Indexed keywords

VIRUS VECTOR;

EID: 0032736676     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (34)

References (92)
  • 1
    • 0000557447 scopus 로고    scopus 로고
    • Adenoviridae: The viruses and their replication
    • Fields BN, Knipe DM, Howley PM (Eds). Lippincott-Raven
    • Shenk T: Adenoviridae: the viruses and their replication. In: Fields Virology, Fields BN, Knipe DM, Howley PM (Eds). Lippincott-Raven (1996):2111-2148.
    • (1996) Fields Virology , pp. 2111-2148
    • Shenk, T.1
  • 2
    • 0023764622 scopus 로고
    • Development of adenovirus vectors for the expression of heterologous genes
    • Berkner KL: Development of adenovirus vectors for the expression of heterologous genes. Biotechniques (1988) 6:616-629.
    • (1988) Biotechniques , vol.6 , pp. 616-629
    • Berkner, K.L.1
  • 3
    • 0029943193 scopus 로고    scopus 로고
    • Sustained expression of therapeutic levels of human factor VIII in mice
    • Connelly S, Gardner JM, Lyons RM, McClelland A, Kaleko M: Sustained expression of therapeutic levels of human factor VIII in mice. Blood (1996) 87:4671-4677.
    • (1996) Blood , vol.87 , pp. 4671-4677
    • Connelly, S.1    Gardner, J.M.2    Lyons, R.M.3    McClelland, A.4    Kaleko, M.5
  • 5
    • 0031008929 scopus 로고    scopus 로고
    • Persistent transgene expression in mouse liver following in vivo gene transfer with a deltaE1/deltaE4 adenovirus vector
    • Wang Q, Greenburg G, Bunch D, Parson D, Finer MH: Persistent transgene expression in mouse liver following In vivo gene transfer with a deltaE1/deltaE4 adenovirus vector. Gene Ther (1997) 4:393-400.
    • (1997) Gene Ther , vol.4 , pp. 393-400
    • Wang, Q.1    Greenburg, G.2    Bunch, D.3    Parson, D.4    Finer, M.H.5
  • 7
    • 0025487393 scopus 로고
    • Evaluation of the transfer and expression in mice of an enzyme-encoding gene using a human adenovirus vector
    • Stratford-Perricaudet LD, Levrero M, Chasse J, Perricaudet M, Briand P: Evaluation of the transfer and expression in mice of an enzyme-encoding gene using a human adenovirus vector. Hum Gene Ther (1990) 1:241-256.
    • (1990) Hum Gene Ther , vol.1 , pp. 241-256
    • Stratford-Perricaudet, L.D.1    Levrero, M.2    Chasse, J.3    Perricaudet, M.4    Briand, P.5
  • 8
    • 0027272371 scopus 로고
    • Efficient adenoviral-mediated ornithine transcarbamylasc expression in deficient mouse and human hepatocytes
    • Morsey MA, Alford EL, Bett A, Graham FL, Caskey CT: Efficient adenoviral-mediated ornithine transcarbamylasc expression in deficient mouse and human hepatocytes. J Clin Invest (1993) 92:1580-1586.
    • (1993) J Clin Invest , vol.92 , pp. 1580-1586
    • Morsey, M.A.1    Alford, E.L.2    Bett, A.3    Graham, F.L.4    Caskey, C.T.5
  • 9
    • 0030042794 scopus 로고    scopus 로고
    • Prolonged metabolic correction in adult ornithine transcarbamylase-deficient mice with adenoviral vectors
    • Ye X, Robinson MB, Batshaw ML, Furth EE, Smith I, Wilson JM: Prolonged metabolic correction in adult ornithine transcarbamylase-deficient mice with adenoviral vectors. J Biol Chem (1996) 271:3639-3646.
    • (1996) J Biol Chem , vol.271 , pp. 3639-3646
    • Ye, X.1    Robinson, M.B.2    Batshaw, M.L.3    Furth, E.E.4    Smith, I.5    Wilson, J.M.6
  • 10
    • 0030961455 scopus 로고    scopus 로고
    • Adenovirus-mediatedin vivo gene transfer rapidly protects ornithine transcarbamylase-deficient mice from an ammonium challenge
    • Ye X, Robinson MB, Pabin C, Quinn T, Jawad A, Wilson JM, Batshaw ML: Adenovirus-mediatedin vivo gene transfer rapidly protects ornithine transcarbamylase-deficient mice from an ammonium challenge. Pediatr Res (1997) 41:527-534.
