Inhibition of interleukin-1 type I receptor expression in human cell-lines by an antisense phosphorothioate oligodeoxynucleotide

International Journal of Immunopharmacology

Volumn 18, Issue 4, 1996, Pages 227-240

  Miraglia, Loren ^a   Geiger, Thomas ^b   Bennett, C Frank ^a   Dean, Nicholas M ^a  

^a ISIS PHARMACEUTICALS   (United States)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Adhesion molecules; Antisense oligonucleotides; Cell signaling; IL 1 type 1 receptor

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1 RECEPTOR; MESSENGER RNA; PHOSPHOROTHIOIC ACID DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CARCINOMA CELL; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN FIBROBLAST;

EID: 0030130581     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/0192-0561(96)84502-4     Document Type: Article

References (39)

1. Aiura, K., Gelfand, J. A., Burke, J. F., Thompson, R. C. & Dinarello, C. A. (1993) Interleukin-1 (IL-1) receptor antagonist prevents staphylococcus epidermidis-induced hypotension and reduces circulating levels of tumor necrosis factor and IL1 beta in rabbits. Infect. Immunity, 61, 3342-3350.
2. Arend, W. P. (1993) Interleukin-1 receptor antagonist. Adv. Immunol., 54, 167-227.
3. Bayever, E., Iversen, P., Smith, S., Spinolo, J. & Zon, G. (1992) Systemic human antisense therapy begins. Antisense Res. Dev., 2, 109-110.
4. Bennett, C. F., Chiang, M. -Y., Chan, H., Shoemaker, J. E. E. & Mirabelli, C. K. (1992) Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides. Mol. Pharmacol., 41, 1023-1033.
5. Bennett, C. F., Condon, T., Grimm, S., Chan, H. & Chiang, M. -Y. (1994) Inhibition of endothelial cell-leukocyte adhesion molecule expression with antisense oligonucleotides. J. Immunol., 152, 3530-3540.
6. Bird, T. A., Sleath, P. R., Deroos, P. C., Dower, S. K. & Duke Virca, G. (1991) Interleukin-1 represents a new modality for the activation of extracellular signal-related kinases/microtuble-associated protein-2 kinases. J. biol. Chem., 266, 22661-22670.
7. Burch, R. M. & Mahan, L. C. (1991) Oligonucleotides antisense to the interleukin 1 receptor mRNA block the effects of interleukin 1 in cultured murine and human fibroblasts and in mice. J. Clin. Invest., 88, 1190-1196.
8. Chiang, M. -Y., Chan, H., Zounes, M. A., Freier, S. M., Lima, W. F. & Bennett, C. F. (1991) Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms. J. biol. Chem., 266, 18162-18171.
9. Colige, A., Sokolov, B. P., Nugent, P., Baserga, R. & Prockop, D. J. (1993) Use of antisense oligonucleotide to inhibit expression of a mutated human procollagen gene (COL1A1) in transfected mouse 3T3 cells. Biochemistry, 32, 7-11.
10. Colota, F., Re, F., Muzio, M., Bertini, R., Polentarutti, N., Sironi, M., Giri, J. G., Dower, S. K., Sims, J. E. & Mantovani, A. (1993) Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. Science, 261, 472-475.
11. Crooke, S. (1994) Guest editorial: Progress in evaluation of the potential of antisense technology. Antisense Res. Dev., 4, 145-146.
12. Crooke, S. T. (1995). Therapeutic Applications of Oligonucleotides. R.G. Landes Company, Austin, Texas, U.S.A.
13. Crooke, S. T. & Lebleu, B. (1993). Antisense Research and Applications. CRC Press, Boca Raton, Florida, U.S.A.
14. Dayer, J. M. & Burger, D. (1994) Interlekin-1, tumor necrosis factor and their specific inhibitors. Eur. Cytokine Netw., 5, 563-571.
15. Dean, N. M., McKay, R., Condon, T. P., Bennett, C. F. Inhibition of protein kinase C-a expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1 (ICAM-1) mRNA by phorbol esters. (1994) J. biol. Chem., 269, 16416-16424.
16. Dean, N. M. & McKay, R. (1994) Inhibition of protein kinase C-alpha expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides. Proc. natn. Acad. Sci. U.S.A., 91, 11762-11766.
17. Dinarello, C. A. & Wolff, S. M. (1993) The role of interleukin-1 in disease. N. Eng. J. Med., 328, 106-113.
18. Dinarello, C. A. (1993) Blocking interleukin-1 in disease. Blood Purif., 11, 118-127.
