메뉴 건너뛰기




Volumn 8, Issue 10, 1997, Pages 1275-1286

Immune responses to reporter proteins and high viral dose limit duration of expression with adenoviral vectors: Comparison of E2a wild type and E2a deleted vectors

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; ANTIBODY; BETA GALACTOSIDASE; VIRUS VECTOR;

EID: 0030824640     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1997.8.10-1275     Document Type: Article
Times cited : (161)

References (47)
  • 1
    • 0029933513 scopus 로고    scopus 로고
    • LacZ gene transfer into tumor cells abrogates tumorigenicity and protects mice against the development of further tumors
    • ABINA, M.A., LEE, M.G., DESCAMPS, V., CORDIER, L., LOPEZ, M., PERRICAUDET, M., and HADDADA, H. (1996). LacZ gene transfer into tumor cells abrogates tumorigenicity and protects mice against the development of further tumors. Gene Ther. 3, 212-216.
    • (1996) Gene Ther. , vol.3 , pp. 212-216
    • Abina, M.A.1    Lee, M.G.2    Descamps, V.3    Cordier, L.4    Lopez, M.5    Perricaudet, M.6    Haddada, H.7
  • 4
    • 0028914687 scopus 로고
    • Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: Comparisons between immunocompetent and immunodeficient inbred strains
    • BARR, D., TUBB, J., FERGUSON, D., SCARIA, A., LIEBER, A., WILSON, C., PERKINS, J., and KAY, M.A. (1995). Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: Comparisons between immunocompetent and immunodeficient inbred strains. Gene Ther. 2, 151-155.
    • (1995) Gene Ther. , vol.2 , pp. 151-155
    • Barr, D.1    Tubb, J.2    Ferguson, D.3    Scaria, A.4    Lieber, A.5    Wilson, C.6    Perkins, J.7    Kay, M.A.8
  • 5
    • 0029971183 scopus 로고    scopus 로고
    • Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice
    • BULLARD, D.C., KUNKEL, E.J., KUBO, H., HICKS, M.J., LORENZO, I., DOYLE, N.A., DOERSCHUK, C.M., LEY, K., and BEAUDET, A.L. (1996). Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J. Exp. Med. 183, 2329-2336.
    • (1996) J. Exp. Med. , vol.183 , pp. 2329-2336
    • Bullard, D.C.1    Kunkel, E.J.2    Kubo, H.3    Hicks, M.J.4    Lorenzo, I.5    Doyle, N.A.6    Doerschuk, C.M.7    Ley, K.8    Beaudet, A.L.9
  • 7
    • 0029943193 scopus 로고    scopus 로고
    • Sustained expression of therapeutic levels of human factor VIII in mice
    • CONNELLY, S., GARDNER, J.M., LYONS, R.M., McCLELLAND, A., and KALEKO, M. (1996). Sustained expression of therapeutic levels of human factor VIII in mice. Blood 87, 4671-4677.
    • (1996) Blood , vol.87 , pp. 4671-4677
    • Connelly, S.1    Gardner, J.M.2    Lyons, R.M.3    McClelland, A.4    Kaleko, M.5
  • 8
    • 0028934815 scopus 로고
    • Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression
    • DAI, Y., SCHWARZ, E.M., GU, D., ZHANG, W., and SARVETNICK, N. (1995). Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression. Proc. Natl. Acad. Sci. USA 92, 1401-1405.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 1401-1405
    • Dai, Y.1    Schwarz, E.M.2    Gu, D.3    Zhang, W.4    Sarvetnick, N.5
  • 9
    • 0028905068 scopus 로고
    • The proximal promoter of the mouse loricrin gene contains a functional Ap-1 element and directs keratinocyte-specific but not differentiation-specific expression
    • DISEPIO, D., JONES, A., LONGLEY, M.A., BUNDMAN, D., ROTHNAGEL, J.A., and ROOP, D.R. (1995). The proximal promoter of the mouse loricrin gene contains a functional Ap-1 element and directs keratinocyte-specific but not differentiation-specific expression. J. Biol. Chem. 270, 10792-10799.
