Relationship of folate to colorectal and cervical cancer: Review and recommendations for practitioners

Journal of the American Dietetic Association

Volumn 102, Issue 9, 2002, Pages 1273-1282

  Rampersaud, Gail C ^a   Bailey, Lynn B ^a   Kauwell, Gail P A ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); DNA; FOLIC ACID;

ALCOHOL CONSUMPTION; CANCER PREVENTION; CANCER RISK; CARCINOGENESIS; COLON CANCER; COLORECTAL ADENOMA; COLORECTAL CANCER; DNA METHYLATION; DNA SYNTHESIS; FOLATE METABOLISM; FOOD INTAKE; FRUIT; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC DIFFERENCE; GENETIC POLYMORPHISM; HEALTH PRACTITIONER; PRACTICE GUIDELINE; PRECANCER; REVIEW; RISK FACTOR; UTERINE CERVIX CANCER; UTERINE CERVIX DYSPLASIA; VEGETABLE; VITAMIN INTAKE; VITAMIN SUPPLEMENTATION; COLORECTAL TUMOR; CONFIDENCE INTERVAL; DNA DAMAGE; DRUG EFFECT; FEMALE; GENETICS; HUMAN; RISK; UTERINE CERVIX TUMOR;

COLORECTAL NEOPLASMS; CONFIDENCE INTERVALS; DNA DAMAGE; DNA METHYLATION; FEMALE; FOLIC ACID; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; ODDS RATIO; RISK FACTORS; UTERINE CERVICAL NEOPLASMS;

EID: 0012971192     PISSN: 00028223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-8223(02)90281-6     Document Type: Review

References (88)

1. Food standards: Amendment of the standards of identity for enriched grain products to require addition of folic acid. Final Rule. (codified at 21 CFR Part 136, 137, and 139) 61 Federal Register 8781-8807 (1996).
2. Gregory JF. Bioavailability of folate. Eur J Clin Nutr. 1997;51(suppl 1):S54-S59.
3. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin 66, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press; 1998.
4. Suitor CW, Bailey LB. Dietary folate equivalents: interpretation and application. J Am Diet Assoc. 2000;100:88-94.
5. Bailey LB, Moyers S, Gregory JF III. Folate. In: Bowman BA, Russell RM, eds. Present Knowledge in Nutrition. 8th ed. Washington, DC: ILSI Press; 2001:214-229.
6. Momparler RL, Bovenzi V. DNA methylation and cancer. J Cell Physiol. 2000;183:145-154.
7. Lai C, Shields PG. The role of interindividual variation in human carcinogenesis. J Nutr. 1999;129:5525-5553.
8. Ames BN. DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutat Res. 2001;475:7-20.
9. James SJ, Basnakian AG, Miller BJ. In vitro folate deficiency induces deoxynucleotide pool imbalance, apoptosis, and mutagenesis in Chinese hamster ovary cells. Cancer Res. 1994;54:5075-5080.
10. Choi S-W, Mason JB. Folate and carcinogenesis: an integrated scheme. J Nutr. 2000;130:129-132.
11. Blount BC, Mack MM, Wehr CM, MacGregor JT, Hiatt RA, Wang G, Wickramasinghe SN, Everson RB, Ames BN. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci. 1997;94:3290-3295.
12. Robertson KD, Jones PA. DNA methylation: past, present and future directions. Carcinogenesis. 2000;21:461-467.
13. World Cancer Research Fund. Food, Nutrition and the Prevention of Cancer: A global perspective. Washington, DC: American Institute for Cancer Research; 1997.
14. Balaghi M, Wagner C. DNA methylation in folate deficiency: use of CpG methylase. Biochemical and Biophysical Research Communications. 1993;193:1184-1190.
15. Kim Y-I, Pogribny IP, Basnakian AG, Miller JW, Selhub J, James SJ, Mason JB. Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene. Am J Clin Nutr. 1997;65:46-52.
16. Jacob RA, Gretz DM, Taylor PC, James SJ, Pogribny IP, Miller BJ, Henning SM, Swendseid ME. Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women. J Nutr. 1998;128:1204-1212.
