A single residue, Lys108, of the δ-opioid receptor prevents the μ- opioid-selective ligand [D-Ala2,N-MePhe4,Gly-ol5]enkephalin from binding to the δ-opioid receptor

Molecular Pharmacology

Volumn 50, Issue 5, 1996, Pages 1413-1422

  Minami, Masabumi ^a   Nakagawa, Takayuki ^a   Seki, Takahiro ^a   Onogi, Tatsuhiro ^a   Aoki, Yasuhide ^a   Katao, Yoshikazu ^a   Katsumata, Seishi ^a   Satoh, Masamichi ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DELTA OPIATE RECEPTOR; DERMORPHIN; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; LYSINE; MU OPIATE RECEPTOR; OPIATE AGONIST;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; DRUG RECEPTOR BINDING; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL;

ADENYLATE CYCLASE; AMINO ACID SEQUENCE; ANALGESICS; ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALINS; KINETICS; LYSINE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, SECONDARY; RATS; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU;

EID: 0029844422     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Pasternak, G. W. Multiple morphine and enkephalin receptors and the relief of pain. JAMA 259:1362-1367 (1988).
2. Childers, S. R. Opioid receptor-coupled second messenger systems, in Opioid. I: Handbook of Experimental Pharmacology. (A. Herz, ed.). Vol. 104. Springer-Verlag, Berlin, 189-216 (1993).
3. North, R. A. Opioid actions on membrane ion channels, in Opioid. I: Handbook of Experimental Pharmacology (A. Herz, ed.). Vol. 104. Springer-Verlag, Berlin, 773-797 (1993).
4. Evans, C. J., D. E. Keith, Jr., H. Morrison, K. Magendzo, and R. H. Edwards. Cloning of a delta opioid receptor by functional expression. Science (Washington D. C.) 258:1952-1955 (1992).
5. Kieffer, B. L., K. Befort, C. Gavriaux-Ruff, and C. G. Hirth. The δ-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. Proc. Natl. Acad. Sci. USA 89:12048-12052 (1992).
6. Chen, Y., A. Mestek, J. Liu, J. A. Hurley, and L. Yu. Molecular cloning and functional expression of a μ-opioid receptor from rat brain. Mol. Pharmacol. 44:8-12 (1993).
7. Thompson, R. C., A. Mansour, H. Akil, and S. J. Watson. Cloning and pharmacological characterization of a rat μ-opioid receptor. Neuron 11: 903-913 (1993).
8. Wang, J. B., Y. Imai, C. M. Eppler, P. Gregor, C. E. Spivak, and G. R. Uhl. μ Opiate receptor: cDNA cloning and expression. Proc. Natl. Acad. Sci. USA 90:10230-10234 (1993).
9. Fukuda, K., S. Kato, K. Mori, M. Nishi, and H. Takeshima. Primary structures and expression from cDNAs of rat opioid receptor from δ and μ-subtypes. FEBS Lett. 327:311-314 (1993).
10. Minami, M., T. Onogi, T. Toya, Y. Katao, Y. Hosoi, K. Maekawa, S. Katsumata, K. Yabuuchi, and M. Satoh. Molecular cloning and in situ hybridization histochemistry for rat μ-opioid receptor. Neurosci. Res. 18: 315-322 (1994).
11. Minami, M., T. Toya, Y. Katao, K. Maekawa, S. Nakamura, T. Onogi, S. Kaneko, and M. Satoh. Cloning and expression of a cDNA for the rat κ-opioid receptor. FEBS Lett. 329:291-295 (1993).
12. Yasuda, K., K. Raynor, H. Kong, C. D. Breder, J. Takeda, T. Reisine, and G. I. Bell. Cloning and functional comparison of κ and δ opioid receptors from mouse brain. Proc. Natl. Acad. Sci. USA 90:6736-6740 (1993).
13. Meng, F., G. X. Xie, R. C. Thompson, A. Mansour, A. Goldstein, S. J. Watson, and H. Akil. Cloning and pharmacological characterization of a rat κ opioid receptor. Proc. Natl. Acad. Sci. USA 90:9954-9958 (1993).
14. Nishi, M., H. Takeshima, K Fukuda, S. Kato, and K. Mori. cDNA cloning and pharmacological characterization of an opioid receptor with high affinities for κ subtype-selective ligands. FEBS Lett. 330:77-80 (1993).
15. Kobilka, B. K., T. S. Kobilka, K. Daniel, J. W. Regan, M. G. Caron, and R. J. Lefkowitz. Chimeric α2-, β2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity. Science (Washington D. C.) 240:1310-1316 (1988).