    • (1995) J. Biol. Chem. , vol.270 , pp. 10792-10799
    • Disepio, D.1    Jones, A.2    Longley, M.A.3    Bundman, D.4    Rothnagel, J.A.5    Roop, D.R.6
  • 11
    • 0028246338 scopus 로고
    • Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver
    • ENGELHARDT, J.F., YE, X., DORANZ, B., and WILSON, J.M. (1994a). Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc. Natl. Acad. Sci. USA 91, 6196-6200.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 6196-6200
    • Engelhardt, J.F.1    Ye, X.2    Doranz, B.3    Wilson, J.M.4
  • 12
    • 0028618419 scopus 로고
    • Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a
    • ENGELHARDT, J.F., LITZKY, L., and WILSON, J.M. (1994b). Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a. Hum. Gene Ther. 5, 1217-1229.
    • (1994) Hum. Gene Ther. , vol.5 , pp. 1217-1229
    • Engelhardt, J.F.1    Litzky, L.2    Wilson, J.M.3
  • 14
    • 0029966514 scopus 로고    scopus 로고
    • Recombinant adenovirus deleted of all viral genes for gene therapy of cystic fibrosis
    • FISHER, K.J., CHOI, H., BURDA, J., CHEN, S., and WILSON, J.M. (1996). Recombinant adenovirus deleted of all viral genes for gene therapy of cystic fibrosis. Virology 217, 11-22.
    • (1996) Virology , vol.217 , pp. 11-22
    • Fisher, K.J.1    Choi, H.2    Burda, J.3    Chen, S.4    Wilson, J.M.5
  • 15
    • 0028148752 scopus 로고
    • Percutaneous transluminal in vivo gene transfer by recombinant adenovirus in normal porcine coronary arteries, atherosclerotic arteries, and two models of coronary restenosis
    • FRENCH, B.A., MAZUR, W., ALI, N.M., GESKE, R.S., FINNIGAN, J.P., RODGERS, G.P., ROBERTS, R., and RAIZNER, A.E. (1994). Percutaneous transluminal in vivo gene transfer by recombinant adenovirus in normal porcine coronary arteries, atherosclerotic arteries, and two models of coronary restenosis. Circulation 90, 2402-2413.
    • (1994) Circulation , vol.90 , pp. 2402-2413
    • French, B.A.1    Mazur, W.2    Ali, N.M.3    Geske, R.S.4    Finnigan, J.P.5    Rodgers, G.P.6    Roberts, R.7    Raizner, A.E.8
  • 16
    • 0029091783 scopus 로고
    • Transfer of the CFTR gene to the lung of nonhuman primates with E1-deleted, E2a-defective recombinant adenoviruses: A preclinical toxicology study
    • GOLDMAN, M.J., LITZKY, L.A., ENGELHARDT, J.F., and WILSON, J.M. (1995). Transfer of the CFTR gene to the lung of nonhuman primates with E1-deleted, E2a-defective recombinant adenoviruses: A preclinical toxicology study. Hum. Gene Ther. 6, 839-851.
    • (1995) Hum. Gene Ther. , vol.6 , pp. 839-851
    • Goldman, M.J.1    Litzky, L.A.2    Engelhardt, J.F.3    Wilson, J.M.4
  • 17
    • 0031055468 scopus 로고    scopus 로고
    • Construction of adenovirus vectors through Cre-lox recombination
    • HARDY, S., KITAMURA, M., HARRIS-STANSIL, T., DAI, Y., and PHIPPS, M.L. (1997). Construction of adenovirus vectors through Cre-lox recombination. J. Virol. 71, 1842-1849.
    • (1997) J. Virol. , vol.71 , pp. 1842-1849
    • Hardy, S.1    Kitamura, M.2    Harris-Stansil, T.3    Dai, Y.4    Phipps, M.L.5
  • 18
    • 0028842611 scopus 로고
    • Interferon-gamma inhibits transgene expression driven by SV40 or CMV promoters but augments expression driven by the mammalian MHC 1 promoter
    • HARMS, J.S., and SPLITTER, G.A. (1995). Interferon-gamma inhibits transgene expression driven by SV40 or CMV promoters but augments expression driven by the mammalian MHC 1 promoter. Hum. Gene Ther. 6, 1291-1297.
