Induction of TCR gene rearrangements in uncommitted stem cells by a subset of IL-7 producing, MHC class II-expressing thymic stromal cells

Immunity

Volumn 6, Issue 3, 1997, Pages 351-360

  Oosterwegel, Mariëtte A ^a   Haks, Marille C ^a   Jeffry, Ursula ^b   Murray, Richard ^b   Kruisbeek, Ada M ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 7; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; FETUS; GENE REARRANGEMENT; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; STROMA CELL; T LYMPHOCYTE RECEPTOR GENE; THYMUS;

EID: 0030964406     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80337-4     Document Type: Article

References (63)

1. Anderson, G., Jenkinson, E.J., Moore, N.C., and Owen, J.J.T. (1993). MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus. Nature 362, 70-72.
2. +thymocytes in vitro. J. Exp. Med. 179, 2027-2031.
3. Anderson, S.J., Levin, S.D., and Perlmutter, R.M. (1994b). Involvement of the protein tyrosine kinase p56lck in T cell signaling and thymocyte development. Adv. Immunol. 56, 151-178.
4. Anderson, G., Moore, N.C., Owen, J.J.T., and Jenkinson, E.J. (1996). Cellular interactions in thymocyte development. Annu. Rev. Immunol. 14, 73-99.
5. Appasamy, P.M., Kenniston, T.W., Jr., Weng, Y., Holt, E.C., Kost, J., and Chambers, W.H. (1993). Interleukin-7-induced expression of specific T cell receptor γ variable region genes in murine fetal liver cultures. J. Exp. Med. 178, 2201-2206.
6. Bookman, D.E., and Kirby, M.L. (1984). Dependence of thymic development on derivatives of the neural crest. Science 223, 498-500.
7. Boehm, T., Nehls, M., and Kyewski, B. (1995). Transcription factors that control development of the thymic microenvironment. Immunol. Today 16, 555-556.
8. Boismenu, R., Rhein, M., Fischer, W.H., and Havran, W.L. (1996). A role for CD81 in early T cell development. Science 271, 198-200.
9. Boyd, R.L., Tucek, C.L., Godfrey, D.I., Izon, D.J., Wilson, T.J., Davidson, N.J., Bean, A.G.D., Ladyman, H.M., Ritter, M.A., and Hugo, P. (1993). The thymic microenvironment. Immunol. Today 14, 445-459.
10. Bruno, L., Rocha, B., Rolink, A., Von Boehmer, H., and Rodewald, H.-R. (1995). Intra- and extra-thymic expression of the pre-T cell receptor gene. Eur. J. Immunol. 25, 1877-1882.
11. Burkly, L., Hession, C., Ogata, L., Reilly, C., Marconi, L.A., Olson, D., Tizard, R., Cate, R., and Lo, D. (1995). Expression of relB is required for the development of thymic medulla and dendritic cells. Nature 373, 531-536.
12. D'Adamio, L., Clayton, L.K., Awad, K.M., and Reinherz, E.L. (1992). Negative selection of thymocytes: a novel polymerase chain reaction-based molecular analysis detects requirements for macromolecular synthesis. J. Immunol. 149, 3550-3553.
13. Dudley, E.C., Petrie, H.T., Shah, L.M., Owen, M.J., and Hayday, A.C. (1994). T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice. Immunity 1, 83-93.
14. Dudley, E.C., Girardi, M.C., Owen, M.J., and Hayday, A.C. (1995). αβ and γδ cells can share a late common precursor. Curr. Biol. 5, 659-669.
15. Farr, A.G., Nelson, A., Truex, J., and Hosier, S. (1991). Epithelial heterogeneity in the murine thymus: cell surface reactive glycoprotein expressed by subcapsular and medullary epithelium. J. Histochem. Cytochem. 39, 645-653.
16. Fehling, H.J., Krotkova, A., Saint-Ruf, C., and Von Boehmer, H. (1995). Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ T cells. Nature 375, 795-797.
17. - thymocyte differentiation. J. Immunol. 152, 4783-4792.
18. Haas, W., and Tonegawa, S. (1992). Development and selection of γδ T cells. Curr. Opin. Immunol. 4, 147-155.
19. Heath, A.W., Wu, W.W., and Howard, M.C. (1994). Monoclonal antibodies to murine CD40 define two distinct functional epitopes. Eur. J. Immunol. 24, 1828-1834.
20. Holländer, G.A., Wang, B., Nichoglannopoulou, A., Platenburg, P.P., Van Ewijk, W., Burakoff, S.J., Gutierrez-Ramos, J.-C., and Terhorst, C. (1995). Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes. Nature 373, 350-352.
