Potent and selective inhibition of gene expression by an antisense heptanucleotide

Nature Biotechnology

Volumn 14, Issue 7, 1996, Pages 840-844

  Wagner, Richard W ^a   Matteucci, Mark D ^a   Grant, Deborah ^a   Huang, Teresa ^a   Froehler, Brian C ^a  

^a GILEAD SCIENCES   (United States)

Author keywords

C 5 propyne; Oligonucleotide; Phosphorothioate; RNA structure; RNase

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; PHOSPHOROTHIOIC ACID; PYRIMIDINE; RIBONUCLEASE H; RNA;

ARTICLE; DRUG POTENCY; DRUG SPECIFICITY; DRUG SYNTHESIS; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; NONHUMAN; PRIORITY JOURNAL; RNA STRUCTURE;

ANIMALS; BASE SEQUENCE; CELL LINE; CERCOPITHECUS AETHIOPS; COST-BENEFIT ANALYSIS; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES, ANTISENSE; RIBONUCLEASE H, CALF THYMUS; RNA;

EID: 0029943016     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt0796-840     Document Type: Article

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