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Volumn 34, Issue 9, 1998, Pages 777-803

Pharmacology of irinotecan

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; IRINOTECAN; PRODRUG;

EID: 0031736659     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.1998.34.9.485276     Document Type: Review
Times cited : (32)

References (186)
  • 1
    • 7144248725 scopus 로고
    • Plant antitumor agents. 1. the isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata
    • Wall, M.E., Wani, M.C., Cook, C.E., Palmer, K.H., McPhail, A.T., Sim, G.A. Plant antitumor agents. 1. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. J Am Chem Soc 1966, 88: 3888-90.
    • (1966) J Am Chem Soc , vol.88 , pp. 3888-3890
    • Wall, M.E.1    Wani, M.C.2    Cook, C.E.3    Palmer, K.H.4    McPhail, A.T.5    Sim, G.A.6
  • 2
    • 0015044313 scopus 로고
    • Studies on the antitumor activity, mechanism of action, and cell cycle effects of camptothecin
    • Gallo, R.C., Whang-Peng, J., Adamson, R.H. Studies on the antitumor activity, mechanism of action, and cell cycle effects of camptothecin. J Natl Cancer Inst 1971, 46: 789-95.
    • (1971) J Natl Cancer Inst , vol.46 , pp. 789-795
    • Gallo, R.C.1    Whang-Peng, J.2    Adamson, R.H.3
  • 3
    • 0014895176 scopus 로고
    • Preliminary pharmacological and clinical evaluation of camptothecin sodium (NSC 100880)
    • Gottlieb, J.A., Guarino, A.M., Call, J.B., Oliverio, V.T., Block, J.B. Preliminary pharmacological and clinical evaluation of camptothecin sodium (NSC 100880). Cancer Chemother Rep 1970, 54: 461-70.
    • (1970) Cancer Chemother Rep , vol.54 , pp. 461-470
    • Gottlieb, J.A.1    Guarino, A.M.2    Call, J.B.3    Oliverio, V.T.4    Block, J.B.5
  • 4
    • 0015378084 scopus 로고
    • Phase I clinical trials of weekly and daily treatment with camptothecin (NSC 100880). Correlation with clinical studies
    • Muggia, F.M., Creaven, P.J., Hansen, H.H., Cohen, M.N., Selawry, D.S. Phase I clinical trials of weekly and daily treatment with camptothecin (NSC 100880). Correlation with clinical studies. Cancer Chemother Rep 1972, 56: 515-2.
    • (1972) Cancer Chemother Rep , vol.56 , pp. 515-522
    • Muggia, F.M.1    Creaven, P.J.2    Hansen, H.H.3    Cohen, M.N.4    Selawry, D.S.5
  • 5
    • 0015291595 scopus 로고
    • Phase II study of camptothecin (NSC-100880) in the treatment of advanced gastrointestinal cancer
    • Moertel, C.G., Schutt, A.J., Reitemeier, R.J., Hahn, R.G. Phase II study of camptothecin (NSC-100880) in the treatment of advanced gastrointestinal cancer. Cancer Chemother Rep 1972, 56: 95-101.
    • (1972) Cancer Chemother Rep , vol.56 , pp. 95-101
    • Moertel, C.G.1    Schutt, A.J.2    Reitemeier, R.J.3    Hahn, R.G.4
  • 6
    • 0018901322 scopus 로고
    • Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues
    • Wani, M.C., Ronman, P.E., Lindley, J.T., Wall, M.E. Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. J Med Chem 1980, 23: 554-60.
    • (1980) J Med Chem , vol.23 , pp. 554-560
    • Wani, M.C.1    Ronman, P.E.2    Lindley, J.T.3    Wall, M.E.4
  • 7
    • 0022340594 scopus 로고
    • Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I
    • Hsiang, Y.H., Hertzberg, R., Hecht, S., Liu, L.F. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem 1985, 260: 14873-8.
    • (1985) J Biol Chem , vol.260 , pp. 14873-14878
    • Hsiang, Y.H.1    Hertzberg, R.2    Hecht, S.3    Liu, L.F.4
  • 8
    • 0023927993 scopus 로고
    • Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells
    • Hsiang, Y.H., Wu, H.Y., Liu, L.F. Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells. Cancer Res 1988, 48: 3230-5.
    • (1988) Cancer Res , vol.48 , pp. 3230-3235
    • Hsiang, Y.H.1    Wu, H.Y.2    Liu, L.F.3
  • 9
    • 0024420685 scopus 로고
    • Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin
    • Hsiang, Y.H., Lihou, M.G., Liu, L.F. Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res 1989, 49: 5077-82.
    • (1989) Cancer Res , vol.49 , pp. 5077-5082
    • Hsiang, Y.H.1    Lihou, M.G.2    Liu, L.F.3
  • 10
    • 0026328062 scopus 로고
    • Synergistic cell killing by ionizing radiation and topoisomerase I inhibitor topotecan (SK&F 104864)
    • Mattern, M.R., Hofmann, G.A., McCabe, F.L., Johnson, R.K. Synergistic cell killing by ionizing radiation and topoisomerase I inhibitor topotecan (SK&F 104864). Cancer Res 1991, 51: 5813-6.
    • (1991) Cancer Res , vol.51 , pp. 5813-5816
    • Mattern, M.R.1    Hofmann, G.A.2    McCabe, F.L.3    Johnson, R.K.4
  • 11
    • 0024560495 scopus 로고
    • Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: Evidence for a specific receptor site and relation to antitumor activity
    • Jaxel, C., Kohn, K.W., Wani, M.C., Wall, M.E., Pommier, Y. Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: Evidence for a specific receptor site and relation to antitumor activity. Cancer Res 1989, 49: 1465-9.
    • (1989) Cancer Res , vol.49 , pp. 1465-1469
    • Jaxel, C.1    Kohn, K.W.2    Wani, M.C.3    Wall, M.E.4    Pommier, Y.5
  • 12
    • 0024853052 scopus 로고
    • Topoisomerase-targeting antitumor drugs
    • D'Arpa, P., Liu, L.F. Topoisomerase-targeting antitumor drugs. Biochim Biophys Acta 1989, 989: 163-77.
    • (1989) Biochim Biophys Acta , vol.989 , pp. 163-177
    • D'Arpa, P.1    Liu, L.F.2
  • 13
    • 0024316466 scopus 로고
    • DNA topoisomerase poisons as antitumor drugs
    • Liu, L.F. DNA topoisomerase poisons as antitumor drugs. Annu Rev Biochem 1989, 58: 351-75.
    • (1989) Annu Rev Biochem , vol.58 , pp. 351-375
    • Liu, L.F.1
  • 14
    • 0025899645 scopus 로고
    • Synthesis and antitumor activity of 20(S)camptothecin derivatives: Carbamate-linked, water-soluble derivatives of 7-ethyl-10- hydroxy-camptothecin
    • Sawada, S., Okajima, S., Aiyama, R. et al. Synthesis and antitumor activity of 20(S)camptothecin derivatives: Carbamate-linked, water-soluble derivatives of 7-ethyl-10- hydroxy-camptothecin. Chem Pharm Bull 1991, 39: 1446-54.
    • (1991) Chem Pharm Bull , vol.39 , pp. 1446-1454
    • Sawada, S.1    Okajima, S.2    Aiyama, R.3
  • 15
    • 0026099599 scopus 로고
    • Synthesis of water-soluble (aminoalkyl)-camptothecin analogues: Inhibition of topoisomerase I and antitumor activity
    • Kingsbury, W.D., Boehm, J.C., Jakas, D.R. et al. Synthesis of water-soluble (aminoalkyl)-camptothecin analogues: Inhibition of topoisomerase I and antitumor activity. J Am Chem Soc 1991, 34: 98-107.
    • (1991) J Am Chem Soc , vol.34 , pp. 98-107
    • Kingsbury, W.D.1    Boehm, J.C.2    Jakas, D.R.3
  • 16
    • 0025996996 scopus 로고
    • Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11. in the antitumor effect of CPT-11
    • Kawato, Y., Aonuma, M., Hirota, Y., Kuga, H., Sato, K. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11. in the antitumor effect of CPT-11. Cancer Res 1991, 51: 4187-91.
    • (1991) Cancer Res , vol.51 , pp. 4187-4191
    • Kawato, Y.1    Aonuma, M.2    Hirota, Y.3    Kuga, H.4    Sato, K.5
  • 17
    • 0025272187 scopus 로고
    • Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse
    • Kaneda, N., Nagata, H., Furuta, T., Yokokura, T. Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse. Cancer Res 1990, 50: 1715-20.
    • (1990) Cancer Res , vol.50 , pp. 1715-1720
    • Kaneda, N.1    Nagata, H.2    Furuta, T.3    Yokokura, T.4
  • 18
    • 0027096415 scopus 로고
    • A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues
    • Fassberg, J., Stella, V.J. A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues. J Pharm Sci 1992, 81: 676-84.
    • (1992) J Pharm Sci , vol.81 , pp. 676-684
    • Fassberg, J.1    Stella, V.J.2
  • 19
    • 0028029604 scopus 로고
    • Kinetic studies of the hydrolysis and lactonization of camptothecin and its derivatives, CPT-11 and SN-38, in aqueous solution
    • Akimoto, K., Kawai, A., Ohya, K. Kinetic studies of the hydrolysis and lactonization of camptothecin and its derivatives, CPT-11 and SN-38, in aqueous solution. Chem Pharm Bull 1994, 42: 2135-8.
    • (1994) Chem Pharm Bull , vol.42 , pp. 2135-2138
    • Akimoto, K.1    Kawai, A.2    Ohya, K.3
  • 20
    • 0026498419 scopus 로고
    • Structural modifications of camptothecin and effects on topoisomerase I inhibition
    • Crow, R.T., Crowthers, D.M. Structural modifications of camptothecin and effects on topoisomerase I inhibition. J Med Chem 1992, 35: 4160-4.
    • (1992) J Med Chem , vol.35 , pp. 4160-4164
    • Crow, R.T.1    Crowthers, D.M.2
  • 21
    • 0027201885 scopus 로고
    • Preferential binding of the carboxylate form of camptothecin by human serum albumin
    • Burke, T.G., Mi, Z. Preferential binding of the carboxylate form of camptothecin by human serum albumin. Anal Biochem 1993, 212: 285-7.
    • (1993) Anal Biochem , vol.212 , pp. 285-287
    • Burke, T.G.1    Mi, Z.2
  • 22
    • 0028012774 scopus 로고
    • The structural basis of camptothecin interactions with human serum albumin: Impact on drug stability
    • Burke, T.G., Mi, Z. The structural basis of camptothecin interactions with human serum albumin: Impact on drug stability. J Med Chem 1994, 37: 40-6.
    • (1994) J Med Chem , vol.37 , pp. 40-46
    • Burke, T.G.1    Mi, Z.2
  • 23
    • 0028937909 scopus 로고
    • The important role of albumin in determining the relative human blood stabilities of the camptothecin anticancer drugs
    • Burke, T.G., Munshi, C.B., Mi, Z., Jiang, Y. The important role of albumin in determining the relative human blood stabilities of the camptothecin anticancer drugs. J Pharm Sci 1995, 84: 518-9.
    • (1995) J Pharm Sci , vol.84 , pp. 518-519
    • Burke, T.G.1    Munshi, C.B.2    Mi, Z.3    Jiang, Y.4
  • 24
    • 0030014783 scopus 로고    scopus 로고
    • DNA topoisomerases
    • Wang, J.C. DNA topoisomerases. Annu Rev Biochem 1996, 65: 635-92.
    • (1996) Annu Rev Biochem , vol.65 , pp. 635-692
    • Wang, J.C.1
  • 25
    • 0028711272 scopus 로고
    • The DNA binding, cleavage, and religation reactions of eukaryotic topoisomerases I and II
    • Andersen, A.H., Svejstrup, J.Q., Westergaard, O. The DNA binding, cleavage, and religation reactions of eukaryotic topoisomerases I and II. Adv Pharmacol 1995, 29A: 83-102.
    • (1995) Adv Pharmacol , vol.29 A , pp. 83-102
    • Andersen, A.H.1    Svejstrup, J.Q.2    Westergaard, O.3
  • 28
    • 0021760306 scopus 로고
    • Nucleotide sequence preference at rat liver and wheat germ type 1 DNA topoisomerase breakage sites in duplex SV4O DNA
    • Been, M.D., Burgess, R.R., Champoux, J.J. Nucleotide sequence preference at rat liver and wheat germ type 1 DNA topoisomerase breakage sites in duplex SV4O DNA. Nucl Acid Res 1984, 12: 3097-111.