21. Ikuta, K., and Weissman, I.L. (1992). Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Proc. Natl. Acad. Sci. USA 89, 1502-1506.
22. Itohara, S., Mombaerts, P., Lafaille, J., Iacomini, J., Nelson, A., Clarke, A.R., Hooper, M.L., Farr, A., and Tonegawa, S. (1993). T cell receptor δ gene mutant mice: independent generation of αβ T cells and programmed rearrangements of γδ TCR genes. Cell 72, 337-348.
23. Izon, D.J., Nieland, J.D., Godfrey, D.I., Boyd, R.L., and Kruisbeek, A.M. (1994). Flow cytometric analysis reveals unexpected shared antigens between histological defined populations of thymic stromal cells. Int. Immunol. 6, 31-39.
24. Jenkins, M.K., and Schwartz, R.H. (1987). Antigen presentation by chemically modified splenocytes induces antigen-specific T-cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165, 302-311.
25. Jenkinson, E.J., Franci, L.L., Kingston, R., and Owen, J.J.T. (1982). Effect of deoxyguanosine on lymphopoiesis in the developing thymus rudiment in vitro: application in the production of chimeric thymus rudiments. Eur. J. Immunol. 12, 583-587.
26. Jenkinson, E.J., Anderson, G., and Owen, J.J.T. (1992). Studies on T cell maturation on defined thymic stromal cell populations. J. Exp. Med. 176, 845-853.
27. Kang, J., Baker, J., and Raulet, D.H. (1995). Evidence that productive rearrangements of TCR γ genes influence the commitment of progenitor cells to differentiate into αβ or γδ T cells. Eur. J. Immunol. 25, 2706-2709.
28. Kingston, R., Jenkinson, J.J., and Owen, J.J.T. (1984). Characterization of stromal cell populations in the developing thymus of normal and nude mice. Eur. J. Immunol. 14, 1052-1056.
29. Kisielow, P., and Von Boehmer, H. (1995). Development and selection of T cells: facts and puzzles. Adv. Immunol. 58, 87-209.
30. Kraal, G., Breel, M., Janse, M., and Bruin, J. (1986). Langerhans' cells, veiled cells and interdigitating cells in the mouse recognized by a monoclonal antibody. J. Exp. Med. 163, 981-988.
31. Leenen, P.J.M., Melis, M., Slieker, W.A.T., and Van Ewijk, W. (1990). Murine macrophage precursor antigens. Eur. J. Immunol. 20, 27-34.
32. Levelt, C.N., and Eichmann, K. (1995). Receptors and signals in early thymic selection. Immunity 3, 667-672.
33. Livak, F., Petrie, H.T., Crispe, I.N., and Schatz, D.G. (1995). In-frame TCR δ gene rearrangements play a critical role in the αβ/γδ T cell lineage decision. Immunity 2, 617-627.
34. Maki, K., Sunaga, S., and Ikuta, K. (1996). The V-J recombination of T cell receptor-γ genes is blocked ininterleukin-7 receptor-deficient mice. J. Exp. Med. 184, 2423-2427.
35. Malissen, M., Gillet, A., Ardouin, L., Bourvier, G., Trucy, J., Ferrier, P., Vivier, E., and Malissen, B. (1995). Altered T cell development in mice with a targeted mutation of the CD3-∈ gene. EMBO J. 14, 4641-4653.
36. Mombaerts, P., Clarke, A.R., Rudnicki, M.A., Iacomini, J., Itohara, S., Lafaille, J.J., Wang, L., Ichikawa, Y., Jaenisch, R., Hooper, M.L., and Tonegawa, S. (1992a). Mutation in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature 360, 225-231.
37. Mombaerts, P., Iacomini, J., Johnson, R.S., Herrup, K., Tonegawa, S., and Papaloannou, V.E. (1992b). RAG-1-deficient mice have no mature B and T lymphocytes. Cell. 68, 869-877.
38. Moore, N.C., Anderson, G., Smith, C.A., Owen, J.J.T., and Jenkinson, E.J. (1993). Analysis of cytokine gene expression in subpopulations of freshly isolated thymocytes and thymic stromal cells using semi-quantitative polymerase chain reaction. Eur. J. Immunol. 23, 922-927.
39. Moore, T.A., and Zlotnik, A. (1995). T-cell lineage commitment and cytokine response of thymic progenitors. Blood 86, 1850-1860.
40. Muegge, K., Vila, M.P., and Durum, S.K. (1993). A cofactor for V(D)J rearrangement of the T cell receptor β gene. Science 261, 93-96.
41. Murray, R., Suda, T., Wrighton, N., Lee, F., and Zlotnik, A. (1989). IL-7 is a growth and maintenance facor for mature and immature thymocyte subsets. Int. Immunol. 1, 526-531.