    • (1997) Pediatr Res , vol.41 , pp. 527-534
    • Ye, X.1    Robinson, M.B.2    Pabin, C.3    Quinn, T.4    Jawad, A.5    Wilson, J.M.6    Batshaw, M.L.7
  • 11
    • 0029928640 scopus 로고    scopus 로고
    • Gene therapy for ornithine transcarbamylase deficiency
    • Kiwaki K, Matsuda I: Gene therapy for ornithine transcarbamylase deficiency. Acta Paediatr Jpn (1996) 38:189-192.
    • (1996) Acta Paediatr Jpn , vol.38 , pp. 189-192
    • Kiwaki, K.1    Matsuda, I.2
  • 12
    • 0027258140 scopus 로고
    • Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
    • Ishibashi S, Brown MS, Goldstein JL, Gerard RD, Hammer RE, Herz J: Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest (1993) 92:883-893.
    • (1993) J Clin Invest , vol.92 , pp. 883-893
    • Ishibashi, S.1    Brown, M.S.2    Goldstein, J.L.3    Gerard, R.D.4    Hammer, R.E.5    Herz, J.6
  • 14
    • 0029988465 scopus 로고    scopus 로고
    • Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene
    • Kozarsky KF, Jooss K, Donahee M, Strauss JF, Wilson JM: Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene. Nature Genet (1996) 13:54-62.
    • (1996) Nature Genet , vol.13 , pp. 54-62
    • Kozarsky, K.F.1    Jooss, K.2    Donahee, M.3    Strauss, J.F.4    Wilson, J.M.5
  • 15
    • 0028234357 scopus 로고
    • In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses
    • Kozarsky KF, McKinley DR, Austin LL, Raper SE, Stratford-Perricaudet LD, Wilson JM: In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses. J Biol Chem (1994) 269:13695-13702.
    • (1994) J Biol Chem , vol.269 , pp. 13695-13702
    • Kozarsky, K.F.1    McKinley, D.R.2    Austin, L.L.3    Raper, S.E.4    Stratford-Perricaudet, L.D.5    Wilson, J.M.6
  • 17
    • 0028464358 scopus 로고
    • Gene therapy for phenylketonuria: Phenotypic correction in a genetically deficient mouse model by adenovirus-mediated hepatic gene transfer
    • Fang B, Eisensmith RC, Li XH, Finegold MJ, Sheldlovsky A, Dove W, Woo SL: Gene therapy for phenylketonuria: phenotypic correction in a genetically deficient mouse model by adenovirus-mediated hepatic gene transfer. Gene Ther (1994) 1:247-254.
    • (1994) Gene Ther , vol.1 , pp. 247-254
    • Fang, B.1    Eisensmith, R.C.2    Li, X.H.3    Finegold, M.J.4    Sheldlovsky, A.5    Dove, W.6    Woo, S.L.7
  • 18
    • 0028899573 scopus 로고
    • Therapeutic serum concentrations of human alpha-1-antitrypsin after adenoviral-mediated gene transfer into mouse hepatocytes
    • Kay MA, Graham F, Leland F, Woo SL: Therapeutic serum concentrations of human alpha-1-antitrypsin after adenoviral-mediated gene transfer into mouse hepatocytes. Hepatology (1995) 21:815-819.
    • (1995) Hepatology , vol.21 , pp. 815-819
    • Kay, M.A.1    Graham, F.2    Leland, F.3    Woo, S.L.4
  • 19
    • 0029970829 scopus 로고    scopus 로고
    • Long term correction of bilirubin-UDP-glucuronosyltransferase deficiency in Gunn rats by administration of a reccmbinant adenovirus during the neonatal period
    • Takahashi M, Ilan Y, Chowdhury NR, Guida J, Horowitz M, Chowdhury JR: Long term correction of bilirubin-UDP-glucuronosyltransferase deficiency in Gunn rats by administration of a reccmbinant adenovirus during the neonatal period. J Biol Chem (1996) 271:26536-26542.