    • (1984) Nucl Acid Res , vol.12 , pp. 3097-3111
    • Been, M.D.1    Burgess, R.R.2    Champoux, J.J.3
  • 29
    • 0024324205 scopus 로고
    • On the mechanism of topoisomerase I inhibition by camptothecin: Evidence for binding to an enzyme-DNA complex
    • Hertzberg, R.P., Caranfa, M.J., Hecht, S. On the mechanism of topoisomerase I inhibition by camptothecin: Evidence for binding to an enzyme-DNA complex. Biochemistry 1989, 28: 4629-38.
    • (1989) Biochemistry , vol.28 , pp. 4629-4638
    • Hertzberg, R.P.1    Caranfa, M.J.2    Hecht, S.3
  • 30
    • 0025719903 scopus 로고
    • Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin
    • Jaxel, C., Capranico, G., Kerrigan, D., Kohn, K.W., Pommier, Y. Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin. J Biol Chem 1991, 266: 20418-23.
    • (1991) J Biol Chem , vol.266 , pp. 20418-20423
    • Jaxel, C.1    Capranico, G.2    Kerrigan, D.3    Kohn, K.W.4    Pommier, Y.5
  • 31
    • 0027501814 scopus 로고
    • Induction of cleavage in topoisomerase I c-DNA by topoisomerase I enzymes from calf thymus and wheat germ in the presence and absence of camptothecin
    • Tanizawa, A., Kohn, K.W., Pommier, Y. Induction of cleavage in topoisomerase I c-DNA by topoisomerase I enzymes from calf thymus and wheat germ in the presence and absence of camptothecin. Nucl Acid Res 1993, 21: 5157-66.
    • (1993) Nucl Acid Res , vol.21 , pp. 5157-5166
    • Tanizawa, A.1    Kohn, K.W.2    Pommier, Y.3
  • 32
    • 0028225471 scopus 로고
    • Comparison of topoisomerase I inhibition, DNA damage and cytotoxicity of camptothecin derivatives presently in clinical trials
    • Tanizawa, A., Fujimori, A., Fujimori, Y., Pommier, Y. Comparison of topoisomerase I inhibition, DNA damage and cytotoxicity of camptothecin derivatives presently in clinical trials. J Natl Cancer Inst 1994, 86: 836-42.
    • (1994) J Natl Cancer Inst , vol.86 , pp. 836-842
    • Tanizawa, A.1    Fujimori, A.2    Fujimori, Y.3    Pommier, Y.4
  • 33
    • 0028999826 scopus 로고
    • Differential stabilization of eukaryotic DNA topoisomerase I deavable complexes by camptothecin derivatives
    • Tanizawa, A., Kohn, K.W., Kohlhagen, G., Leteurtre, F., Pommier, Y. Differential stabilization of eukaryotic DNA topoisomerase I deavable complexes by camptothecin derivatives. Biochemistry 1995, 34: 7200-6.
    • (1995) Biochemistry , vol.34 , pp. 7200-7206
    • Tanizawa, A.1    Kohn, K.W.2    Kohlhagen, G.3    Leteurtre, F.4    Pommier, Y.5
  • 34
    • 0025276858 scopus 로고
    • A model for tumour cell killing by topoisomerase poisons
    • Zhang, H., D'Arpa, P., Liu, L.F. A model for tumour cell killing by topoisomerase poisons. Cancer Cells 1990, 2: 23-7.
    • (1990) Cancer Cells , vol.2 , pp. 23-27
    • Zhang, H.1    D'Arpa, P.2    Liu, L.F.3
  • 35
    • 0025812689 scopus 로고
    • Camptothecin cytotoxicity in mammalian cells is associated with the induction of persistent double strand breaks in replicating DNA
    • Ryan, A.J., Squires, S., Strutt, H.L., Johnson, R.T. Camptothecin cytotoxicity in mammalian cells is associated with the induction of persistent double strand breaks in replicating DNA. Nucl Acid Res 1991, 19: 3295-300.
    • (1991) Nucl Acid Res , vol.19 , pp. 3295-3300
    • Ryan, A.J.1    Squires, S.2    Strutt, H.L.3    Johnson, R.T.4
  • 36
    • 0027211007 scopus 로고
    • Eukaryotic topoisomerase I-mediated cleavage requires bipartite DNA interaction. Cleavage of DNA substrates containing strand interruptions implicates a role for topoisomerase I in illegitimate recombination
    • Christiansen, K., Dirac Svejstrup, A.B., Andersen, A.M., Westergaard, O. Eukaryotic topoisomerase I-mediated cleavage requires bipartite DNA interaction. Cleavage of DNA substrates containing strand interruptions implicates a role for topoisomerase I in illegitimate recombination. J Biol Chem 1993, 268: 9690-701.
    • (1993) J Biol Chem , vol.268 , pp. 9690-9701
    • Christiansen, K.1    Diracsvejstrup, A.B.2    Andersen, A.M.3    Westergaard, O.4
  • 37
    • 0027432215 scopus 로고
    • Importance of replication fork progression for the induction of chromosome damage and SCE by inhibitors of DNA topoisomerases
    • Cortes, F., Pinero, J., Ortiz, T. Importance of replication fork progression for the induction of chromosome damage and SCE by inhibitors of DNA topoisomerases. Mutat Res 1993, 303: 71-6.
    • (1993) Mutat Res , vol.303 , pp. 71-76
    • Cortes, F.1    Pinero, J.2    Ortiz, T.3
  • 38
    • 0025877991 scopus 로고
    • Camptothecin. teniposide, or 4′-(9-acridinylamino)-3-methanesulfon-m-anisidide, but not mitoxantrone or doxorubicin, induces degradation of nuclear DNA in the S phase of HL-60 cells
    • Del Bino, G., Darzynkiewicz, Z. Camptothecin. teniposide, or 4′-(9-acridinylamino)-3-methanesulfon-m-anisidide, but not mitoxantrone or doxorubicin, induces degradation of nuclear DNA in the S phase of HL-60 cells. Cancer Res 1991, 51: 1165-9.
    • (1991) Cancer Res , vol.51 , pp. 1165-1169
    • Del Bino, G.1    Darzynkiewicz, Z.2
  • 39
    • 0029661932 scopus 로고    scopus 로고
    • 2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells
    • 2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells. Cancer Res 1996, 56: 4430-7.
    • (1996) Cancer Res , vol.56 , pp. 4430-4437
    • Goldwasser, F.1    Shimizu, T.2    Jackman, J.3
  • 40
    • 0031007155 scopus 로고    scopus 로고
    • Down-regulation of DNA replication in extracts of camptothecin-treated cells: Activation of an S-phase checkpoint?
    • Wang, Y., Perrault, A.R., Iliakis, G. Down-regulation of DNA replication in extracts of camptothecin-treated cells: Activation of an S-phase checkpoint? Cancer Res 1997, 57: 1654-9.
    • (1997) Cancer Res , vol.57 , pp. 1654-1659
    • Wang, Y.1    Perrault, A.R.2    Iliakis, G.3
  • 41
    • 0027386228 scopus 로고
    • Different patterns of apoptosis of HL-60 cells induced by cycloheximide and camptothecin
    • Gong, J., Li, X., Darzynkiewicz, Z. Different patterns of apoptosis of HL-60 cells induced by cycloheximide and camptothecin. J Cell Physiol 1993, 157: 263-70.
    • (1993) J Cell Physiol , vol.157 , pp. 263-270
    • Gong, J.1    Li, X.2    Darzynkiewicz, Z.3
  • 42
    • 0026339352 scopus 로고
    • Camptothecin over-comes MDR1-mediated resistance in human KB carcinoma cells
    • Chen, A.Y., Yu, C., Potmetsil, M., Wall, M.E., Wani, M.C., Liu, L.F. Camptothecin over-comes MDR1-mediated resistance in human KB carcinoma cells. Cancer Res 1991, 51: 6039-44.
    • (1991) Cancer Res , vol.51 , pp. 6039-6044
    • Chen, A.Y.1    Yu, C.2    Potmetsil, M.3    Wall, M.E.4    Wani, M.C.5    Liu, L.F.6
  • 43
    • 0026772298 scopus 로고
    • Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue
    • Hendricks, C.B., Rowinsky, E.K., Grochow, L.B., Donehower, R.C., Kaufmann, S.H. Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue. Cancer Res 1992, 52: 2268-78.
    • (1992) Cancer Res , vol.52 , pp. 2268-2278
    • Hendricks, C.B.1    Rowinsky, E.K.2    Grochow, L.B.3    Donehower, R.C.4    Kaufmann, S.H.5
  • 44
    • 0025785082 scopus 로고
    • Antitumour activity of a camptothecin derivative, CPT-11, against human tumour xenografts in nude mice
    • Kawato, Y., Furuta, T., Aonuma, M., Yasuoka, M., Yokokura, T., Matsumoto, K. Antitumour activity of a camptothecin derivative, CPT-11, against human tumour xenografts in nude mice. Cancer Chemother Pharmacol 1991, 28: 192-8.
    • (1991) Cancer Chemother Pharmacol , vol.28 , pp. 192-198
    • Kawato, Y.1    Furuta, T.2    Aonuma, M.3    Yasuoka, M.4    Yokokura, T.5    Matsumoto, K.6
  • 45
    • 0025084410 scopus 로고
    • Establishment of a camptothecin analogue (CPT-11)-resistant cell line of human non-small cell lung cancer: Characterization and mechanism of resistance
    • Kanzawa, F., Sugimoto, Y., Minato, K. et al. Establishment of a camptothecin analogue (CPT-11)-resistant cell line of human non-small cell lung cancer: Characterization and mechanism of resistance. Cancer Res 1990, 50: 5919-24.
    • (1990) Cancer Res , vol.50 , pp. 5919-5924
    • Kanzawa, F.1    Sugimoto, Y.2    Minato, K.3
  • 46
    • 0026595541 scopus 로고
    • Mechanism of cross-resistance to a camptothecin analogue (CPT-11) in a human ovarian cancer cell line selected by cisplatin
    • Niimi, S., Nakagawa, K., Sugimoto Y. et al. Mechanism of cross-resistance to a camptothecin analogue (CPT-11) in a human ovarian cancer cell line selected by cisplatin. Cancer Res 1992, 52: 328-33.
    • (1992) Cancer Res , vol.52 , pp. 328-333
    • Niimi, S.1    Nakagawa, K.2    Sugimoto, Y.3
  • 47
    • 0027005977 scopus 로고
    • Camptothecin hyper-resistant P388 cells: Drug-dependent reduction in topoisomerase I content
    • Woessner R.D., Eng, W.K., Hofmann, G.A. et al. Camptothecin hyper-resistant P388 cells: Drug-dependent reduction in topoisomerase I content. Oncol Res 1992, 4: 481-8.
    • (1992) Oncol Res , vol.4 , pp. 481-488
    • Woessner, R.D.1    Eng, W.K.2    Hofmann, G.A.3
  • 48
    • 0026503077 scopus 로고
    • Overexpression of human topoisomerase I in baby hamster kidney cells: Hypersensitivity of clonal isolates to camptothecin
    • Madden, K.R., Champoux, J.J. Overexpression of human topoisomerase I in baby hamster kidney cells: Hypersensitivity of clonal isolates to camptothecin. Cancer Res 1992, 52: 525-32.
    • (1992) Cancer Res , vol.52 , pp. 525-532
    • Madden, K.R.1    Champoux, J.J.2
  • 49
    • 0026683277 scopus 로고
    • Differential expression of DNA topoisomerase I gene between CPT-11 acquired- and native-resistant human pancreatic tumor cell lines: Detected by RNA/PCR-based quantitation assay
    • Takeda, S., Shimazoe, T., Sato, K., Sugimoto, Y., Tsuruo, T., Kono, A. Differential expression of DNA topoisomerase I gene between CPT-11 acquired- and native-resistant human pancreatic tumor cell lines: Detected by RNA/PCR-based quantitation assay. Biochem Biophys Res Commun 1992, 184: 618-25.
