Mapping the receptor domains critical for the binding selectivity of δ-opioid receptor ligands

European Journal of Pharmacology

Volumn 311, Issue 2-3, 1996, Pages 285-292

  Meng, Fan ^a,b   Ueda, Yasuko ^a   Hoversten, Mary T ^a   Thompson, Robert C ^a   Taylor, Larry ^a   Watson, Stanley J ^a   Akil, Huda ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Chimeric receptor; Mutagenesis; Opioid receptor; Structure function relationship; Opioid receptor ligand

Indexed keywords

BREMAZOCINE; CHIMERIC PROTEIN; DELTA OPIATE RECEPTOR; DELTORPHIN; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; ETHYLKETAZOCINE; KAPPA OPIATE RECEPTOR; LEUCINE ENKEPHALIN; METENKEPHALIN; MU OPIATE RECEPTOR; NALTREXONE; NALTRIBEN; NALTRINDOLE; OPIATE RECEPTOR; RECEPTOR SUBTYPE; TYROSYLCYCLO[DEXTRO CYSTEINYLPHENYLALANYL DEXTRO PENICILLAMINE];

ARTICLE; BINDING AFFINITY; HUMAN; IN VITRO STUDY; LIGAND BINDING; MODEL; MUTATION; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT;

EID: 0030581509     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00431-1     Document Type: Article

References (33)