    • (1996) J Biol Chem , vol.271 , pp. 26536-26542
    • Takahashi, M.1    Ilan, Y.2    Chowdhury, N.R.3    Guida, J.4    Horowitz, M.5    Chowdhury, J.R.6
  • 23
    • 0031828432 scopus 로고    scopus 로고
    • Haemophilia A gene therapy
    • Connelly S, Kaleko M: Haemophilia A gene therapy. Haemophilia (1998) 4:380-388.
    • (1998) Haemophilia , vol.4 , pp. 380-388
    • Connelly, S.1    Kaleko, M.2
  • 25
    • 0031877214 scopus 로고    scopus 로고
    • Hepatic gene therapy for haemophilia B
    • Kay MA: Hepatic gene therapy for haemophilia B. Haemophilia (1998) 4:389-392.
    • (1998) Haemophilia , vol.4 , pp. 389-392
    • Kay, M.A.1
  • 26
    • 0032580348 scopus 로고    scopus 로고
    • Human gene therapy
    • Anderson WF: Human gene therapy. Nature (1998) 392:25-30.
    • (1998) Nature , vol.392 , pp. 25-30
    • Anderson, W.F.1
  • 29
    • 0033544952 scopus 로고    scopus 로고
    • Adenoviral vector-mediated expression of physiological levels of human factor VIII in non-human primates
    • in press
    • Brann T, Kayda DB, Lyons R, Shirley P, Roy S, Kaleko M, Smith TAG: Adenoviral vector-mediated expression of physiological levels of human factor VIII in non-human primates. Hum Gene Ther (1999) in press.
    • (1999) Hum Gene Ther
    • Brann, T.1    Kayda, D.B.2    Lyons, R.3    Shirley, P.4    Roy, S.5    Kaleko, M.6    Smith, T.A.G.7
  • 30
    • 0030069229 scopus 로고    scopus 로고
    • High-level tissue-specific expression of functional human factor VIII in mice
    • Connelly S, Gardner JM, McClelland A, Kaleko M: High-level tissue-specific expression of functional human factor VIII in mice. Hum Gene Ther (1996) 7:183-195.
    • (1996) Hum Gene Ther , vol.7 , pp. 183-195
    • Connelly, S.1    Gardner, J.M.2    McClelland, A.3    Kaleko, M.4
  • 32
    • 0032796661 scopus 로고    scopus 로고
    • Efficient adenoviral vector transduction and expression of functional human factor VIII in cultured primary human hepatocytes
    • Andrews JL, Weaver L, Kaleko M, Connelly S: Efficient adenoviral vector transduction and expression of functional human factor VIII in cultured primary human hepatocytes. Haemophilia (1999) 5:160-168.
    • (1999) Haemophilia , vol.5 , pp. 160-168
    • Andrews, J.L.1    Weaver, L.2    Kaleko, M.3    Connelly, S.4
  • 33
    • 0029972263 scopus 로고    scopus 로고
    • Gene therapy for hepatocellular carcinoma: Long-term remission of primary and metastatic tumors in mice by interleukin-2 gene therapyin vivo
    • Huang H, Chen SH, Kosai K, Finegold MJ, Woo SLC: Gene therapy for hepatocellular carcinoma: long-term remission of primary and metastatic tumors in mice by interleukin-2 gene therapyin vivo. Gene Ther (1996) 3:980-987.
    • (1996) Gene Ther , vol.3 , pp. 980-987
    • Huang, H.1    Chen, S.H.2    Kosai, K.3    Finegold, M.J.4    Woo, S.L.C.5
  • 40
    • 0029970824 scopus 로고    scopus 로고
    • Elimination of hepatitis C virus RNA in infected human hepatocytes by adenovirus-mediated expression of ribozymes
    • Lieber A, He CY, Polyak SJ, Gretch DR, Barr D, Kay MA: Elimination of hepatitis C virus RNA in infected human hepatocytes by adenovirus-mediated expression of ribozymes. J Virol (1996) 70:8782-8791.
    • (1996) J Virol , vol.70 , pp. 8782-8791
    • Lieber, A.1    He, C.Y.2    Polyak, S.J.3    Gretch, D.R.4    Barr, D.5    Kay, M.A.6
  • 41
    • 2442738508 scopus 로고    scopus 로고
    • Treatment of type 2 diabetes through adenovirus mediated overexpression of glucokinase in a diet-induced diabetic murine model
    • Abs 47
    • Desai U, Slosberg E, Caplan S, Bottcher B, Kaleko M, Connelly S: Treatment of type 2 diabetes through adenovirus mediated overexpression of glucokinase in a diet-induced diabetic murine model. Am Soc Gene Ther (1999) 2:Abs 47.
