An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 14, 1998, Pages 7866-7871

  Morsy, Manal A ^a   Gu, MingCheng ^a   Motzel, Sherri ^a   Zhao, Jing ^a   Lin, Jing ^a   Su, Qin ^a   Allen, Henry ^a   Franlin, Laura ^a   Parks, Robin J ^b   Graham, Frank L ^b   Kochanek, Stefan ^c   Bett, Andrew J ^a   Caskey, C Thomas ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b MCMASTER UNIVERSITY   (Canada)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; LEPTIN; RNA; VIRUS PROTEIN;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; EXPRESSION VECTOR; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; HISTOPATHOLOGY; INFLAMMATION; LIVER TOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SAFETY; TRANSGENE; WEIGHT REDUCTION;

ADENOVIRIDAE; ANIMALS; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; LEPTIN; MICE; MICE, OBESE; MICE, TRANSGENIC; OBESITY; PROTEINS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 13144283616     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.14.7866     Document Type: Article

References (36)

1. Stratford-Perricaudet, L. D., Levrero, M., Chasse, J., Perricaudet, M. & Briand, P. (1990) Hum. Gene Ther. 1, 241-256.
2. Kay, M. A., Li, Q., Liu, R.-J., Leland, F., Roman, C., Finegold, M. & Woo, S. L. C. (1992) Hum. Gene Ther. 3, 641-647.
3. Herz, J. & Gerard, R. D. (1993) Proc. Natl. Acad. Sci. USA 90, 2812-2816.
4. Engelhardt, J. F., Simon, R. H., Yang, Y., Zepeda, M., Weber-Pendleton, S., Doranz, B., Grossman, M. & Wilson, J. M. (1993) Hum. Gene Ther. 4, 757-769.
5. Morsy, M. A., Alford, E. L., Bett, A., Graham, F. L. & Caskey, C.T. (1993) J. Clin. Invest. 92, 1580-1586.
6. Morsy, M. A., Zhao, J. Z., Warman, A. W., O'Brien, W. E., Graham, F. L. & Caskey, C. T. (1996) J. Clin. Invest. 97, 826-832.
7. Muzzin, P., Eisensmith, R. C., Copeland, K. C. & Woo, S. L. C. (1996) Proc. Natl. Acad. Sci. USA 93, 14804-14808.
8. Yang, Y., Nunes, F. A., Berencsi, K., Furth, E. E., Gonczol, E. & Wilson, J. M. (1994) Proc. Natl. Acad. Sci. USA 91, 4407-4411.
9. Yang, Y., Ertl, H. D. & Wilson, J. M. (1995) J. Virol. 69, 2004-2015.
10. Lochmuller, H., Petrof, B. J., Pari, G., Larochelle, N., Dodelet, V., Wang, Q., Allen, C., Prescott, S., Massie, B., Nalbantoglu, J., et al. (1996) Gene Ther. 3, 706-716.
11. Gahery-Segard, H., Juillard, V., Gaston, J., Lengagne, R., Pavirani, A., Boulanger, P. & Guillet, J. G. (1997) Eur. J. Immunol. 27, 653-659.
12. Kajiwara, K., Byrnes, A. P., Charlton, H. M., Wood, M. J. & Wood, K. J. (1997) Hum. Gene Ther. 8, 253-265.
13. Kaplan, J. M., Armentano, D., Sparer, T. E., Wynn, S. G., Peterson, P. A., Wadsworth, S. C., Couture, K. K., Pennington, S. E., St. George, J. A., Gooding, L. R. & Smith, A. E. (1997) Hum. Gene Ther. 8, 45-56.
14. Worgall, S., Wolff, G., Falck-Pedersen, E. & Crystal, R. G. (1997) Hum. Gene Ther. 8, 37-44.
15. Tripathy, S. K., Black, H. B., Goldwasser, E. & Leiden, J. M. (1996) Nat. Med. 2, 545-550.
16. Mitani, K., Graham, F. L., Caskey, C. T. & Kochanek, S. (1995) Proc. Natl. Acad. Sci. USA 92, 3854-3858.
17. Kochanek, S., Clemens, P. R., Mitani, K., Chen, H. H., Chan, S. & Caskey, C. T. (1996) Proc. Natl. Acad. Sci. USA 93, 5731-5736.
18. Clemens, P. R., Kochanek, S., Sunada, Y., Chan, S., Chen, H. H., Campbell, K. P. & Caskey, C. T. (1996) Gene Ther. 3, 965-72.
19. Chen, H. H., Mack, L. M., Kelly, R., Ontell, M., Kochanek, S. & Clemens, P. R. (1997) Proc. Natl. Acad. Sci. USA 94, 965-972.
20. Fisher, K. J., Choi, H., Burda, J., Chen, S. & Wilson, J. M. (1996) Virology 217, 11-22.
21. Kumar-Singh, R. & Chamberlain, J. S. (1996) Hum. Mol. Genet. 5, 913-921.
22. Hardy, S., Kitamura, M., Harris-Stansil, T., Dai, Y. & Phipps, M. L. (1997) J. Virol. 71, 1842-1849.
23. Lieber, A., He, C., Kirillova, I. & Kay, M. A. (1996) J. Virol. 70, 8944-8960.
24. Parks, R. J., Chen, L., Anton, M., Sankar, U., Rudnicki, M. A. & Graham, F. L. (1996) Proc. Natl. Acad. Sci. USA 93, 13565-13570.
25. Haecker, S. E., Stedman, H. H., Balice-Gordon, R. J., Smith, D. B., Greelish, J. P., Mitchell, M. A., Wells, A., Sweeney, H. L. & Wilson, J. M. (1996) Hum. Gen Ther. 7, 1907-1914.
26. Schiedner, G., Morral, N., Parks, R. J., Wu, Y., Koopmans, S. C., Langston, C., Graham, F. L., Beaudet, A. L. & Kochanek, S. (1998) Nat. Genet. 18, 180-183.
27. Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K. & Friedman, J. M. (1995) Science 269, 543-546.
28. Pelleymounter, M. A., Cullen, M. J., Hecht, R., Winters, D., Boone, T. & Collins, F. (1995) Science 269, 540-543.
29. Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R. & Burn, P. (1995) Science 269, 546-549.
30. Morsy, M. A., Gu, M., Zhao, J. Z., Holder, D. J., Rogers, I. T., Pouch, W., Motzel, S. L., Klein, H. J., Gupta, S. K., Liang, X., et al. (1998) Gene Ther. 5, 8-18.
31. Graham, F. L., Smiley, J., Russell, W. C. & Nairn, R. (1977) J. Gen. Virol. 36, 59-72.
32. Graham, F. L. & Prevec, L. (1991) in Gene Transfer and Expression Protocols., ed. Murray, E. J. (Humana, Clinton, NJ), pp. 109-128.
33. Chen, L., Anton, M. & Graham, F. L. (1996) Som. Cell Mol. Genet. 22, 477-488.
34. Parks, R. J. & Graham, F. L. (1997) J. Virol. 71, 3293-3298.
35. Maniatis, T., Fritsch, E. F. & Sambrook, J. (1982) Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY).
36. Sykes, R. C., Lin, D., Hwang, S. J., Framson, P. E. & Chinault, A. C. (1988) Mol. Gene. Genet. 212, 301-309.