17. Rampersaud GC, Kauwell GPA, Hutson AD, Cerda JJ, Bailey LB. Genomic DNA methylation decreases in response to moderate folate depletion in elderly women. Am J Clin Nutr. 2000;72:998-1003.
18. Halsted CH. Alcohol and folate interactions: Clinical implications. In: Bailey LB, ed. Folate in Health and Disease. New York, NY: Marcel Dekker; 1995:313-327.
19. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJH, den Heijer M, Kluijtmans LAJ, van den Heuvel LP, Rozen R. A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995;10:111-113.
20. Stern LL, Mason JB, Selhub J, Choi S-W. Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiol Biomarkers Prev. 2000;9:849-853.
21. Nelen WLDM, Blom HJ, Thomas CMG, Steegers EAP, Boers GHJ, Eskes TKAB. Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages. J Nutr. 1998;128:1336-1341.
22. Molloy AM, Daly S, Mills JL, Whitehead AS, Ramsbottom D, Conley MR, Weir DG, Scott JM. Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: Implications for folate intake recommendations. Lancet. 1997;349:1591-1593.
23. Brattstrom L, Wilchen DEI, Ohrvik J, Brudin L. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease-the result of a meta-analysis. Circulation. 1998;98:2520-2526.
24. Gudnason V, Stansbie D, Scott J, Browron A, Nicaud V, Humphries S. C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR): Its frequency and impact on plasma homocysteine concentration in different European populations. Atherosclerosis. 1998;136:347-354.
25. Ou CY, Stevenson RE, Brown VK, Schwartz CE, Allen WP, Khoury MJ, Rozen R, Oakley GP, Adams MJ. 5,10-methylenetetrahydrofolate reductase genetic polymorphism as a risk factor for neural tube defects. Am J Med Genet. 1996;63:610-614.
26. van der Put, NM, Steeger-Theunissen RP, Fross P, Trijbels FJ, Eskes TK, van den Heuvel LP, Mariman EC, den Heyer M, Roxen R, Blom HJ. Mutated methlenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet. 1995;346:1070-1071.
27. van der Put NM, Eskes TK, Blom HJ. Is the common 677C→T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A meta-analysis. Q J Med. 1997;90:111-115.
28. Whitehead AS, Gallagher P, Mills JL, Kirke PN, Burke H, Molloy AM, Weir DG, Shields DC, Scott JMA. A genetic defect in 5,10-methylenetetrahydrofolate reductase in neural tube defects. Q J Med. 1995;88:763-766.
29. Kauwell GPA, Wilsky CE, Cerda JJ, Herrlinger-Garcia K, Hutson AD, Theriaque DW, Boddie A, Rampersaud GC, Bailey LB. Methylenetetrahydrofolate reductase mutation (677C→T) negatively influences plasma homocysteine response to marginal folate intake in elderly women. Metabolism. 2000;49:1440-1443.
30. Rosenberg IH, Rosenberg LE. The implications of genetic diversity for nutrient requirements: The case of folate. Nutr Rev. 1998;56:S47-S53.
31. Steinmetz KA, Potter JD. Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc. 1996;96:1027-1039.
32. Willet WC. Diet and cancer. Oncologist. 2000;5:393-404.
33. Kim Y-I. Folate and cancer prevention: a new medical application of folate beyond hyperhomocysteinemia and neural tube defects. Nutr Rev. 1999;57:314-321.
34. Ulvik A, Evensen ET, Lien EA, Hoff G, Vollset SE, Majak BM, Ueland PM. Smoking, folate and methylenetetrahydrofolate reductase status as interactive determinants of adenomatous and hyperplastic polyps of colorectum. Am J Med Gen. 2001;101:246-254.
35. Su LJ, Arab L. Nutritional status of folate and colon cancer risk: Evidence from NHANES I Epidemiologic Follow-up Study. Ann Epidemiol. 2001;11:65-72.
36. Giovannucci E, Stampfer MJ, Colditz GA, Hunter DJ, Fuchs C, Rosner BA, Speizer FE, Willett WC. Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study. Ann Intern Med. 1998;129:517-524.
