The methylenetetrahydrofolate reductase 677C→T polymorphism and distal colorectal adenoma risk

Cancer Epidemiology Biomarkers and Prevention

Volumn 9, Issue 7, 2000, Pages 657-663

  Levine, A Joan ^a   Siegmund, Kimberly D ^a   Ervin, Carolyn M ^a   Diep, Anh ^a   Lee, Eric R ^b   Frankl, Harold D ^c   Haile, Robert W ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b KAISER PERMANENTE   (United States)

^c KAISER PERMANENTE MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLENETETRAHYDROFOLIC ACID;

ADULT; ALLELE; ARTICLE; CANCER RISK; COLORECTAL CARCINOMA; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; FEMALE; FOLIC ACID BLOOD LEVEL; GENE EXPRESSION; GENETIC POLYMORPHISM; HEALTH CARE PLANNING; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; METHYLATION; PRIORITY JOURNAL; QUESTIONNAIRE; RISK ASSESSMENT; SIGMOIDOSCOPY; STATISTICAL ANALYSIS;

ADENOMA; AGED; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; CYTOSINE; FEMALE; GENOTYPE; HUMANS; LOSS OF HETEROZYGOSITY; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; POINT MUTATION; POLYMORPHISM, GENETIC; RISK ASSESSMENT; SIGMOIDOSCOPY; THYMINE;

