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Volumn 54, Issue 9, 1998, Pages 910-919

Monogenic determinants of familial Alzheimer's disease: Presenilin-2 mutations

Author keywords

A ; Alzheimer's disease; Apoptosis; APP; Presenilin 1; Presenilin 2; Sel 12

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; PRESENILIN 1; PRESENILIN 2;

EID: 0031706026     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000180050220     Document Type: Article
Times cited : (16)

References (74)
  • 2
    • 0029101491 scopus 로고
    • Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's type 3 gene
    • Rogaev E. I., Sherrington R., Rogaeva E., Levesque G., Ikeda M., Liang Y. et al. (1995) Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's type 3 gene. Nature 376: 775-778
    • (1995) Nature , vol.376 , pp. 775-778
    • Rogaev, E.I.1    Sherrington, R.2    Rogaeva, E.3    Levesque, G.4    Ikeda, M.5    Liang, Y.6
  • 3
    • 0026088977 scopus 로고
    • Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
    • Goate A., Chartier-Harlin M., Mullan M., Brown J., Crawford F., Fidani L. et al. (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349: 704-706
    • (1991) Nature , vol.349 , pp. 704-706
    • Goate, A.1    Chartier-Harlin, M.2    Mullan, M.3    Brown, J.4    Crawford, F.5    Fidani, L.6
  • 4
    • 0029004341 scopus 로고
    • Cloning of a novel gene bearing missense mutations in early onset familial Alzheimer's disease
    • Sherrington R., Rogaev E. I., Liang Y. Rogaeva E. A., Levesque G., Ikeda M. et al. (1995) Cloning of a novel gene bearing missense mutations in early onset familial Alzheimer's disease. Nature 375: 754-760
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1    Rogaev, E.I.2    Liang, Y.3    Rogaeva, E.A.4    Levesque, G.5    Ikeda, M.6
  • 6
    • 0023731159 scopus 로고
    • Familial Alzheimer's disease in American descendants of the Volga Germans: Probable genetic founder effect
    • Bird T. D., Lampe T. H. and Nemens E. J. (1988) Familial Alzheimer's disease in American descendants of the Volga Germans: probable genetic founder effect. Ann. Neurol. 23: 25-31
    • (1988) Ann. Neurol. , vol.23 , pp. 25-31
    • Bird, T.D.1    Lampe, T.H.2    Nemens, E.J.3
  • 8
    • 6844255860 scopus 로고    scopus 로고
    • Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease
    • Cruts M., van Duijn M., Backhovens H., Van den Broeck M., Wehnert A., Serneels S. et al. (1998) Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease. Hum. Mol. Genet. 7: 43-51
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 43-51
    • Cruts, M.1    Van Duijn, M.2    Backhovens, H.3    Van Den Broeck, M.4    Wehnert, A.5    Serneels, S.6
  • 9
    • 0030483182 scopus 로고    scopus 로고
    • Genetic factors in Alzheimer's disease: A review of recent advances
    • Levy-Lahad E. and Bird T. D. (1996) Genetic factors in Alzheimer's disease: a review of recent advances. Ann. Neurol. 40: 829-840
    • (1996) Ann. Neurol. , vol.40 , pp. 829-840
    • Levy-Lahad, E.1    Bird, T.D.2
  • 10
    • 8944241774 scopus 로고    scopus 로고
    • Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant
    • Sherrington R., Froelich S., Sorbi S., Campion D., Chi H., Rogaeva E. A. et al. (1996) Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant. Hom. Mol. Genet. 5: 985-988
    • (1996) Hom. Mol. Genet. , vol.5 , pp. 985-988
    • Sherrington, R.1    Froelich, S.2    Sorbi, S.3    Campion, D.4    Chi, H.5    Rogaeva, E.A.6