    • (1999) Am Soc Gene Ther , vol.2
    • Desai, U.1    Slosberg, E.2    Caplan, S.3    Bottcher, B.4    Kaleko, M.5    Connelly, S.6
  • 43
    • 0028484704 scopus 로고
    • MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses
    • Yang Y, Ertl HCJ, Wilson JM: MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity (1994) 1:433-442.
    • (1994) Immunity , vol.1 , pp. 433-442
    • Yang, Y.1    Ertl, H.C.J.2    Wilson, J.M.3
  • 44
    • 0029936764 scopus 로고    scopus 로고
    • Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors
    • Tripathy SK, Black HB, Goldwasser E, Leiden JM: Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors. Nature Med (1996) 5:545-550.
    • (1996) Nature Med , vol.5 , pp. 545-550
    • Tripathy, S.K.1    Black, H.B.2    Goldwasser, E.3    Leiden, J.M.4
  • 45
    • 0033540652 scopus 로고    scopus 로고
    • Persistence of an [E1-, polymerase-] adenovirus vector despite transduction of a neoantigen into immune-competent mice
    • Hu H, Serra D, Amalfitano A: Persistence of an [E1-, polymerase-] adenovirus vector despite transduction of a neoantigen into immune-competent mice. Hum Gene Ther (1999) 10:355-364.
    • (1999) Hum Gene Ther , vol.10 , pp. 355-364
    • Hu, H.1    Serra, D.2    Amalfitano, A.3
  • 46
    • 0030824640 scopus 로고    scopus 로고
    • Immune responses to reporter proteins and high viral dose limit duration of expression with adenoviral vectors: Comparison of E2a wild type and E2a deleted vectors
    • Morral N, O'Neal W, Zhou H, Langsten C, Beaudet A: Immune responses to reporter proteins and high viral dose limit duration of expression with adenoviral vectors: comparison of E2a wild type and E2a deleted vectors. Hum Gene Ther (1997) 8:1275-1286.
    • (1997) Hum Gene Ther , vol.8 , pp. 1275-1286
    • Morral, N.1    O'Neal, W.2    Zhou, H.3    Langsten, C.4    Beaudet, A.5
  • 47
    • 0028914687 scopus 로고
    • Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: Comparisons between immunocompetent and immunodeficient inbred strains
    • Barr D, Tubb J, Ferguson D, Sana A, Lieber A, Wilson C, Perkins J, Kay MA: Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: Comparisons between immunocompetent and immunodeficient inbred strains. Gene Ther (1995) 2:151-155.
    • (1995) Gene Ther , vol.2 , pp. 151-155
    • Barr, D.1    Tubb, J.2    Ferguson, D.3    Sana, A.4    Lieber, A.5    Wilson, C.6    Perkins, J.7    Kay, M.A.8
  • 49
    • 0028807696 scopus 로고
    • FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfer
    • Vilquin J, Guérette B, Kinoshita I, Roy B, Goulet M, Gravel C, Roy R, Tremblay JP: FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfer. Hum Gene Ther (1995) 6:1391-1401.
    • (1995) Hum Gene Ther , vol.6 , pp. 1391-1401
    • Vilquin, J.1    Guérette, B.2    Kinoshita, I.3    Roy, B.4    Goulet, M.5    Gravel, C.6    Roy, R.7    Tremblay, J.P.8
  • 50
    • 0029153297 scopus 로고
    • Immunosuppression by FK506 markedly prolongs expression of adenovirus-delivered transgene in skeletal muscles of adult dystrophic [mdx] mice
    • Lochmüller H, Petrof BJ, Allen C, Presscott S, Massie B, Karpati G: Immunosuppression by FK506 markedly prolongs expression of adenovirus-delivered transgene in skeletal muscles of adult dystrophic [mdx] mice. Biochem Biophys Res Commun (1995) 213:569-574.
