Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a 4-week study in CD-1 mice

Antisense and Nucleic Acid Drug Development

Volumn 7, Issue 5, 1997, Pages 473-481

  Henry, Scott P ^a   Taylor, Jack ^b   Midgley, Leonora ^b   Levin, Arthur A ^a   Kornbrust, Douglas J ^c  

^a ISIS PHARMACEUTICALS   (United States)

^b Utah Biomedical Test Laboratory   (United States)

^c CHARLES RIVER LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALICAFORSEN; ALKALINE PHOSPHATASE; ANTIINFLAMMATORY AGENT; ANTISENSE OLIGONUCLEOTIDE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHOLESTEROL; INTERCELLULAR ADHESION MOLECULE 1; ISIS 3082; MESSENGER RNA; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CELL INFILTRATION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG FATALITY; DRUG SAFETY; FEMALE; FOOD INTAKE; INTRAVENOUS DRUG ADMINISTRATION; LYMPHOID HYPERPLASIA; MALE; MONOCYTOSIS; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLENOMEGALY; THROMBOCYTOPENIA; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN;

ANIMALIA; MURINAE;

EID: 0030806664     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1997.7.473     Document Type: Article

References (7)

1. BENNETT, C.F. (1993). Antisense oligonucleotides in inflammation research and therapeutics. In: Antisense Research and Applications. S.T. Crooke and B. Leblue, eds. (CRC Press, Boca Raton, FL), pp. 547-562.
2. BENNETT, C.F., CONDON, T.P., GRIMM, S., CHAN, H., and CHIANG, M.Y. (1994). Inhibition of endothelial cell adhesion molecule expression with antisense oligonucleotides. J. Immunol. 152, 3530-3540.
3. BENNETT, C.F., KORNBRUST, D.J., HENRY, S.P., DUTSON, S., HALL, W., and JACOBY, H.I. (1997). An ICAM-1 oligonucleotide, ISIS 3082, prevents and reverses dextran sulfate sodium-induced colitis in mice. J. Pharmacol. Exp. Ther. 280, 1-13.
4. BENNETT, R.M., GABOR, G.T., and MERRIT, M.M. (1985). DNA binding to human leukocytes: Evidence for a receptor-mediated association, internalization and degradation of DNA. J. Clin. Invest. 76, 2182-2190.
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