Involvement of β-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats

Cancer Research

Volumn 56, Issue 16, 1996, Pages 3752-3757

  Takasuna, Kiyoshi ^a   Hagiwara, Takehiro ^a   Hirohashi, Masaaki ^a   Kato, Michiyuki ^a   Nomura, Mamoru ^a   Nagai, Eiichi ^a   Yokoi, Tsuyoshi ^b   Kamataki, Tetsuya ^b  

^a DAIICHI SANKYO CO   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; BETA GLUCURONIDASE; CAMPTOTHECIN DERIVATIVE; CARBOXYLESTERASE; IRINOTECAN; PENICILLIN G; STREPTOMYCIN;

ANIMAL MODEL; ANIMAL TISSUE; ANOREXIA; ANTIBIOTIC THERAPY; ARTICLE; CECUM DISEASE; CHRONIC DIARRHEA; CONTROLLED STUDY; DRUG CONJUGATION; DRUG INDUCED DISEASE; ENZYME ACTIVITY; ENZYME INHIBITION; INTESTINE FLORA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; WEIGHT REDUCTION;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BACTERIA; CAMPTOTHECIN; DIARRHEA; GLUCURONIDASE; INTESTINES; MALE; RATS; RATS, WISTAR;

EID: 0029741368     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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