    • (1995) Biochem Biophys Res Commun , vol.213 , pp. 569-574
    • Lochmüller, H.1    Petrof, B.J.2    Allen, C.3    Presscott, S.4    Massie, B.5    Karpati, G.6
  • 51
    • 0029741231 scopus 로고    scopus 로고
    • Transient immunosuppression by FK506 permits a sustained high-level dystrophin expression after adenovirus-mediated dystrophin minigene transfer to skeletal muscles of adult dystrophic (mdx) mice
    • Lochmüller H, Petrof BJ, Pari G, Larochelle N, Dodelet V, Wang Q, Allen C, Presscott S, Massie B, Nalbantoglu J, Karpati G: Transient immunosuppression by FK506 permits a sustained high-level dystrophin expression after adenovirus-mediated dystrophin minigene transfer to skeletal muscles of adult dystrophic (mdx) mice. Gene Ther (1996) 3:706-716.
    • (1996) Gene Ther , vol.3 , pp. 706-716
    • Lochmüller, H.1    Petrof, B.J.2    Pari, G.3    Larochelle, N.4    Dodelet, V.5    Wang, Q.6    Allen, C.7    Presscott, S.8    Massie, B.9    Nalbantoglu, J.10    Karpati, G.11
  • 52
    • 0029743163 scopus 로고    scopus 로고
    • Cyclophosphamide diminishes inflammation and prolongs transgene expression following delivery of adenoviral vectors to mouse liver and lung
    • Jooss K, Yang Y, Wilson JM: Cyclophosphamide diminishes inflammation and prolongs transgene expression following delivery of adenoviral vectors to mouse liver and lung. Hum Gene Ther (1996) 7:1555-1566.
    • (1996) Hum Gene Ther , vol.7 , pp. 1555-1566
    • Jooss, K.1    Yang, Y.2    Wilson, J.M.3
  • 53
    • 0028934815 scopus 로고
    • Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression
    • Dai Y, Schwarz EM, Gu D, Zhang WW, Sarvetnick N, Verma IM: Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression. Proc Natl Acad Sci USA (1995) 92:1401-1405.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1401-1405
    • Dai, Y.1    Schwarz, E.M.2    Gu, D.3    Zhang, W.W.4    Sarvetnick, N.5    Verma, I.M.6
  • 55
    • 0029790327 scopus 로고    scopus 로고
    • Prevention of immune reactions triggered by first-generation adenoviral vectors by monoclonal antibodies and CTLA4lg
    • Guéreete B, Vilquin JT, Gingras M, Gravel C, Wood KJ, Tremblay JP: Prevention of immune reactions triggered by first-generation adenoviral vectors by monoclonal antibodies and CTLA4lg. Hum Gene Ther (1996) 7:1455-1463.
    • (1996) Hum Gene Ther , vol.7 , pp. 1455-1463
    • Guéreete, B.1    Vilquin, J.T.2    Gingras, M.3    Gravel, C.4    Wood, K.J.5    Tremblay, J.P.6
  • 56
    • 0029944988 scopus 로고    scopus 로고
    • Transient immune blockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver
    • Yang Y, Greenough K, Wilson JM: Transient immune blockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver. Gene Ther (1996) 3:412-420.
    • (1996) Gene Ther , vol.3 , pp. 412-420
    • Yang, Y.1    Greenough, K.2    Wilson, J.M.3
  • 57
    • 0031903186 scopus 로고    scopus 로고
    • Circumvention of immunity to the adenovirus major coat protein hexon
    • Roy S, Shirley PS, McClelland A, Kaleko M: Circumvention of immunity to the adenovirus major coat protein hexon. J Virol (1998) 72:6875-6879.
    • (1998) J Virol , vol.72 , pp. 6875-6879
    • Roy, S.1    Shirley, P.S.2    McClelland, A.3    Kaleko, M.4
  • 59
    • 0029983685 scopus 로고    scopus 로고
    • 'Sero-switch' adenovirus-mediated in vivo gene transfer: Circumvention of anti-adenovirus humoral immune defenses against repeat adenovirus vector administration by changing the adenovirus serotype
    • Mastrangeli IA, Harvey BG, Yao J, Wolff G, Kovesdi I, Crystal RG, Falck-Pedersen E: 'Sero-switch' adenovirus-mediated In vivo gene transfer: circumvention of anti-adenovirus humoral immune defenses against repeat adenovirus vector administration by changing the adenovirus serotype. Hum Gene Ther (1996) 7:79-87.