  • 11
    • 0030791972 scopus 로고    scopus 로고
    • Presenilin I, presenilin II and VLDL-R associations in early-onset Alzheimer's disease
    • Brookes A. J., Howell W. M., Woodburn K., Johnstone E. C. and Carothers A. (1997) Presenilin I, presenilin II and VLDL-R associations in early-onset Alzheimer's disease. Lancet 350: 336-337
    • (1997) Lancet , vol.350 , pp. 336-337
    • Brookes, A.J.1    Howell, W.M.2    Woodburn, K.3    Johnstone, E.C.4    Carothers, A.5
  • 12
    • 0031941389 scopus 로고    scopus 로고
    • Amyloid angiopathy in a Volga German family with Alzheimer's disease and a presenilin-2 mutation (N1411)
    • Nochlin D., Bird T. D., Nemens E.J., Ball M. J. and Sumi S. M. (1998) Amyloid angiopathy in a Volga German family with Alzheimer's disease and a presenilin-2 mutation (N1411). Ann. Neurol. 43: 131-135
    • (1998) Ann. Neurol. , vol.43 , pp. 131-135
    • Nochlin, D.1    Bird, T.D.2    Nemens, E.J.3    Ball, M.J.4    Sumi, S.M.5
  • 13
    • 0030614569 scopus 로고    scopus 로고
    • Amyloid (Aβ) deposition in chromosome 1 linked Alzheimer's disease: The Volga German families
    • Mann D. M. A., Iwatsubo T., Nochlin D., Sumi S. M., Levy-Lahad E. and Bird T. D. (1997) Amyloid (Aβ) deposition in chromosome 1 linked Alzheimer's disease: the Volga German families. Ann. Neurol. 41: 52-57
    • (1997) Ann. Neurol. , vol.41 , pp. 52-57
    • Mann, D.M.A.1    Iwatsubo, T.2    Nochlin, D.3    Sumi, S.M.4    Levy-Lahad, E.5    Bird, T.D.6
  • 14
    • 0025296269 scopus 로고
    • Mutation of the Alzheimers' disease amyloid gene in hereditary cerebral hemorrhage, Dutch type
    • Levy E., Carman M. D., Fernandez-Madrid I. J., Power M. D., Lieberburg I., van Duinen S. G. et al. (1990) Mutation of the Alzheimers' disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science 248: 1124-1126
    • (1990) Science , vol.248 , pp. 1124-1126
    • Levy, E.1    Carman, M.D.2    Fernandez-Madrid, I.J.3    Power, M.D.4    Lieberburg, I.5    Van Duinen, S.G.6
  • 15
    • 0026879650 scopus 로고
    • Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene
    • Hendriks L., Van Duijn C., Cras P., Cruts M., Van Hul W., van Harskamp F. et al. (1992) Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene. Nat. Genet. 1: 218-221
    • (1992) Nat. Genet. , vol.1 , pp. 218-221
    • Hendriks, L.1    Van Duijn, C.2    Cras, P.3    Cruts, M.4    Van Hul, W.5    Van Harskamp, F.6
  • 16
    • 0030499031 scopus 로고    scopus 로고
    • Wide range in age-of-onset variation in families with chromosome 1 related Alzheimer's' disease
    • Bird T. D., Levy-Lahad E., Poorkaj P., Sharma V., Nemens E., Lahad A. et al. (1996) Wide range in age-of-onset variation in families with chromosome 1 related Alzheimer's' disease. Ann. Neurol. 40: 932-936
    • (1996) Ann. Neurol. , vol.40 , pp. 932-936
    • Bird, T.D.1    Levy-Lahad, E.2    Poorkaj, P.3    Sharma, V.4    Nemens, E.5    Lahad, A.6
  • 17
    • 0030848149 scopus 로고    scopus 로고
    • Early-onset Alzheimer's disease with a presenilin-1 mutation at the site corresponding to the Volga German presenilin-2 mutation
    • Crook R., Ellis R., Shanks M., Thal L. J., Perez-Tur J., Baker M. et al. (1997) Early-onset Alzheimer's disease with a presenilin-1 mutation at the site corresponding to the Volga German presenilin-2 mutation. Ann. Neurol. 42: 124-128
    • (1997) Ann. Neurol. , vol.42 , pp. 124-128
