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Volumn 70, Issue 12, 1996, Pages 8934-8943

Biology of adenovirus vectors with E1 and E4 deletions for liver- directed gene therapy

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; GENE PRODUCT; VIRUS PROTEIN; VIRUS VECTOR;

EID: 0029959867     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.12.8934-8943.1996     Document Type: Article
Times cited : (340)

References (49)
  • 2
    • 0028914687 scopus 로고
    • Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: Comparisons between immunocompetent and immunodeficient inbred strains
    • Barr, D., J. Tubb, D. Ferguson, A. Scaria, A. Lieber, C. Wilson, J. Perkins, and M. Kay. 1995. Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains. Gene Ther, 2:151-155.
    • (1995) Gene Ther , vol.2 , pp. 151-155
    • Barr, D.1    Tubb, J.2    Ferguson, D.3    Scaria, A.4    Lieber, A.5    Wilson, C.6    Perkins, J.7    Kay, M.8
  • 3
    • 0024571586 scopus 로고
    • Redundant control of adenovirus late gene expression by early region 4
    • Bridge, E., and G. Ketner. 1989. Redundant control of adenovirus late gene expression by early region 4. J. Virol. 63:631-638.
    • (1989) J. Virol. , vol.63 , pp. 631-638
    • Bridge, E.1    Ketner, G.2
  • 4
    • 0030069229 scopus 로고    scopus 로고
    • High-level tissue-specific expression of functional human factor VIII in mice
    • Connelly, S., J. M. Gardner, A. McClelland, and M. Kaleko. 1996. High-level tissue-specific expression of functional human factor VIII in mice. Hum. Gene Ther. 7:183-195.
    • (1996) Hum. Gene Ther. , vol.7 , pp. 183-195
    • Connelly, S.1    Gardner, J.M.2    McClelland, A.3    Kaleko, M.4
  • 5
    • 0023114593 scopus 로고
    • Analysis of adenovirus early region 4-encoded polypeptides synthesized in productively infected cells
    • Cutt, J. R., T. Shenk, and P. Hearing. 1987. Analysis of adenovirus early region 4-encoded polypeptides synthesized in productively infected cells. J. Virol. 61:543-552.
    • (1987) J. Virol. , vol.61 , pp. 543-552
    • Cutt, J.R.1    Shenk, T.2    Hearing, P.3
  • 6
    • 0028934815 scopus 로고
    • Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression
    • Dai, Y., E. Schwartz, D. Gu, W. Zhang, N. Sarvetnick, and I. Verma. 1995. Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression. Proc. Natl. Acad. Sci. USA 92:1401-1405.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 1401-1405
    • Dai, Y.1    Schwartz, E.2    Gu, D.3    Zhang, W.4    Sarvetnick, N.5    Verma, I.6
  • 7
    • 0030001373 scopus 로고    scopus 로고
    • Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor
    • Dobner, T., N. Horikoshi, S. Rubenwolf, and T. Shenk. 1996. Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor. Science 272:1470-1473.
    • (1996) Science , vol.272 , pp. 1470-1473
    • Dobner, T.1    Horikoshi, N.2    Rubenwolf, S.3    Shenk, T.4
  • 8
    • 0028618419 scopus 로고
    • Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a
    • Engelhardt, J., L. Litzky, and J. Wilson. 1994. Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a. Hum. Gene Ther. 5:1217-1229.
    • (1994) Hum. Gene Ther. , vol.5 , pp. 1217-1229
    • Engelhardt, J.1    Litzky, L.2    Wilson, J.3
  • 10
    • 0029923638 scopus 로고    scopus 로고
    • Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors
    • Ferrari, F. K., T. Samulski, T. Shenk, and R, J. Samulski. 1996. Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors. J. Virol. 70:3227-3234.
    • (1996) J. Virol. , vol.70 , pp. 3227-3234
    • Ferrari, F.K.1    Samulski, T.2    Shenk, T.3    Samulski, R.J.4
  • 11
    • 0029655894 scopus 로고    scopus 로고
    • Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis
    • Fisher, K. J., G.-P. Gao, M. D. Weitzman, R. DeMatteo, J. F. Burda, and J. M. Wilson. 1996. Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis. J. Virol, 70:520-532.