    • (1996) Hum Gene Ther , vol.7 , pp. 79-87
    • Mastrangeli, I.A.1    Harvey, B.G.2    Yao, J.3    Wolff, G.4    Kovesdi, I.5    Crystal, R.G.6    Falck-Pedersen, E.7
  • 60
    • 0029934048 scopus 로고    scopus 로고
    • Transient immunosuppression permits successful repetitive intravenous administration of an adenovirus vector
    • Smith TAG, White BD, Gardner JM, Kaleko M, McClelland A: Transient immunosuppression permits successful repetitive intravenous administration of an adenovirus vector. Gene Ther (1996) 3:496-502.
    • (1996) Gene Ther , vol.3 , pp. 496-502
    • Smith, T.A.G.1    White, B.D.2    Gardner, J.M.3    Kaleko, M.4    McClelland, A.5
  • 61
    • 0028978493 scopus 로고
    • Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung
    • Yang Y, Trinchieri G, Wilson JM: Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung. Nature Med (1995) 1:890-893.
    • (1995) Nature Med , vol.1 , pp. 890-893
    • Yang, Y.1    Trinchieri, G.2    Wilson, J.M.3
  • 62
    • 0029817036 scopus 로고    scopus 로고
    • Transient subversion of CD40 ligand function diminishes immune responses to adenovirus vectors in mouse liver and lung tissues
    • Yang Y, Su Q, Grewal IS, Schliz R, Flavell RA, Wilson JM: Transient subversion of CD40 ligand function diminishes immune responses to adenovirus vectors in mouse liver and lung tissues. J Virol (1996) 70:6370-6377.
    • (1996) J Virol , vol.70 , pp. 6370-6377
    • Yang, Y.1    Su, Q.2    Grewal, I.S.3    Schliz, R.4    Flavell, R.A.5    Wilson, J.M.6
  • 63
    • 0030984335 scopus 로고    scopus 로고
    • Transient immunomodulation with anti-CD40 ligand antibody and CTLA4lg enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver
    • Kay MA, Meuse L, Gown AM, Linsley P, Hollenbough D, Arrufo A, Ochs HD, Wilson CB: Transient immunomodulation with anti-CD40 ligand antibody and CTLA4lg enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver. Proc Natl Acad Sci USA (1997) 94:4686-4691.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4686-4691
    • Kay, M.A.1    Meuse, L.2    Gown, A.M.3    Linsley, P.4    Hollenbough, D.5    Arrufo, A.6    Ochs, H.D.7    Wilson, C.B.8
  • 64
    • 0029916598 scopus 로고    scopus 로고
    • Successful expression of human factor IX following repeat administration of adenoviral vector in mice
    • Walter J, You Q, Hagstrom JN, Sands M, High KA: Successful expression of human factor IX following repeat administration of adenoviral vector in mice. Proc Natl Acad Sci USA (1996) 93:3056-3061.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3056-3061
    • Walter, J.1    You, Q.2    Hagstrom, J.N.3    Sands, M.4    High, K.A.5
  • 65
    • 0029849639 scopus 로고    scopus 로고
    • Induction of central tolerance by intrathymic inoculation of adenoviral antigens into the host thymus permits long-term gene therapy in Gunn rats
    • Ilan Y, Attavar P, Takahashi M, Davidson A, Horowitz MS, Guida J, Chowdhury NR, Chowdhury JR: Induction of central tolerance by intrathymic inoculation of adenoviral antigens into the host thymus permits long-term gene therapy in Gunn rats. J Clin Invest (1996) 98:2640-2647.
    • (1996) J Clin Invest , vol.98 , pp. 2640-2647
    • Ilan, Y.1    Attavar, P.2    Takahashi, M.3    Davidson, A.4    Horowitz, M.S.5    Guida, J.6    Chowdhury, N.R.7    Chowdhury, J.R.8
  • 67
    • 0032605547 scopus 로고    scopus 로고
    • Expanded-capacity adenoviral vectors-the helper-dependent vectors
    • Morsy MA, Caskey CT: Expanded-capacity adenoviral vectors-the helper-dependent vectors. Mol Med Today (1999) 5:18-24.