    • (1995) Hum. Gene Ther. , vol.6 , pp. 1291-1297
    • Harms, J.S.1    Splitter, G.A.2
  • 20
    • 0027033259 scopus 로고
    • Hepatic gene therapy: Persistent expression of human alpha-1-antitrypsin in mice after direct gene delivery in vivo
    • KAY, M., LI, Q.T., LIU, T.J., LELAND, F., TOMAN, C., FINEGOLD, M., and WOO, S.L.C. (1992). Hepatic gene therapy: Persistent expression of human alpha-1-antitrypsin in mice after direct gene delivery in vivo. Hum. Gene Ther. 3, 641-647.
    • (1992) Hum. Gene Ther. , vol.3 , pp. 641-647
    • Kay, M.1    Li, Q.T.2    Liu, T.J.3    Leland, F.4    Toman, C.5    Finegold, M.6    Woo, S.L.C.7
  • 21
    • 0019813866 scopus 로고
    • Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis
    • KNODELL, R.G., ISHAK, K.G., BLACK, W.C., CHEN, T.S., CRAIG, R., KAPLOWITZ, N., KIERNAN, T.W., and WOLLMAN, J. (1981). Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1, 431-435.
    • (1981) Hepatology , vol.1 , pp. 431-435
    • Knodell, R.G.1    Ishak, K.G.2    Black, W.C.3    Chen, T.S.4    Craig, R.5    Kaplowitz, N.6    Kiernan, T.W.7    Wollman, J.8
  • 22
    • 0029943155 scopus 로고    scopus 로고
    • A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and β-galactosidase
    • KOCHANEK, S., CLEMENS, P.R., MITANI, K., CHEN, H.-H., CHAN, S., and CASKEY, C.T. (1996). A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and β-galactosidase. Proc. Natl. Acad. Sci. USA 93, 5731-5736.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 5731-5736
    • Kochanek, S.1    Clemens, P.R.2    Mitani, K.3    Chen, H.-H.4    Chan, S.5    Caskey, C.T.6
  • 23
    • 0029988465 scopus 로고    scopus 로고
    • Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene
    • KOZARSKY, K.F., JOOSS, K., DONAHEE, M., STRAUSS, J.F., and WILSON, J.M. (1996). Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene. Nature Genet. 13, 54-62.
    • (1996) Nature Genet. , vol.13 , pp. 54-62
    • Kozarsky, K.F.1    Jooss, K.2    Donahee, M.3    Strauss, J.F.4    Wilson, J.M.5
  • 24
    • 0029616020 scopus 로고
    • Development of cell lines capable of complementing E1, E4, and protein IX defective adenovirus type 5 mutants
    • KROUGLIAK, V., and GRAHAM, F.L. (1995). Development of cell lines capable of complementing E1, E4, and protein IX defective adenovirus type 5 mutants. Hum. Gene Ther. 6, 1575-1586.
    • (1995) Hum. Gene Ther. , vol.6 , pp. 1575-1586
    • Krougliak, V.1    Graham, F.L.2
  • 25
    • 0029861452 scopus 로고    scopus 로고
    • Recombinant adenoviruses with large deletions generated by cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo
    • LIEBER, A., HE, C., KIRILLOVA, I., and KAY, M.A. (1996). Recombinant adenoviruses with large deletions generated by cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo. J. Virol. 70, 8944-8960.
    • (1996) J. Virol. , vol.70 , pp. 8944-8960
    • Lieber, A.1    He, C.2    Kirillova, I.3    Kay, M.A.4
  • 26
    • 0023243262 scopus 로고
    • Histochemical staining of clonal mammalian cell lines expressing E. coli β-galactosidase indicate heterogeneous expression of the bacterial gene
    • MACGREGOR, G.R., MOGG, A.E., BURKE, J.F., and CASKEY, C.T. (1987). Histochemical staining of clonal mammalian cell lines expressing E. coli β-galactosidase indicate heterogeneous expression of the bacterial gene. Somatic Cell Mol. Genet. 13, 253-365.
