Development of a novel scintillation proximity competitive hybridization assay for the determination of phosphorothioate antisense oligonucleotide plasma concentrations in a toxicokinetic study

Analytical Biochemistry

Volumn 233, Issue 2, 1996, Pages 228-233

  De Serres, Mark ^a   McNulty, Michael J ^a   Christensen, Laura ^b   Gerald, Zon ^b   Findlay, John W A ^a  

^a GLAXOSMITHKLINE   (United States)

^b ILLUMINA INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INVERSE PROBLEMS; NUCLEIC ACIDS; OLIGONUCLEOTIDES; PROTEINS;

ANTISENSE OLIGONUCLEOTIDES; BINDING COMPLEXES; COMPETITIVE HYBRIDIZATION; INVERSE RELATIONSHIP; PATHOLOGICAL DISORDERS; PHOSPHOROTHIOATES; PHYSICAL SEPARATION; PLASMA CONCENTRATION;

SCINTILLATION;

OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE;

ANIMAL CELL; ARTICLE; BASE PAIRING; COMPETITIVE INHIBITION; CORONARY ARTERY DILATATION; CROSS REACTION; HYBRIDIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; RADIOIMMUNOASSAY; RHESUS MONKEY; SCINTILLATION COUNTING; TOXICOKINETICS;

ANIMALIA; MACACA MULATTA;

EID: 0030026790     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1006/abio.1996.0033     Document Type: Article

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