16. Frielle, T., K. W. Daniel, M. G. Caron, and R. J. Lefkowitz. Structural basis of β-adrenergic receptor subtype specificity studied with chimeric β1/β2-adrenergic receptors. Proc. Natl. Acad. Sci. USA 85:9494-9498 (1988).
17. Wess, J., D. Gdula, and M. R. Brann. Structural basis of the subtype selectivity of muscarinic antagonists: a study with chimeric m2/m5 muscarinic receptors. Mol. Pharmacol. 41:369-374 (1992).
18. McAllister, G., M. R. Knowles, S. Patel, R. Marwood, F. Emms, G. R. Seabrook, M. Graziano, D. Borkowski, P. J. Hey, and S. B. Freedman. Characterization of a chimeric hD3/D2 dopamine receptor expressed in CHO cells. FEBS Lett. 324:81-86 (1993).
19. Yokota, Y., C. Akazawa, H. Ohkubo, and S. Nakanishi. Delineation of structural domains involved in the subtype specificity of tachykinin receptors through chimeric formation of substance P/substance K receptors. EMBO J. 11:3585-3591 (1992).
20. 3 (neurokinin B) receptors: identification of domains determining the binding specificity of tachykinin agonists. J. Biol. Chem. 268:7893-7898 (1993).
21. Onogi, T., M. Minami, Y. Katao, T. Nakagawa, Y. Aoki, T. Toya, S. Katsumata, and M. Satoh. DAMGO, a μ-opioid receptor selective agonist, distinguishes between μ- and δ-opioid receptors around their first extracellular loops. FEBS Lett. 357:93-97 (1995).
22. Selden, R. F. Transfection using DEAE-dextran, in Current Protocols in Molecular Biology (F. M. Ausubel, R. Brent, and R. E. Kingston, eds.). Wiley, New York, 9.2.1-9.2.6 (1987).
23. 50) of an enzymatic reaction. Biochem. Pharmacol. 22:3099-3108 (1973).
24. Minami, M., T. Onogi, T. Nakagawa, Y. Katao, Y. Aoki, S. Katsumata, and M. Satoh. DAMGO, a μ-opioid receptor selective ligand, distinguishes between μ- and κ-opioid receptors at different regions from that for the distinction between μ- and δ-opioid receptors. FEBS Lett. 364:23-27 (1995).
25. Xue, J.-C., C. Chen, J. Zhu, S. P. Kunapuli, J. K. deRiel, L. Yu, and L.-Y. Liu-Chen. The third extracellular loop of the μ opioid receptor is important for agonist selectivity. J. Biol. Chem. 270:12977-12979 (1995).
26. Fukuda, K., K. Terasako, S. Kato, and K. Mori. Identification of the amino acid residues involved in selective agonist binding in the first extracellular loop of the δ- and μ-opioid receptors. FEBS Lett. 373:177-181 (1995).
27. Hjorth, S. A., K. Thirstrup, D. K. Grandy, and T. W. Schwartz. Analysis of selective binding epitopes for the κ-opioid receptor antagonist norbinaltorphimine. Mol. Pharmacol. 47:1089-1094 (1995).
28. Portoghese, P. S., C. E. Lin, F. Farouz-Grant, and A. Takemori. Structure-activity relationship of N17′-substituted norbinaltorphimine congeners: role of the N17' basic group in the interaction with a putative address subsite on the κ opioid receptor. J. Med. Chem. 37:1495-1500 (1994).
29. Gether, U., L. Nilsson, J. A. Lowe III, and T. W. Schwartz. Specific residues at the top of transmembrane segment V and VI of the neurokinin-1 receptor involved in binding of the nonpeptide antagonist CP96,345. J. Biol. Chem. 260:23959-23964 (1994).
30. Kong, H., K. Raynor, K. Yasuda, S. T. Moe, P. S. Portoghese, G. I. Bell, and T. Reisine. A single residue, aspartic acid 95, in the δ opioid receptor specifies selective high affinity agonist binding. J. Biol. Chem. 268:23055-23058 (1993).
31. Surratt, C. K., P. S. Johnson, A. Moriwaki, B. K. Seidleck, C. J. Blaschak, J. B. Wang, and G. R. Uhl. μ Opiate receptor: charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity. J. Biol. Chem. 269:20548-20553 (1994).
32. Fukuda, K., S. Kato, and K. Mori. Location of regions of the opioid receptor involved in selective agonist binding. J. Biol. Chem. 270:6702-6709 (1995).