    • (1992) Biochem Biophys Res Commun , vol.184 , pp. 618-625
    • Takeda, S.1    Shimazoe, T.2    Sato, K.3    Sugimoto, Y.4    Tsuruo, T.5    Kono, A.6
  • 50
    • 0029072716 scopus 로고
    • Camptothecin induction of a time-and concentration-dependent decrease of topoisomerase I and its implication in camptothecin activity
    • Beidler, D.R., Cheng, Y.C. Camptothecin induction of a time-and concentration-dependent decrease of topoisomerase I and its implication in camptothecin activity. Mol Pharmacol 1995, 47: 907-14.
    • (1995) Mol Pharmacol , vol.47 , pp. 907-914
    • Beidler, D.R.1    Cheng, Y.C.2
  • 51
    • 0027153395 scopus 로고
    • Quantitative analysis of DNA topoisomerase I activity in human and rat glioma: Characterization and mechanism of resistance to antitopoisomerase chemical, camptothecin-11
    • Matsumoto, Y., Fujiwara, T., Honjo, Y., Sasaoka, N., Tsuchida, R., Nagao, S. Quantitative analysis of DNA topoisomerase I activity in human and rat glioma: Characterization and mechanism of resistance to antitopoisomerase chemical, camptothecin-11. J Surg Oncol 1993, 53: 97-103.
    • (1993) J Surg Oncol , vol.53 , pp. 97-103
    • Matsumoto, Y.1    Fujiwara, T.2    Honjo, Y.3    Sasaoka, N.4    Tsuchida, R.5    Nagao, S.6
  • 52
    • 0027963424 scopus 로고
    • Semi-quantitative analysis of DNA-topoisomerase I mRNA level using reverse transcription-polymerase chain reaction in cancer cell lines: Its relation to cytotoxicity against camptothecin derivative
    • Niwa, K., Misao, R., Hanabayashi, T. et al. Semi-quantitative analysis of DNA-topoisomerase I mRNA level using reverse transcription-polymerase chain reaction in cancer cell lines: Its relation to cytotoxicity against camptothecin derivative. Jpn J Cancer Res 1994, 85: 869-74.
    • (1994) Jpn J Cancer Res , vol.85 , pp. 869-874
    • Niwa, K.1    Misao, R.2    Hanabayashi, T.3
  • 53
    • 0029758307 scopus 로고    scopus 로고
    • Variation in topoisomerase I gene copy number as a mechanism for intrinsic drug sensitivity
    • McLeod, H.L., Keith, W.N. Variation in topoisomerase I gene copy number as a mechanism for intrinsic drug sensitivity. Br J Cancer 1996, 74: 508-12.
    • (1996) Br J Cancer , vol.74 , pp. 508-512
    • McLeod, H.L.1    Keith, W.N.2
  • 55
    • 0027472338 scopus 로고
    • Sequential modifications of topoisomerase I activity in a camptothecin-resistant cell line established by progressive adaptation
    • Madelaine, I., Prost, S., Naudin, A., Riou, G., Lavelle, F., Riou, J.F. Sequential modifications of topoisomerase I activity in a camptothecin-resistant cell line established by progressive adaptation. Biochem Pharmacol 1993, 45: 339-48.
    • (1993) Biochem Pharmacol , vol.45 , pp. 339-348
    • Madelaine, I.1    Prost, S.2    Naudin, A.3    Riou, G.4    Lavelle, F.5    Riou, J.F.6
  • 56
    • 0027963526 scopus 로고
    • Establishment of a CRT-11-resistant human ovarian cancer cell line
    • Kijima, T., Kubota, N., Nishio, K. Establishment of a CRT-11-resistant human ovarian cancer cell line. Anticancer Res 1994, 14: 799-804.
    • (1994) Anticancer Res , vol.14 , pp. 799-804
    • Kijima, T.1    Kubota, N.2    Nishio, K.3
  • 57
    • 0029003314 scopus 로고
    • Altered topoisomerase I expression in two subclones of human CEM leukemia selected for resistance to camptothecin
    • Kapoor, R., Slade, D.L., Fujimori, A., Pommier, Y., Harker, W.G. Altered topoisomerase I expression in two subclones of human CEM leukemia selected for resistance to camptothecin. Oncol Res 1995, 7: 83-95.
    • (1995) Oncol Res , vol.7 , pp. 83-95
    • Kapoor, R.1    Slade, D.L.2    Fujimori, A.3    Pommier, Y.4    Harker, W.G.5
  • 58
    • 0025115965 scopus 로고
    • Development of a stable camptothecin-resistant subline of P388 leukemia with reduced topoisomerase I content
    • Eng, W.K., McCabe, F.L., Tan, K.B. et al. Development of a stable camptothecin-resistant subline of P388 leukemia with reduced topoisomerase I content. Mol Pharmacol 1990, 38: 471-80.
    • (1990) Mol Pharmacol , vol.38 , pp. 471-480
    • Eng, W.K.1    McCabe, F.L.2    Tan, K.B.3
  • 59
    • 0025151823 scopus 로고
    • Decreased expression of DNA topoisomerase I in camptothecin-resistant tumor cell lines as determined by a monoclonal antibody
    • Sugimoto, Y., Tsukahara, S., Oh-hara, T., Isoe, T., Tsuruo, T. Decreased expression of DNA topoisomerase I in camptothecin-resistant tumor cell lines as determined by a monoclonal antibody. Cancer Res 1990, 50: 6925-30.
    • (1990) Cancer Res , vol.50 , pp. 6925-6930
    • Sugimoto, Y.1    Tsukahara, S.2    Oh-hara, T.3    Isoe, T.4    Tsuruo, T.5
  • 60
    • 0026694495 scopus 로고
    • Topoisomerase I alteration in a camptothecin-resistant cell line derived from Chinese hamster DC3F cells in culture
    • Tanizawa, A., Pommier, Y. Topoisomerase I alteration in a camptothecin-resistant cell line derived from Chinese hamster DC3F cells in culture. Cancer Res 1992, 52: 1848-54.
    • (1992) Cancer Res , vol.52 , pp. 1848-1854
    • Tanizawa, A.1    Pommier, Y.2
  • 61
    • 0026497895 scopus 로고
    • Detection of topoisomerase I gene point mutation in CPT-11 resistant lung cancer cell line
    • Kubota, N., Kanzawa, F., Mishio, K. et al. Detection of topoisomerase I gene point mutation in CPT-11 resistant lung cancer cell line. Biochem Biophys Res Commun 1992, 188: 571-7.
    • (1992) Biochem Biophys Res Commun , vol.188 , pp. 571-577
    • Kubota, N.1    Kanzawa, F.2    Mishio, K.3
  • 62
    • 0030899190 scopus 로고    scopus 로고
    • Identifications of mutations at DNA topoisomerase I responsible for camptothecin resistance
    • Wang, L.F., Ting, C.Y., Lo, C.K. et al. Identifications of mutations at DNA topoisomerase I responsible for camptothecin resistance. Cancer Res 1997, 57: 1516-22.
    • (1997) Cancer Res , vol.57 , pp. 1516-1522
    • Wang, L.F.1    Ting, C.Y.2    Lo, C.K.3
  • 63
    • 0028957974 scopus 로고
    • Mutation at the catalytic site of topoisomerase I in CEM/C2, a human leukemia cell line resistant to camptothecin
    • Fujimori, A., Harker, W.G., Kohlhagen, G., Hoki, Y., Pommier, Y. Mutation at the catalytic site of topoisomerase I in CEM/C2, a human leukemia cell line resistant to camptothecin. Cancer Res 1995, 55: 1339-46.
    • (1995) Cancer Res , vol.55 , pp. 1339-1346
    • Fujimori, A.1    Harker, W.G.2    Kohlhagen, G.3    Hoki, Y.4    Pommier, Y.5
  • 64
    • 0026032557 scopus 로고
    • Molecular cloning of a cDNA camptothecin-resistant human DNA topoisomerase I and identification of mutation sites
    • Tamura, H., Kohchi, C., Yamada, R. et al. Molecular cloning of a cDNA camptothecin-resistant human DNA topoisomerase I and identification of mutation sites. Nucl Acid Res 1991, 19: 69-75.
    • (1991) Nucl Acid Res , vol.19 , pp. 69-75
    • Tamura, H.1    Kohchi, C.2    Yamada, R.3
  • 66
    • 0027368901 scopus 로고
    • Cloning of Chinese hamster DNA topoisomerase I cDNA and identification of a single point mutation responsible for camptothecin resistance
    • Tanizawa, A., Bertrand, R., Kohlhagen, G., Tabuchi, A., Jenkins, J., Pommier, Y. Cloning of Chinese hamster DNA topoisomerase I cDNA and identification of a single point mutation responsible for camptothecin resistance. J Biol Chem 1993, 268: 25463-8.
    • (1993) J Biol Chem , vol.268 , pp. 25463-25468
    • Tanizawa, A.1    Bertrand, R.2    Kohlhagen, G.3    Tabuchi, A.4    Jenkins, J.5    Pommier, Y.6
  • 67
    • 0030972846 scopus 로고    scopus 로고
    • Involvement of amino acids 361 to 364 of human topoisomerase I in camptothecin resistance and enzyme catalysis
    • Li, X.G., Haluska, P., Hsiang, Y.H. et al. Involvement of amino acids 361 to 364 of human topoisomerase I in camptothecin resistance and enzyme catalysis. Biochem Pharmacol 1997, 53: 1019-27.
    • (1997) Biochem Pharmacol , vol.53 , pp. 1019-1027
    • Li, X.G.1    Haluska, P.2    Hsiang, Y.H.3
  • 68
    • 0030057744 scopus 로고    scopus 로고
    • Camptothecin resistance involving steps subsequent to the formation of protein-linked DNA breaks in human camptothecin-resistant KB cell lines
    • Beidler, D.R., Chang, J.Y., Zhou, B.S., Cheng, Y.C. Camptothecin resistance involving steps subsequent to the formation of protein-linked DNA breaks in human camptothecin-resistant KB cell lines. Cancer Res 1996, 56: 345-53.
    • (1996) Cancer Res , vol.56 , pp. 345-353
    • Beidler, D.R.1    Chang, J.Y.2    Zhou, B.S.3    Cheng, Y.C.4
  • 69
    • 0030476665 scopus 로고    scopus 로고
    • Acquired camptothecin resistance of human breast cancer MCF-7/C4 cells with normal topoisomerase I and elevated DNA repair
    • Fujimori, A., Gupta, M., Hoki, Y., Pommier, Y. Acquired camptothecin resistance of human breast cancer MCF-7/C4 cells with normal topoisomerase I and elevated DNA repair. Mol Pharmacol 1996, 50: 1472-8.
    • (1996) Mol Pharmacol , vol.50 , pp. 1472-1478
    • Fujimori, A.1    Gupta, M.2    Hoki, Y.3    Pommier, Y.4
  • 70
    • 0029029436 scopus 로고
    • Topoisomerase I-related parameters and camptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen
    • Goldwasser, F., Bae, I., Valenti, M., Torres, K., Pommier, Y. Topoisomerase I-related parameters and camptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen. Cancer Res 1995, 55: 2116-21.
    • (1995) Cancer Res , vol.55 , pp. 2116-2121
    • Goldwasser, F.1    Bae, I.2    Valenti, M.3    Torres, K.4    Pommier, Y.5
  • 71
    • 0023395222 scopus 로고
    • Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I
    • Andoh, T., Ishii, K., Susuki, Y. et al. Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I. Proc Natl Acad Sci USA 1987, 84: 5565-9.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 5565-5569
    • Andoh, T.1    Ishii, K.2    Susuki, Y.3
  • 72
    • 0025686125 scopus 로고
    • Elevated expression of DNA topoisomerase II in camptothecin-resistant human tumor cells lines
    • Sugimoto, Y., Tsukahara, S., Oh-hara, T., Liu, L.F., Tsuruo, T. Elevated expression of DNA topoisomerase II in camptothecin-resistant human tumor cells lines. Cancer Res 1990, 50: 7962-5.
    • (1990) Cancer Res , vol.50 , pp. 7962-7965
    • Sugimoto, Y.1    Tsukahara, S.2    Oh-hara, T.3    Liu, L.F.4    Tsuruo, T.5
  • 73
    • 0028068128 scopus 로고
    • Synergistic effect of inhibitors of topoisomerase I and II on chromosome damage and cell killing in cultured Chinese hamster ovary cells
    • Cortes, F., Pinero, J. Synergistic effect of inhibitors of topoisomerase I and II on chromosome damage and cell killing in cultured Chinese hamster ovary cells. Cancer Chemother Pharmacol 1994, 34: 411-5.
