The third extracellular loop of the human δ-opioid receptor determines the selectivity of δ-opioid agonists

Molecular Pharmacology

Volumn 50, Issue 6, 1996, Pages 1619-1624

  Varga, Eva V ^a   Li, Xiaoping ^a   Stropova, Dagmar ^a   Zalewska, Teresa ^a   Landsman, Robert S ^a   Knapp, Richard J ^a   Malatynska, Ewa ^a   Kawai, Kohji ^b   Mizusura, Akira ^b   Nagase, Hiroshi ^b   Calderon, Silvia N ^c   Rice, Kenner ^c   Hruby, Victor J ^a   Roeske, William R ^a   Yamamura, Henry I ^a,d  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b TORAY INDUSTRIES INC   (Japan)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DELTA OPIATE RECEPTOR; DELTORPHIN; DIPRENORPHINE; ENKEPHALIN DERIVATIVE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; LIGAND; MORPHINE; OPIATE AGONIST;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CERCOPITHECIDAE; CHIMERA; LIGAND BINDING; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; COS CELLS; ENKEPHALINS; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OLIGOPEPTIDES; QUINOLINES; RECEPTORS, OPIOID, DELTA; RECOMBINANT FUSION PROTEINS;

EID: 8044237103     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Knapp, R. J., E. Malatynska, L. Fang, X. Li, E. Babin, M. Nguyen, G. Santoro, E. V. Varga, V. J. Hruby, W. R. Roeske, and H. I. Yamamura. Identification of a human delta opioid receptor: cloning and expression. Life Sci. 54:463-469 (1994).
2. Wang, J. B., P. S. Johnson, A. M. Persico, A. L. Hawkins, C. A. Griffins, and G. R. Uhl. Human μ opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment. FEBS Lett. 388: 217-222 (1994).
3. Manson, E., L. Bare, and D. Yang. Isolation of a human κ opioid receptor cDNA from placenta. Biochem. Biophys. Res. Commun. 202:1431-1437 (1994).
4. Strader, C. D., T. M. Fong, M. P. Graziano, and M. R. Tota. The family of G-protein-coupled receptors. FASEB J. 9:745-754 (1995).
5. Oprian, D. D. The ligand-binding domain of rhodopsin and other G protein linked receptors. J. Bioenerg. Biomembr. 24:211-217 (1992).
6. Spalding, T. A., N. J. M. Birdsall, C. A. M. Curtis, and E. C. Hulme. Acetylcholine mustard labels the binding site aspartate in muscarinic acetylcholine receptors. J. Biol. Chem. 269:4092-4097 (1994).
7. Horton, R. M., Z. Cai, S. N. Ho, and L. R. Pease. Gene splicing by overlap extension: tailor-made genes using the polymerase chain reaction. Biotechniques 5:528-535 (1990).
8. Deng, W. P., and J. A. Nickoloff. Site-directed mutagenesis of virtually any plasmid by eliminating a unique site. Anal. Biochem. 200:81-87 (1992).
9. 5]enkephalin analogues with increased affinity and selectivity for δ opioid receptor. J. Med. Chem. 33:249-253 (1989).
10. 3H]SNC 121, a novel, selective, and high affinity ligand for opioid delta receptors. Analgesia 1:185-193 (1995).
11. Nagase, H., H. Wakita, K Kawai, T. Endoh, H. Matsura, C. Tanaka, and Y. Takezawa. Synthesis of nonpeptide delta opioid agonists and their structure activity relationships. Jpn. J. Pharmacol. 64:35-39 (1994).
12. i) and the concentration of inhibitor which causes 50 percent inhibition. Biochem. Pharmacol. 22:3099-3108 (1973).
13. 284 of the human δ opioid receptor is required for SNC 121 binding but not binding of pCl-DPDPE, Deltorphin II or naltrindole. Analgesia 1:539-542 (1995).
14. Onogi, T., M. Minami, Y. Katao, T. Nakagawa, Y. Aoki, T. Toya, S. Katsumata, and M. Satoh. DAMGO, a μ-opioid receptor selective agonist, distinguishes between μ- and δ- opioid receptors around their first extracellular loops. FEBS Lett. 357:93-97 (1995).
15. Minami, M., T. Onogi, T. Nakagawa, Y. Katao, Y. Aoki, S. Katsumata, and M. Satoh. DAMGO, a μ-opioid receptor selective ligand, distinguishes between μ- and κ-opioid receptors at a different region from that for the distinction between μ- and δ-opioid receptors. FEBS Lett. 364:23-27 (1995).
16. Xue, J. C., C. Chen, J. Zhu, S. Kunapuli, J. K. DeRie, L. Yu, and L. Y. Liu-Chen. Differential binding domains of peptide and nonpeptide ligands in the cloned rat κ opioid receptor. J. Biol. Chem. 269:30195-30199 (1994).
17. Meng, F., M. T. Hoverstein, R. C. Thompson, L. Taylor, S. J. Watson, and H. Akil. A chimeric study of the molecular basis of affinity and selectivity of the κ and the δ opioid receptors. J. Biol. Chem. 270:12730-12736 (1995).
18. Fukuda, K., S. Kato, and K. Mori. Location of regions of the opioid receptor involved in selective agonist binding. J. Biol. Chem. 270:6702-6709 (1995).
19. Kong, H., K. Raynor, K. Yasuda, S. T. Moe, P. S. Portoghese, G. I. Bell, and T. Reisine. A single residue, aspartic acid 95, in the δ opioid receptor specifies selective high affinity agonist binding. J. Biol. Chem. 268:23055-23058 (1993).
20. Li, X., E. V. Varga, D. M. Stropova, T. Zalewska, E. Malatynska, R. J. Knapp, W. R. Roeske, and H. I. Yamamura. Delta opioid receptor: the third extracellular loop determines naltrindole selectivity. Eur. J. Pharmacol. 300:R1-R2 (1996).
21. Fukuda, K., K. Terasako, S. Kato, and K. Mori. Identification of the amino acid residues involved in selective agonist binding in the first extracellular loop of the δ- and μ-opioid receptors. FEBS Lett. 373:177-181 (1995).
22. Schwyzer, R. Molecular mechanism of opioid receptor selection. Biochemistry 25:6335-6342 (1986).
23. Wang, W. W., M. Shahrestanifar, J. Jin, and R. D. Howells. Studies on μ and δ opioid receptor selectivity utilizing chimeric and site-mutagenized receptors. Proc. Natl. Acad. Sci. USA 92:12436-12440 (1995).