The transformation of irinotecan (CPT-11) to its active metabolite SN-38 by human liver microsomes. Differential hydrolysis for the lactone and carboxylate forms

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 356, Issue 2, 1997, Pages 257-262

  Haaz, Marie Christine ^a   Rivory, Laurent P ^a,c   Riché, Christian ^b   Robert, Jacques ^a  

^a INSTITUT BERGONIÉ   (France)

^b FACULTÉ DE MÉDECINE ET DES SCIENCES DE LA SANTÉ   (France)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Camptothecine; Carboxylesterases; Irinotecan; Topoisomerase I inhibitors

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; ACETORPHAN; AMIKACIN; ANALGESIC AGENT; ANTIBIOTIC AGENT; ANTIDIARRHEAL AGENT; ANTIEMETIC AGENT; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; CARBOXYLESTERASE; CARBOXYLIC ACID DERIVATIVE; CEFTRIAXONE; CIPROFLOXACIN; COTRIMOXAZOLE; DRUG METABOLITE; FLUOROURACIL; IRINOTECAN; LACTONE; LOPERAMIDE; METOCLOPRAMIDE; MORPHINE; ONDANSETRON; PARACETAMOL;

ADULT; AGE; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DEACYLATION; DONOR; FEMALE; FLUOROMETRY; GENDER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; HYDROLYSIS; KINETICS; LIVER MICROSOME METABOLISM; MALE; STEADY STATE;

BIOTRANSFORMATION; CAMPTOTHECIN; CARBOXYLESTERASE; CARBOXYLIC ESTER HYDROLASES; DRUG INTERACTIONS; HUMANS; KINETICS; MICROSOMES, LIVER;

EID: 0030790137     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005049     Document Type: Article

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