    • Crook, R.1    Ellis, R.2    Shanks, M.3    Thal, L.J.4    Perez-Tur, J.5    Baker, M.6
  • 19
    • 0027194791 scopus 로고
    • Gene dose of the apolipoprotein e type-4 allele and the risk of Alzheimer's disease in late-onset families
    • Corder E. H., Saunders A. M., Stritmatter W. J., Schmechel D. E., Gaskell P. C., Small G. N. et al. (1993) Gene dose of the apolipoprotein E type-4 allele and the risk of Alzheimer's disease in late-onset families. Science 261: 921-923
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Stritmatter, W.J.3    Schmechel, D.E.4    Gaskell, P.C.5    Small, G.N.6
  • 21
    • 0029984784 scopus 로고    scopus 로고
    • Genomic structure and expression of STM-2, the chromosome 1 familial Alzheimer's disease gene
    • Levy-Lahad E., Poorkaj P., Wang K., Fu Y. H., Oshima J., Mulligan J. et al. (1996) Genomic structure and expression of STM-2, the chromosome 1 familial Alzheimer's disease gene. Genomics 34: 198-204
    • (1996) Genomics , vol.34 , pp. 198-204
    • Levy-Lahad, E.1    Poorkaj, P.2    Wang, K.3    Fu, Y.H.4    Oshima, J.5    Mulligan, J.6
  • 22
    • 0031569390 scopus 로고    scopus 로고
    • Analysis of the 5′ sequence, genomic structure and alternative splicing of the presenilin-1 gene (PSEN1) associated with early-onset Alzheimer's disease
    • Rogaev E. I., Sherrington R., Wu C., Levesque G., Liang Y., Rogaeva E. A. et al. (1997) Analysis of the 5′ sequence, genomic structure and alternative splicing of the presenilin-1 gene (PSEN1) associated with early-onset Alzheimer's disease. Genomics 40: 415-424
    • (1997) Genomics , vol.40 , pp. 415-424
    • Rogaev, E.I.1    Sherrington, R.2    Wu, C.3    Levesque, G.4    Liang, Y.5    Rogaeva, E.A.6
  • 23
    • 0029116848 scopus 로고
    • Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
    • Levitan D. and Greenwald I. (1995) Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377: 351-354
    • (1995) Nature , vol.377 , pp. 351-354
    • Levitan, D.1    Greenwald, I.2
  • 24
    • 0030889705 scopus 로고    scopus 로고
    • Isolation and characterization of the Drosophila presenilin homolog
    • Hong C.-S. and Koo E. H. (1997) Isolation and characterization of the Drosophila presenilin homolog. Neuroreport 8: 665-668
    • (1997) Neuroreport , vol.8 , pp. 665-668
    • Hong, C.-S.1    Koo, E.H.2
  • 26
    • 0030767333 scopus 로고    scopus 로고
    • Cloning of cDNA and expression of the gene encoding rat presenilin-2
    • Takahashi H., Mercken M., Nakazato Y., Kaori N., Murayaina M., Imahori K. et al. (1997) Cloning of cDNA and expression of the gene encoding rat presenilin-2. Gene 197: 383-387
    • (1997) Gene , vol.197 , pp. 383-387
    • Takahashi, H.1    Mercken, M.2    Nakazato, Y.3    Kaori, N.4    Murayaina, M.5    Imahori, K.6
  • 28
    • 13344282063 scopus 로고    scopus 로고
    • Alzheimer associated presenilin 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells
    • Kovacs D. M., Fausett H. J., Page K. J., Kim T.-W., Mori R. D., Merriam D. E. et al. (1996) Alzheimer associated presenilin 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nature Med. 2: 224-229
    • (1996) Nature Med. , vol.2 , pp. 224-229
    • Kovacs, D.M.1    Fausett, H.J.2    Page, K.J.3    Kim, T.-W.4    Mori, R.D.5    Merriam, D.E.6
  • 29
    • 0029909225 scopus 로고    scopus 로고
    • Regional and cellular presenilin 2 (STM2) gene expression in the human brain