    • (1994) Cancer Chemother Pharmacol , vol.34 , pp. 411-415
    • Cortes, F.1    Pinero, J.2
  • 74
    • 0026594602 scopus 로고
    • Sequential administration of camptothecin and etoposide circumvents the antagonistic cytotoxicity of simultaneous drug administration in slowly growing human colon carcinoma HT-29 cells
    • Bertrand, R., O'Connor, P.M., Kerrigan, D., Pommier, Y. Sequential administration of camptothecin and etoposide circumvents the antagonistic cytotoxicity of simultaneous drug administration in slowly growing human colon carcinoma HT-29 cells. Eur J Cancer 1992, 28A: 743-8.
    • (1992) Eur J Cancer , vol.28 A , pp. 743-748
    • Bertrand, R.1    O'Connor, P.M.2    Kerrigan, D.3    Pommier, Y.4
  • 75
    • 0026600884 scopus 로고
    • Experimental studies on biochemical modulation targeting topoisomerase I and II in human tumour xenografts in nude mice
    • Kim, R., Hirabayashi, N., Nishiyama, M., Jinushi, K., Toge, T., Okada, K. Experimental studies on biochemical modulation targeting topoisomerase I and II in human tumour xenografts in nude mice. Int J Cancer 1992, 50: 760-6.
    • (1992) Int J Cancer , vol.50 , pp. 760-766
    • Kim, R.1    Hirabayashi, N.2    Nishiyama, M.3    Jinushi, K.4    Toge, T.5    Okada, K.6
  • 76
    • 0026441127 scopus 로고
    • Posttreatment exposure to camptothecin enhances the lethal effects of x-rays on radioresistant human malignant melanoma cells
    • Boothman, D.A., Wang, M., Schea, R.A., Burrows, H.L., Strickfaden, S., Owens, J.K. Posttreatment exposure to camptothecin enhances the lethal effects of x-rays on radioresistant human malignant melanoma cells. Int J Radiat Oncol Biol Phys 1992, 24: 939-48.
    • (1992) Int J Radiat Oncol Biol Phys , vol.24 , pp. 939-948
    • Boothman, D.A.1    Wang, M.2    Schea, R.A.3    Burrows, H.L.4    Strickfaden, S.5    Owens, J.K.6
  • 77
    • 0027377069 scopus 로고
    • Beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin
    • Li, C.J., Averboukh, L., Pardee, A.B. beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. J Biol Chem 1993, 268: 22463-8.
    • (1993) J Biol Chem , vol.268 , pp. 22463-22468
    • Li, C.J.1    Averboukh, L.2    Pardee, A.B.3
  • 78
    • 0026328062 scopus 로고
    • Synergistic cell killing by ionizing radiation and topoisomerase I inhibitor topotecan (SK&F 104864)
    • Mattern, M.R., Hofmann, G.A., McCabe, F.L., Johnson. R.K. Synergistic cell killing by ionizing radiation and topoisomerase I inhibitor topotecan (SK&F 104864). Cancer Res 1991, 51: 5813-6.
    • (1991) Cancer Res , vol.51 , pp. 5813-5816
    • Mattern, M.R.1    Hofmann, G.A.2    McCabe, F.L.3    Johnson, R.K.4
  • 79
    • 0028198312 scopus 로고
    • Potentiation of radioimmunotherapy by inhibition of topoisomerase I
    • Roffler, S.R., Chan, J., Yeh, M.Y. Potentiation of radioimmunotherapy by inhibition of topoisomerase I. Cancer Res 1994, 54: 1276-85.
    • (1994) Cancer Res , vol.54 , pp. 1276-1285
    • Roffler, S.R.1    Chan, J.2    Yeh, M.Y.3
  • 80
    • 0030907319 scopus 로고    scopus 로고
    • Mammalian DNA topoisomerase I mediates the enhancement of radiation cytotoxicity by camptothecin derivatives
    • Chen, A.Y., Okunieff. P., Pommier, Y., Mitchell, J.B. Mammalian DNA topoisomerase I mediates the enhancement of radiation cytotoxicity by camptothecin derivatives. Cancer Res 1997, 57: 1529-36.
    • (1997) Cancer Res , vol.57 , pp. 1529-1536
    • Chen, A.Y.1    Okunieff, P.2    Pommier, Y.3    Mitchell, J.B.4
  • 81
    • 0027965156 scopus 로고
    • Synergistic enhancement of cisplatin cytotoxicity by SN-38, an active metabolite of CPT-11, for cisplatin-resistant HeLa cells
    • Minagawa, Y., Kigawa, J., Ishihara, H., Itamochi, H., Terakawa, N. Synergistic enhancement of cisplatin cytotoxicity by SN-38, an active metabolite of CPT-11, for cisplatin-resistant HeLa cells. Jpn J Cancer Res 1994, 85: 966-71.
    • (1994) Jpn J Cancer Res , vol.85 , pp. 966-971
    • Minagawa, Y.1    Kigawa, J.2    Ishihara, H.3    Itamochi, H.4    Terakawa, N.5
  • 82
    • 0030068657 scopus 로고    scopus 로고
    • Synergism between cisplatin and topoisomerase I inhibitors, NB-506 and SN-38. in human small cell lung cancer cells
    • Fukuda, M., Nishio, K., Kanzawa, F. et al. Synergism between cisplatin and topoisomerase I inhibitors, NB-506 and SN-38. in human small cell lung cancer cells. Cancer Res 1996, 56: 789-93.
    • (1996) Cancer Res , vol.56 , pp. 789-793
    • Fukuda, M.1    Nishio, K.2    Kanzawa, F.3
  • 83
    • 0028363694 scopus 로고
    • Increased expression of DNA topoisomerase I gene and collateral sensitivity to camptothecin in human cisplatin-resistant bladder cancer cells
    • Kotoh, S., Naito, S., Yokomizo, A. et al. Increased expression of DNA topoisomerase I gene and collateral sensitivity to camptothecin in human cisplatin-resistant bladder cancer cells. Cancer Res 1994, 54: 3248-52.
    • (1994) Cancer Res , vol.54 , pp. 3248-3252
    • Kotoh, S.1    Naito, S.2    Yokomizo, A.3
  • 84
    • 0029073863 scopus 로고
    • Cytotoxicity of CPT-11 for gastrointestinal cancer cells cultured on fixed-contact sensitive plates
    • Matsuoka, H., Yano, K., Seo, Y. et al. Cytotoxicity of CPT-11 for gastrointestinal cancer cells cultured on fixed-contact sensitive plates. Anticancer Drugs 1995, 6: 413-8.
    • (1995) Anticancer Drugs , vol.6 , pp. 413-418
    • Matsuoka, H.1    Yano, K.2    Seo, Y.3
  • 85
    • 0030014198 scopus 로고    scopus 로고
    • Experimental antitumor activity and pharmacokinetics of the camptothecin analog irinotecan (CPT-11) in mice
    • Bissery, M.C., Vrignaud, P., Lavelle, F., Chabot, G.G. Experimental antitumor activity and pharmacokinetics of the camptothecin analog irinotecan (CPT-11) in mice. Anti-cancer Drugs 1996, 7: 437-60.
    • (1996) Anti-cancer Drugs , vol.7 , pp. 437-460
    • Bissery, M.C.1    Vrignaud, P.2    Lavelle, F.3    Chabot, G.G.4
  • 86
    • 0028221421 scopus 로고
    • Activity of CPT-11 (irinotecan hydrochloride), a topoisomerase I inhibitor, against human tumor colony-forming units
    • Shimada, Y., Rothenberg, M., Hilsenbeck, S.G., Burris, H.A., Degen, D., Von Hoff, D.D. Activity of CPT-11 (irinotecan hydrochloride), a topoisomerase I inhibitor, against human tumor colony-forming units. Anticancer Drugs 1994, 5: 202-6.
    • (1994) Anticancer Drugs , vol.5 , pp. 202-206
    • Shimada, Y.1    Rothenberg, M.2    Hilsenbeck, S.G.3    Burris, H.A.4    Degen, D.5    Von Hoff, D.D.6
  • 87
    • 0023864510 scopus 로고
    • Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo
    • Tsuruo, T., Matsusaki, T., Matsushita, M., Saito, H., Yokokura, T. Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo. Cancer Chemother Pharmacol 1988, 21: 71-4.
    • (1988) Cancer Chemother Pharmacol , vol.21 , pp. 71-74
    • Tsuruo, T.1    Matsusaki, T.2    Matsushita, M.3    Saito, H.4    Yokokura, T.5
  • 88
    • 0027813132 scopus 로고
    • In vitro and in vivo effects of clinically important camptothecin analogues on multidrug resistant cells
    • Mattern, M.R., Hofman, G.A., Polsky, R.M., Funk, L.R., McCabe, F.L., Johnson, R.K. In vitro and in vivo effects of clinically important camptothecin analogues on multidrug resistant cells. Oncol Res 1993, 5: 467-74.
    • (1993) Oncol Res , vol.5 , pp. 467-474
    • Mattern, M.R.1    Hofman, G.A.2    Polsky, R.M.3    Funk, L.R.4    McCabe, F.L.5    Johnson, R.K.6
  • 89
    • 84878736475 scopus 로고    scopus 로고
    • Sequence-dependent activity of the irinotecan-5-fluorouracil combination in the human colon cancer model HT-29 in vitro and in vivo
    • in press
    • Guichard, S., Cussac, D., Hennebelle, I., Bugat, R., Canal. P. Sequence-dependent activity of the irinotecan-5-fluorouracil combination in the human colon cancer model HT-29 in vitro and in vivo. Int J Cancer, in press.
    • Int J Cancer
    • Guichard, S.1    Cussac, D.2    Hennebelle, I.3    Bugat, R.4    Canal, P.5
  • 90
    • 0023552964 scopus 로고
    • Antitumor activity of 7-ethyl-10-(-4-[1-piperidino]-1-piperidino)-carbonyloxycamptothecin, a novel water-soluble derivative of camptothecin, against murine tumors
    • Kunimoto, T., Nitta, K., Tanaka, T. et al. Antitumor activity of 7-ethyl-10-(-4-[1-piperidino]-1-piperidino)-carbonyloxycamptothecin, a novel water-soluble derivative of camptothecin, against murine tumors. Cancer Res 1987, 47: 5944-7.
    • (1987) Cancer Res , vol.47 , pp. 5944-5947
    • Kunimoto, T.1    Nitta, K.2    Tanaka, T.3
  • 91
    • 0027324850 scopus 로고
    • Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(-4-[1-piperidino]-1-piperidino)-carbonyloxycamptothecin against human tumor xenographs: Lack of cross-resistance in vivo in tumors with acquired resistance to the topoisomerase I inhibitor 9-dimethylaminomethyl-10-hydroxycamptothecin
    • Houghton, P.J., Cheshire, P.J., Hallman, J.C., Bissery, M.C., Mathieu-Boué, A., Houghton, J.A. Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(-4-[1-piperidino]-1-piperidino)-carbonyloxycamptothecin against human tumor xenographs: Lack of cross-resistance in vivo in tumors with acquired resistance to the topoisomerase I inhibitor 9-dimethylaminomethyl-10-hydroxycamptothecin. Cancer Res 1993, 53: 2823-9.
    • (1993) Cancer Res , vol.53 , pp. 2823-2829
    • Houghton, P.J.1    Cheshire, P.J.2    Hallman, J.C.3    Bissery, M.C.4    Mathieu-Boué, A.5    Houghton, J.A.6
  • 92
    • 0029116438 scopus 로고
    • Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors
    • Houghton, P.J., Cheshire, P.J., Hallman, J.C. et al. Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors. Cancer Chemother Pharmacol 1995, 36: 393-403.
    • (1995) Cancer Chemother Pharmacol , vol.36 , pp. 393-403
    • Houghton, P.J.1    Cheshire, P.J.2    Hallman, J.C.3
  • 93
    • 9444258554 scopus 로고    scopus 로고
    • Therapeutic activity of CPT-11, a DNA-topoisomerase I inhibitor, against peripheral primitive neuroectodermal tumour and neuroblastoma xenografts
    • Vassal, G., Terrier-Lacombe, M.J., Bissery, M.C. et al. Therapeutic activity of CPT-11, a DNA-topoisomerase I inhibitor, against peripheral primitive neuroectodermal tumour and neuroblastoma xenografts. Br J Cancer 1996, 74: 537-45.