    • (1996) J. Virol , vol.70 , pp. 520-532
    • Fisher, K.J.1    Gao, G.-P.2    Weitzman, M.D.3    DeMatteo, R.4    Burda, J.F.5    Wilson, J.M.6
  • 12
    • 0025992469 scopus 로고
    • Promoter traps in embryonic stem cells: A genetic screen to identify and mutate developmental genes in mice
    • Friedrich, G., and P. Soriano. 1991. Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 5:1513-1523.
    • (1991) Genes Dev. , vol.5 , pp. 1513-1523
    • Friedrich, G.1    Soriano, P.2
  • 13
    • 0027409026 scopus 로고
    • Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice
    • Herz, J., and R. Gerard. 1993. Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc. Natl. Acad. Sci. USA 90:2812-2816.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 2812-2816
    • Herz, J.1    Gerard, R.2
  • 14
    • 0024344731 scopus 로고
    • Adenovirus early region 4 encodes two gene products with redundant effects in lytic infection
    • Huang, M. M., and P. Hearing. 1989. Adenovirus early region 4 encodes two gene products with redundant effects in lytic infection. J. Virol. 63:2605-2615.
    • (1989) J. Virol. , vol.63 , pp. 2605-2615
    • Huang, M.M.1    Hearing, P.2
  • 15
    • 0024756945 scopus 로고
    • The adenovirus early region 4 open reading frame 6/7 protein regulates the DNA binding activity of the cellular transcription factor, E2F, through a direct complex
    • Huang, M. M., and P. Hearing. 1989. The adenovirus early region 4 open reading frame 6/7 protein regulates the DNA binding activity of the cellular transcription factor, E2F, through a direct complex. Genes Dev. 3:1699-1710.
    • (1989) Genes Dev. , vol.3 , pp. 1699-1710
    • Huang, M.M.1    Hearing, P.2
  • 16
    • 0027258140 scopus 로고
    • Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
    • Ishibashi, S., M. Brown, J. Goldstein, R. Gerard, R. Hammer, and J. Herz. 1993. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J. Clin. Invest. 92:883-893.
    • (1993) J. Clin. Invest. , vol.92 , pp. 883-893
    • Ishibashi, S.1    Brown, M.2    Goldstein, J.3    Gerard, R.4    Hammer, R.5    Herz, J.6
  • 19
    • 0029743163 scopus 로고    scopus 로고
    • Cyclophosphamide diminishes inflammation and prolongs transgene expression following delivery of adenoviral vectors to mouse liver and lung
    • in press
    • Jooss, K., Y. Yang, and J. M. Wilson. Cyclophosphamide diminishes inflammation and prolongs transgene expression following delivery of adenoviral vectors to mouse liver and lung. Hum. Gene Ther., in press.
    • Hum. Gene Ther.
    • Jooss, K.1    Yang, Y.2    Wilson, J.M.3
  • 20
    • 0028899573 scopus 로고
    • Therapeutic serum concentrations of human alpha-1-antitrypsin after adenoviral-mediated gene transfer into mouse hepatocytes
    • Kay, M., F. Graham, F. Leland, and S. Woo. 1995. Therapeutic serum concentrations of human alpha-1-antitrypsin after adenoviral-mediated gene transfer into mouse hepatocytes. Hepatology 21:815-819.
    • (1995) Hepatology , vol.21 , pp. 815-819
    • Kay, M.1    Graham, F.2    Leland, F.3    Woo, S.4
  • 22
    • 0027360098 scopus 로고
    • Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1 A-enhanced junB transcription
    • Kleinberger, T., and T. Shenk. 1993. Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1 A-enhanced junB transcription. J. Virol. 67:7556-7560.
    • (1993) J. Virol. , vol.67 , pp. 7556-7560
    • Kleinberger, T.1    Shenk, T.2
  • 23
    • 0027723616 scopus 로고
    • Adenovirus-mediated correction of the genetic defect in hepatocytes from patients with familial hypercholesterolemia
    • Kozarsky, K., M. Grossman, and J. Wilson. 1993. Adenovirus-mediated correction of the genetic defect in hepatocytes from patients with familial hypercholesterolemia. Somatic Cell Mol. Genet. 19:449-45
    • (1993) Somatic Cell Mol. Genet. , vol.19 , pp. 449-545
    • Kozarsky, K.1    Grossman, M.2    Wilson, J.3
  • 24
    • 0028234357 scopus 로고
    • In vivo correction of LDL receptor deficiency in the watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses
    • Kozarsky, K., D. McKinley, L. Austin, S. Raper, L. Stratford-Perricaudet, and J. Wilson. 1994. In vivo correction of LDL receptor deficiency in the watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses. J. Biol. Chem. 269:13695-13702.