37. Glynn SA, Albanes D, Pietinen P, Brown CC, Rautalahti M, Tangrea JA, Gunter EW, Barrett MJ, Virtamo J, Taylor PR. Colorectal cancer and folate status: a nested case-control study among male smokers. Cancer Epidemiol Biomarkers Prev. 1996;5:487-494.
38. Giovannucci E, Stampfer MJ, Colditz GA, Rimm EB, Trichopoulos D, Rosner BA, Speizer FE, Willett WC. Folate, methionine, and alcohol intake and risk of colorectal adenoma. J Natl Cancer Inst. 1993;85:875-884.
39. White E, Shannon JS, Patterson RE. Relationship between vitamin and calcium supplement use and colon cancer. Cancer Epidemiol Biomarkers Prev. 1997;6:769-774.
40. Ferraroni M, La Vecchia C, D'Avanzo B, Negri E, Franceschi S, Decarli A. Selected micronutrient intake and the risk of colorectal cancer. Br J Cancer. 1994;70:1150-1155.
41. Freudenheim JL, Graham S, Marshall JR, Haughey BP, Cholewinski S, Wilkinson G. Folate intake and carcinogenesis of the colon and rectum. Int J Epidemiol. 1991;20:368-374.
42. Bird CL, Swendseid ME, Witte JS, Shikany JM, Hunt IF, Frankl HD, Lee ER, Longnecker MP, Haile RW. Red cell and plasma folate, folate consumption, and the risk of colorectal adenomatous polyps. Cancer Epidemiol Biomarkers Prev. 1995;4:709-714.
43. Giovannucci E, Rimm EB, Ascherio A, Stampfer MJ, Colditz GA, Willett WC. Alcohol, low-methionine-low-folate diets, and risk of colon cancer in men. J Natl Cancer Inst. 1995;87:265-273.
44. Baron JA, Sandler RS, Haile RW, Mandel JS, Mott LA, Greenberg ER. Folate intake, alcohol consumption, cigarette smoking, and risk of colorectal adenomas. J Natl Cancer Inst. 1998;90:57-62.
45. Boutron-Ruault M-C, Senesse P, Faivre J, Couillault C, Belghiti C. Folate and alcohol intakes: related or independent roles in the adenoma-carcinoma sequence? Nutr Cancer. 1996;26:337-346.
46. Lashner BA, Heidenreich PA, Su GL, Kane SV, Hanauer SB. Effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis. Gastroenterology. 1989;97:255-259.
47. Lashner BA, Provencher KS, Seidner DL, Knesebeck A, Brzezinski A. The effect of folio acid supplementation on the risk for cancer or dysplasia in ulcerative colitis. Gastroenterology. 1997;112:29-32.
48. Benito E, Stiggelbout A, Bosch FX, Obrador A, Kaldor J, Mulet M, Munoz N. Nutritional factors in colorectal cancer risk: a case-control study in Majorca. Int J Cancer. 1991;49:161-167.
49. Tavani A, Ferraroni M, Mezzetti M, Franceschi S, Lo Re A, La Vecchia C. Alcohol intake and risk of cancers of the colon and rectum. Nutr Cancer. 1998;30:213-219.
50. Levi F, Pasche C, Lucchini F, La Vecchia C. Selected micronutrients and colorectal cancer: A case-control study from the Canton of Vaud, Switzerland. Eur J Cancer. 2000;36:2115-2119.
51. Meyer F, White E. Alcohol and nutrients in relation to colon cancer in middle-aged adults. Am J Epidemiol. 1993;138:225-236.
52. Slattery ML, Schaffer D, Edwards SL, Ma, K-N, Potter JD. Are dietary factors involved in DNA methylation associated with colon cancer? Nutr Cancer. 1997;28:52-62.
53. Benito E, Cabeza E, Moreno V, Obrador A, Bosch FX. Diet and colorectal adenomas: A case-control study in Majorca. Int J Cancer. 1993;55:213-219.