    • (1996) Br J Cancer , vol.74 , pp. 537-545
    • Vassal, G.1    Terrier-Lacombe, M.J.2    Bissery, M.C.3
  • 94
    • 0031060230 scopus 로고    scopus 로고
    • Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(-4-[1-piperidino]-1 -piperidino)carbonyloxycamptothecin against pediatric and adult central nervous system tumor xenografts
    • Hare, C.B., Elion, G.B., Houghton, P.J. et al. Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(-4-[1-piperidino]-1 -piperidino)carbonyloxycamptothecin against pediatric and adult central nervous system tumor xenografts. Cancer Chemother Pharmacol 1997, 39: 187-91.
    • (1997) Cancer Chemother Pharmacol , vol.39 , pp. 187-191
    • Hare, C.B.1    Elion, G.B.2    Houghton, P.J.3
  • 95
    • 0030974770 scopus 로고    scopus 로고
    • Efficacy of oral irinotecan against neuroblastoma xenografts
    • Thomson, J., Zamboni, W.C., Cheshire, P.J. et al. Efficacy of oral irinotecan against neuroblastoma xenografts. Anticancer Drugs 1997, 8: 313-22.
    • (1997) Anticancer Drugs , vol.8 , pp. 313-322
    • Thomson, J.1    Zamboni, W.C.2    Cheshire, P.J.3
  • 96
    • 0027479925 scopus 로고
    • Enhanced antitumor efficacy of a combination of CPT-11, a new derivative of camptothecin, and cisplatin against human lung tumor xenografts
    • Kudoh, S., Takada, M., Masuda, N. et al. Enhanced antitumor efficacy of a combination of CPT-11, a new derivative of camptothecin, and cisplatin against human lung tumor xenografts. Jpn J Cancer Res 1993, 84: 203-7.
    • (1993) Jpn J Cancer Res , vol.84 , pp. 203-207
    • Kudoh, S.1    Takada, M.2    Masuda, N.3
  • 97
    • 0030034610 scopus 로고    scopus 로고
    • Evaluation of irinotecan in combination with 5-fluorouracil or etoposide in xenograft models of colon adenocarcinoma and rhabdomyosarcoma
    • Houghton, J.A., Cheshire, P.J., Hallman, J.D. et al. Evaluation of irinotecan in combination with 5-fluorouracil or etoposide in xenograft models of colon adenocarcinoma and rhabdomyosarcoma. Clin Cancer Res 1996, 2: 108-18.
    • (1996) Clin Cancer Res , vol.2 , pp. 108-118
    • Houghton, J.A.1    Cheshire, P.J.2    Hallman, J.D.3
  • 98
    • 0025342506 scopus 로고
    • Nonlinear pharmacokinetics of CPT-11 in rats
    • Kaneda, N., Yokokura, T. Nonlinear pharmacokinetics of CPT-11 in rats. Cancer Res 1990, 50: 1721-5.
    • (1990) Cancer Res , vol.50 , pp. 1721-1725
    • Kaneda, N.1    Yokokura, T.2
  • 99
    • 0027242140 scopus 로고
    • Relationship between development of diarrhea and the concentration of SN-38, an active metabolite of CPT-11, in the intestine and the blood plasma of athymic mice following intraperitoneal administration of CPT-11
    • Araki, E., Ishikawa, M., Iigo, M., Koide, M., Itabashi, M., Hoshi, A. Relationship between development of diarrhea and the concentration of SN-38, an active metabolite of CPT-11, in the intestine and the blood plasma of athymic mice following intraperitoneal administration of CPT-11. Jpn J Cancer Res 1993, 84: 697-702.
    • (1993) Jpn J Cancer Res , vol.84 , pp. 697-702
    • Araki, E.1    Ishikawa, M.2    Iigo, M.3    Koide, M.4    Itabashi, M.5    Hoshi, A.6
  • 101
    • 0025851286 scopus 로고
    • Phase 1 study of weekly intravenous infusions of CPT-11, a new derivative of camptothecin, in the treatment of advanced non-small-cell lung cancer
    • Negoro, S., Fukuoka, M., Masuda, N. et al. Phase 1 study of weekly intravenous infusions of CPT-11, a new derivative of camptothecin, in the treatment of advanced non-small-cell lung cancer. J Natl Cancer Inst 1991, 83: 1164-8.
    • (1991) J Natl Cancer Inst , vol.83 , pp. 1164-1168
    • Negoro, S.1    Fukuoka, M.2    Masuda, N.3
  • 102
    • 0027140524 scopus 로고
    • Phase I and pharmacokinetic trial of weekly CPT-11
    • Rothenberg, M.L., Kuhn, J.G., Burris, H.A. et al. Phase I and pharmacokinetic trial of weekly CPT-11. J Clin Oncol 1993, 11: 2194-204.
    • (1993) J Clin Oncol , vol.11 , pp. 2194-2204
    • Rothenberg, M.L.1    Kuhn, J.G.2    Burris, H.A.3
  • 103
    • 0027933519 scopus 로고
    • Phase I and pharmacokinetic study of the camptothecin derivative irinotecan, administered on a weekly schedule in cancer patients
    • de Forni, M., Bugat, R., Chabot, G.G. et al. Phase I and pharmacokinetic study of the camptothecin derivative irinotecan, administered on a weekly schedule in cancer patients. Cancer Res 1994, 54: 4347-54.
    • (1994) Cancer Res , vol.54 , pp. 4347-4354
    • De Forni, M.1    Bugat, R.2    Chabot, G.G.3
  • 104
    • 0028158012 scopus 로고
    • Phase I and pharmacological study of the novel topoisomerase I inhibitor 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxy-camptothecin (CPT-11) administered as a ninety-minute infusion every 3 weeks
    • Rowinsky, E.K., Grochow, L.B., Ettinger, D.S. et al. Phase I and pharmacological study of the novel topoisomerase I inhibitor 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxy-camptothecin (CPT-11) administered as a ninety-minute infusion every 3 weeks. Cancer Res 1994, 54: 427-36.
    • (1994) Cancer Res , vol.54 , pp. 427-436
    • Rowinsky, E.K.1    Grochow, L.B.2    Ettinger, D.S.3
  • 105
    • 0028854897 scopus 로고
    • Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every 3 weeks in cancer patients
    • Abigerges, D., Chabot, G.G., Armand, J.P., Hérait, P., Gouyette, A., Gandia, D. Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every 3 weeks in cancer patients. J Clin Oncol 1995, 13: 210-21.
    • (1995) J Clin Oncol , vol.13 , pp. 210-221
    • Abigerges, D.1    Chabot, G.G.2    Armand, J.P.3    Hérait, P.4    Gouyette, A.5    Gandia, D.6
  • 106
    • 0028840093 scopus 로고
    • Phase I and pharmacokinetic study of irinotecan (CPT-11) administered daily for three consecutive days every 3 weeks in patients with advanced solid tumors
    • Catimel G., Chabot G.G., Guastalla, J.P. et al. Phase I and pharmacokinetic study of irinotecan (CPT-11) administered daily for three consecutive days every 3 weeks in patients with advanced solid tumors. Ann Oncol 1995, 6: 133-40.
    • (1995) Ann Oncol , vol.6 , pp. 133-140
    • Catimel, G.1    Chabot, G.G.2    Guastalla, J.P.3
  • 107
    • 0026631164 scopus 로고
    • Phase I study and pharmacokinetics of CPT-11 with 5-day continuous infusion
    • Ohe, Y., Sasaki, Y., Shinkai, T. et al. Phase I study and pharmacokinetics of CPT-11 with 5-day continuous infusion. J Natl Cancer Inst 1992, 84: 972-4.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 972-974
    • Ohe, Y.1    Sasaki, Y.2    Shinkai, T.3
  • 108
    • 0029857839 scopus 로고    scopus 로고
    • Rationale for the dosage and schedules of CPT-11 (irinotecan) selected for phase II studies, as determined by European phase I studies
    • Armand, J.P., Extra, J.M., Catimel, G., Abigerges, D., Marty, M., Clavel, M. Rationale for the dosage and schedules of CPT-11 (irinotecan) selected for phase II studies, as determined by European phase I studies. Ann Oncol 1996, 7: 837-42.
    • (1996) Ann Oncol , vol.7 , pp. 837-842
    • Armand, J.P.1    Extra, J.M.2    Catimel, G.3    Abigerges, D.4    Marty, M.5    Clavel, M.6
  • 109
    • 0031059575 scopus 로고    scopus 로고
    • High-dose intensity of irinotecan administered every 3 weeks in advanced cancer patients: A feasibility study
    • Merrouche, Y., Extra, J.M., Abigerges, D. et al. High-dose intensity of irinotecan administered every 3 weeks in advanced cancer patients: A feasibility study. J Clin Oncol 1997, 15: 1080-6.
    • (1997) J Clin Oncol , vol.15 , pp. 1080-1086
    • Merrouche, Y.1    Extra, J.M.2    Abigerges, D.3
  • 110
    • 0027534590 scopus 로고
    • CPT-11-induced cholinergic effects in cancer patients
    • Gandia, D., Abigerges, D., Armand, J.P. et al. CPT-11-induced cholinergic effects in cancer patients. J Clin Oncol 1993, 11: 196-7.
    • (1993) J Clin Oncol , vol.11 , pp. 196-197
    • Gandia, D.1    Abigerges, D.2    Armand, J.P.3
  • 111
    • 0031926749 scopus 로고    scopus 로고
    • Pathophysiology and therapy of irinotecan-induced delayed-onset diarrhea in patients with advanced colorectal cancer: A prospective assessment
    • Saliba, F., Hagipantelli, R., Misset, J.L. et al. Pathophysiology and therapy of irinotecan-induced delayed-onset diarrhea in patients with advanced colorectal cancer: A prospective assessment. J Clin Oncol 1998, 16: 2745-51.
    • (1998) J Clin Oncol , vol.16 , pp. 2745-2751
    • Saliba, F.1    Hagipantelli, R.2    Misset, J.L.3
  • 112
    • 0027372606 scopus 로고
    • Phase I and pharmacologic study of irinotecan in combination with cisplatin for advanced lung cancer
    • Masuda, N., Fukuoka, M., Kudoh, S. et al. Phase I and pharmacologic study of irinotecan in combination with cisplatin for advanced lung cancer. Br J Cancer 1993, 68: 777-82.
    • (1993) Br J Cancer , vol.68 , pp. 777-782
    • Masuda, N.1    Fukuoka, M.2    Kudoh, S.3
  • 113
    • 0028357591 scopus 로고
    • Phase I clinical trial of irinotecan (CPT-11), 7-ethyl-10-4-(1-piperidino)-1-piperidinoJcar-bonyloxycamptothecin, and cisplatin in combination with fixed dose of vindesine in advanced non-small cell lung cancer
    • Shinkai, T., Arioka, H., Kunikane, H. et al. Phase I clinical trial of irinotecan (CPT-11), 7-ethyl-10-[4-(1-piperidino)-1-piperidinoJcar-bonyloxycamptothecin, and cisplatin in combination with fixed dose of vindesine in advanced non-small cell lung cancer. Cancer Res 1994, 54: 2636-42.
    • (1994) Cancer Res , vol.54 , pp. 2636-2642
    • Shinkai, T.1    Arioka, H.2    Kunikane, H.3
  • 114
    • 0028175150 scopus 로고
    • Phase I study of irinotecan and cisplatin with granulocyte colony-stimultating factor support for advanced non-small cell lung cancer
    • Masuda, N., Fukuoka, M., Kudoh, S. et al. Phase I study of irinotecan and cisplatin with granulocyte colony-stimultating factor support for advanced non-small cell lung cancer. J Clin Oncol 1994, 12: 90-6.
    • (1994) J Clin Oncol , vol.12 , pp. 90-96
    • Masuda, N.1    Fukuoka, M.2    Kudoh, S.3
  • 115
    • 0028035248 scopus 로고
    • Phase I and pharmacologic study of irinotecan and etoposide with recombinant granulocyte colony-stimultating factor support for advanced lung cancer
    • Masuda, N., Fukuoka, M., Kudoh, S. et al. Phase I and pharmacologic study of irinotecan and etoposide with recombinant granulocyte colony-stimultating factor support for advanced lung cancer. J Clin Oncol 1994, 12: 1833-41.
    • (1994) J Clin Oncol , vol.12 , pp. 1833-1841
    • Masuda, N.1    Fukuoka, M.2    Kudoh, S.3
  • 116
    • 0029084773 scopus 로고
    • CPT-11 (irinotecan) in the treatment of colorectal cancer
    • Armand, J.P., Ducreux, M., Mahjoubi, M. et al. CPT-11 (irinotecan) in the treatment of colorectal cancer. Eur J Cancer 1995, 31A: 1283-7.