    • (1999) Mol Med Today , vol.5 , pp. 18-24
    • Morsy, M.A.1    Caskey, C.T.2
  • 68
    • 0028148019 scopus 로고
    • Evaluation of the efficacy and safety of in vitro adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA
    • Mittereder N, Yei S, Bachurski C, Cuppoletti J, Whitsett JA, Tolstoshev P, Trapnell BC: Evaluation of the efficacy and safety of in vitro adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA. Hum Gene Ther (1994) 5:717-729.
    • (1994) Hum Gene Ther , vol.5 , pp. 717-729
    • Mittereder, N.1    Yei, S.2    Bachurski, C.3    Cuppoletti, J.4    Whitsett, J.A.5    Tolstoshev, P.6    Trapnell, B.C.7
  • 69
    • 0028937785 scopus 로고
    • Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses
    • Yang Y, Li Q, Ertl HC, Wilson JM: Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J Virol (1995) 69:2004-2015.
    • (1995) J Virol , vol.69 , pp. 2004-2015
    • Yang, Y.1    Li, Q.2    Ertl, H.C.3    Wilson, J.M.4
  • 70
    • 0029836503 scopus 로고    scopus 로고
    • Role of viral antigens in destructive cellular immune responses to adenovirus vector-transduced cells in mouse lungs
    • Yang Y, Su Q, Wilson JM: Role of viral antigens In destructive cellular immune responses to adenovirus vector-transduced cells in mouse lungs. J Virol (1996) 70:7209-7212.
    • (1996) J Virol , vol.70 , pp. 7209-7212
    • Yang, Y.1    Su, Q.2    Wilson, J.M.3
  • 71
    • 0028246338 scopus 로고
    • Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver
    • Engelhardt JF, Ye X, Doranz B, Wilson JM: Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc Natl Acad Sci USA (1994) 91:6196-6200.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 6196-6200
    • Engelhardt, J.F.1    Ye, X.2    Doranz, B.3    Wilson, J.M.4
  • 72
    • 0028229147 scopus 로고
    • Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis
    • Yang Y, Nunes FA, Berencsi K, Gönczöl E, Engelhardt JF, Wilson JM: Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. Nature Genet (1994) 7:362-369.
    • (1994) Nature Genet , vol.7 , pp. 362-369
    • Yang, Y.1    Nunes, F.A.2    Berencsi, K.3    Gönczöl, E.4    Engelhardt, J.F.5    Wilson, J.M.6
  • 73
    • 0029670374 scopus 로고    scopus 로고
    • Lack of persistence of E1-recombinant adenoviral vectors containing a temperature-sensitive E2A mutation in immunocompetent mice and hemophilia B dogs
    • Fang B, Wang H, Gordon G, Bellinger DA, Read MS, Brinkhous KM, Woo SL, Eisensmith RC: Lack of persistence of E1-recombinant adenoviral vectors containing a temperature-sensitive E2A mutation in immunocompetent mice and hemophilia B dogs. Gene Ther (1996) 3:217-222.
    • (1996) Gene Ther , vol.3 , pp. 217-222
    • Fang, B.1    Wang, H.2    Gordon, G.3    Bellinger, D.A.4    Read, M.S.5    Brinkhous, K.M.6    Woo, S.L.7    Eisensmith, R.C.8
  • 74
    • 0029664338 scopus 로고    scopus 로고
    • Elimination of both E1 and E2a from adenovirus vectors further improves prospects for in vivo human gene therapy
    • Gorziglia Ml, Kadan MJ, Yei S, Lim J, Lee GM. Luthra R, Trapnell BC: Elimination of both E1 and E2a from adenovirus vectors further improves prospects for in vivo human gene therapy. J Virol (1996) 6:4173-4178.
    • (1996) J Virol , vol.6 , pp. 4173-4178
    • Gorziglia, M.I.1    Kadan, M.J.2    Yei, S.3    Lim, J.4    Lee, G.M.5    Luthra, R.6    Trapnell, B.C.7
  • 75
    • 0030728433 scopus 로고    scopus 로고
    • Activation of transgene expression by early region 4 is responsible for a high level of persistent transgene expression from adenovirus vectors in vivo
    • Brough DE, Hsu C, Kulesa VA, Lee GM, Cantolupo LJ, Lizonova A, Kovesdi I: Activation of transgene expression by early region 4 is responsible for a high level of persistent transgene expression from adenovirus vectors In vivo. J Virol (1997) 71:9206-9213.