54. Tseng M, Murray SC, Kupper LL, Sandler RS. Micronutrients and the risk of colorectal adenomas. Am J Epidemiol. 1996;144:1005-1014.
55. Giuliano AR, Gapstur S. Can cervical dysplasia and cancer be prevented with nutrients? Nutr Rev. 1998;56:9-16.
56. Alberg AJ, Selhub J, Shah KV, Viscidi RP, Comstock GW, Helzlsouer KJ. The risk of cervical cancer in relation to serum concentrations of folate, vitamin B12, and homocysteine. Cancer Epioemiol Biomarkers Prev. 2000;9:761-764.
57. Brock KE, Berry G, Mock PA, MacLennan R, Truswell AS, Brinton LA. Nutrients in diet and plasma and risk of in situ cervical cancer. J Natl Cancer Inst. 1988;80:580-585.
58. Ziegler RG, Jones CJ, Brinton LA, Norman SA, Mallin K, Levine RS, Lehman HF, Hamman RF, Trumble AC, Rosenthal JF, Hoover RN. Diet and the risk of in situ cervical cancer among white women in the United States. Cancer Causes Control. 1991;2:17-29.
59. Verreault R, Chu J, Mandelson M, Shy K. A case-control study of diet and invasive cervical cancer. Int J Cancer. 1989;43:1050-1054.
60. Ziegler RG, Brinton LA, Hamman RF, Lehman HF, Levine RS, Mallin K, Norman SA, Rosenthal JF, Trumble AC, Hoover RN. Diet and the risk of invasive cervical cancer among white women in the United States. Am J Epidemiol. 1990;132:432-445.
61. Weinstein SJ, Ziegler RG, Frongillo EA, Colman N, Sauberlich HE, Brinton LA, Hamman RF, Levine RS, Mallin K, Stolley PD, Bisogni CA. Low serum and red blood cell folate are moderately but nonsignificantly associated with increased risk of invasive cervical cancer in US women. J Nutr. 2001;131:2040-2048.
62. Potischman N, Brinton LA, Laiming VA, Reeves WC, Brenes MM, Herrero R, Tenorio F, de Britton RC, Gaitan E. A case-control study of serum folate levels and invasive cervical cancer. Cancer Res. 1991;51:4785-4789.
63. Buckley DI, McPherson RS, North CQ, Becker TM. Dietary micronutrients and cervical dysplasia in southwestern American Indian women. Nutr Cancer. 1992;17:179-185.
64. VanEenwyk J, Davis FG, Colman N. Folate, vitamin C, and cervical intraepithelial neoplasia. Cancer Epidemiol Biomarkers Prev. 1992;1:119-124.
65. Liu T, Soong S-J, Wilson NP, Craig CB, Cole P, Macatuso M, Butterworth CE. A case control study of nutritional factors and cervical dysplasia. Cancer Epidemiol Biomarkers Prev. 1993;2:525-530.
66. Wideroff I, Potischman N, Glass AG, Greer CE, Manos MM, Scott DR, Burk RD, Sherman ME, Wacholder S, Schiffman M. A nested case-control study of dietary factors and the risk of incident cytological abnormalities of the cervix. Nutr Cancer. 1998;30:130-136.
67. Butterworth CE, Hatch KD, Macaluso M, Cole P, Sauberlich HE, Soong S-J, Borst M, Baker VV. Folate deficiency and cervical dysplasia. JAMA. 1992;267:528-533.
68. Goodman MT, McDuffie K, Hernandez B, Wilkens LR, Selhub J. Case-control study of plasma folate, homocysteine, vitamin B12, and cysteine as markers of cervical dysplasia. Cancer. 2000;89:376-382.
69. Kwasniewska A, Tukendorf A, Semczuk M. Folate deficiency and cervical intraepithelial neoplasia. Eur J Gynaec Oncol. 1997;18:526-530.
70. Butterworth CE, Hatch KD, Gore H, Mueller H, Krumdieck CL. Improvement in cervical dysplasia associated with folic acid therapy in users of oral contraceptives. Am J Clin Nutr. 1982;35:73-82.