    • (1995) Eur J Cancer , vol.31 A , pp. 1283-1287
    • Armand, J.P.1    Ducreux, M.2    Mahjoubi, M.3
  • 117
    • 0027194943 scopus 로고
    • Phase II study of CPT-11, a new camptothecin derivative, in metastatic colorectal cancer
    • Shimada, Y., Yoshino, M., Wakui A. et al. Phase II study of CPT-11, a new camptothecin derivative, in metastatic colorectal cancer. J Clin Oncol 1993, 11: 909-13.
    • (1993) J Clin Oncol , vol.11 , pp. 909-913
    • Shimada, Y.1    Yoshino, M.2    Wakui, A.3
  • 118
    • 0029919598 scopus 로고    scopus 로고
    • Irinotecan is an active agent in untreated patients with metastatic colorectal cancer
    • Conti, J.A., Kemeny, N.B., Saltz, L.B. et al. Irinotecan is an active agent in untreated patients with metastatic colorectal cancer. J Clin Oncol 1996, 14: 709-15.
    • (1996) J Clin Oncol , vol.14 , pp. 709-715
    • Conti, J.A.1    Kemeny, N.B.2    Saltz, L.B.3
  • 119
    • 0029966672 scopus 로고    scopus 로고
    • Phase II trial of irinotecan inpatients wth progressive or rapidly recurrent colorectal cancer
    • Rothenberg. M.L., Eckardt, J.R., Kuhn, J.G. et al. Phase II trial of irinotecan inpatients wth progressive or rapidly recurrent colorectal cancer. J Clin Oncol 1996, 14: 1128-35.
    • (1996) J Clin Oncol , vol.14 , pp. 1128-1135
    • Rothenberg, M.L.1    Eckardt, J.R.2    Kuhn, J.G.3
  • 120
    • 0031014627 scopus 로고    scopus 로고
    • Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy
    • Rougier, P., Bugat, R., Douillard, J.Y. et al. Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy. J Clin Oncol 1997, 15: 251-60.
    • (1997) J Clin Oncol , vol.15 , pp. 251-260
    • Rougier, P.1    Bugat, R.2    Douillard, J.Y.3
  • 121
    • 0026531753 scopus 로고
    • A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small cell lung cancer
    • Fukuoka, M., Nitani, H., Suzuki, A. et al. A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small cell lung cancer. J Clin Oncol 1992, 10: 16-20.
    • (1992) J Clin Oncol , vol.10 , pp. 16-20
    • Fukuoka, M.1    Nitani, H.2    Suzuki, A.3
  • 122
    • 0031037244 scopus 로고    scopus 로고
    • Phase II study of irinotecan in prior chemotherapy-treated squamous cell carcinoma of the cervix
    • Verschraegen, C.F., Levy, T., Kudelka, A.P. et al. Phase II study of irinotecan in prior chemotherapy-treated squamous cell carcinoma of the cervix. J Clin Oncol 1997, 15: 625-31.
    • (1997) J Clin Oncol , vol.15 , pp. 625-631
    • Verschraegen, C.F.1    Levy, T.2    Kudelka, A.P.3
  • 123
    • 0025129894 scopus 로고
    • An early phase II study of CPT-11, a new derivative of camptothecin, for the treatment of leukemia and lymphoma
    • Ohno, R., Okada, K., Masaoka, T. et al. An early phase II study of CPT-11, a new derivative of camptothecin, for the treatment of leukemia and lymphoma. J Clin Oncol 1990, 8: 1907-12.
    • (1990) J Clin Oncol , vol.8 , pp. 1907-1912
    • Ohno, R.1    Okada, K.2    Masaoka, T.3
  • 124
    • 0028145132 scopus 로고
    • Treatment of adult T-cell leukemia-lymphoma with irinotecan hydrochloride
    • Tsuda, H., Takatsuki, K., Ohno, R. et al. Treatment of adult T-cell leukemia-lymphoma with irinotecan hydrochloride. Br J Cancer 1994, 70: 771-4.
    • (1994) Br J Cancer , vol.70 , pp. 771-774
    • Tsuda, H.1    Takatsuki, K.2    Ohno, R.3
  • 125
    • 0028839053 scopus 로고
    • Phase II trial of CPT-11 in patients with advanced pancreatic cancer, an Early Clinical Trials Group study
    • Wagener, D.J., Verdonk, H.E., Dirix, L.Y. et al. Phase II trial of CPT-11 in patients with advanced pancreatic cancer, an Early Clinical Trials Group study. Ann Oncol 1995, 6: 129-32.
    • (1995) Ann Oncol , vol.6 , pp. 129-132
    • Wagener, D.J.1    Verdonk, H.E.2    Dirix, L.Y.3
  • 126
    • 0002625490 scopus 로고
    • A phase II study of a new camptothecin analog CPT-11 in previously treated advanced breast cancer patients
    • Bonneterre, J., Pion, J.M., Adenis, A. et al. A phase II study of a new camptothecin analog CPT-11 in previously treated advanced breast cancer patients. Proc Am Soc Clin Oncol 1993, 12: 94.
    • (1993) Proc Am Soc Clin Oncol , vol.12 , pp. 94
    • Bonneterre, J.1    Pion, J.M.2    Adenis, A.3
  • 127
    • 84878723788 scopus 로고    scopus 로고
    • Ducreux, M., Rougier, P., Ychou, M. et al.
    • Ducreux, M., Rougier, P., Ychou, M. et al.
  • 128
    • 0031055829 scopus 로고    scopus 로고
    • Phase I-II study of irinotecan hydrochloride combined with cisplatin in patients with advanced gastric cancer
    • Shirao, K., Shimada, Y., Kondo, H. et al. Phase I-II study of irinotecan hydrochloride combined with cisplatin in patients with advanced gastric cancer. J Cin Oncol 1997, 15: 921-7.
    • (1997) J Cin Oncol , vol.15 , pp. 921-927
    • Shirao, K.1    Shimada, Y.2    Kondo, H.3
  • 129
    • 0031015192 scopus 로고    scopus 로고
    • Phase II study of irinotecan and etoposide in patients with metastatic non-small cell lung cancer
    • Oshita, F., Noda, K., Nishiwaki, Y. et al. Phase II study of irinotecan and etoposide in patients with metastatic non-small cell lung cancer. J Clin Oncol 1997, 15: 304-9.
    • (1997) J Clin Oncol , vol.15 , pp. 304-309
    • Oshita, F.1    Noda, K.2    Nishiwaki, Y.3
  • 130
    • 0028364014 scopus 로고
    • Metabolic activation opf CPT-11, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin, a novel antitumor agent, by carboxylesterase
    • Satoh, T., Hosokawa, M., Atsumi, R., Susuki, W., Hakusui, H., Nagai, E. Metabolic activation opf CPT-11, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin, a novel antitumor agent, by carboxylesterase. Biol Pharm Bull 1994, 17: 662-41.
    • (1994) Biol Pharm Bull , vol.17 , pp. 662-741
    • Satoh, T.1    Hosokawa, M.2    Atsumi, R.3    Susuki, W.4    Hakusui, H.5    Nagai, E.6
  • 131
    • 0026538734 scopus 로고
    • Simultaneous determination of the camptothecin analogue CPT-11 and its active metabolite SN-38 by high-performance liquid chromatography: Application to plasma pharmacokinetic studies in cancer patients
    • Barilero, I., Gandia, D., Armand, J.P. et al. Simultaneous determination of the camptothecin analogue CPT-11 and its active metabolite SN-38 by high-performance liquid chromatography: Application to plasma pharmacokinetic studies in cancer patients. J Chromatogr 1992, 575B: 275-80.
    • (1992) J Chromatogr , vol.575 B , pp. 275-280
    • Barilero, I.1    Gandia, D.2    Armand, J.P.3
  • 132
    • 0029164578 scopus 로고
    • High-performance liquid Chromatographic determination of irinotecan (CPT-11) and its active metabolite SN-38 in human plasma
    • Sumiyoshi, H., Fujiwara, Y., Ohune, T., Yamaoka, N., Tamura, K., Yamakido, M. High-performance liquid Chromatographic determination of irinotecan (CPT-11) and its active metabolite SN-38 in human plasma. J Chromatogr 1995, 670B: 309-16.
    • (1995) J Chromatogr , vol.670 B , pp. 309-316
    • Sumiyoshi, H.1    Fujiwara, Y.2    Ohune, T.3    Yamaoka, N.4    Tamura, K.5    Yamakido, M.6
  • 133
    • 0027937924 scopus 로고
    • Reversed-phase high-performance liquid Chromatographic method for the simultaneous quantisation of the carboxylate and lactone forms of the camptothecin derivative irinotecan, CPT-11, and its metabolite SN-38 in plasma
    • Rivory, L.P., Robert, J. Reversed-phase high-performance liquid Chromatographic method for the simultaneous quantisation of the carboxylate and lactone forms of the camptothecin derivative irinotecan, CPT-11, and its metabolite SN-38 in plasma. J Chromatogr 1994, 661B: 133-41.
    • (1994) J Chromatogr , vol.661 B , pp. 133-141
    • Rivory, L.P.1    Robert, J.2
  • 134
    • 0030891273 scopus 로고    scopus 로고
    • Simple and versatile high-performance liquid Chromatographic method for the simultaneous quantitation of the lactone and carboxylate forms of camptothecin anticancer drugs
    • Warner, D.L., Burke, T.G. Simple and versatile high-performance liquid Chromatographic method for the simultaneous quantitation of the lactone and carboxylate forms of camptothecin anticancer drugs. J Chromatogr 1997, 691B: 161-71.
    • (1997) J Chromatogr , vol.691 B , pp. 161-171
    • Warner, D.L.1    Burke, T.G.2
  • 135
    • 0028670840 scopus 로고
    • Kinetics of the in vivo interconversion of the lactone and carboxylate forms of irinotecan (CPT-11) and of its metabolite SN-38 in patients
    • Rivory, L.P., Chatelut, E., Canal, P., Mathieu-Boué, A., Robert, J. Kinetics of the in vivo interconversion of the lactone and carboxylate forms of irinotecan (CPT-11) and of its metabolite SN-38 in patients. Cancer Res 1994, 54: 6330-3.
    • (1994) Cancer Res , vol.54 , pp. 6330-6333
    • Rivory, L.P.1    Chatelut, E.2    Canal, P.3    Mathieu-Boué, A.4    Robert, J.5
  • 136
    • 0010917253 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic irinotecan during a phase II clinical trial in colorectal cancer
    • Gupta, E., Mick, R., Ramirez, J. et al. Pharmacokinetic and pharmacodynamic irinotecan during a phase II clinical trial in colorectal cancer. J Clin Oncol 1996, 14: 2688-95.
    • (1996) J Clin Oncol , vol.14 , pp. 2688-2695
    • Gupta, E.1    Mick, R.2    Ramirez, J.3
  • 137
    • 0028340348 scopus 로고
    • Simultaneous administration of CPT-11 and fluorouracil: Alteration of the pharmacokinetics of CPT-11 and SN-38 in patients with advanced colorectal cancer
    • Sasaki, Y., Ohtsu, A., Shimada, Y., Ono, K., Saijo, N. Simultaneous administration of CPT-11 and fluorouracil: Alteration of the pharmacokinetics of CPT-11 and SN-38 in patients with advanced colorectal cancer. J Natl Cancer Inst 1994, 86: 1096-8.
    • (1994) J Natl Cancer Inst , vol.86 , pp. 1096-1098
    • Sasaki, Y.1    Ohtsu, A.2    Shimada, Y.3    Ono, K.4    Saijo, N.5
  • 138
    • 0028813952 scopus 로고
    • A pharmacokinetic and pharmacodynamic analysis of CPT-11 and its active metabolite SN-38
    • Sasaki, Y., Hakusui, H., Mizuno, S. et al. A pharmacokinetic and pharmacodynamic analysis of CPT-11 and its active metabolite SN-38. Jpn J Cancer Res 1995, 86: 101-10.
    • (1995) Jpn J Cancer Res , vol.86 , pp. 101-110
    • Sasaki, Y.1    Hakusui, H.2    Mizuno, S.3
  • 139
    • 0028843263 scopus 로고
    • Pharmacological correlation between total drug concentration and lactones of CPT-11 and SN-38 in patients treated with CPR-11
    • Sasaki, Y., Yoshida, Y., Sudoh, K. et al. Pharmacological correlation between total drug concentration and lactones of CPT-11 and SN-38 in patients treated with CPR-11. Jpn J Cancer Res 1995, 86: 111-6.