    • (1987) Somatic Cell Mol. Genet. , vol.13 , pp. 253-365
    • Macgregor, G.R.1    Mogg, A.E.2    Burke, J.F.3    Caskey, C.T.4
  • 28
    • 0025884056 scopus 로고
    • Efficient selectin for high-expression transfectants with a novel eukaryotic vector
    • NIWA, H., YAMAMURA, K., and MIYAZAKI, J. (1991). Efficient selectin for high-expression transfectants with a novel eukaryotic vector. Gene 108, 193-200.
    • (1991) Gene , vol.108 , pp. 193-200
    • Niwa, H.1    Yamamura, K.2    Miyazaki, J.3
  • 29
    • 0028040836 scopus 로고
    • Gene therapy for vascular smooth muscle cell proliferation after arterial injury
    • OHNO, T., GORDON, D., SAN, H., POMPILI, V.J., IMPERIALE, M.J., NABEL, G.J., and NABEL, E.G. (1994). Gene therapy for vascular smooth muscle cell proliferation after arterial injury. Science 265, 781-784.
    • (1994) Science , vol.265 , pp. 781-784
    • Ohno, T.1    Gordon, D.2    San, H.3    Pompili, V.J.4    Imperiale, M.J.5    Nabel, G.J.6    Nabel, E.G.7
  • 30
    • 0030462599 scopus 로고    scopus 로고
    • A helper-dependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal
    • PARKS, R.J., CHEN, L., ANTON, M., SANKAR, U., RUDNICKI, M.A., and GRAHAM, F.L. (1996). A helper-dependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc. Natl. Acad. Sci. USA 93, 13565-13570.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13565-13570
    • Parks, R.J.1    Chen, L.2    Anton, M.3    Sankar, U.4    Rudnicki, M.A.5    Graham, F.L.6
  • 34
    • 0025487393 scopus 로고
    • Evaluation of the trnasfer and expression in mice of an enzyme-encoding code using a human adenovirus vector
    • STRATFORD-PERRICAUDET, L.D., LEVRERO, M., CHASSE, J., PERRICAUDET, M., and BRIAND, P. (1990). Evaluation of the trnasfer and expression in mice of an enzyme-encoding code using a human adenovirus vector. Hum. Gene Ther. 1, 241-256.
    • (1990) Hum. Gene Ther. , vol.1 , pp. 241-256
    • Stratford-Perricaudet, L.D.1    Levrero, M.2    Chasse, J.3    Perricaudet, M.4    Briand, P.5
  • 35
    • 0029936764 scopus 로고    scopus 로고
    • Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors
    • TRIPATHY, S.K., BLACK, H.B., GOLDWASSER, E., and LEIDEN, J.M. (1996). Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors. Nature Med. 2, 545-550.
    • (1996) Nature Med. , vol.2 , pp. 545-550
    • Tripathy, S.K.1    Black, H.B.2    Goldwasser, E.3    Leiden, J.M.4
  • 36
    • 0030910842 scopus 로고    scopus 로고
    • Adenovirus vector transfected cells can escape adenovirus antigen-specific CTL killing in vivo
    • in press
    • WADSWORTH, S., ZHOU, H., SMITH, A.E., and KAPLAN, J.M. (1997). Adenovirus vector transfected cells can escape adenovirus antigen-specific CTL killing in vivo. J. Virol. (in press).
    • (1997) J. Virol.
    • Wadsworth, S.1    Zhou, H.2    Smith, A.E.3    Kaplan, J.M.4
  • 37
    • 0029582770 scopus 로고
    • A packaging cell line for propagation of recombinant adenovirus vectors containing two lethal gene-region deletions
    • WANG, Q., JIA, X., and FINER, M.H. (1995). A packaging cell line for propagation of recombinant adenovirus vectors containing two lethal gene-region deletions. Gene Ther. 2, 775-783.