    • Boissiere F., Pradier L., Delaere P., Faucheux B., Revah F., Brice A. et al. (1996) Regional and cellular presenilin 2 (STM2) gene expression in the human brain. Neuroreport 7: 2021-2025
    • (1996) Neuroreport , vol.7 , pp. 2021-2025
    • Boissiere, F.1    Pradier, L.2    Delaere, P.3    Faucheux, B.4    Revah, F.5    Brice, A.6
  • 30
    • 0030599136 scopus 로고    scopus 로고
    • Gene expression of Alzheimer-associated presenilin-2 in the frontal cortex of Alzheimer and aged control brain
    • Deng G., Su J. H. and Cotman C. W. (1996) Gene expression of Alzheimer-associated presenilin-2 in the frontal cortex of Alzheimer and aged control brain. FEBS Lett. 394: 17-20
    • (1996) FEBS Lett. , vol.394 , pp. 17-20
    • Deng, G.1    Su, J.H.2    Cotman, C.W.3
  • 31
    • 0031044834 scopus 로고    scopus 로고
    • Expression of presenilin-1 and -2 mRNAs in rat and Alzheimer's disease brains
    • Takami K., Terai K., Matsuo A., Walker D. G. and McGeer P. L. (1997) Expression of presenilin-1 and -2 mRNAs in rat and Alzheimer's disease brains. Brain Res. 748: 122-130
    • (1997) Brain Res. , vol.748 , pp. 122-130
    • Takami, K.1    Terai, K.2    Matsuo, A.3    Walker, D.G.4    McGeer, P.L.5
  • 32
    • 10544239098 scopus 로고    scopus 로고
    • Antibodies to presenilin proteins detect neurofibrillary tangles in Alzheimer's disease
    • Murphy G. M., Forno L. S., Ellis W. G., Nochlin D., Levy-Lahad E., Poorkaj P. et al. (1996) Antibodies to presenilin proteins detect neurofibrillary tangles in Alzheimer's disease. Am. J. Pathol. 149: 1839-1846
    • (1996) Am. J. Pathol. , vol.149 , pp. 1839-1846
    • Murphy, G.M.1    Forno, L.S.2    Ellis, W.G.3    Nochlin, D.4    Levy-Lahad, E.5    Poorkaj, P.6
  • 33
    • 0028822488 scopus 로고
    • S182 protein in Alzheimer's disease neuritic plaques
    • Wisniewski T., Palha J. A., Ghiso J. and Frangione B. (1995) S182 protein in Alzheimer's disease neuritic plaques. Lancet 346: 1366
    • (1995) Lancet , vol.346 , pp. 1366
    • Wisniewski, T.1    Palha, J.A.2    Ghiso, J.3    Frangione, B.4
  • 34
    • 8044231311 scopus 로고    scopus 로고
    • The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum
    • Walter J., Capell A., Grunberg J., Pesold B., Schindzielorz A., Prior R. et al. (1996) The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Mol. Med. 2: 673-691
    • (1996) Mol. Med. , vol.2 , pp. 673-691
    • Walter, J.1    Capell, A.2    Grunberg, J.3    Pesold, B.4    Schindzielorz, A.5    Prior, R.6
  • 35
    • 0030771534 scopus 로고    scopus 로고
    • Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N1411)
    • Janicki S. and Monteiro M. J. (1997) Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N1411). J. Cell Biol. 139: 485-495
    • (1997) J. Cell Biol. , vol.139 , pp. 485-495
    • Janicki, S.1    Monteiro, M.J.2
  • 36
    • 15444341611 scopus 로고    scopus 로고
    • Phosphorylation, subcellular localization and membrane orientation of the Alzheimer's disease-associated presenilins
    • De Strooper B., Beullens M., Contreras B., Levesque L., Craessaerts K., Cordell B. et al. (1997) Phosphorylation, subcellular localization and membrane orientation of the Alzheimer's disease-associated presenilins. J. Biol. Chem. 272: 3590-3598
    • (1997) J. Biol. Chem. , vol.272 , pp. 3590-3598
    • De Strooper, B.1    Beullens, M.2    Contreras, B.3    Levesque, L.4    Craessaerts, K.5    Cordell, B.6
  • 37
    • 0030917601 scopus 로고    scopus 로고
    • Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid β-peptide: Involvement of calcium and oxyradicals