42. Nehls, M., Pfeifer, D., Schorpp, M., Hedrich, H., and Boehm, T. (1994). New member of the winged-helix protein family disrupted in mouse and rat nude mutations. Nature 372, 103-105.
43. Nehls, M., Kyewski, B., Messerle, M., Waldschütz, R., Schüddekopf, K., Smith, A.J.H., and Boehm, T. (1996). Two genetically separable steps in the differentiation of thymic epithelium. Science 272, 886-889.
44. Palmer, D.B., Viney, J.I., Ritter, M.A., Hayday, A.C., and Owen, M.J. (1993). Expression of the αβ T-cell receptor is necessary for generation of the thymic medulla. Dev. Immunol. 3, 175-179.
45. Peschon, J.J., Morrissey, P.J., Grabstein, K.H., Ramsdell, F.J., Maraskovsky, E., Gliniak, B.C., Park, L.S., Ziegler, S.F., Williams, D.E., Ware, C.B., Meyer, J.D., and Davison, B.L. (1994). Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 180, 1955-1960.
46. Ramsdell, F. (1992). Fetal thymus organ culture for T cell development studies. In Current Protocols in Immunology, J.E. Coligan, A.M. Kruisbeek, D.H. Margulies, E.M. Shevach, and W. Strober, eds. (New York: John Wiley & Sons), Unit 3.18, pp. 1-10.
47. Rinke de Wit, T., Izon, D.J., Revilla, C., Oosterwegel, M., Bakker, A.Q., Van Ewijk, W., and Kruisbeek, A.M. (1996). Expression of tyrosine kinase genes in mouse thymic stromal cells. Int. Immunol. 8, 1787-1795.
48. Ritter, M.A., and Boyd, R.L. (1993). Development in the thymus: it takes two to tango. Immunol. Today 14, 462-468.
49. Rodewald, H.-R., Kretzschmar, K., Swat, W., and Takeda, S. (1995). Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo. Immunity 3, 313-319.
50. Rouse, R.V., Bolin, L.M., Bender, J.R., and Kyewski, B.A. (1988). Monoclonal antibodies reactive with subsets of mouse and human thymic epithelial cells. J. Histochem. Cytochem. 36, 1511-1517.
51. Saint-Ruf, C., Ungewiss, K., Groettrup, M., Bruno, L., Fehling, H.J., and Von Boehmer, H. (1994). Analysis and expression of a cloned pre-T cell receptor gene. Science 266, 1208-1212.
52. Shores, E.W., Van Ewijk, W., and Singer, A. (1994). Maturation of medullary thymic epithelium requires thymocytes expressing fully assembled CD3-TCR complexes. Int. Immunol. 6, 1393-1402.
53. Shortman, K., and Wu, L. (1996). Early T lymphocyte progenitors. Annu. Rev. Immunol. 14, 29-47.
54. Surh, C.D., and Sprent, J. (1994). T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372, 100-103.
55. Van Ewijk, W., Shores, E.W., and Singer, A. (1994). Crosstalk in the mouse thymus. Immunol. Today 15, 214-217.
56. + T cells: a new family of T cells. Immunol. Today 17, 71-76.
57. Von Freeden-Jeffry, U., Vieira, P., Lucian, L.A., McNeil, T., Burdach, S.E.G., and Murray, R. (1995). Lymphopenia in interleukin-7 gene deleted mice identifies interleukin-7 as a non-redundant cytokine. J. Exp. Med. 181, 1519-1526.
58. Watson, J.K., Morrissey, P.J., Namen, A.E., Conlon, P.J., and Widmer, M.B. (1989). Effect of IL-7 on the growth of fetal thymocytes in culture. J. Immunol. 143, 1215-1222.
59. Weih, F., Carrasco, D., Durham, S.T., Baron, D.S., Rizzo, C.A., Ryseck, R.-P., Lira, S.A., and Bravo, R. (1995). Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family. Cell 80, 331-340.
60. Wilson, A., Held, W., and MacDonald, H.R. (1994). Two waves of recombinase gene expression in developing thymocytes. J. Exp. Med. 179, 1355-1360.
61. Wilson, A., De Villartay, J.-P., and MacDonald, H.R. (1996). T cell receptor δ gene rearrangement and T early α (TEA) expression in immature αβ lineage thymocytes: implications for αβ/γδ lineage commitment. Immunity 4, 37-45.
62. Zúniga-Pflücker, J.C., and Lenardo, M.J. (1996). Regulation of thymocyte development from immature progenitors. Curr. Opin. Immunol. 8, 215-224.
63. Zúniga-Pflücker, J.C., Jiang, D., and Lenardo, M.J. (1995). Requirement for TNF-α and IL-1α in fetal thymocyte commitment and differentiation. Science 268, 1906-1909.