    • (1995) Jpn J Cancer Res , vol.86 , pp. 111-116
    • Sasaki, Y.1    Yoshida, Y.2    Sudoh, K.3
  • 140
    • 0028947192 scopus 로고
    • Relationship between the pharmacokinetics of irinotecan and diarrhea during combination chemotherapy with cisplatin
    • Kudoh, S., Fukuoka, M., Masuda, N. et al. Relationship between the pharmacokinetics of irinotecan and diarrhea during combination chemotherapy with cisplatin. Jpn J Cancer Res 1995, 86: 406-13.
    • (1995) Jpn J Cancer Res , vol.86 , pp. 406-413
    • Kudoh, S.1    Fukuoka, M.2    Masuda, N.3
  • 141
    • 0008461578 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of irinotecan, fluorouracil, and leucovorin in patients with advanced solid tumors
    • Saltz, L.B., Kanowitz, J., Kemeny, N.E. et al. Phase I clinical and pharmacokinetic study of irinotecan, fluorouracil, and leucovorin in patients with advanced solid tumors. J Clin Oncol 1996, 14: 2959-67.
    • (1996) J Clin Oncol , vol.14 , pp. 2959-2967
    • Saltz, L.B.1    Kanowitz, J.2    Kemeny, N.E.3
  • 142
    • 0030856521 scopus 로고    scopus 로고
    • Pharmacokinetic interrelationships of irinotecan (CPT-11) and its three major plasma metabolites in patients enrolled in phase I/II trials
    • Rivory, L.P., Haaz, M.C., Canal, P., Lokiec, F., Armand, J.P., Robert, J. Pharmacokinetic interrelationships of irinotecan (CPT-11) and its three major plasma metabolites in patients enrolled in phase I/II trials. Clin Cancer Res 1997, 3: 1261-6.
    • (1997) Clin Cancer Res , vol.3 , pp. 1261-1266
    • Rivory, L.P.1    Haaz, M.C.2    Canal, P.3    Lokiec, F.4    Armand, J.P.5    Robert, J.6
  • 143
    • 0028989171 scopus 로고
    • Identification and kinetics of a β-glucuronide metabolite of SN-38 in human plasma after administration of the camptothecin derivative irinotecan
    • Rivory, L.P., Robert, J. Identification and kinetics of a β-glucuronide metabolite of SN-38 in human plasma after administration of the camptothecin derivative irinotecan. Cancer Chemother Pharmacol 1995, 36: 176-9.
    • (1995) Cancer Chemother Pharmacol , vol.36 , pp. 176-179
    • Rivory, L.P.1    Robert, J.2
  • 144
    • 0028022585 scopus 로고
    • Metabolic fate of irinotecan in humans: Correlation of glucuronidation with diarrhea
    • Gupta, E., Lestingi, T.M., Mick, R., Ramirez, J., Vokes, E.E., Ratain, M.J. Metabolic fate of irinotecan in humans: Correlation of glucuronidation with diarrhea. Cancer Res 1994, 54: 3723-5.
    • (1994) Cancer Res , vol.54 , pp. 3723-3725
    • Gupta, E.1    Lestingi, T.M.2    Mick, R.3    Ramirez, J.4    Vokes, E.E.5    Ratain, M.J.6
  • 145
    • 0029760995 scopus 로고    scopus 로고
    • Identification and properties of a major plasma metabolite of irinotecan (CPT-11) isolated from the plasma of patients
    • Rivory, L.P., Riou, J.F., Haaz, M.C. et al. Identification and properties of a major plasma metabolite of irinotecan (CPT-11) isolated from the plasma of patients. Cancer Res 1996, 56: 3689-94.
    • (1996) Cancer Res , vol.56 , pp. 3689-3694
    • Rivory, L.P.1    Riou, J.F.2    Haaz, M.C.3
  • 147
    • 0028952739 scopus 로고
    • Pharmacokinetics of irinotecan and its metabolites in human blood, bile, and urine
    • Lokiec, F., Canal, P., Gay, C. et al. Pharmacokinetics of irinotecan and its metabolites in human blood, bile, and urine. Cancer Chemother Pharmacol 1995, 36: 79-82.
    • (1995) Cancer Chemother Pharmacol , vol.36 , pp. 79-82
    • Lokiec, F.1    Canal, P.2    Gay, C.3
  • 148
    • 0030959378 scopus 로고    scopus 로고
    • Muftispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats
    • Chu, X.Y., Kato, Y., Niinuma, K., Sudo, K.I., Hakusui, H., Sugiyama, Y. Muftispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats. J Pharmacol Exp Ther 1997, 281: 304-14.
    • (1997) J Pharmacol Exp Ther , vol.281 , pp. 304-314
    • Chu, X.Y.1    Kato, Y.2    Niinuma, K.3    Sudo, K.I.4    Hakusui, H.5    Sugiyama, Y.6
  • 149
    • 0029876561 scopus 로고    scopus 로고
    • Pharmacokinetic modulation of irinotecan and metabolites by cyclosporine A
    • Gupta, E., Safa, A.R., Wang, X., Ratain, M.J. Pharmacokinetic modulation of irinotecan and metabolites by cyclosporine A. Cancer Res 1996, 56: 1309-14.
    • (1996) Cancer Res , vol.56 , pp. 1309-1314
    • Gupta, E.1    Safa, A.R.2    Wang, X.3    Ratain, M.J.4
  • 150
    • 0344643053 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of irinotecan (CPT-11) administered with cyclosporine A
    • Fagbemi, S., Iyer, L., Mani, S. et al. Phase I and pharmacokinetic study of irinotecan (CPT-11) administered with cyclosporine A. Proc Am Soc Clin Oncol 1997, 16: 219a.
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Fagbemi, S.1    Iyer, L.2    Mani, S.3
  • 151
    • 0028853410 scopus 로고
    • Population pharmacokinetics and pharmacodynamics of irinotecan (CPT-11) and active metabolite SN-38 during phase I trials
    • Chabot, G.G., Abigerges, D., Catimel, G. et al. Population pharmacokinetics and pharmacodynamics of irinotecan (CPT-11) and active metabolite SN-38 during phase I trials. Ann Oncol 1995, 6: 141-51.
    • (1995) Ann Oncol , vol.6 , pp. 141-151
    • Chabot, G.G.1    Abigerges, D.2    Catimel, G.3
  • 152
    • 0029089278 scopus 로고
    • Limited sampling models for simultaneous estimation of the pharmacokinetics of irinotecan and its active metabolite SN-38
    • Chabot, G.G. Limited sampling models for simultaneous estimation of the pharmacokinetics of irinotecan and its active metabolite SN-38. Cancer Chemother Pharmacol 1995, 36: 463-72.
    • (1995) Cancer Chemother Pharmacol , vol.36 , pp. 463-472
    • Chabot, G.G.1
  • 153
    • 0028887473 scopus 로고
    • A limited sampling model for estimating pharmacokinetics of CPT-11 and its metabolite SN-38
    • Sasaki, Y., Mizuno, S., Fujii, H. et al. A limited sampling model for estimating pharmacokinetics of CPT-11 and its metabolite SN-38. Jpn J Cancer Res 1995, 86: 117-23.
    • (1995) Jpn J Cancer Res , vol.86 , pp. 117-123
    • Sasaki, Y.1    Mizuno, S.2    Fujii, H.3
  • 154
    • 0029902106 scopus 로고    scopus 로고
    • Limited sampling models for irinotecan pharmacokinetics-pharmacodynamics: Prediction of biliary index and intestinal toxicity
    • Mick, R., Gupta, E., Vokes, E.E., Ratain, M.J. Limited sampling models for irinotecan pharmacokinetics-pharmacodynamics: Prediction of biliary index and intestinal toxicity. J Clin Oncol 1996, 14: 2012-9.
    • (1996) J Clin Oncol , vol.14 , pp. 2012-2019
    • Mick, R.1    Gupta, E.2    Vokes, E.E.3    Ratain, M.J.4
  • 155
    • 0028168687 scopus 로고
    • CPT-11: Population pharmacokinetic model and estimation of pharmacokinetics using the Bayesian method in patients with lung cancer
    • Yamamoto, N., Tamura, T., Karato, A. et al. CPT-11: Population pharmacokinetic model and estimation of pharmacokinetics using the Bayesian method in patients with lung cancer. Jpn J Cancer Res 1994, 8: 972-7.
    • (1994) Jpn J Cancer Res , vol.8 , pp. 972-977
    • Yamamoto, N.1    Tamura, T.2    Karato, A.3
  • 156
    • 0029004492 scopus 로고
    • Efficient sampling strategies for forecasting pharmacokinetic parameters of irinotecan (CPT-11): Implications for area under the concentration-time curve monitoring
    • Nakashima, H., Lieberman, R., Karato, A. et al. Efficient sampling strategies for forecasting pharmacokinetic parameters of irinotecan (CPT-11): Implications for area under the concentration-time curve monitoring. Ther Drug Monit 1995, 17: 221-9.
    • (1995) Ther Drug Monit , vol.17 , pp. 221-229
    • Nakashima, H.1    Lieberman, R.2    Karato, A.3
  • 157
    • 0030859295 scopus 로고    scopus 로고
    • Limited sampling model for the area under the concentration versus time curve of irinotecan and its application to a multicentric phase II trial
    • Yamamoto, N., Tamura, T., Nishiwaki, Y. et al. Limited sampling model for the area under the concentration versus time curve of irinotecan and its application to a multicentric phase II trial. Clin Cancer Res 1997, 3: 1087-92.
    • (1997) Clin Cancer Res , vol.3 , pp. 1087-1092
    • Yamamoto, N.1    Tamura, T.2    Nishiwaki, Y.3
  • 159
    • 0029863926 scopus 로고    scopus 로고
    • The role of rat serum carboxylesterase in the activation of paclitaxel and camptothecin prodrugs
    • Senter, P.D., Marquardt, H., Thomas, B.A., Hammock, B.D., Franck, I.S., Svensson, H.P. The role of rat serum carboxylesterase in the activation of paclitaxel and camptothecin prodrugs. Cancer Res 1996, 56: 1471-4.
    • (1996) Cancer Res , vol.56 , pp. 1471-1474
    • Senter, P.D.1    Marquardt, H.2    Thomas, B.A.3    Hammock, B.D.4    Franck, I.S.5    Svensson, H.P.6
  • 160
    • 0029144306 scopus 로고
    • Metabolism of irinotecan to SN-38 in a tissue-isolated tumor model
    • Atsumi, R., Okasaki, O., Kakusui, H. Metabolism of irinotecan to SN-38 in a tissue-isolated tumor model. Biol Pharm Bull 1995, 18: 1024-6.
    • (1995) Biol Pharm Bull , vol.18 , pp. 1024-1026
    • Atsumi, R.1    Okasaki, O.2    Kakusui, H.3
  • 161
    • 0024854434 scopus 로고
    • Purification and characterization of two human liver carboxylesterases
    • Ketterman, A.J., Bowles, M.R., Pond, S.M. Purification and characterization of two human liver carboxylesterases. Int J Biochem 1989, 21: 1303-12.
    • (1989) Int J Biochem , vol.21 , pp. 1303-1312
    • Ketterman, A.J.1    Bowles, M.R.2    Pond, S.M.3
  • 162
    • 0030580064 scopus 로고    scopus 로고
    • Conversion of irinotecan (CPT-11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by human liver carboxylesterase
    • Rivory, L.P., Bowles, M.R., Robert, J., Pond, S.M. Conversion of irinotecan (CPT-11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by human liver carboxylesterase. Biochem Pharmacol 1996, 52: 1103-11.
    • (1996) Biochem Pharmacol , vol.52 , pp. 1103-1111
    • Rivory, L.P.1    Bowles, M.R.2    Robert, J.3    Pond, S.M.4
  • 163
    • 0030790137 scopus 로고    scopus 로고
    • The transformation of irinotecan (CPT-11) to its active metabolite SN-38 by human liver microsomes. Differential hydrolysis for the lactone and carboxylate forms
    • Haaz, M.C., Rivory, L.P., Riché, C., Robert, J. The transformation of irinotecan (CPT-11) to its active metabolite SN-38 by human liver microsomes. Differential hydrolysis for the lactone and carboxylate forms. Naunyn Schmied Arch Pharmacol 1997, 356: 257-62.
