Immunostimulatory CpG-oligodeoxynucleotides cause extramedullary murine hemopoiesis

Journal of Immunology

Volumn 162, Issue 4, 1999, Pages 2368-2374

  Sparwasser, Tim ^a   Hültner, Lothar ^b   Koch, Eva Sophie ^a   Arne, Luz ^b   Lipford, Grayson B ^a   Wagner, Hermann ^a,c  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c Inst Med Microbiol Immunol Hyg   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI LIPOPOLYSACCHARIDE; OLIGODEOXYNUCLEOTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; BONE MARROW SUPPRESSION; BURST FORMING UNIT E; CELL COUNT; COLONY FORMING UNIT GM; CONTROLLED STUDY; CPG ISLAND; CYTOTOXIC T LYMPHOCYTE; ERYTHROID PRECURSOR CELL; EXTRAMEDULLARY HEMATOPOIESIS; FEMALE; FLOW CYTOMETRY; IMMUNOSTIMULATION; INFECTION RESISTANCE; IRRADIATION; LISTERIA MONOCYTOGENES; LISTERIOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN WEIGHT; SPLENOMEGALY;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BONE MARROW; COLONY-FORMING UNITS ASSAY; CPG ISLANDS; FEMALE; HEMATOPOIESIS, EXTRAMEDULLARY; HEMATOPOIETIC STEM CELLS; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, SCID; OLIGODEOXYRIBONUCLEOTIDES; RADIATION CHIMERA; RADIATION-PROTECTIVE AGENTS; SPLENOMEGALY;