    • (1994) J. Biol. Chem. , vol.269 , pp. 13695-13702
    • Kozarsky, K.1    McKinley, D.2    Austin, L.3    Raper, S.4    Stratford-Perricaudet, L.5    Wilson, J.6
  • 25
    • 0029988465 scopus 로고    scopus 로고
    • Effective treatment of familial hypercholesterolemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene
    • Kozursky K. F., M. Donahee, K. Jooss, J. F. Strauss, and J. M. Wilson. 1996. Effective treatment of familial hypercholesterolemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene. Nat. Genet. 13:54-62.
    • (1996) Nat. Genet. , vol.13 , pp. 54-62
    • Kozursky, K.F.1    Donahee, M.2    Jooss, K.3    Strauss, J.F.4    Wilson, J.M.5
  • 26
    • 0029616020 scopus 로고
    • Development of cell lines capable of complementing El, E4, and protein IX defective adenovirus type 5 mutants
    • Krougliak, V., and F. L. Graham. 1995. Development of cell lines capable of complementing El, E4, and protein IX defective adenovirus type 5 mutants. Hum. Gene Ther. 6:1575-1586.
    • (1995) Hum. Gene Ther. , vol.6 , pp. 1575-1586
    • Krougliak, V.1    Graham, F.L.2
  • 28
    • 0025267802 scopus 로고
    • The adenovirus E4 17-kilodalton protein complexes with the cellular transcription factor E2F, altering its DNA-binding properties and stimulating EA-independent accumulation of E2 mRNA
    • Marton, M. J., S. B. Bairn, D. A. Ornelles, and T. Shenk. 1990. The adenovirus E4 17-kilodalton protein complexes with the cellular transcription factor E2F, altering its DNA-binding properties and stimulating EA-independent accumulation of E2 mRNA. J. Virol. 64:2345-2359.
    • (1990) J. Virol. , vol.64 , pp. 2345-2359
    • Marton, M.J.1    Bairn, S.B.2    Ornelles, D.A.3    Shenk, T.4
  • 29
    • 0027272371 scopus 로고
    • Efficient adenoviral-mediated ornithine transcarhamylase expression in deficient mouse and human hepatocytes
    • Morsy, M. A., E. L. Alford, A. Bett, F. L. Graham, and C. T. Caskey. 1993. Efficient adenoviral-mediated ornithine transcarhamylase expression in deficient mouse and human hepatocytes. J. Clin. Invest. 92:1580-1586.
    • (1993) J. Clin. Invest. , vol.92 , pp. 1580-1586
    • Morsy, M.A.1    Alford, E.L.2    Bett, A.3    Graham, F.L.4    Caskey, C.T.5
  • 30
    • 0026669557 scopus 로고
    • Adenovirus E4orf4 protein reduces phosphorylation of c-Fos and EA proteins while simultaneously reducing the level of AP-I
    • Muller, U., T. Kleinberger, and T. Shenk. 1992, Adenovirus E4orf4 protein reduces phosphorylation of c-Fos and EA proteins while simultaneously reducing the level of AP-I. J. Virol. 66:5867-5878.
    • (1992) J. Virol. , vol.66 , pp. 5867-5878
    • Muller, U.1    Kleinberger, T.2    Shenk, T.3
  • 31
    • 0025213545 scopus 로고
    • An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F
    • Neill, S. D., C. Hemstrom, A. Virtanen, and J. R. Nevins. 1990. An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F. Proc. Natl. Acad. Sci. USA 87:2008-2012.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 2008-2012
    • Neill, S.D.1    Hemstrom, C.2    Virtanen, A.3    Nevins, J.R.4
  • 32
    • 0027976793 scopus 로고
    • The adenovirus E4-6/7 protein transactivates the E2 promoter by inducing dimerization of a heteromeric E2F complex
    • Obert, S., R. J. O'Connor, S. Schmid, and P. Hearing. 1994. The adenovirus E4-6/7 protein transactivates the E2 promoter by inducing dimerization of a heteromeric E2F complex. Mol. Cell. Biol. 14:1333-1346.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 1333-1346
    • Obert, S.1    O'Connor, R.J.2    Schmid, S.3    Hearing, P.4
  • 34
    • 0029936764 scopus 로고    scopus 로고
    • Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors
    • Tripathy, S. K., H. B. Black, E. Goldwasser, and J. M. Leiden. 1996. Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors. Nat. Med. 2:545-550.