71. Butterworth CE, Hatch KD, Soong S-J, Cole P, Tamura T, Sauberlich HE, Borst M, Macaluso M, Baker V. Oral folic acid supplementation for cervical dysplasia: A clinical intervention trial. Am J Obstet Gynecol. 1992;166:803-809.
72. Childers JM, Chu J, Voigt LF, Feigi P, Tamimi HK, Franklin EW, Alberts DS, Meyskens FL. Chemoprevention of cervical cancer with folic acid: a phase III Southwest Oncology Group Intergroup study. Cancer Epidemiol Biomarkers Prev. 1995;4:155-159.
73. Lyle BJ, Mares-Perlman JA, Klein BEK, Klein R, Greger JL. Supplement users differ from nonusers in demographic, lifestyle, dietary and health characteristics. J Nutr. 1998;128:2355-2362.
74. Patterson RE, Neuhouser ML, White E, Hunt JR, Kristal AR. Cancer-related behavior of vitamin supplement users. Cancer Epidemiol Biomarkers Prev. 1998;7:79-81.
75. Piyathilake CJ, Macaluso M, Johanning GL, Whiteside M, Heimburger DC, Giuliano A. Methylenetetrahydrofolate reductase (MTHFR) polymorphism increases the risk of cervical intraepithelial neoplasia. Anticancer Res. 2000;20:1751-1758.
76. Ma J, Stampfer MJ, Giovannucci E, Artigas C, Hunter DJ, Fuchs C, Willett WC, Selhub J, Hennekens CH, Rozen R. Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res. 1997;57:1098-1102.
77. Slattery ML, Potter JD, Samowitz W, Schaffer D, Leppert M. Methylenetetrahydrofolate reductase, diet, and risk of colon cancer. Cancer Epidemiol Biomarkers Prev. 1999;8:513-518.
78. Chen J, Giovannucci E, Kelsey K, Rimm EB, Stampfer MJ, Colditz GA, Spiegelman D, Willett WC, Hunter DJ. Amethylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. Cancer Res. 1996;56:4862-4864.
79. Park KS, Mok JW, Kim JC. The 677C→T mutation in 5,10- methylenetetrahydrofolate reductase and colorectal cancer risk. Genet Test. 1999;3:233-236.
80. Marugame T, Tsuji E, Inoue H, Shinomiya S, Kiyohara C, Onuma K, Hamada H, Koga H, Handa K, Hayabucni H, Kono S. Methylenetetrahydrofolate reductase polymorphism and risk of colorectal adenomas. Cancer Lett. 2000;151:181-186.
81. Ulrich CM, Kampman E, Bigler J, Schwartz SM, Chen C, Bostick R, Fosdick L, Beresford SAA, Yasui Y, Potter JD. Colorectal adenomas and the C677T MTHFR polymorphism: evidence for gene-environment interaction? Cancer Epidemiol Biomarkers Prev. 1999;8:659-668.
82. Levine AJ, Siegmund KD, Ervin CM, Diep A, Lee ER, Frankl HD, Haile RW. The methylenetetrahydrofolate reductase 677CÆT polymorphism and distal colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev. 2000;9:657-663.
83. Chen J, Giovannucci E, Hankinson SE, Ma J, Willett WC, Spiegelman D, Kelsey KT, Hunter DJ. A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma. Carcinogenesis. 1998;19:2129-2132.
84. Ryan BM, Weir DG. Relevance of folate metabolism in the pathogenesis of colorectal cancer. J Lab Clin Med. 2001;138:164-176.
85. Centers for Disease Control and Prevention. Folate status in women of childbearing age - United States, 1999. MMWR. 2000;49:962-965.
86. Jacques PF, Selhub J, Bostom AG, Wilson PWF, Rosenberg IH. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med. 1999;340:1449-1454.
87. Lawrence JM, Petitti DB, Watkins M, Umekubo MA. Trends in serum folate after food fortification. Lancet. 1999;354:915-916.
88. Caudill MA, Le T, Moonie SA, Esfahani ST, Cogger EA. Folate status in women of childbearing age residing in Southern California after folic acid fortification. J Am Coll Nutr. 2001;20:129-134.