    • Guo Q., Sopher B. L., Furukawa K., Pham D. G., Robinson N., Martin G. M. et al. (1997) Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid β-peptide: involvement of calcium and oxyradicals. J. Neurosci. 17: 4212-4222
    • (1997) J. Neurosci. , vol.17 , pp. 4212-4222
    • Guo, Q.1    Sopher, B.L.2    Furukawa, K.3    Pham, D.G.4    Robinson, N.5    Martin, G.M.6
  • 38
    • 0030924177 scopus 로고    scopus 로고
    • Cell surface expression of the Alzheimer disease-related presenilin proteins
    • Dewji N. N. and Singer S. J (1997) Cell surface expression of the Alzheimer disease-related presenilin proteins. Proc. Natl. Acad. Sci. USA 94: 9926-9931
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9926-9931
    • Dewji, N.N.1    Singer, S.J.2
  • 39
    • 0030024278 scopus 로고    scopus 로고
    • Genetic clues to Alzheimer's disease
    • Dewji N. N. and Singer S. J. (1996) Genetic clues to Alzheimer's disease. Science 271: 159-160
    • (1996) Science , vol.271 , pp. 159-160
    • Dewji, N.N.1    Singer, S.J.2
  • 40
    • 0030657665 scopus 로고    scopus 로고
    • Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation
    • Capell A., Satiric R., Olivo J.-C., Meyn L., Walter J., Grunberg J, et al. (1997) Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation. J. Neurochem. 69: 2432-2440
    • (1997) J. Neurochem. , vol.69 , pp. 2432-2440
    • Capell, A.1    Satiric, R.2    Olivo, J.-C.3    Meyn, L.4    Walter, J.5    Grunberg, J.6
  • 41
    • 0030761059 scopus 로고    scopus 로고
    • Alzheimer presenilins in the nuclear membrane, interphase kinetochores and centrosomes suggest a role in chromosome segregation
    • Li J., Xu M., Zhou H., Ma J. and Potter H. (1997) Alzheimer presenilins in the nuclear membrane, interphase kinetochores and centrosomes suggest a role in chromosome segregation. Cell 90: 917-927
    • (1997) Cell , vol.90 , pp. 917-927
    • Li, J.1    Xu, M.2    Zhou, H.3    Ma, J.4    Potter, H.5
  • 42
    • 0028891759 scopus 로고
    • Nucleotide sequence of the chromosome 14-encoded S182 cDNA and revised secondary structure prediction
    • Slunt H. H., Thinakaran G., Lee M. K. and Sisodia S. S. (1995) Nucleotide sequence of the chromosome 14-encoded S182 cDNA and revised secondary structure prediction. Amyloid. Int. J. Exp. Clin. Invest. 2: 188-190
    • (1995) Amyloid. Int. J. Exp. Clin. Invest. , vol.2 , pp. 188-190
    • Slunt, H.H.1    Thinakaran, G.2    Lee, M.K.3    Sisodia, S.S.4
  • 44
    • 0030293894 scopus 로고    scopus 로고
    • Membrane topology of the C. elegans SEL-12 presenilin
    • Li X. and Greenwald I. (1996) Membrane topology of the C. elegans SEL-12 presenilin. Neuron 17: 1015-1021
    • (1996) Neuron , vol.17 , pp. 1015-1021
    • Li, X.1    Greenwald, I.2
  • 45
    • 0030922146 scopus 로고    scopus 로고
    • Evidence for a six-transmembrane domain structure of presenilin 1
    • Lehmann S., Chiesa R. and Harris D. A. (1997) Evidence for a six-transmembrane domain structure of presenilin 1. J. Biol. Chem. 272: 12047-12051
    • (1997) J. Biol. Chem. , vol.272 , pp. 12047-12051
    • Lehmann, S.1    Chiesa, R.2    Harris, D.A.3
  • 46
    • 15844425969 scopus 로고    scopus 로고
    • Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
    • Thinakaran G., Borchelt D. R., Lee M. K., Slunt H. H., Spitzer L., Kim G. et al. (1996) Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17: 181-190