1. Chen, C. and H. Okayama, 1987, High-efficiency transformation of mammalian cells by plasmid DNA, Mol. Cell. Biol. 7, 2745.
2. Chen, C., J.C. Xue, J. Zhu, Y.W. Chen, S. Kunapuli, J. Kim de Riel, L. Yu and L.-Y. Liu-Chen, 1995, Characterization of irreversible binding of beta-funaltrexamine to the cloned rat mu opioid receptor, J. Biol. Chem. 270, 17866.
3. Deng, W.P. and J.A. Nickoloff, 1991, Site-directed mutagenesis of virtually any plasmid by eliminating a unique site, Analyt. Biochem. 200, 81.
4. Fukuda, K., S. Kato, K. Mori, M. Nishi and H. Takeshima, 1993, Primary structures and expression from a cDNA of rat opioid receptor delta- and mu-subtypes, FEBS Lett. 327, 311.
5. Fukuda, K., S. Kato and K. Mori, 1995, Location of regions of the opioid receptor involved in selective agonist binding, J. Biol. Chem. 270, 6702.
6. Goldstein, A. and A. Naidu, 1989, Multiple opioid receptors: ligand selectivity profiles and binding site signatures, Mol. Pharmacol. 36, 265.
7. Hjorth, S.A., K. Thirstrup, D.K. Grandy, and T.W. Schwartz, 1995, Analysis of selective binding epitopes for the kappa-opioid receptor antagonist nor-binaltorphimine, Mol. Pharmacol. 47, 1089.
8. Huggenvik, J.I., M.W. Collard, R.E. Stofko, A.F. Seasholtz and M.D. Uhler, 1991, Regulation of the human enkephalin promoter by two isoforms of the catalytic subunit of cyclic adenosine 3′, 5′-monophosphate-dependent protein kinase, Mol. Endocrinol. 5, 921.
9. Knapp, R.J. and H.I. Yamamura, 1992, Delta opioid receptor radioligands, Biochem. Pharmacol. 44, 1687.
10. Kong, H., K. Raynor, K. Yasuda, S.T. Moe, P.S. Portoghese, G.I. Bell and T. Reisine, 1993, A single residue, aspartic acid 95, in the delta opioid receptor specifies selective high affinity agonist binding, J. Biol. Chem. 268, 23055.
11. Kong, H., K. Raynor, H. Yano, J. Takeda, G.I. Bell and T. Reisine, 1994, Agonists and antagonists bind to different domains of the cloned kappa opioid receptor, Proc. Natl. Acad. Sci. 91, 8042.
12. Krystek, S.R., P.S. Patel, P.M. Rose, S.M. Fisher, B.K. Kienzle, D.A. Lach, E.C. Liu, J.S. Lynch, J. Novotny and M.L. Webb, 1994, Mutation of peptide binding site in transmembrane region of a G protein-coupled receptor accounts for endothelin receptor subtype selectivity, J. Biol. Chem. 269, 12383.
13. Meng, F., G.-X. Xie, R.C. Thompson, A. Mansour, A. Goldstein, S.J. Watson and H. Akil, 1993, Cloning and pharmacological characterization of a rat kappa opioid receptor, Proc. Natl. Acad. Sci. 90, 9954.
14. Meng, F., M. Hoversten, R.C. Thompson, L. Taylor, S.J. Watson and H. Akil, 1995, A chimeric study of the molecular basis of affinity and selectivity of the κ and the δ opioid receptors: potential role of extracellular domains, J. Biol. Chem. 270, 12730.
15. Minami, M., T. Onogi, T. Nakagawa, Y. Katao, Y. Aoki, S. Katsumata and M. Satoh, 1995, DAMGO, a mu-opioid receptor selective ligand, distinguishes between mu- and kappa-opioid receptors at a different region from that for the distinction between mu- and delta-opioid receptors, FEBS Lett. 364, 23.
16. Munson, P.J. and D. Rodbard, 1980, Ligand: a versatile computerized approach for characterization of ligand-binding systems, Anal. Biochem. 107, 220.
17. Onogi, T., M. Minami, Y. Katao, T. Nakagawa, Y. Aoki, T. Toya, S. Katsumata and M. Satoh, 1995, DAMGO, a μ-opioid receptor selective agonist, distinguishes between μ- and δ-opioid receptors around their first extracellular loops, FEBS Lett. 357, 93.
18. Ostrowski, J., M.A. Kjelsberg, M.G. Caron and R.J. Lefkowitz, 1992, Mutagenesis of the beta 2-adrenergic receptor: how structure elucidates function, Ann. Rev. Pharmacol. Toxicol. 32, 167.
19. Portoghese, P.S., 1993, Selective nonpeptide opioid antagonists, in: Opioid I, ed. A. Herz (Springer-Verlag, Berling) p. 279.
20. Reisine, T. and G. Bell, 1993, Molecular biology of opioid receptors, Trends Neurosci. 16, 506.
21. Schwyzer, R., 1977, ACTH: a short introductory review, Ann. NY Acad. Sci. 297, 3.
22. Shahrestanifar, M., W.W. Wang and R.D. Howells, 1996, Studies on inhibition of mu and delta opioid receptor binding by dithiothreitol and N-ethylmaleimide, J. Biol. Chem. 271, 5505.
23. Simon, E.J., 1991, Opioid receptors and endogenous opioid peptides, Med. Res. Rev. 11, 357.
24. Strader, C.D., T.M. Fong, M.R. Tota, D. Underwood and R.A. Dixon, 1994, Structure and function of G protein-coupled receptors, Annu. Rev. Biochem. 63, 101.
25. Surratt, C.K., P.S. Johnson, A. Moriwaki, B.K. Seidleck, C.J. Blaschak, J.B. Wang and G.R. Uhl, 1994, Mu opiate receptor: charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity, J. Biol. Chem. 269, 20548.
26. Thompson, R.C., A. Mansour, H. Akil and S.J. Watson, 1993, Cloning and pharmacological characterization of a rat mu opioid receptor, Neuron 11, 903.
27. Uhl, G.R., S. Childers and G. Pasternak, 1994, An opiate-receptor gene family reunion, Trends Neurosci. 17, 89.
28. Wang, J.B., P.S. Johnson, J.M. Wu, W.F. Wang and G.R. Uhl, 1994, Human kappa opiate receptor second extracellular loop elevates dynorphin's affinity for mu/kappa chimeras, J. Biol. Chem. 269, 25966.
29. Wang, W.W., M. Shahrestanifar, J. Jin and R.D. Howells, 1995, Studies on μ, and δ opioid receptor selectivity utilizing chimeric and site-mutagenized receptors, Proc. Natl. Acad. Sci. 92, 12436.
30. Watson, B., F. Meng and H. Akil, 1996, A chimeric analysis of the opioid receptor domains critical for the binding selectivity of mu opioid ligands, Neurobiology of Disease 3, 87.
31. Xue, J.C., C.-G. Chen, J.M. Zhu, S. Kunapuli, J.K. DeRiel, Y. Lei and L.-Y. Liu-Chen, 1994, Differential binding domains of peptide and non-peptide ligands in the cloned rat κ opioid receptor, J. Biol. Chem. 269, 30195.
32. Xue, J.C., C.-G. Chen, J.M. Zhu, S. Kunapuli, J.K. DeRiel, Y. Lei and L.-Y. Liu-Chen, 1995, The third extracellular loop of the mu opioid receptor is important for agonist selectivity, J. Biol. Chem. 269, 12977.
33. Zhu, J., J. Yin, P.Y. Law, P.A. Claude, K.C. Rice, C.J. Evans, C. Chen, L. Yu and L.-Y. Liu-Chen, 1996, Irreversible binding of cis( + )-3-methylfentanyl isothiocyanate to the delta opioid receptor and determination of its binding domain, J. Biol. Chem. 271, 1430.