    • (1997) Naunyn Schmied Arch Pharmacol , vol.356 , pp. 257-262
    • Haaz, M.C.1    Rivory, L.P.2    Riché, C.3    Robert, J.4
  • 164
    • 0025858296 scopus 로고
    • Identification of the metabolites of irinotecan, a new derivative of camptothecin, in rat bile and its biliary excretion
    • Atsumi, R., Suzuki, W., Hakusui, H. Identification of the metabolites of irinotecan, a new derivative of camptothecin, in rat bile and its biliary excretion. Xenobiotica 1991, 21: 1159-69.
    • (1991) Xenobiotica , vol.21 , pp. 1159-1169
    • Atsumi, R.1    Suzuki, W.2    Hakusui, H.3
  • 166
    • 0032519431 scopus 로고    scopus 로고
    • Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of UDP-glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes
    • Iyer, L., King, D.D., Whitington, P.F. et al. Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of UDP-glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes. J Clin Invest 1998, 101. 847-54.
    • (1998) J Clin Invest , vol.101 , pp. 847-854
    • Iyer, L.1    King, D.D.2    Whitington, P.F.3
  • 167
    • 84878727744 scopus 로고    scopus 로고
    • Oxaliplatin/CPT-11 combination: Preliminary results of a phase I study of an active combination in gastrointestinal malignancies
    • Wasserman, E., Cvitkovic, E., Goldwasser, F. et al. Oxaliplatin/CPT-11 combination: Preliminary results of a phase I study of an active combination in gastrointestinal malignancies. Proc Am Assoc Cancer Res 1997, 38: 224.
    • (1997) Proc Am Assoc Cancer Res , vol.38 , pp. 224
    • Wasserman, E.1    Cvitkovic, E.2    Goldwasser, F.3
  • 168
    • 0030716924 scopus 로고    scopus 로고
    • Severe CPT-11 toxicity in patients with Gilbert's syndrome: Two case reports
    • Wasserman, E., Myara, A., Lokiec F., et al. Severe CPT-11 toxicity in patients with Gilbert's syndrome: Two case reports. Ann Oncol 1997, 8: 1049-51.
    • (1997) Ann Oncol , vol.8 , pp. 1049-1051
    • Wasserman, E.1    Myara, A.2    Lokiec, F.3
  • 169
    • 0029741368 scopus 로고    scopus 로고
    • Involvement of β-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats
    • Takasuna, K., Hagiwara, T., Hirohashi, M. et al. Involvement of β-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats. Cancer Res 1996, 56: 3752-7.
    • (1996) Cancer Res , vol.56 , pp. 3752-3757
    • Takasuna, K.1    Hagiwara, T.2    Hirohashi, M.3
  • 170
    • 0027461221 scopus 로고
    • Inhibition of β-glucuronidase by natural glucuronides of Kampo medicines using glucuronide of SN-38 (7-ethyl-10-hydroxycamptothecin) as a substrate
    • Narita, M., Nagai, E., Hagiwara, H. et al. Inhibition of β-glucuronidase by natural glucuronides of Kampo medicines using glucuronide of SN-38 (7-ethyl-10-hydroxycamptothecin) as a substrate. Xenobiotica 1993, 23: 5-10.
    • (1993) Xenobiotica , vol.23 , pp. 5-10
    • Narita, M.1    Nagai, E.2    Hagiwara, H.3
  • 171
    • 0028971415 scopus 로고
    • Preventive effects of Kampo medicines and baicalin against intestinal toxicity of a new anticancer camptothecin derivative, irinotecan hydrochloride (CPT-11) in rats
    • Takasuna, K., Kasai, Y., Kitano, Y. et al. Preventive effects of Kampo medicines and baicalin against intestinal toxicity of a new anticancer camptothecin derivative, irinotecan hydrochloride (CPT-11) in rats. Jpn J Cancer Res 1995, 86: 978-84.
    • (1995) Jpn J Cancer Res , vol.86 , pp. 978-984
    • Takasuna, K.1    Kasai, Y.2    Kitano, Y.3
  • 172
    • 85004809753 scopus 로고
    • Inhibition of UDP-glucuronosyltransferase by aglycones of natural glucuronides in Kampo medicines using SN-38 as a substrate
    • Yokoi, T., Narita, M., Nagai, E. et al. Inhibition of UDP-glucuronosyltransferase by aglycones of natural glucuronides in Kampo medicines using SN-38 as a substrate. Jpn J Cancer Res 1995, 86: 985-9.
    • (1995) Jpn J Cancer Res , vol.86 , pp. 985-989
    • Yokoi, T.1    Narita, M.2    Nagai, E.3
  • 173
    • 0032005259 scopus 로고    scopus 로고
    • Metabolism of irinotecan (CPT-11) by human hepatic microsomes: Participation of cytochrome P450 3A and drug interactions
    • Haaz, M.C., Rivory, L.P., Riche, C., Vernillet, L., Robert, J. Metabolism of irinotecan (CPT-11) by human hepatic microsomes: Participation of cytochrome P450 3A and drug interactions. Cancer Res 1998, 58: 468-72.
    • (1998) Cancer Res , vol.58 , pp. 468-472
    • Haaz, M.C.1    Rivory, L.P.2    Riche, C.3    Vernillet, L.4    Robert, J.5
  • 174
    • 0031871505 scopus 로고    scopus 로고
    • Identification of a new metabolite of irinotecan (CPT-11). I. Pharmacological properties and activation to SN-38
    • Dodds, H.M., Haaz, M.C., Riou, J.F., Robert, J., Rivory, L.P. Identification of a new metabolite of irinotecan (CPT-11). I. Pharmacological properties and activation to SN-38. J Pharmacol Exp Ther 1998, 286: 578-83.
    • (1998) J Pharmacol Exp Ther , vol.286 , pp. 578-583
    • Dodds, H.M.1    Haaz, M.C.2    Riou, J.F.3    Robert, J.4    Rivory, L.P.5
  • 175
    • 0031845966 scopus 로고    scopus 로고
    • Biosynthesis of an aminopiperidino metabolite of irinotecan by human hepatic microsomes
    • Haaz, M.C., Riché, C., Rivory, L.P., Robert, J. Biosynthesis of an aminopiperidino metabolite of irinotecan by human hepatic microsomes. Drug Metab Dispos 1998, 26: 769-74.
    • (1998) Drug Metab Dispos , vol.26 , pp. 769-774
    • Haaz, M.C.1    Riché, C.2    Rivory, L.P.3    Robert, J.4
  • 177
    • 0029944225 scopus 로고    scopus 로고
    • Simultaneous determination of a camptothecin derivative, used as an anticancer drug, and its photodegradation products by high-performance liquid chromatography
    • Akimoto, K., Kawai, A., Ohya, K. Simultaneous determination of a camptothecin derivative, used as an anticancer drug, and its photodegradation products by high-performance liquid chromatography. J Chromatogr 1996, 734A: 401-4.
    • (1996) J Chromatogr , vol.734 A , pp. 401-404
    • Akimoto, K.1    Kawai, A.2    Ohya, K.3
  • 178
    • 0031441796 scopus 로고    scopus 로고
    • Photodegradation of irinotecan (CPT-11) in aqueous solutions: Identification of fluorescent products and influence of solution composition
    • Dodds, H.M., Craik, D.J., Rivory, L.P. Photodegradation of irinotecan (CPT-11) in aqueous solutions: Identification of fluorescent products and influence of solution composition. J Pharm Sci 1997, 86: 1410-6.
    • (1997) J Pharm Sci , vol.86 , pp. 1410-1416
    • Dodds, H.M.1    Craik, D.J.2    Rivory, L.P.3
  • 179
    • 0031046059 scopus 로고    scopus 로고
    • CPT-11 in human colon cancer cell lines and xenografts: Characterization of cellular sensitivity determinants
    • Jansen, W.J.M., Zwart, B., Hulscher, S.T.M., Giaccone, G., Pinedo, H.M., Boven, E. CPT-11 in human colon cancer cell lines and xenografts: Characterization of cellular sensitivity determinants. Int J Cancer 1997, 70: 335-40.
    • (1997) Int J Cancer , vol.70 , pp. 335-340
    • Jansen, W.J.M.1    Zwart, B.2    Hulscher, S.T.M.3    Giaccone, G.4    Pinedo, H.M.5    Boven, E.6
  • 180
    • 0031800370 scopus 로고    scopus 로고
    • Determinants of CPT-11 and SN-38 activities in human lung cancer cells
    • Van Ark-Otte, J., Kedde, M.A., van der Vijgh, W.J.F. et al. Determinants of CPT-11 and SN-38 activities in human lung cancer cells. Br J Cancer 1998, 77: 2171-6.
    • (1998) Br J Cancer , vol.77 , pp. 2171-2176
    • Van Ark-Otte, J.1    Kedde, M.A.2    Van der Vijgh, W.J.F.3
  • 181
    • 0028796779 scopus 로고
    • Intracellular carboxylesterase activity as a determinant of cellular sensitivity to the antineoplastic agent KW-2189 in cell lines resistant to cisplatin and CPT-11
    • Ogasawara, H., Nishio, K., Kanzawa, F. et al. Intracellular carboxylesterase activity as a determinant of cellular sensitivity to the antineoplastic agent KW-2189 in cell lines resistant to cisplatin and CPT-11. Jpn J Cancer Res 1995, 86: 124-9.
    • (1995) Jpn J Cancer Res , vol.86 , pp. 124-129
    • Ogasawara, H.1    Nishio, K.2    Kanzawa, F.3
  • 182
    • 0030453707 scopus 로고    scopus 로고
    • Phase I and pharmacological studies of 20(S)-camptothecin and 20(S)-9-nitrocamptothecin as anticancer agents
    • Natelson, E.A., Giovanella, B.C., Verschraegen, C.F. et al. Phase I and pharmacological studies of 20(S)-camptothecin and 20(S)-9-nitrocamptothecin as anticancer agents. Ann NY Acad Sci 1996, 803: 224-30.
    • (1996) Ann NY Acad Sci , vol.803 , pp. 224-230
    • Natelson, E.A.1    Giovanella, B.C.2    Verschraegen, C.F.3
  • 183
    • 0031056424 scopus 로고    scopus 로고
    • Phase I and pharmacological study of oral topotecan administered twice daily for 21 days to adult patients with solid tumors
    • Creamers, G., Gerrits, C., Eckardt, J. et al. Phase I and pharmacological study of oral topotecan administered twice daily for 21 days to adult patients with solid tumors. J Clin Oncol 1997, 15: 1087-93.
    • (1997) J Clin Oncol , vol.15 , pp. 1087-1093
    • Creamers, G.1    Gerrits, C.2    Eckardt, J.3
  • 184
    • 0001765988 scopus 로고    scopus 로고
    • Irinotecan therapy for patients with previously treated metastatic colorectal cancer: Overall results of FDA-reviewed pivotal US clinical trials
    • Von Hoff, D.D., Rothenberg, M., Pitot H. et al. Irinotecan therapy for patients with previously treated metastatic colorectal cancer: Overall results of FDA-reviewed pivotal US clinical trials. Proc Am Soc Clin Oncol 1997, 16: 228a.
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Von Hoff, D.D.1    Rothenberg, M.2    Pitot, H.3
  • 185
    • 0028067913 scopus 로고
    • Topoisomerase I gene expression and cell sensitivity to camptothecin in human cell lines of different tumor types
    • Perego, P., Capranico, G., Supino, R., Zunino, F. Topoisomerase I gene expression and cell sensitivity to camptothecin in human cell lines of different tumor types. Anticancer Drugs 1994, 5: 645-9.
    • (1994) Anticancer Drugs , vol.5 , pp. 645-649
    • Perego, P.1    Capranico, G.2    Supino, R.3    Zunino, F.4
  • 186
    • 0029041130 scopus 로고
    • Analysis of topoisomerase I/DNA complexes in patients administered topotecan
    • Subramanian, D., Kraut, E., Staubus, A., Young, D.C., Muller, M.T. Analysis of topoisomerase I/DNA complexes in patients administered topotecan. Cancer Res 1995, 55: 2097-103.
    • (1995) Cancer Res , vol.55 , pp. 2097-2103
    • Subramanian, D.1    Kraut, E.2    Staubus, A.3    Young, D.C.4    Muller, M.T.5


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