    • (1996) Neuron , vol.17 , pp. 181-190
    • Thinakaran, G.1    Borchelt, D.R.2    Lee, M.K.3    Slunt, H.H.4    Spitzer, L.5    Kim, G.6
  • 47
    • 0030890399 scopus 로고    scopus 로고
    • Endoproteolytic cleavage and proteasomal degredation of Presenilin 2 in transfected cells
    • Kim T.-W., Pettingel W. H., Hallmark O. G., Moir R. D., Wasco W. and Tanzi R. E. (1997) Endoproteolytic cleavage and proteasomal degredation of Presenilin 2 in transfected cells. J. Biol. Chem. 272: 11006-11010
    • (1997) J. Biol. Chem. , vol.272 , pp. 11006-11010
    • Kim, T.-W.1    Pettingel, W.H.2    Hallmark, O.G.3    Moir, R.D.4    Wasco, W.5    Tanzi, R.E.6
  • 48
    • 12644258498 scopus 로고    scopus 로고
    • The presenilin 2 mutation (N1411) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue
    • Tomita T., Maruyama K., Saido T. C., Kume H., Shinozaki K., Tokihuro S. et al. (1997) The presenilin 2 mutation (N1411) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue. Proc. Natl. Acad. Sci. USA 94: 2025-2030
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2025-2030
    • Tomita, T.1    Maruyama, K.2    Saido, T.C.3    Kume, H.4    Shinozaki, K.5    Tokihuro, S.6
  • 49
    • 0031587396 scopus 로고    scopus 로고
    • Determination of a cleavage site of presenilin 2 protein in stably transfecled SH-SY5Y human neuroblastoma cell lines
    • Shirotani K., Takahashi K., Ozawa K., Kunishita T. and Tabira T. (1997) Determination of a cleavage site of presenilin 2 protein in stably transfecled SH-SY5Y human neuroblastoma cell lines. Biochem. Biophys. Res. Commun. 240: 728-731
    • (1997) Biochem. Biophys. Res. Commun. , vol.240 , pp. 728-731
    • Shirotani, K.1    Takahashi, K.2    Ozawa, K.3    Kunishita, T.4    Tabira, T.5
  • 50
    • 0030667426 scopus 로고    scopus 로고
    • Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors
    • Thinakaran G., Harris C. L., Ravitovski T., Davenport F., Slunt H. H., Price D. L. et al. (1997) Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors. J. Biol. Chem. 45: 28415-28422
    • (1997) J. Biol. Chem. , vol.45 , pp. 28415-28422
    • Thinakaran, G.1    Harris, C.L.2    Ravitovski, T.3    Davenport, F.4    Slunt, H.H.5    Price, D.L.6
  • 52
    • 0031054505 scopus 로고    scopus 로고
    • Formation of stable complexes between two Alzheimer's disease gene products: Presenilin-2 and beta-amyloid precursor protein
    • Weidmann A., Paliga K., Durrwang U., Czech C., Evin G., Masters C. L. et al. (1997) Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein. Nature Med. 3: 328-332
    • (1997) Nature Med. , vol.3 , pp. 328-332
    • Weidmann, A.1    Paliga, K.2    Durrwang, U.3    Czech, C.4    Evin, G.5    Masters, C.L.6
  • 53
    • 0031473796 scopus 로고    scopus 로고
    • On the spurious endoproteolytic processing of the presenilin proteins in cultured cells and tissues
    • Dewji N. N., Do C. and Singer S. J. (1997) On the spurious endoproteolytic processing of the presenilin proteins in cultured cells and tissues. Proc. Natl. Acad. Sci. USA 94: 14031-14036
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 14031-14036
    • Dewji, N.N.1    Do, C.2    Singer, S.J.3
  • 54
    • 0029073383 scopus 로고
    • Genetic dissection of Alzheimer's disease, a heterogeneous disorder
    • Schellenberg G. D. (1995) Genetic dissection of Alzheimer's disease, a heterogeneous disorder. Proc. Natl. Acad. Sci. USA 92: 8552-8559
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 8552-8559
