Conformational determinants of agonist versus antagonist properties of [D-Pen2,D-Pen5]enkephalin (DPDPE) analogs at opioid receptors. Comparison of X-ray crystallographic structure, solution 1H NMR data, and molecular dynamic simulations of [L-Ala3]DPDPE and [D-Ala3]DPDPE

Journal of the American Chemical Society

Volumn 118, Issue 9, 1996, Pages 2143-2152

  Collins, Nathan ^a,c   Flippen Anderson, Judith L ^b   Haaseth, Ronald C ^a,d   Deschamps, Jeffery R ^b   George, Clifford ^b   Kövér, Katalin ^a,e   Hruby, Victor J ^a  

^a University of Arizona   (United States)

^b NAVAL RESEARCH LABORATORY   (United States)

^c Arris Pharmaceutical Corporation   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

^e UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

DELTA OPIATE RECEPTOR; ENKEPHALIN DERIVATIVE; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE 3 ALANINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE 3 DEXTRO ALANINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; UNCLASSIFIED DRUG;

ANTINOCICEPTION; ARTICLE; DRUG RECEPTOR BINDING; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY;

EID: 0029870521     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9531081     Document Type: Article

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