Involvement of amino acids 361 to 364 of human topoisomerase I in camptothecin resistance and enzyme catalysis

Biochemical Pharmacology

Volumn 53, Issue 7, 1997, Pages 1019-1027

  Li, Xi Guang ^a   Haluska Jr , Paul ^a   Hsiang, Yaw Huei ^b   Bharti, Ajit K ^b   Kufe, Donald W ^b   Liu, Leroy F ^a   Rubin, Eric H ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

camptothecin; DNA binding; DNA cleavage; drug resistance; enzyme mutations; topoisomerase

Indexed keywords

CAMPTOTHECIN; DNA TOPOISOMERASE;

AMINO ACID SUBSTITUTION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CATALYSIS; DNA BINDING; DNA CLEAVAGE; DRUG RESISTANCE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BINDING SITES; CAMPTOTHECIN; CATALYSIS; DNA; DNA DAMAGE; DNA TOPOISOMERASES, TYPE I; DRUG RESISTANCE; GENETIC VECTORS; HUMANS; MUTATION;

EID: 0030972846     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(96)00899-4     Document Type: Article

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