    • Schellenberg, G.D.1
  • 56
    • 17744401440 scopus 로고    scopus 로고
    • Presenilin 1 is required for Notch1 and Dll1 expression in the paraxial mesoderm
    • Wong P. C., Zheng H., Chen H., Becher M. W., Sirinathsinghji D. J. S., Trumbauer M. E. et al. (1997) Presenilin 1 is required for Notch1 and Dll1 expression in the paraxial mesoderm. Nature 387: 288-292
    • (1997) Nature , vol.387 , pp. 288-292
    • Wong, P.C.1    Zheng, H.2    Chen, H.3    Becher, M.W.4    Sirinathsinghji, D.J.S.5    Trumbauer, M.E.6
  • 57
    • 0028945660 scopus 로고
    • Evidence that Aβ42 is the real culprit in Alzheimer's disease
    • Younkin S. G. (1995) Evidence that Aβ42 is the real culprit in Alzheimer's disease. Ann. Neurol. 37: 287-288
    • (1995) Ann. Neurol. , vol.37 , pp. 287-288
    • Younkin, S.G.1
  • 58
    • 0027526419 scopus 로고
    • Release of excess beta-amyloid protein from a mutant amyloid beta protein precursor
    • Cai X. D., Golde T. E. and Younkin S. G. (1993) Release of excess beta-amyloid protein from a mutant amyloid beta protein precursor. Science 259: 514-516
    • (1993) Science , vol.259 , pp. 514-516
    • Cai, X.D.1    Golde, T.E.2    Younkin, S.G.3
  • 59
    • 0028322017 scopus 로고
    • An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (APP717) mutants
    • Suzuki N., Cheung T. T., Cai X. D., Odaka A., Otvos L. Jr., Eckman C. et al. (1994) An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (APP717) mutants. Science 264: 1336-1340
    • (1994) Science , vol.264 , pp. 1336-1340
    • Suzuki, N.1    Cheung, T.T.2    Cai, X.D.3    Odaka, A.4    Otvos Jr., L.5    Eckman, C.6
  • 60
    • 16044373524 scopus 로고    scopus 로고
    • The amyloid β-protein deposited in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
    • Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N. et al. (1996) The amyloid β-protein deposited in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med. 2: 864-870
    • (1996) Nature Med. , vol.2 , pp. 864-870
    • Scheuner, D.1    Eckman, C.2    Jensen, M.3    Song, X.4    Citron, M.5    Suzuki, N.6
  • 61
    • 16944362157 scopus 로고    scopus 로고
    • Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice
    • Citron M., Westaway D., Xia W., Carlson G., Diehl T., Levesque G. et al. (1997) Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice. Nature Med. 3: 67-72
    • (1997) Nature Med. , vol.3 , pp. 67-72
    • Citron, M.1    Westaway, D.2    Xia, W.3    Carlson, G.4    Diehl, T.5    Levesque, G.6
  • 62
    • 0029861413 scopus 로고    scopus 로고
    • Specific transcellular binding between membrane proteins crucial to Alzheimer disease
    • Dewji N. N. and Singer S. J. (1996) Specific transcellular binding between membrane proteins crucial to Alzheimer disease. Proc. Natl. Acad. Sci. USA 93: 12575-12580
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 12575-12580
    • Dewji, N.N.1    Singer, S.J.2
  • 63
    • 0030753089 scopus 로고    scopus 로고
    • Interaction between amyloid precursor protein and presenilins in mammaliam cells: Implications for the pathogenesis of Alzheimer's disease
    • Xia W., Jhang J., Perez R., Koo E. H. and Selkoe D. J. (1997) Interaction between amyloid precursor protein and presenilins in mammaliam cells: implications for the pathogenesis of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 94: 8208-8213
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 8208-8213