    • (1995) Gene Ther. , vol.2 , pp. 775-783
    • Wang, Q.1    Jia, X.2    Finer, M.H.3
  • 40
    • 0028229147 scopus 로고
    • Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis
    • YANG, Y., NUNES, F.A., BERENCSI, K., GÖNCZÖPL, E., ENGELHARDT, J.F., and WILSON, J.M. (1994b). Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. Nature Genet. 7, 362-369.
    • (1994) Nature Genet. , vol.7 , pp. 362-369
    • Yang, Y.1    Nunes, F.A.2    Berencsi, K.3    Gönczöpl, E.4    Engelhardt, J.F.5    Wilson, J.M.6
  • 41
    • 0028484704 scopus 로고
    • MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses
    • YANG, Y., ERTL, H.C., and WILSON, J.M. (1994c). MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity 1, 433-442.
    • (1994) Immunity , vol.1 , pp. 433-442
    • Yang, Y.1    Ertl, H.C.2    Wilson, J.M.3
  • 42
    • 0028937785 scopus 로고
    • Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses
    • YANG, Y., LI, Q., ERTL, H.C.J., and WILSON, J.M. (1995). Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 69, 2004-2015.
    • (1995) J. Virol. , vol.69 , pp. 2004-2015
    • Yang, Y.1    Li, Q.2    Ertl, H.C.J.3    Wilson, J.M.4
  • 43
    • 0029836503 scopus 로고    scopus 로고
    • Role of viral antigens in destructive cellular immune responses to adenovirus vector-transduced cells in mouse lungs
    • YANG, Y., SU, Q., and WILSON, J.M. (1996a). Role of viral antigens in destructive cellular immune responses to adenovirus vector-transduced cells in mouse lungs. J. Virol. 70, 7209-7212.
    • (1996) J. Virol. , vol.70 , pp. 7209-7212
    • Yang, Y.1    Su, Q.2    Wilson, J.M.3
  • 44
    • 9244220682 scopus 로고    scopus 로고
    • Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo
    • YANG, Y., JOOSS, K.U., SU, Q., ERTL, H.C.J., and WILSON, J.M. (1996b). Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo. Gene Ther. 3, 137-144.
    • (1996) Gene Ther. , vol.3 , pp. 137-144
    • Yang, Y.1    Jooss, K.U.2    Su, Q.3    Ertl, H.C.J.4    Wilson, J.M.5
  • 45
    • 0029825458 scopus 로고    scopus 로고
    • Immunology of gene therapy with adenoviral vectors in mouse skeletal muscle
    • YANG, Y., HAECKER, S.E., SU, Q., and WILSON, J.M. (1996c). Immunology of gene therapy with adenoviral vectors in mouse skeletal muscle. Hum. Mol. Genet. 5, 1703-1712.
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 1703-1712
    • Yang, Y.1    Haecker, S.E.2    Su, Q.3    Wilson, J.M.4
  • 46
    • 0029843063 scopus 로고    scopus 로고
    • Development of a complementing cell line and a system for construction of adenoviral vectors deleted for E1 and E2a
    • ZHOU, H., O'NEAL, W., MORRAL, N., and BEAUDET, A.L. (1996). Development of a complementing cell line and a system for construction of adenoviral vectors deleted for E1 and E2a. J. Virol. 70, 7030-7038.
    • (1996) J. Virol. , vol.70 , pp. 7030-7038
    • Zhou, H.1    O'Neal, W.2    Morral, N.3    Beaudet, A.L.4
  • 47
    • 0028991829 scopus 로고
    • Persistence of replication-deficient adenovirus-mediated gene transfer in lungs of immune-deficient (nu/nu) mice
    • ZSENGELLER, Z.K., WERT, S.E., HULL, W.M., HU, X., YEI, S., TRAPNELL, B.C., and WHITSETT, J.A. (1995). Persistence of replication-deficient adenovirus-mediated gene transfer in lungs of immune-deficient (nu/nu) mice. Hum. Gene Ther. 6, 457-467.
    • (1995) Hum. Gene Ther. , vol.6 , pp. 457-467
    • Zsengeller, Z.K.1    Wert, S.E.2    Hull, W.M.3    Hu, X.4    Yei, S.5    Trapnell, B.C.6    Whitsett, J.A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.