    • (1996) Nat. Med. , vol.2 , pp. 545-550
    • Tripathy, S.K.1    Black, H.B.2    Goldwasser, E.3    Leiden, J.M.4
  • 35
    • 0029145960 scopus 로고
    • Intratracheal gene delivery with adenoviral vector induces elevated systemic IgG and mucosal IgA antibodies to adenovirus and β-galactosidase
    • Van Ginkel, F., C. Liu, J. Simecka, J. Dong, T. Greenway, R. Frizzell, H. Kiyono, J. McGhee, and D. Pascual. 1995. Intratracheal gene delivery with adenoviral vector induces elevated systemic IgG and mucosal IgA antibodies to adenovirus and β-galactosidase. Hum. Gene Ther. 6:895-903.
    • (1995) Hum. Gene Ther. , vol.6 , pp. 895-903
    • Van Ginkel, F.1    Liu, C.2    Simecka, J.3    Dong, J.4    Greenway, T.5    Frizzell, R.6    Kiyono, H.7    McGhee, J.8    Pascual, D.9
  • 36
    • 0029582770 scopus 로고
    • A packaging cell line for propogation of recombinant adenovirus vectors containing two lethal generegion deletions
    • Wang, Q., X.-C. Jia, and M. H. Finer. 1995. A packaging cell line for propogation of recombinant adenovirus vectors containing two lethal generegion deletions. Gene Ther. 2:775-783.
    • (1995) Gene Ther. , vol.2 , pp. 775-783
    • Wang, Q.1    Jia, X.-C.2    Finer, M.H.3
  • 37
    • 0020822949 scopus 로고
    • A cell line that supports the growth of a defective early region 4 deletion mutant of human adenovirus type 2
    • Weinberg, D. H., and G. Ketner. 1983. A cell line that supports the growth of a defective early region 4 deletion mutant of human adenovirus type 2. Proc. Natl. Acad. Sci. USA 80:5383-5386.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 5383-5386
    • Weinberg, D.H.1    Ketner, G.2
  • 38
    • 0028484704 scopus 로고
    • MHC class 1 restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1 deleted recombinant adenoviruses
    • Yang, Y., H. Ertl, and J. Wilson. 1994. MHC class 1 restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1 deleted recombinant adenoviruses. Immunity 1:433-442.
    • (1994) Immunity , vol.1 , pp. 433-442
    • Yang, Y.1    Ertl, H.2    Wilson, J.3
  • 39
    • 0029825458 scopus 로고    scopus 로고
    • Immunology of gene therapy with adenoviral vectors in mouse skeletal muscle
    • in press
    • Yang, Y., S. E. Haecker, Q. Su, and J. M. Wilson. Immunology of gene therapy with adenoviral vectors in mouse skeletal muscle. Hum. Mol. Genet., in press.
    • Hum. Mol. Genet.
    • Yang, Y.1    Haecker, S.E.2    Su, Q.3    Wilson, J.M.4
  • 40
    • 9244220682 scopus 로고    scopus 로고
    • Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo
    • Yang, Y., K. U. Jooss, Q. Su, H. C, J. Ertl, and J. M. Wilson. 1996. Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo. Gene Ther. 3:137-144.
    • (1996) Gene Ther. , vol.3 , pp. 137-144
    • Yang, Y.1    Jooss, K.U.2    Su, Q.3    Ertl, H.C.J.4    Wilson, J.M.5
  • 41
    • 0028937785 scopus 로고
    • Cellular and humoral immune responses to viral antigens create harriers to lung-directed gene therapy with recombinant adenoviruses
    • Yang, Y., Q. Li, H. Ertl, and J. Wilson. 1995. Cellular and humoral immune responses to viral antigens create harriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 69:2004-2015.