    • Xia, W.1    Jhang, J.2    Perez, R.3    Koo, E.H.4    Selkoe, D.J.5
  • 64
    • 0031196094 scopus 로고    scopus 로고
    • Lack of interactions between amyloid precursor protein and hydrophilic domains of presenilin 1 and 2 using the yeast two hybrid system
    • Kim S. S., Shoi Y. M. and Suh Y. H. (1997) Lack of interactions between amyloid precursor protein and hydrophilic domains of presenilin 1 and 2 using the yeast two hybrid system. J. Mol. Neurosci. 9: 49-54
    • (1997) J. Mol. Neurosci. , vol.9 , pp. 49-54
    • Kim, S.S.1    Shoi, Y.M.2    Suh, Y.H.3
  • 65
    • 0029976253 scopus 로고    scopus 로고
    • DNA damage and apoptosis in Alzheimer's disease: Colocalization with c-Jun immunoreactivity, relationship to brain area and effect of postmortem delay
    • Anderson A. J., Su J. H. and Cotman C. W. (1996) DNA damage and apoptosis in Alzheimer's disease: colocalization with c-Jun immunoreactivity, relationship to brain area and effect of postmortem delay. J. Neurosci. 16: 1710-1719
    • (1996) J. Neurosci. , vol.16 , pp. 1710-1719
    • Anderson, A.J.1    Su, J.H.2    Cotman, C.W.3
  • 68
    • 0029671219 scopus 로고    scopus 로고
    • +2-binding protein ALG-2 and Alzheimer's disease gene ALG-3
    • +2-binding protein ALG-2 and Alzheimer's disease gene ALG-3. Science 271: 521-525
    • (1996) Science , vol.271 , pp. 521-525
    • Vito, P.1    Lacana, E.2    D'Adamio, L.3
  • 69
    • 0030580281 scopus 로고    scopus 로고
    • Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells
    • Deng G., Pike C. J. and Cotman C. W. (1996) Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells. FEBS Lett. 397: 50-54
    • (1996) FEBS Lett. , vol.397 , pp. 50-54
    • Deng, G.1    Pike, C.J.2    Cotman, C.W.3
  • 70
    • 10544224542 scopus 로고    scopus 로고
    • Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation
    • Wolozin B., Iwasaki K., Vito P., Ganjei J. K., Lacana E., Sunderland T. et al. (1996) Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science 274: 1710-1713
    • (1996) Science , vol.274 , pp. 1710-1713
    • Wolozin, B.1    Iwasaki, K.2    Vito, P.3    Ganjei, J.K.4    Lacana, E.5    Sunderland, T.6
  • 71
    • 0030680151 scopus 로고    scopus 로고
    • Generation of anti-apoptotic Presenilin-2 polypeptides by alternative transcription, proteolysis and caspase-3 cleavace
    • Vito P., Ghayur T. and D'Adamio L. (1997) Generation of anti-apoptotic Presenilin-2 polypeptides by alternative transcription, proteolysis and caspase-3 cleavace. J. Biol. Chem. 272: 28315-28320
    • (1997) J. Biol. Chem. , vol.272 , pp. 28315-28320
    • Vito, P.1    Ghayur, T.2    D'Adamio, L.3
  • 72
    • 0030868903 scopus 로고    scopus 로고
    • Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-s family protease
    • Kim T.-W., Pettingel W. H., Jung Y.-K., Kovacs D. M. and Tanzi R. E. (1997) Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-s family protease. Science 277: 373-376
    • (1997) Science , vol.277 , pp. 373-376
    • Kim, T.-W.1    Pettingel, W.H.2    Jung, Y.-K.3    Kovacs, D.M.4    Tanzi, R.E.5
  • 73
    • 0030756576 scopus 로고    scopus 로고
    • Caspases: A treatment target for neurodegenerative disease?
    • Holtzman D. M. and Deshmukh M (1997) Caspases: a treatment target for neurodegenerative disease? Nature Med. 3: 954-955
    • (1997) Nature Med. , vol.3 , pp. 954-955
    • Holtzman, D.M.1    Deshmukh, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.