EID: 0344436049     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Tokunaga, T., H. Yamamoto, S. Shimada, H. Abe, T. Fukada, Y. Fujisawa, Y. Furutani, O. Yano, T. Kataoka, T. Sudo, N. Makiguchi, and T. Suganuma. 1984. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG: isolation, physicochemical characterization, and antitumor activity. J. Natl. Cancer Inst. 72:955.
2. Tokunaga, T., O. Yano, E. Kuramoto, Y. Kimura, T. Yamamoto, T. Kataoka, and S. Yamamoto. 1992. Synthetic oligonucleotides with particular base sequences from the cDNA-encoding proteins of Mycobacterium bovis BCG induce interferons and activate natural killer cells. Microbiol. Immunol. 36:55.
3. Messina, J. P., G. S. Gilkeson, and D. S. Pisetsky. 1991. Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. J. immunol. 147:1759.
4. Krieg, A. M., A. K. Yi, S. Matson, T. J. Waldschmidt, G. A. Bishop, R. Teasdale, G. A. Koretzky, and D. M. Klinman. 1995. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374:546.
5. Sparwasser, T., T. Miethke, G. Lipford, K. Borschert, H. Häcker, K. Heeg, and H. Wagner. 1997. Bacterial DNA causes septic shock. Nature 386:336.
6. Sparwasser, T., T. Miethke, G. Lipford, A. Erdmann, H. Haecker, K. Heeg, and H. Wager. 1997. Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-α-mediated shock. Eur. J. Immunol. 27:1671.
7. Sparwasser, T., E.-S. Koch, R. M. Vabulas, G. B. Lipford, K. Heeg, J. W. Ellwart, and H. Wagner. 1998. Bacterial DNA and immunostimulalory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur. J. Immunol. 28:2045.
8. Stacey, K. J., M. J. Sweet, and D. A. Hume. 1996. Macrophages ingest and are activated by bacterial DNA. J. Immunol. 157:2116.
9. Häcker, H., H. Mischak, T. Miethke, S. Liptay, R. Schmid, T. Sparwasser, K. Heeg, G. B. Lipford, and H. Wagner. 1998. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J. 17:6230.
10. Lipford, G. B., M. Bauer, C. Blank, R. Reiter, H. Wagner, and K. Heeg. 1997. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants. Eur. J. Immunol. 27:2340.
11. Chu, R. S., O. S. Targoni, A. M. Krieg, P. V. Lehmann, and C. V. Harding. 1997. CpG oligodeoxynucleotides act as adjuvants that switch on T helper (Th1) immunity. J. Exp. Med. 186:1623.
12. Lipford, G. B., T. Sparwasser, M. Bauer, S. Zimmermann, E.-S. Koch, K. Heeg, and H. Wagner. 1997. Immunostimulatory DNA: sequence-dependent production of potentially harmful or useful cytokines. Eur. J. Immunol. 27:3420.
13. Zimmermann, S., O. Egeter, S. Hausmann, G. B. Lipford, M. Röcken, H. Wagner, and K. Heeg. 1998. CpG oligonucleotides trigger curative Th1 responses in lethal murine leishmaniasis. J. Immunol. 160:3627.
14. Bird, A. 1992. The essentials of DNA methylation. Cell 70:5.
15. Doerfler, W. 1991. Patterns of DNA methylation: evolutionary vestiges of foreign DNA inactivation as a host defense mechanism. Biol. Chem. Hoppe Seyler 372: 557.
16. Pisetsky, D. S. 1996. Immune activation by bacterial DNA: a new genetic code. Immunity 5:303.
17. Pisetsky, D. S. 1997. Immunostimulatory DNA: a clear and present danger? Nat. Med. 3:829.
18. Pugin, J., D. Heumann, A. Tomasz, V. Kravchenko, Y. Akamatsu, M. Nishijimi, M.-P. Glauser, P. S. Tobias, and R. J. Ulevitch. 1994. CD14 is a pattern recognition receptor. Immunity 1:509.
19. Apte, R. N., C. Galanos, and D. H. Pluznik. 1976. Lipid A, the active part of bacterial endotoxins in inducing serum colony-stimulating activity and proliferation of splenic granulocyte/macrophage progenitor cells. J. Cell Physiol. 87:71.
20. Apte, R. N., and D. H. Pluznik. 1976. Control mechanisms of endotoxin and particulate material stimulation of hemopoietic colony-forming cell differentiation. Exp. Hematol. 4:10.
21. Staber, F. G., and D. Metcalf. 1980. Cellular and molecular basis of the increased splenic hemopoiesis in mice treated with bacterial cell wall components. Proc. Natl. Acad. Sci. USA 77:4322.
22. + cytotoxic T cells. Vaccine 12:73.
23. Reisbach, G., J. Bartke, B. Kempkes, G. Kostka, J. Ellwart, A. Birner, K. Thalmeier, R. Mailhammer, G. W. Bornkamm, A. Ullrich, and P. Dörmer. 1993. Characterization of hemopoietic cell populations from human cord blood expressing c-kit. J. Exp. Hematol. 21:74.
24. Karasuyama, H., and F. Melchers. 1988. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4. or 5, using modified cDNA expression vectors. Eur. J. Immunol. 18:97.
25. Hültner, L., J. Moeller, F. Schmitt, G. Jäger, G. Reisbach, J. Ring, and P. Dörmer. 1989. Thiol-sensitive mast cell lines derived from mouse bone marrow respond to a mast cell growth-enhancing activity different from IL-3 and IL-4. J. Immunol. 142:3440.
26. Staber, F. G., L. Hültner, F. Marcucci, and P. H. Krammer. 1982. Production of colony-stimulating factors by murine T cells in limiting-dilution and long-term cultures. Nature 298:79.
27. Till, J. E., and E. A. McCulloch. 1961. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat. Res. 14:213.
28. McIntyre, K. W., K. Lombard-Gillooly, J. R. Perez, C. Karsch, U. M. Sarmiento, J. D. Larigan, K. T. Landreth, and R. Narayanan. 1993. A sense phosphorothioate oligonucleotide directed to the initiation codon of transcription factor NF-κB p65 causes sequence-specific immune stimulation. Antisense Res. Dev. 3:309.
29. Branda, R. F., A. L. Moore, L. Mathews, J. J. McCormack, and G. Zon. 1993. Immune stimulation by an antisense oligomer complementary to the rev gene of HIV-1. Biochem. Pharmacol. 45:2037.
30. Morrison, S. J., N. Uchida, and I. L. Weissman. 1995. The biology of hematopoietic stem cells. Annu. Rev. Cell Dev. Biol. 11:35.
31. Spangrade, G. J., S. Heimfeld, and I. L. Weissman. 1988. Purification and characterization of mouse hematopoietic stem cells. Science 241:58.
32. -/- mice: protection despite absence of ROI and susceptibility despite presence of RNI. Immunity 7:419.
33. Halpern, M. D., R. J. Kurlander, and D. S. Pisetsky. 1996. Bacterial DNA induces murine interferon-γ production by stimulation of interleukin-12 and tumor necrosis factor-α. Cell Immunol. 167:72.
34. Chace, J. H., N. A. Hooker, K. L. Mildenstein, A. M. Krieg, and J. S. Cowdery. 1997. Bacterial DNA-induced NK cell IFN-γ production is dependent on macrophage secretion of IL-12. Clin. Immunol. Immunopathol. 84:185.
35. Roman, M., E. Martin-Orozco, J. S. Goodman, M.-D. Nguyen, Y. Sato, A. Ronaghy, R. S. Kombluth, D. D. Richman, D. A. Carson, and E. Raz. 1997. Immunostimulatory DNA sequences function as Th1-promoting adjuvants. Nat. Med. 3:849.
36. McNeill, T. A. 1970. Antigenic stimulation of bone marrow colony-forming cells. Immunology 18:61.
37. Monteith, D. K., S. P. Henry, R. B. Howard, S. Flournoy, A. A. Levin. C. F. Bennett, and S. T. Crooke. 1997. Immune stimulation: a class effect of phosphorothioate oligodeoxynucleotides in rodents. Anticancer Drug Des. 12: 421.