    • (1995) J. Virol. , vol.69 , pp. 2004-2015
    • Yang, Y.1    Li, Q.2    Ertl, H.3    Wilson, J.4
  • 43
    • 0028229147 scopus 로고
    • Inactivalion of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis
    • Yang, Y., F. Nunes, K. Berencsi, E. Gønczøl, J. Engelhardt, and J. Wilson. 1994. Inactivalion of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. Nature Genet. 7:362-369.
    • (1994) Nature Genet. , vol.7 , pp. 362-369
    • Yang, Y.1    Nunes, F.2    Berencsi, K.3    Gønczøl, E.4    Engelhardt, J.5    Wilson, J.6
  • 44
    • 0029093070 scopus 로고
    • Upregulation of class I MHC antigens by interferon-γ is necessary for the T cell-mediated elimination of recombinant adenovirus infected hepatocytes in vivo
    • Yang, Y., Z. Xiang, H. C. J. Ertl, and J. M. Wilson. 1995. Upregulation of class I MHC antigens by interferon-γ is necessary for the T cell-mediated elimination of recombinant adenovirus infected hepatocytes in vivo. Proc. Natl. Acad. Sci. USA 92:7257-7261.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7257-7261
    • Yang, Y.1    Xiang, Z.2    Ertl, H.C.J.3    Wilson, J.M.4
  • 45
    • 0030042794 scopus 로고    scopus 로고
    • Prolonged metabolic correction in adult ornithine transcarbamylase deficient mice with adenoviral vectors
    • Ye, X., M. B. Robinson, M. L. Batshaw, E. E. Furth, I. Smith, and J. M. Wilson. 1996. Prolonged metabolic correction in adult ornithine transcarbamylase deficient mice with adenoviral vectors. J. Biol. Chem. 271:3639-3946.
    • (1996) J. Biol. Chem. , vol.271 , pp. 3639-3946
    • Ye, X.1    Robinson, M.B.2    Batshaw, M.L.3    Furth, E.E.4    Smith, I.5    Wilson, J.M.6
  • 46
    • 0029655456 scopus 로고    scopus 로고
    • Efficient dual transcomplementation of adenovirus El and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit
    • Yeh, P., J.-F. Dedieu, C. Orsini, E. Vigne, P. Denefle, and M. Perricaudet. 1996. Efficient dual transcomplementation of adenovirus El and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit. J. Virol. 70:559-565.
    • (1996) J. Virol. , vol.70 , pp. 559-565
    • Yeh, P.1    Dedieu, J.-F.2    Orsini, C.3    Vigne, E.4    Denefle, P.5    Perricaudet, M.6
  • 47
    • 0028429545 scopus 로고
    • Adenovirus-mediated gene transfer for cystic fibrosis: Quantitative evaluation of repeated in vivo vector administration to the lung
    • Yei, S., N. Mittereder, K. Tang, C. O'Sullivan, and B. C. Trapnell. 1994. Adenovirus-mediated gene transfer for cystic fibrosis: quantitative evaluation of repeated in vivo vector administration to the lung. Gene Ther. 1:192-200.
    • (1994) Gene Ther. , vol.1 , pp. 192-200
    • Yei, S.1    Mittereder, N.2    Tang, K.3    O'Sullivan, C.4    Trapnell, B.C.5
  • 48
    • 10344244697 scopus 로고    scopus 로고
    • Immune responses to viruses
    • D. D. Richman, R. J. Whitely. and F. G. Hayden (ed.), Churchill Livingstone, Edinburgh
    • Yewdell, J. W., and J. R. Bennink. Immune responses to viruses. In D. D. Richman, R. J. Whitely. and F. G. Hayden (ed.), Clinical virology. Churchill Livingstone, Edinburgh.
    • Clinical Virology
    • Yewdell, J.W.1    Bennink, J.R.2
  • 49
    • 0028991829 scopus 로고
    • Persistence of replication-deficient adenovirus-mediated gene transfer in lungs of immune-deficient (nu/nu) mice
    • Zsengeller, Z., S. Wert, W. Hull, X. Hu, S. Yei, B. Trapnell, and J. Whitsett. 1995. Persistence of replication-deficient adenovirus-mediated gene transfer in lungs of immune-deficient (nu/nu) mice. Human Gene Ther. 6:457-467.
    • (1995) Human Gene Ther. , vol.6 , pp. 457-467
    • Zsengeller, Z.1    Wert, S.2    Hull, W.3    Hu, X.4    Yei, S.5    Trapnell, B.6    Whitsett, J.7


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