EID: 0033942127     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Eto, I., and Krumdieck, C. L. Role of vitamin B12 and folate deficiencies in carcinogenesis. Adv. Exp. Med. Biol., 206: 313-330, 1986.
2. Selhub, J., and Miller, J. W. The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine. Am. J. Clin. Nutr., 55: 131-138, 1992.
3. Frosst, P., Blom, H. J., Milos, R., Goyette, P., Sheppard, C. A., Matthews, R. G., Boers, G. J., den Heijer, M., Kluijtmans, L. A., van den Heuvel, L. P., et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat. Genet., 10: 111-113, 1995.
4. Deloughery, T. G., Evans, A., Sadeghi, A., McWilliams, J., Henner, W. D., Taylor, L. M., Jr., and Press, R. D. Common mutation in methylenetetrahydrofolate reductase: correlation with homocysteine metabolism and late-onset vascular disease. Circulation, 94: 3074-3078, 1996.
5. Jacques, P. F., Bostom, A. G., Williams, R. R., Ellison, R. C., Eckfeldt, J. H., Rosenberg, I. H., Selhub, J., and Rozen, R. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations [see comments]. Circulation, 93: 7-9, 1996.
6. Harmon, D. L., McMaster, D., Shields, D. C., Whitehead, A. S., and Rea, I. M. MTHFR thermolabile genotype frequencies and longevity in Northern Ireland. Atherosclerosis, 131: 137-138, 1997.
7. Christensen, B., Frosst, P., Lussier-Cacan, S., Selhub, J., Goyette, P., Rosenblatt, D. S., Genest, J., Jr., and Rozen, R. Correlation of a common mutation in the methylenetetrahydrofolate reductase gene with plasma homocysteine in patients with premature coronary artery disease. Arterioscler. Thromb. Vasc. Biol., 17: 569-573, 1997.
8. Malinow, M. R., Nieto, F. J., Kruger, W. D., Duell, P. B., Hess, D. L., Gluckman, R. A., Block, P. C., Holzgang, C. R., Anderson, P. H., Seltzer, D., Upson, B., and Lin, Q. R. The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes. Arterioscler. Thromb. Vasc. Biol., 17: 1157-1162, 1997.
9. Nelen, W. L., Blom, H. J., Thomas, C. M., Steegers, E. A., Boers, G. H., and Eskes, T. K. Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages. J. Nutr., 128: 1336-1341, 1998.
10. Chen, J., Giovannucci, E., Kelsey, K., Rimm, E. B., Stampfer, M. J., Colditz, G. A., Spiegelman, D., Willett, W. C., and Hunter, D. J. A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. Cancer Res., 56: 4862-4864, 1996.
11. Ma, J., Stampfer, M. J., Giovannucci, E., Artigas, C., Hunter, D. J., Fuchs, C., Willett, W. C., Selhub, J., Hennekens, C. H., and Rozen, R. Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res., 57: 1098-1102, 1997.
12. Slattery, M. L., Potter, J. D., Samowitz, W., Schaffer, D., and Leppert, M. Methylenetetrahydrofolate reductase, diet, and risk of colon cancer. Cancer Epidemiol. Biomark. Prev., 8: 513-518, 1999.
13. Chen, J., Giovannucci, E., Hankinson, S. E., Ma, J., Willett, W. C., Spiegelman. D., Kelsey, K. T., and Hunter, D. J. A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma. Carcinogenesis (Lond.), 19: 2129-2132, 1998.
14. Ulrich, C. M., Bigler, J., Chen, J., Chu, C., Kampman, E., Schwartz, S., Fodsick, L., Dosdick, R., and Potter, J. D. MTHFR polymorphism and risk of adenomatous polyps. Cancer Epidemiol. Biomark. Prev., 8: 659-658, 1999.
15. Morson, B. C. Polyps and cancer of the large bowel. Monogr. Pathol., 18: 101-108, 1977.
16. Haile, R. W., Witte, J. S., Longnecker, M. P., Probst-Hensch, N., Chen, M. J., Harper, J., Frankl, H. D., and Lee, E. R. A sigmoidoscopy-based case-control study of polyps: macronutrients, fiber and meat consumption. Int. J. Cancer, 73: 497-502, 1997.
17. Rimm, E. B., Giovannucci, E. L., Stampfer, M. J., Colditz, G. A., Litin, L. B., and Willett, W. C. Reproducibility and validity of an expanded self-administered semiquantitative food frequency questionnaire among male health professionals. Am. J. Epidemiol., 135: 1114-1126, 1992.
18. Willett, W. C. Nutritional Epidemiology. New York: Oxford University Press, pp 69-132, 1990.
19. United States Department of Agriculture, Monitoring Division Survey Statistics Branch, Human Nutrition Information Service. Machine-readable data sets on composition of foods and results from food consumption surveys. In: S. S. Branch (ed.), Administrative Report No. 378. Hyattsville, MD: United States Department of Agriculture, 1991.
20. Bird, C. L., Swendseid, M. E., Witte, J. S., Shikany, J. M., Hunt, I. F., Frankl, H. D., Lee, E. R., Longnecker, M. P., and Haile, R. W. Red cell and plasma folate, folate consumption, and the risk of colorectal adenomatous polyps. Cancer Epidemiol. Biomark. Prev., 4: 709-714, 1995.
21. Kune, G. A., Kune, S., Read, A., MacGowan, K., Penfold, C., and Watson, L. F. Colorectal polyps, diet, alcohol, and family history of colorectal cancer: a case-control study. Nutr. Cancer, 16: 25-30, 1991.
22. Hoffbrand, A. V., Newcombe, F. A., and Mollin, D. L. Method of assay of red cell folate activity and the value of the assay as a test for folate deficiency. J. Clin. Pathol., 19: 17-28, 1966.
23. Giovannucci, E., Rimm, E. B., Ascherio, A., Stampfer, M. J., Colditz, G. A., and Willett, W. C. Alcohol, low-methionine: low-folate diets, and risk of colon cancer in men. J. Natl. Cancer Inst., 87: 265-273, 1995.
24. Giovannucci, E., Stampfer, M. J., Colditz, G. A., Rimm, E. B., Trichopoulos, D., Rosner, B. A., Speizer, F. E., and Willett, W. C. Folate, methionine, and alcohol intake and risk of colorectal adenoma. J. Natl. Cancer Inst., 85: 875-884, 1993.
25. Foutch, P. G., Mai, H., Pardy, K., DiSario, J. A., Manne, R. K., and Kerr, D. Flexible sigmoidoscopy may be ineffective for secondary prevention of colorectal cancer in asymptomatic, average-risk men. Dig. Dis. Sci., 36: 924-928, 1991.
26. Rex, D. K., Lehman, G. A., Ulbright, T. M., Smith, J. J., Pound, D. C., Hawes, R. H., Helper, D. J., Wiersema, M. J., Langefeld, C. D., and Li, W. Colonic neoplasia in asymptomatic persons with negative fecal occult blood tests: influence of age, gender, and family history. Am. J. Gastroenterol., 88: 825-831, 1993.
27. Hoff, G. Colorectal polyps: clinical implications: screening and cancer prevention. Scand. J. Gastroenterol., 22: 769-775, 1987.
28. Harmon, D. L., Woodside, J. V., Yarnell, J. W., McMaster, D., Young, I. S., McCrum, E. E., Gey, K. F., Whitehead, A. S., and Evans, A. E. The common "thermolabile" variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia. Q. J. Med., 89: 571-577, 1996.
29. Kim, Y. I., Fawaz, K., Knox, T., Lee, Y. M., Norton, R., Arora, S., Paiva, L., and Mason, J. B. Colonic mucosal concentrations of folate correlate well with blood measurements of folate status in persons with colorectal polyps [see comments]. Am. J. Clin. Nutr., 68: 866-872, 1998.
30. Kim, Y. I., Pogribny, I. P., Basnakian, A. G., Miller, J. W., Selhub, J., James, S. J., and Mason, J. B. Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene. Am. J. Clin. Nutr., 65: 46-52, 1997.
31. James, S. J., Yin, L., and Swendseid, M. E. DNA strand break accumulation, thymidylate synthesis and NAD levels in lymphocytes from methyl donor-deficient rats. J. Nutr., 119: 661-664, 1989.
32. Blount, B. C., and Ames, B. N. DNA damage in folate deficiency. Baillieres Clin. Haematol., 8: 461-478, 1995.
33. Molloy, A. M., Daly, S., Mills, J. L., Kirke, P. N., Whitehead, A. S., Ramsbottom, D., Conley, M. R., Weir, D. G., and Scott, J. M. Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations. Lancet, 349: 1591-1593, 1997.
34. van der Put, N. M., Steegers-Theunissen, R. P., Frosst, P., Trijbels, F. J., Eskes, T. K., van den Heuvel, L. P., Mariman, E. C., den Heyer, M., Rozen, R., and Blom, H. J. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet, 346: 1070-1071, 1995.
35. Seitz, H. K., and Simanowski, U. A. Alcohol and carcinogenesis. Annu. Rev. Nutr., 8: 99-119, 1988.