    • (1997) J Virol , vol.71 , pp. 9206-9213
    • Brough, D.E.1    Hsu, C.2    Kulesa, V.A.3    Lee, G.M.4    Cantolupo, L.J.5    Lizonova, A.6    Kovesdi, I.7
  • 77
    • 0029959867 scopus 로고    scopus 로고
    • Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy
    • Gao GP, Yang Y, Wilson JM: Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy. J Virol (1996) 70:8934-8943.
    • (1996) J Virol , vol.70 , pp. 8934-8943
    • Gao, G.P.1    Yang, Y.2    Wilson, J.M.3
  • 79
  • 80
    • 0030900511 scopus 로고    scopus 로고
    • A helper-dependent system for adenovirus vector production helps define a lower limit for efficient DNA packaging
    • Parks RJ, Graham FL: A helper-dependent system for adenovirus vector production helps define a lower limit for efficient DNA packaging. J Virol (1997) 71:3293-3298.
    • (1997) J Virol , vol.71 , pp. 3293-3298
    • Parks, R.J.1    Graham, F.L.2
  • 82
    • 0031055468 scopus 로고    scopus 로고
    • Construction of adenovirus vectors through Cre-lox recombination
    • Hardy S, Kitamura M, Harris-Stansil T, Dai Y, Phipps ML: Construction of adenovirus vectors through Cre-lox recombination. J Virol (1997) 71:1842-1849.
    • (1997) J Virol , vol.71 , pp. 1842-1849
    • Hardy, S.1    Kitamura, M.2    Harris-Stansil, T.3    Dai, Y.4    Phipps, M.L.5
  • 83
    • 0031916435 scopus 로고    scopus 로고
    • Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity
    • Schiedner G, Morral N, Parks RJ, Wu Y, Koopmans SC. Langsten C, Graham FL, Beaudet AL, Kochanek S: Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity. Nature Genet (1998) 18:180-183.
    • (1998) Nature Genet , vol.18 , pp. 180-183
    • Schiedner, G.1    Morral, N.2    Parks, R.J.3    Wu, Y.4    Langsten C, K.S.C.5    Graham, F.L.6    Beaudet, A.L.7    Kochanek, S.8
  • 84
    • 0029943155 scopus 로고    scopus 로고
    • A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase
    • Kochanek S, Clemens PR, Mitani K, Chen HH, Chan S, Caskey CT: A new adenoviral vector: replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase. Proc Natl Acad Sci USA (1996) 93:5731-5736.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5731-5736
    • Kochanek, S.1    Clemens, P.R.2    Mitani, K.3    Chen, H.H.4    Chan, S.5    Caskey, C.T.6
  • 85
    • 0030462599 scopus 로고    scopus 로고
    • A helper-dependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal
    • Parks RJ, Chen L, Anton M, Sankar U, Rudnicki MA, Graham FL: A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc Natl Acad Sci USA (1996) 93:13565-13570.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13565-13570
    • Parks, R.J.1    Chen, L.2    Anton, M.3    Sankar, U.4    Rudnicki, M.A.5    Graham, F.L.6
  • 86
    • 0027422291 scopus 로고
    • Site-specific recombinases; tools for genome engineering
    • Kilby NJ, Snaith MR, Murray J: Site-specific recombinases; tools for genome engineering. Trends Genet (1993) 9:413-421.
    • (1993) Trends Genet , vol.9 , pp. 413-421
    • Kilby, N.J.1    Snaith, M.R.2    Murray, J.3
  • 87
    • 0033021697 scopus 로고    scopus 로고
    • Molecular switches for regulating therapeutic genes
    • Webster KA: Molecular switches for regulating therapeutic genes. Gene Ther (1999) 6:951-953.
    • (1999) Gene Ther , vol.6 , pp. 951-953
    • Webster, K.A.1
  • 89
    • 0032618661 scopus 로고    scopus 로고
    • Chimeric viral vectors the best of both worlds?
    • Reynolds PN, Feng M, Curiel DT: Chimeric viral vectors the best of both worlds? Mol Med Today (1999) 5:25-31.
    • (1999) Mol Med Today , vol.5 , pp. 25-31
    • Reynolds, P.N.1    Feng, M.2    Curiel, D.T.3


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