19. Dinarello, C. A. (1993) Modalities for reducing interleukin-1 activity in disease. Trends Pharmacol. Sci., 14, 155-159.
20. Dinarello, C. A. (1994) The biological properties of interleukin-1. Eur. Cvtokine Netw., 5, 517-531.
21. Dinarello, C. A. (1994) The interleukin-1 family: 10 years of discovery. FASEB J., 8, 1314-1325.
22. Dinarello, C. A. & Thompson, R. C. (1991) Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro. Immunol. Today, 12, 404-410.
23. Dolnick, B. J. (1991) Antisense agents in cancer research and therapeutics. Cancer Invest., 9, 185-194.
24. Fisher Jr, C. J., Dhainaut, J. F. A., Opal, S. M., Pribble, J. P., Balk, R. A., Slotman, G. J., Iberti, T. J., Rackow, E. C., Shapiro, M. J., Greenman, R. L., Reines, H. D., Shelly, M. P., Thompson, B. W., Labrecque, J. F., Catalano, M. A., Knaus, W. A. & Sadoff, J. C. (1994) Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome: results from a randomized, double-blind, placebo-controlled trial. JAMA, 271, 1836-1843.
25. Gallis, B., Prickett, K. S., Jackson, J., Slack, J., Schooley, K., Sims, J. E. & Dower, S. K. (1989) IL-1 induces rapid phosphorylation of the IL-1 receptor. J. Immunol., 143, 3235-3240.
26. Geiger, T., Towbin, H., Cosenti-Vargas, A., Zingel, O., Arnold, J., Rordorf, C., Glatt, M., Vosbeck, K. Neutralization of interleukin 1B activity in vivo with a monoclonal antibody alleviates collagen-induced arthritis in DBA/1 mice and prevents the associated acute-phase response. (1993) Clin. exp. Rheumatol., 11, 515-522.
27. McNnamara, M. J., Norton, J. A., Nauta, R. J. & Alexander, H. R. (1993) Interleukin-1 receptor antibody (IL-1rab) protection and treatment against lethal endotoxemia in mice. J. surg. Res., 54, 316-321.
28. Mizel, S. B., Kilian, P. L., Lewis, J. C., Paganelli, K. A. & Chizzonite, R. A. (1987) Dynamics of interleukin 1 binding and internalization in T cells and fibroblasts. J. Immunol., 138, 2906-2912.
29. Poli, G., Kinter, A. L., Fauci, A. S. Interleukin 1 induces expression of the human immunodeficiency virus alone and in synergy with interleukin 6 in chronically infected U1 cells: inhibition of inductive effects by the interleukin 1 receptor antagonist. (1994) Proc. natn. Acad. Sci. U.S.A., 91, 108-112.
30. Rychlik, W. & Rhoads, R. E. (1989) A computer program for choosing optimal oligonucleotides for filter hybridization, sequencing and in vitro amplification of DNA. Nucleic Acids Res., 17, 8543-8551.
31. Sandberg, J., Eizirik, D. L., Sandler, S., Tracey, D. E. & Andersson, A. (1993) Treatment with an interleukin-1 receptor antagonist protein prolongs mouse islet allograft survival. Diabetes, 42, 1845-1851.
32. Schotanus, K., Tilders, F. J. H. & Berkenbosch, F. (1993) Human recombinant interleukin-1 receptor antagonist prevents adrenocorticotropin, but not interleukin-6 responses to bacterial endotoxin in rats. Endocrinology, 133, 2461-2468.
33. Sims, J. E., Giri, J. G. & Dower, S. K. (1994) The two interleukin-1 receptors play different roles in IL-1 actions. Clin. Immunol. Immunopath., 72, 9-14.
34. Sims, J. E. & Dower, S. K. (1994) Interleukin-1 receptors. Eur. Cytokine Netw., 5, 539-546.
35. Stein, C. A. & Cheng, Y. -C. (1993) Antisense oligonucleotides as therapeutic agents - Is the bullet really magical?. Science, 261, 1004-1012.
36. Stein, C. A. & Krieg, A. M. (1994) Problems in interpretation of data derived from in vitro and in vivo use of antisense oligodeoxynucleotides. Antisense Res. Dev., 4, 67-69.
37. Vidal-Vnaclocha, F., Amezaga, C., Asumendi, A., Kaplanski, G. & Dinarello, C. A. (1994) Interleukin-1 receptor blockade reduces the number and size of murine B16 melanoma hepatic metastases. Cancer Res., 54, 2667-2672.
38. Wagner, R. W. (1994) Gene inhibition using antisense oligodeoxynucleotides. Nature, 372, 333-335.
39. Wakita, T. & Wands, J. R. (1994) Specific inhibition of hepatitis C virus expression by antisense oligodeoxynucleotides. In vitro model for selection of target sequence. J. biol. Chem., 269, 14205-14210.