Inhibition of coagulation by a phosphorothioate oligonucleotide

Antisense and Nucleic Acid Drug Development

Volumn 7, Issue 5, 1997, Pages 503-510

  Henry, Scott P ^a   Novotny, William ^b   Leeds, Janet ^a   Auletta, Carol ^c   Kornbrust, Douglas J ^d  

^a ISIS PHARMACEUTICALS   (United States)

^b SCRIPPS RESEARCH   (United States)

^c Huntingdon Life Sciences New Jersey   (United States)

^d CHARLES RIVER LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALICAFORSEN; ANTIINFLAMMATORY AGENT; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 11A; BLOOD CLOTTING INHIBITOR; CHROMOGENIC SUBSTRATE; HEPARIN; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; THROMBIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTICOAGULATION; ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING TIME; CONTROLLED STUDY; DRUG BLOOD LEVEL; ENZYME ACTIVITY; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; MONKEY; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALIA; MACACA FASCICULARIS;

EID: 0030829919     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1997.7.503     Document Type: Article

References (6)

1. AGRAWAL, S., TEMSAMANI, J., GALBRAITH, W., and TANG, J. (1995). Pharmacokinetics of antisense oligonucleotides. Drug Disposition 28, 7-16.
2. ALTMANN, K.H., FABBRO, D., DEAN, N.M., GEIGER, T., MONIA, B.P., MUULER, M., and NICKLIN, P. (1996). Second-generation antisense oligonucleotides: Structure-activity relationships and the design of improved signal transduction inhibitors. Biochem. Soc. Trans. 24, 630-637.
3. ANDRADE, M., SCOZZARI, A., COLE, D.L., and RAVIJUMAR, V.T. (1994). Efficient synthesis of antisense oligodeoxynucleotide phosphorothioates. Bioorg. Med. Chem. Lett. 4, 2017-2022.
4. BELL, W.R., ANDERSON, N.D., and ANDERSON, A.O. (1977). Heparin-induced coagulopathy. J. Lab. Clin. Med. 89, 741-750.
5. BENNETT, C.F., DEAN, N., ECKER, D.J., and MONIA, B.P. (1996). In: Pharmacology of Antisense Therapeutic Agents: Cancer and Inflammation. (Humana Press, Totowa, NJ), pp. 13-46.
6. WU, Q., TSIANG, M., and SADLER, J.E. (1992). Localization of the single-stranded DNA binding site in the thrombin anion-binding exosite. J. Biol. Chem. 264, 24408-24412.